GREMLIN Database
DUF3362 - Domain of unknown function (DUF3362)
PFAM: PF11842 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 150 (135)
Sequences: 3354 (2520)
Seq/√Len: 216.9
META: 0.757

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
77_N85_P4.9211.00
42_R64_E3.6241.00
67_K72_A3.0521.00
22_K32_S2.8551.00
22_K34_P2.8471.00
63_R67_K2.8031.00
63_R83_I2.5771.00
59_W63_R2.4501.00
72_A75_I2.4461.00
50_L62_V2.4401.00
36_Y43_E2.2321.00
41_P45_R2.2131.00
26_T33_E2.1791.00
64_E68_K2.1371.00
96_Y99_A2.0711.00
29_T32_S1.9061.00
22_K28_V1.8361.00
109_K112_K1.7861.00
23_N26_T1.7641.00
38_P43_E1.7421.00
111_K114_K1.7171.00
59_W83_I1.7021.00
13_L16_A1.6571.00
108_K111_K1.6311.00
46_L65_A1.6211.00
63_R84_P1.5861.00
9_S13_L1.5721.00
7_Y15_T1.5361.00
16_A20_T1.5321.00
21_G34_P1.5001.00
131_S134_K1.4421.00
5_D38_P1.4021.00
25_L32_S1.3981.00
104_S107_G1.3971.00
77_N86_R1.3861.00
62_V69_M1.3791.00
48_K52_R1.3491.00
124_K127_K1.3391.00
110_K113_R1.3091.00
112_K115_K1.2481.00
98_S102_K1.2471.00
17_M24_P1.2431.00
99_A103_N1.2201.00
113_R116_K1.2141.00
13_L25_L1.2111.00
127_K130_K1.2001.00
21_G39_K1.1961.00
75_I83_I1.1921.00
11_M51_L1.1561.00
107_G110_K1.1531.00
50_L65_A1.1341.00
112_K116_K1.0981.00
125_A130_K1.0791.00
131_S135_P1.0761.00
53_Y59_W1.0541.00
17_M37_V1.0501.00
100_R103_N1.0451.00
97_Q101_R1.0451.00
53_Y58_N1.0421.00
7_Y11_M1.0391.00
22_K27_K1.0331.00
9_S12_A1.0271.00
23_N33_E1.0231.00
116_K119_K0.9931.00
78_G81_C0.9861.00
106_K111_K0.9801.00
129_R132_K0.9731.00
110_K114_K0.9661.00
49_A65_A0.9631.00
124_K129_R0.9631.00
11_M16_A0.9471.00
123_K127_K0.9451.00
9_S15_T0.9431.00
40_G45_R0.9421.00
124_K128_G0.9340.99
11_M40_G0.9300.99
126_G130_K0.9270.99
124_K133_K0.9250.99
101_R104_S0.9160.99
76_G82_L0.8840.99
107_G111_K0.8830.99
16_A38_P0.8730.99
95_R100_R0.8710.99
129_R134_K0.8530.99
128_G132_K0.8500.99
114_K117_K0.8390.99
121_K124_K0.8380.99
111_K115_K0.8320.99
18_Y45_R0.8260.99
7_Y41_P0.8240.99
50_L71_R0.8220.99
9_S41_P0.8160.99
25_L54_H0.8160.99
122_R125_A0.8140.99
12_A15_T0.8110.99
117_K120_G0.8060.99
49_A61_L0.8030.98
125_A128_G0.7990.98
130_K133_K0.7980.98
40_G43_E0.7970.98
106_K109_K0.7960.98
130_K134_K0.7920.98
84_P88_P0.7840.98
59_W86_R0.7800.98
60_P63_R0.7790.98
42_R68_K0.7780.98
122_R127_K0.7750.98
103_N108_K0.7750.98
130_K135_P0.7750.98
98_S101_R0.7600.98
126_G129_R0.7560.98
27_K31_K0.7510.98
106_K110_K0.7500.98
90_G93_K0.7360.97
110_K115_K0.7250.97
60_P86_R0.7250.97
96_Y103_N0.7150.97
111_K116_K0.7130.97
55_D60_P0.7120.97
11_M25_L0.7090.97
127_K133_K0.7080.97
60_P87_Q0.7070.97
7_Y51_L0.7000.96
26_T29_T0.6970.96
108_K112_K0.6950.96
21_G36_Y0.6840.96
87_Q90_G0.6820.96
121_K125_A0.6810.96
56_P86_R0.6740.96
98_S104_S0.6720.95
36_Y41_P0.6720.95
28_V31_K0.6680.95
18_Y51_L0.6660.95
123_K128_G0.6590.95
5_D36_Y0.6580.95
129_R135_P0.6560.95
5_D44_R0.6520.95
40_G46_L0.6520.95
124_K130_K0.6460.94
53_Y60_P0.6340.94
102_K105_T0.6330.94
99_A105_T0.6320.94
61_L65_A0.6300.94
77_N88_P0.6290.94
100_R104_S0.6290.94
127_K132_K0.6240.93
109_K113_R0.6230.93
54_H84_P0.6220.93
95_R98_S0.6220.93
61_L64_E0.6200.93
128_G131_S0.6180.93
17_M58_N0.6180.93
52_R58_N0.6170.93
30_R43_E0.6160.93
79_K87_Q0.6110.93
99_A102_K0.6100.93
113_R117_K0.6090.92
132_K135_P0.6070.92
96_Y100_R0.6060.92
28_V34_P0.6040.92
127_K134_K0.6010.92
5_D41_P0.5990.92
121_K126_G0.5920.91
114_K120_G0.5890.91
5_D47_H0.5860.91
11_M44_R0.5800.91
98_S105_T0.5790.90
122_R126_G0.5780.90
90_G95_R0.5780.90
50_L69_M0.5780.90
1_D52_R0.5710.90
50_L73_D0.5700.90
27_K32_S0.5680.90
7_Y13_L0.5660.89
125_A131_S0.5660.89
51_L54_H0.5640.89
83_I86_R0.5600.89
26_T32_S0.5600.89
76_G81_C0.5590.89
122_R132_K0.5590.89
7_Y12_A0.5490.88
119_K122_R0.5480.88
24_P27_K0.5460.88
126_G132_K0.5450.88
91_T94_A0.5430.87
95_R105_T0.5380.87
6_F15_T0.5320.86
13_L23_N0.5300.86
23_N54_H0.5300.86
9_S44_R0.5290.86
115_K118_K0.5250.86
127_K131_S0.5210.85
63_R86_R0.5190.85
28_V33_E0.5180.85
102_K107_G0.5130.84
97_Q103_N0.5110.84
55_D58_N0.5090.84
108_K114_K0.5060.84
97_Q100_R0.5030.83
121_K128_G0.5020.83
45_R61_L0.5020.83
45_R51_L0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3fn5A 1 0.3667 11.9 0.951 Contact Map
3heiB 1 0.2867 11.6 0.951 Contact Map
3fayA 1 0.4867 9.9 0.953 Contact Map
4pkdB 1 0.6867 9.5 0.953 Contact Map
3g5bA 1 0.4733 9.2 0.953 Contact Map
4g1hA 1 0.2267 8.7 0.954 Contact Map
4o8tA 2 0.3667 7.4 0.956 Contact Map
3zg9A 1 0.2733 7.3 0.956 Contact Map
3pn3A 2 0.3867 7.1 0.956 Contact Map
3g66A 1 0.2467 6.9 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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