DUF3352 - PFAM28P - GREMLIN Contacts

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DUF3352 - Protein of unknown function (DUF3352)

PFAM:	PF11832	Sequences: LLAAAVVLLGLGGAAAYWLLAQSPLALLAGGSLPPPAAAKFVPADAPLYVSLSTDPDQWQKLRQFGTPEDQAALDKELDQLRDRLLADSGLDYEKDIKPWLGGEVTLAVLPPDADRDAANGAQPGYLLVLAIKDPAKARAFLQKLKQKRALAGAKDLERETYKGVTIISGRGGEPGATAVVGDDFVLIANDPKVLEAAIDTSQGGGLSLADSPGYQAALAQLPADRLLAQAYVNVPLAALAAWLGSPPPQTLAQLQQLQGLAASLGLEDDGLRLDAALLVSWLDPALRKLASEPVASKLLSRLPADTLAALSGGNLGQLWQQLLAALASNPELAQLLDQLLAQLKSALGLDLDKDLLSWMDGEFALALVPGSGLGPGGVLVVETSDRAAAEATLAKLDALAASQGLSVSPLTLGGQTVTAWTSPQGGPLALQAAHGWLDGDVVFATSGAALAAALAAKPGNSLADSPAFQAAIASLPSPNNGYFYLDVEKLLALLERQLLPALKLAELPAKPLLDAIRSLGVTSAGSDDRTTRYDIFLAL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	540 (518)
Sequences:	1085 (985)
Seq/√Len:	43.3
META:	0.735

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
162_Y	200_D	8.808	1.00
42_V	46_A	6.022	1.00
127_L	198_A	5.375	1.00
189_A	195_L	5.096	1.00
92_D	95_K	4.986	1.00
445_A	448_G	4.806	1.00
303_L	307_T	4.719	1.00
412_T	415_G	4.340	1.00
341_L	353_D	4.258	1.00
268_E	273_R	4.065	1.00
162_Y	196_E	4.049	1.00
132_I	138_A	3.883	1.00
313_G	364_F	3.761	1.00
487_D	490_K	3.509	1.00
100_W	141_F	3.396	1.00
179_A	199_I	3.387	1.00
345_K	351_D	3.333	1.00
215_Y	234_N	3.211	1.00
300_L	469_F	3.190	1.00
351_D	354_K	3.099	1.00
303_L	367_A	2.835	1.00
298_K	363_E	2.811	1.00
187_L	198_A	2.683	1.00
132_I	135_P	2.651	1.00
445_A	451_L	2.645	1.00
303_L	310_A	2.630	1.00
387_R	391_E	2.617	1.00
218_A	262_A	2.611	1.00
413_L	418_V	2.540	1.00
42_V	108_A	2.472	1.00
411_L	420_A	2.472	1.00
135_P	139_R	2.340	1.00
192_P	196_E	2.318	1.00
165_V	179_A	2.303	1.00
67_T	70_D	2.278	1.00
167_I	195_L	2.244	1.00
441_D	447_S	2.216	1.00
467_P	470_Q	2.182	1.00
42_V	129_V	2.177	1.00
441_D	448_G	2.173	1.00
165_V	199_I	2.154	1.00
108_A	127_L	2.149	1.00
480_N	483_Y	2.149	1.00
398_D	435_H	2.117	0.99
161_T	166_T	2.114	0.99
305_A	460_G	2.108	0.99
441_D	445_A	2.099	0.99
94_E	98_K	2.070	0.99
53_S	56_P	2.026	0.99
129_V	187_L	2.026	0.99
435_H	439_D	1.984	0.99
93_Y	98_K	1.963	0.99
100_W	138_A	1.930	0.99
58_Q	61_K	1.829	0.98
177_A	180_V	1.789	0.98
436_G	448_G	1.785	0.98
398_D	421_W	1.769	0.98
162_Y	199_I	1.768	0.98
179_A	195_L	1.743	0.98
444_F	448_G	1.740	0.98
384_T	390_A	1.738	0.98
96_D	99_P	1.738	0.98
6_V	9_L	1.737	0.98
