GREMLIN Database
DUF3363 - Protein of unknown function (DUF3363)
PFAM: PF11843 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 378 (374)
Sequences: 1513 (840)
Seq/√Len: 43.4
META: 0.771

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
337_D340_E7.8091.00
43_R46_H6.4101.00
353_R356_Q4.5711.00
292_E296_A3.7471.00
16_E20_G3.7131.00
327_L330_G3.4831.00
148_P165_V3.3471.00
6_Q9_E2.9171.00
37_E47_R2.8231.00
36_G40_D2.6721.00
220_P224_Q2.5921.00
321_Y354_L2.5541.00
57_D60_I2.5261.00
79_G89_Y2.5221.00
16_E19_P2.5021.00
75_V90_L2.4511.00
4_R8_L2.4401.00
353_R371_L2.4231.00
29_E33_R2.3651.00
27_D30_P2.3581.00
175_L180_I2.3221.00
283_N287_T2.3011.00
102_V121_V2.2921.00
56_R60_I2.2021.00
247_D252_R2.1961.00
173_E176_R2.1841.00
75_V119_V2.1751.00
238_V284_L2.1581.00
237_L258_L2.1551.00
37_E43_R2.1421.00
9_E16_E2.1190.99
118_I250_F2.0940.99
175_L202_Y2.0880.99
323_R334_M2.0630.99
347_R368_S2.0560.99
326_D331_R2.0350.99
194_D198_R2.0120.99
48_A77_A1.9980.99
138_I150_L1.9750.99
2_I9_E1.9530.99
227_A328_A1.9150.99
152_L165_V1.8810.99
321_Y364_G1.8570.99
120_E216_L1.8570.99
192_P195_L1.8470.99
321_Y324_S1.8170.98
256_E260_Q1.7690.98
15_E23_R1.7570.98
46_H49_L1.7520.98
324_S331_R1.7490.98
126_A207_A1.7430.98
236_E239_S1.7420.98
55_P58_L1.7380.98
2_I6_Q1.7340.98
199_A203_D1.7330.98
131_A134_T1.7100.98
308_F342_T1.7070.98
146_Y151_H1.6930.97
147_S150_L1.6880.97
120_E214_E1.6640.97
163_A166_E1.6600.97
195_L199_A1.6560.97
358_V361_I1.6550.97
82_D85_R1.6340.97
74_R253_E1.6150.97
296_A327_L1.6120.97
280_L284_L1.6060.96
301_A304_T1.5850.96
237_L329_S1.5740.96
44_T101_Y1.5730.96
145_R184_E1.5650.96
3_G12_G1.5560.96
228_D295_R1.5500.96
233_L258_L1.5500.96
176_R183_R1.5470.96
206_R209_R1.5210.95
56_R62_D1.5210.95
135_I195_L1.5180.95
36_G39_G1.5180.95
86_D101_Y1.5000.95
219_L328_A1.4920.95
80_L83_E1.4860.95
192_P198_R1.4750.94
350_L358_V1.4720.94
259_A262_R1.4720.94
24_L28_L1.4590.94
170_R173_E1.4370.93
36_G41_I1.4030.93
92_V119_V1.3910.92
147_S186_D1.3860.92
232_W288_L1.3760.92
62_D68_A1.3720.92
336_E340_E1.3590.91
312_A315_E1.3480.91
300_L304_T1.3410.91
264_W268_Q1.3330.91
43_R49_L1.3260.90
180_I192_P1.3260.90
196_L199_A1.3080.90
122_G214_E1.3070.90
152_L162_E1.2980.89
181_V192_P1.2960.89
316_R359_S1.2840.89
170_R176_R1.2810.89
7_K10_R1.2690.88
229_G328_A1.2670.88
175_L199_A1.2650.88
332_F351_E1.2640.88