14_A	18_W	1.666	0.97
444_F	447_S	1.647	0.97
134_D	137_K	1.644	0.97
378_G	382_V	1.635	0.97
62_L	108_A	1.632	0.97
10_G	15_A	1.625	0.97
189_A	205_G	1.606	0.96
398_D	401_A	1.603	0.96
51_S	104_E	1.587	0.96
511_K	515_D	1.585	0.96
48_L	231_A	1.581	0.96
510_A	514_L	1.576	0.96
307_T	463_L	1.566	0.96
359_W	390_A	1.545	0.96
77_E	80_Q	1.543	0.96
231_A	263_A	1.539	0.95
527_S	532_T	1.535	0.95
100_W	132_I	1.534	0.95
4_A	9_L	1.524	0.95
319_L	324_L	1.515	0.95
42_V	49_Y	1.510	0.95
4_A	10_G	1.510	0.95
472_A	521_G	1.504	0.95
161_T	164_G	1.482	0.94
442_V	445_A	1.481	0.94
367_A	370_P	1.475	0.94
331_P	334_A	1.471	0.94
477_P	483_Y	1.471	0.94
93_Y	99_P	1.467	0.94
355_D	396_K	1.452	0.94
121_G	157_L	1.451	0.94
468_A	487_D	1.447	0.94
258_L	266_G	1.443	0.94
167_I	177_A	1.439	0.93
299_L	312_S	1.432	0.93
360_M	390_A	1.426	0.93
41_F	185_F	1.418	0.93
65_F	71_Q	1.417	0.93
201_T	206_G	1.417	0.93
135_P	184_D	1.413	0.93
451_L	455_L	1.412	0.93
212_S	234_N	1.394	0.92
508_L	513_L	1.393	0.92
434_A	437_W	1.390	0.92
463_L	469_F	1.384	0.92
435_H	444_F	1.382	0.92
209_L	215_Y	1.381	0.92
391_E	395_A	1.378	0.92
137_K	140_A	1.375	0.92
51_S	215_Y	1.375	0.92
88_D	265_L	1.372	0.92
100_W	134_D	1.367	0.92
96_D	100_W	1.360	0.91
294_P	464_A	1.354	0.91
362_G	369_V	1.350	0.91
271_G	477_P	1.348	0.91
168_I	380_L	1.339	0.91
313_G	316_L	1.337	0.91
441_D	446_T	1.328	0.90
46_A	66_G	1.326	0.90
187_L	215_Y	1.322	0.90
41_F	187_L	1.320	0.90
106_T	111_P	1.319	0.90
20_L	23_S	1.316	0.90
360_M	382_V	1.312	0.90
158_E	311_L	1.310	0.90
67_T	72_A	1.305	0.90
63_R	66_G	1.300	0.89
350_L	356_L	1.297	0.89
137_K	365_A	1.288	0.89
479_P	482_G	1.283	0.89
223_P	264_S	1.283	0.89
77_E	83_D	1.281	0.89
5_A	8_L	1.280	0.89
160_E	196_E	1.279	0.89
8_L	13_G	1.267	0.88
387_R	390_A	1.260	0.88
169_S	173_G	1.259	0.88
285_P	291_A	1.259	0.88
468_A	485_Y	1.259	0.88
303_L	463_L	1.256	0.88
185_F	443_V	1.253	0.88
183_D	186_V	1.253	0.88
312_S	457_A	1.251	0.87
186_V	292_S	1.249	0.87
312_S	480_N	1.249	0.87
348_L	355_D	1.247	0.87
448_G	456_A	1.244	0.87
57_D	60_Q	1.241	0.87
341_L	345_K	1.234	0.87
495_L	522_V	1.231	0.87
103_G	266_G	1.219	0.86
5_A	9_L	1.218	0.86
132_I	186_V	1.214	0.86
520_L	528_D	1.214	0.86
343_Q	346_S	1.212	0.86
79_D	98_K	1.210	0.86
50_V	107_L	1.206	0.85
239_A	242_A	1.204	0.85
223_P	227_L	1.200	0.85
161_T	188_I	1.196	0.85
274_L	297_S	1.195	0.85
496_E	499_L	1.194	0.85
4_A	15_A	1.192	0.85
101_L	130_L	1.187	0.85
113_D	125_G	1.182	0.84
80_Q	83_D	1.181	0.84
272_L	392_A	1.176	0.84
6_V	10_G	1.175	0.84
528_D	533_R	1.173	0.84
102_G	355_D	1.160	0.83
505_L	509_P	1.156	0.83
224_A	264_S	1.155	0.83
476_L	483_Y	1.153	0.83
265_L	274_L	1.152	0.83
19_L	22_Q	1.149	0.83
466_S	485_Y	1.148	0.83
102_G	131_A	1.147	0.82
392_A	396_K	1.145	0.82
307_T	367_A	1.136	0.82
78_L	311_L	1.135	0.82
319_L	405_G	1.133	0.82
93_Y	467_P	1.132	0.82
41_F	53_S	1.132	0.82
337_L	340_L	1.129	0.81
66_G	69_E	1.128	0.81
436_G	441_D	1.124	0.81
163_K	200_D	1.120	0.81
53_S	58_Q	1.113	0.81
79_D	82_R	1.111	0.80
59_W	230_Q	1.109	0.80
242_A	245_G	1.106	0.80
194_V	365_A	1.104	0.80
226_R	230_Q	1.104	0.80
381_V	441_D	1.103	0.80
252_L	470_Q	1.095	0.79
30_G	315_N	1.093	0.79
186_V	189_A	1.093	0.79
438_L	455_L	1.090	0.79
199_I	307_T	1.087	0.79
351_D	355_D	1.079	0.78
3_A	6_V	1.074	0.78
42_V	215_Y	1.066	0.78
411_L	418_V	1.058	0.77
52_L	326_A	1.056	0.77
10_G	20_L	1.055	0.77
62_L	257_Q	1.049	0.76
96_D	207_L	1.048	0.76
156_D	159_R	1.046	0.76
299_L	381_V	1.044	0.76
477_P	480_N	1.043	0.76
512_P	515_D	1.041	0.76
340_L	343_Q	1.041	0.76
106_T	109_V	1.040	0.76
410_P	417_T	1.040	0.76
443_V	447_S	1.038	0.76
452_A	456_A	1.035	0.75
441_D	444_F	1.034	0.75
130_L	397_L	1.033	0.75
503_L	509_P	1.027	0.75
340_L	345_K	1.026	0.75
436_G	444_F	1.025	0.75
177_A	192_P	1.020	0.74
362_G	436_G	1.010	0.74
296_A	299_L	1.009	0.74
508_L	520_L	1.007	0.73
52_L	70_D	1.003	0.73
386_D	390_A	1.003	0.73
103_G	131_A	1.003	0.73
421_W	424_P	1.000	0.73
307_T	364_F	0.997	0.73
195_L	337_L	0.996	0.73
418_V	421_W	0.991	0.72
97_I	501_P	0.989	0.72
144_K	365_A	0.980	0.71
201_T	356_L	0.979	0.71
453_A	457_A	0.978	0.71
36_P	49_Y	0.976	0.71
129_V	201_T	0.976	0.71
9_L	22_Q	0.971	0.71
477_P	487_D	0.970	0.71
227_L	397_L	0.970	0.71
43_P	361_D	0.966	0.70
302_R	357_L	0.965	0.70
447_S	451_L	0.963	0.70
215_Y	219_L	0.963	0.70
255_L	258_L	0.962	0.70
56_P	59_W	0.962	0.70
406_L	421_W	0.962	0.70
290_L	294_P	0.961	0.70
530_R	533_R	0.958	0.70
447_S	450_A	0.957	0.69
138_A	189_A	0.956	0.69
238_A	243_W	0.956	0.69
352_L	355_D	0.953	0.69
90_G	107_L	0.953	0.69
105_V	254_Q	0.952	0.69
157_L	160_E	0.951	0.69
507_E	529_D	0.950	0.69
130_L	465_D	0.949	0.69
16_A	20_L	0.949	0.69
67_T	71_Q	0.947	0.69
267_L	419_T	0.946	0.69
3_A	34_P	0.944	0.68
12_G	17_Y	0.942	0.68