91_V243_S1.2460.87
55_P62_D1.2450.87
360_G367_I1.2410.87
326_D332_F1.2380.87
91_V371_L1.2370.87
17_V23_R1.2310.87
173_E177_R1.2300.87
197_E200_R1.2250.86
71_I81_A1.2240.86
202_Y206_R1.2230.86
295_R299_Q1.2210.86
371_L374_Q1.2200.86
114_P117_A1.2200.86
20_G26_P1.2160.86
358_V368_S1.2130.86
184_E190_R1.2090.86
4_R14_A1.2080.86
139_A142_N1.2060.86
61_F99_A1.2050.86
18_G21_R1.2050.86
63_P68_A1.2050.86
249_G254_V1.2050.86
292_E327_L1.1900.85
87_R103_E1.1880.85
78_K88_H1.1880.85
21_R49_L1.1840.85
245_L254_V1.1720.84
346_W351_E1.1690.84
229_G308_F1.1690.84
39_G42_I1.1620.83
25_A28_L1.1600.83
311_A342_T1.1550.83
8_L14_A1.1530.83
347_R351_E1.1490.83
219_L229_G1.1470.83
105_G210_P1.1410.82
342_T347_R1.1410.82
155_D158_A1.1380.82
42_I46_H1.1330.82
175_L192_P1.1270.81
150_L153_A1.1250.81
9_E22_W1.1250.81
5_L8_L1.1170.81
84_L224_Q1.1140.81
278_V284_L1.1070.80
165_V169_V1.1060.80
182_E190_R1.1040.80
173_E183_R1.1020.80
55_P60_I1.1020.80
334_M340_E1.0990.80
30_P34_A1.0980.80
95_V243_S1.0980.80
94_G100_H1.0980.80
48_A91_V1.0780.78
49_L320_I1.0720.78
262_R266_I1.0710.78
138_I158_A1.0700.78
327_L332_F1.0670.78
62_D65_G1.0660.78
372_G377_L1.0660.78
269_G376_G1.0650.78
69_R198_R1.0650.78
336_E339_R1.0600.77
41_I46_H1.0480.76
262_R273_R1.0460.76
155_D164_F1.0460.76
76_V99_A1.0450.76
351_E354_L1.0430.76
5_L20_G1.0420.76
71_I94_G1.0360.76
15_E25_A1.0200.74
286_A289_R1.0160.74
61_F102_V1.0140.74
147_S188_S1.0130.74
9_E45_M1.0120.74
318_E359_S1.0100.74
351_E356_Q1.0090.74
273_R276_G1.0090.74
278_V310_P1.0020.73
228_D264_W1.0020.73
326_D330_G1.0000.73
199_A202_Y0.9930.72
8_L13_L0.9920.72
296_A300_L0.9910.72
3_G6_Q0.9890.72
149_D152_L0.9840.72
80_L250_F0.9820.72
130_A197_E0.9800.71
149_D162_E0.9770.71
40_D43_R0.9740.71
224_Q328_A0.9680.71
27_D205_Q0.9610.70
293_L308_F0.9580.70
148_P301_A0.9570.70
42_I45_M0.9540.69
329_S332_F0.9530.69
227_A330_G0.9490.69
337_D342_T0.9490.69
311_A317_V0.9490.69
34_A37_E0.9480.69
225_V260_Q0.9460.69
158_A164_F0.9400.68
357_Q377_L0.9390.68
230_A285_L0.9350.68
238_V280_L0.9290.67
152_L156_P0.9230.67
131_A167_A0.9230.67
25_A31_T0.9210.67
75_V107_G0.9160.66
220_P223_R0.9150.66
131_A243_S0.9140.66
70_P120_E0.9140.66
145_R188_S0.9130.66
9_E46_H0.9110.66
230_A329_S0.9090.66
349_V360_G0.9080.66
72_V120_E0.9050.65
60_I63_P0.9020.65
39_G43_R0.9010.65
176_R347_R0.8980.65
356_Q361_I0.8980.65