9_L	14_A	0.939	0.68
359_W	382_V	0.938	0.68
21_A	473_I	0.934	0.68
134_D	311_L	0.934	0.68
309_A	487_D	0.934	0.68
17_Y	23_S	0.930	0.67
365_A	486_L	0.930	0.67
71_Q	203_Q	0.926	0.67
361_D	385_S	0.925	0.67
505_L	515_D	0.921	0.67
435_H	448_G	0.918	0.66
439_D	443_V	0.917	0.66
46_A	485_Y	0.915	0.66
75_D	143_Q	0.914	0.66
130_L	474_A	0.913	0.66
237_L	485_Y	0.913	0.66
270_D	350_L	0.912	0.66
86_L	271_G	0.911	0.66
173_G	430_A	0.911	0.66
134_D	184_D	0.910	0.66
368_L	486_L	0.909	0.65
97_I	212_S	0.907	0.65
470_Q	524_S	0.905	0.65
108_A	231_A	0.904	0.65
451_L	454_A	0.903	0.65
213_P	515_D	0.903	0.65
465_D	470_Q	0.902	0.65
501_P	504_K	0.900	0.65
443_V	485_Y	0.899	0.65
416_Q	419_T	0.899	0.65
264_S	523_T	0.898	0.65
177_A	188_I	0.895	0.64
127_L	194_V	0.895	0.64
17_Y	20_L	0.894	0.64
7_V	16_A	0.894	0.64
231_A	368_L	0.893	0.64
14_A	26_A	0.891	0.64
107_L	522_V	0.890	0.64
134_D	386_D	0.888	0.64
334_A	338_D	0.882	0.63
311_L	342_A	0.880	0.63
248_P	252_L	0.880	0.63
320_W	469_F	0.879	0.63
415_G	420_A	0.878	0.63
181_V	434_A	0.878	0.63
513_L	516_A	0.875	0.62
113_D	121_G	0.874	0.62
54_T	59_W	0.873	0.62
495_L	498_Q	0.869	0.62
132_I	215_Y	0.868	0.62
85_L	415_G	0.866	0.62
96_D	144_K	0.865	0.62
80_Q	398_D	0.864	0.62
307_T	315_N	0.864	0.62
38_A	127_L	0.862	0.61
93_Y	219_L	0.861	0.61
477_P	525_A	0.861	0.61
305_A	426_G	0.861	0.61
52_L	56_P	0.859	0.61
127_L	187_L	0.858	0.61
435_H	446_T	0.858	0.61
442_V	448_G	0.858	0.61
187_L	424_P	0.857	0.61
290_L	293_E	0.856	0.61
345_K	366_L	0.856	0.61
124_P	323_L	0.855	0.61
229_A	265_L	0.854	0.61
34_P	440_G	0.852	0.60
138_A	186_V	0.848	0.60
495_L	499_L	0.847	0.60
164_G	454_A	0.846	0.60
97_I	406_L	0.843	0.60
496_E	520_L	0.842	0.60
439_D	469_F	0.841	0.59
241_A	451_L	0.841	0.59
44_A	207_L	0.837	0.59
369_V	372_S	0.837	0.59
71_Q	77_E	0.835	0.59
421_W	426_G	0.833	0.59
41_F	95_K	0.833	0.59
274_L	469_F	0.830	0.58
107_L	188_I	0.830	0.58
437_W	444_F	0.828	0.58
323_L	444_F	0.827	0.58
473_I	476_L	0.824	0.58
488_V	517_I	0.823	0.58
273_R	477_P	0.819	0.57
46_A	263_A	0.817	0.57
97_I	265_L	0.817	0.57
43_P	490_K	0.814	0.57
41_F	51_S	0.813	0.57
345_K	358_S	0.812	0.57
187_L	205_G	0.811	0.57
91_L	247_P	0.811	0.57
299_L	309_A	0.810	0.57
359_W	442_V	0.810	0.57
378_G	488_V	0.809	0.56
282_W	287_L	0.807	0.56
167_I	196_E	0.806	0.56
307_T	313_G	0.804	0.56
436_G	445_A	0.801	0.56
408_V	437_W	0.801	0.56