16_E21_R0.8960.64
304_T307_P0.8900.64
98_R235_R0.8810.63
87_R303_E0.8810.63
57_D62_D0.8790.63
145_R198_R0.8790.63
193_P196_L0.8780.63
61_F123_P0.8780.63
93_D249_G0.8770.63
350_L370_T0.8730.62
343_L346_W0.8700.62
43_R297_A0.8700.62
263_Q266_I0.8680.62
196_L203_D0.8670.62
309_R342_T0.8660.62
270_L291_R0.8640.62
239_S242_P0.8640.62
136_A140_A0.8640.62
37_E46_H0.8610.61
129_R203_D0.8600.61
321_Y353_R0.8580.61
169_V176_R0.8570.61
245_L306_L0.8560.61
4_R13_L0.8560.61
118_I121_V0.8530.61
174_A202_Y0.8500.60
49_L58_L0.8410.60
25_A297_A0.8380.59
6_Q22_W0.8360.59
45_M48_A0.8360.59
78_K90_L0.8330.59
190_R233_L0.8230.58
145_R150_L0.8210.58
197_E202_Y0.8210.58
145_R190_R0.8200.58
300_L347_R0.8180.57
215_L218_H0.8180.57
189_W341_F0.8180.57
297_A301_A0.8180.57
138_I156_P0.8120.57
102_V335_I0.8120.57
132_D171_R0.8080.56
167_A184_E0.8070.56
10_R16_E0.8070.56
138_I157_S0.8040.56
318_E375_R0.8030.56
284_L287_T0.8020.56
296_A299_Q0.8020.56
155_D159_S0.7970.55
50_T53_G0.7970.55
2_I26_P0.7950.55
158_A210_P0.7950.55
290_R302_A0.7930.55
324_S334_M0.7900.55
9_E19_P0.7890.55
170_R183_R0.7880.55
103_E338_S0.7880.55
30_P43_R0.7870.54
130_A224_Q0.7810.54
172_L183_R0.7800.54
128_P196_L0.7790.54
241_G244_G0.7790.54
206_R256_E0.7780.54
80_L88_H0.7780.54
138_I155_D0.7780.54
367_I370_T0.7770.54
274_R277_R0.7760.53
75_V113_L0.7750.53
11_M35_M0.7730.53
374_Q377_L0.7730.53
297_A300_L0.7720.53
6_Q16_E0.7710.53
79_G101_Y0.7680.53
350_L365_G0.7650.52
327_L331_R0.7630.52
356_Q371_L0.7630.52
137_A140_A0.7620.52
2_I20_G0.7620.52
94_G98_R0.7600.52
169_V254_V0.7530.51
164_F168_H0.7520.51
134_T168_H0.7490.51
213_V361_I0.7480.51
29_E49_L0.7480.51
357_Q368_S0.7460.51
46_H50_T0.7450.50
162_E166_E0.7450.50
308_F366_G0.7420.50
37_E41_I0.7390.50
58_L62_D0.7320.49
366_G369_W0.7310.49
81_A101_Y0.7280.49
127_E213_V0.7260.49
260_Q325_V0.7250.49
229_G284_L0.7240.48
339_R342_T0.7230.48
219_L224_Q0.7220.48
50_T54_L0.7220.48
134_T164_F0.7190.48
136_A269_G0.7160.48
92_V256_E0.7160.48
120_E180_I0.7150.48
255_R292_E0.7140.48
175_L195_L0.7120.47
119_V179_G0.7120.47
5_L28_L0.7120.47
84_L199_A0.7110.47
290_R294_A0.7100.47
148_P169_V0.7100.47
174_A183_R0.7090.47
7_K11_M0.7080.47
304_T323_R0.7080.47
334_M339_R0.7080.47
167_A279_R0.7060.47
301_A310_P0.7060.47
369_W375_R0.7050.47
6_Q57_D0.7050.47
179_G182_E0.7050.47
294_A310_P0.7040.47
28_L199_A0.7040.47
352_R370_T0.7020.46
308_F311_A0.7010.46
155_D262_R0.6960.46
135_I232_W0.6930.46
193_P197_E0.6920.45
346_W360_G0.6920.45
138_I154_H0.6910.45
135_I175_L0.6870.45
67_D143_G0.6870.45
44_T79_G0.6820.44
159_S165_V0.6810.44
317_V362_V0.6790.44
27_D31_T0.6770.44
138_I159_S0.6750.44
256_E259_A0.6750.44
359_S363_R0.6740.44
131_A282_R0.6740.44
33_R39_G0.6730.44
54_L93_D0.6730.44
224_Q269_G0.6720.44
71_I238_V0.6710.43
67_D213_V0.6710.43
29_E41_I0.6670.43
23_R26_P0.6660.43
29_E39_G0.6660.43
331_R342_T0.6650.43
302_A312_A0.6620.43
148_P152_L0.6620.43
11_M190_R0.6610.43
199_A354_L0.6600.42
351_E360_G0.6550.42
224_Q229_G0.6550.42
262_R311_A0.6520.42
313_D359_S0.6510.42
2_I21_R0.6510.42
89_Y196_L0.6490.41
91_V99_A0.6470.41
267_E273_R0.6440.41
299_Q303_E0.6430.41
262_R278_V0.6430.41
128_P198_R0.6420.41
219_L289_R0.6410.41
88_H110_L0.6410.41
289_R332_F0.6380.40
84_L311_A0.6360.40
86_D312_A0.6350.40
150_L201_A0.6350.40
220_P227_A0.6350.40
76_V285_L0.6340.40
131_A152_L0.6340.40
179_G215_L0.6320.40
10_R15_E0.6320.40
28_L156_P0.6310.40
130_A137_A0.6300.40
31_T35_M0.6300.40
52_R253_E0.6300.40
219_L286_A0.6300.40
133_R137_A0.6300.40
56_R59_A0.6290.40
170_R177_R0.6280.39
227_A354_L0.6280.39
325_V342_T0.6270.39
89_Y202_Y0.6250.39
24_L155_D0.6250.39
52_R224_Q0.6250.39
131_A168_H0.6210.39
110_L367_I0.6210.39
292_E328_A0.6200.39
369_W372_G0.6200.39
48_A93_D0.6190.39
372_G376_G0.6170.38
43_R229_G0.6160.38
38_R189_W0.6150.38
175_L179_G0.6140.38
37_E45_M0.6130.38
267_E274_R0.6120.38
227_A321_Y0.6110.38
149_D153_A0.6110.38
213_V332_F0.6100.38
104_L107_G0.6090.38
127_E275_G0.6080.38
240_G351_E0.6070.38
285_L322_R0.6060.37
123_P204_A0.6050.37
66_E122_G0.6030.37
142_N147_S0.6030.37
190_R235_R0.6030.37
122_G320_I0.6020.37
209_R212_A0.6020.37
189_W230_A0.6020.37
318_E357_Q0.5980.37
191_I259_A0.5960.37
127_E199_A0.5940.36
138_I165_V0.5920.36
8_L32_L0.5900.36
65_G68_A0.5880.36
217_S225_V0.5880.36
367_I371_L0.5870.36
214_E220_P0.5870.36
140_A143_G0.5870.36
331_R334_M0.5870.36
2_I28_L0.5860.36
201_A205_Q0.5840.36
146_Y168_H0.5830.35
39_G46_H0.5810.35
321_Y335_I0.5810.35
95_V251_G0.5800.35
92_V213_V0.5790.35
331_R338_S0.5790.35
18_G371_L0.5780.35
89_Y291_R0.5770.35
91_V192_P0.5750.35
98_R138_I0.5740.35
71_I102_V0.5730.35
221_L255_R0.5720.34
131_A222_E0.5710.34
364_G368_S0.5690.34
87_R249_G0.5690.34
242_P335_I0.5680.34
52_R201_A0.5670.34
130_A157_S0.5670.34
177_R347_R0.5660.34
175_L227_A0.5660.34
357_Q370_T0.5650.34
77_A115_R0.5650.34
131_A236_E0.5630.34
72_V216_L0.5620.34
154_H263_Q0.5610.34
2_I205_Q0.5600.33
166_E193_P0.5600.33
360_G368_S0.5560.33
103_E112_E0.5550.33
29_E40_D0.5550.33
84_L301_A0.5550.33
36_G144_G0.5540.33
75_V79_G0.5530.33
272_E280_L0.5530.33
119_V375_R0.5530.33
199_A210_P0.5510.33
341_F344_V0.5500.33
103_E200_R0.5500.33
204_A290_R0.5490.33
113_L117_A0.5480.32
205_Q254_V0.5480.32
354_L363_R0.5470.32
125_A275_G0.5450.32
223_R361_I0.5440.32
50_T64_A0.5430.32
240_G287_T0.5430.32
181_V351_E0.5430.32
93_D96_D0.5420.32
61_F263_Q0.5410.32
61_F117_A0.5390.32
2_I5_L0.5360.31
81_A103_E0.5350.31
156_P159_S0.5350.31
359_S371_L0.5350.31
92_V270_L0.5330.31
90_L102_V0.5330.31
331_R340_E0.5320.31
114_P224_Q0.5320.31
10_R260_Q0.5290.31
77_A245_L0.5280.31
28_L50_T0.5270.31
117_A324_S0.5260.31
112_E115_R0.5260.31
75_V342_T0.5230.30
200_R204_A0.5230.30
277_R283_N0.5220.30
68_A277_R0.5220.30
350_L354_L0.5220.30
121_V292_E0.5220.30
44_T176_R0.5220.30
33_R41_I0.5210.30
128_P200_R0.5210.30
64_A376_G0.5210.30
198_R201_A0.5200.30
338_S341_F0.5190.30
370_T374_Q0.5190.30
48_A249_G0.5190.30
71_I254_V0.5180.30
281_R287_T0.5170.30
164_F211_V0.5170.30
206_R309_R0.5160.30
203_D210_P0.5140.30
352_R368_S0.5130.30
137_A266_I0.5130.30
361_I365_G0.5130.30
149_D165_V0.5130.30
73_G132_D0.5130.30
85_R91_V0.5130.30
89_Y270_L0.5120.30
176_R189_W0.5120.30
235_R283_N0.5120.30
121_V359_S0.5110.29
292_E299_Q0.5090.29
92_V247_D0.5080.29
75_V117_A0.5080.29
315_E363_R0.5080.29
35_M49_L0.5070.29
200_R213_V0.5070.29
116_G196_L0.5070.29
166_E358_V0.5060.29
168_H173_E0.5040.29
205_Q294_A0.5040.29
218_H326_D0.5030.29
370_T375_R0.5030.29
48_A56_R0.5020.29
309_R340_E0.5010.29
111_E222_E0.5010.29
334_M337_D0.5010.29
148_P192_P0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qlzA 2 0.4471 38.7 0.971 Contact Map
2kbnA 1 0.2672 38.5 0.971 Contact Map
2rcfA 3 0.1984 18.5 0.976 Contact Map
1a62A 1 0.2989 18 0.976 Contact Map
2heoA 1 0.1534 15.4 0.976 Contact Map
2wg5A 3 0.2169 12.2 0.977 Contact Map
2f2eA 4 0.2328 8.5 0.979 Contact Map
4i7aA 3 0.2011 8.5 0.979 Contact Map
5aj3Q 1 0.2672 7.2 0.98 Contact Map
1y0uA 2 0.0794 7 0.98 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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