8_L	113_D	0.800	0.56
97_I	370_P	0.799	0.55
304_P	315_N	0.799	0.55
51_S	234_N	0.798	0.55
299_L	360_M	0.795	0.55
268_E	331_P	0.795	0.55
386_D	389_A	0.794	0.55
15_A	18_W	0.793	0.55
454_A	457_A	0.792	0.55
124_P	184_D	0.792	0.55
179_A	187_L	0.790	0.55
211_D	350_L	0.790	0.55
313_G	335_Q	0.789	0.55
126_Y	189_A	0.789	0.55
324_L	328_A	0.789	0.55
387_R	441_D	0.789	0.55
355_D	358_S	0.786	0.54
502_A	509_P	0.785	0.54
449_A	452_A	0.785	0.54
189_A	395_A	0.785	0.54
439_D	448_G	0.784	0.54
376_P	384_T	0.783	0.54
202_S	230_Q	0.782	0.54
180_V	367_A	0.778	0.54
312_S	367_A	0.776	0.53
442_V	451_L	0.776	0.53
4_A	392_A	0.775	0.53
448_G	452_A	0.775	0.53
16_A	166_T	0.773	0.53
308_L	314_G	0.773	0.53
507_E	514_L	0.773	0.53
78_L	92_D	0.773	0.53
185_F	192_P	0.772	0.53
410_P	415_G	0.771	0.53
95_K	212_S	0.770	0.53
482_G	487_D	0.770	0.53
336_L	339_Q	0.770	0.53
360_M	469_F	0.769	0.53
10_G	13_G	0.769	0.53
98_K	342_A	0.768	0.53
491_L	495_L	0.768	0.53
467_P	489_E	0.767	0.52
66_G	70_D	0.765	0.52
66_G	71_Q	0.764	0.52
55_D	357_L	0.762	0.52
424_P	444_F	0.761	0.52
491_L	496_E	0.760	0.52
39_A	290_L	0.759	0.52
472_A	475_S	0.758	0.52
19_L	23_S	0.757	0.52
18_W	23_S	0.756	0.51
6_V	15_A	0.756	0.51
508_L	512_P	0.752	0.51
15_A	20_L	0.752	0.51
412_T	417_T	0.750	0.51
293_E	306_D	0.748	0.51
29_A	33_L	0.747	0.51
318_Q	477_P	0.747	0.51
292_S	464_A	0.746	0.50
146_K	221_Q	0.746	0.50
36_P	275_D	0.745	0.50
370_P	524_S	0.745	0.50
108_A	416_Q	0.744	0.50
16_A	21_A	0.742	0.50
439_D	445_A	0.738	0.50
246_S	272_L	0.737	0.50
42_V	142_L	0.735	0.49
518_R	522_V	0.735	0.49
132_I	180_V	0.734	0.49
3_A	10_G	0.733	0.49
438_L	445_A	0.732	0.49
446_T	469_F	0.729	0.49
512_P	517_I	0.728	0.49
255_L	484_F	0.727	0.49
399_A	462_S	0.726	0.49
352_L	414_G	0.726	0.49
163_K	199_I	0.725	0.48
399_A	403_S	0.725	0.48
234_N	349_G	0.723	0.48
259_Q	277_A	0.723	0.48
178_T	182_G	0.719	0.48
398_D	485_Y	0.719	0.48
38_A	198_A	0.718	0.48
487_D	491_L	0.717	0.48
298_K	301_S	0.717	0.48
129_V	139_R	0.714	0.47
313_G	324_L	0.714	0.47
505_L	521_G	0.711	0.47
239_A	245_G	0.710	0.47
434_A	442_V	0.709	0.47
181_V	300_L	0.708	0.47
189_A	466_S	0.707	0.47
199_I	478_S	0.706	0.47
3_A	8_L	0.705	0.47
41_F	201_T	0.704	0.46
91_L	141_F	0.703	0.46
206_G	440_G	0.703	0.46
407_S	440_G	0.703	0.46
359_W	385_S	0.703	0.46
201_T	207_L	0.702	0.46
212_S	232_Y	0.702	0.46
7_V	23_S	0.702	0.46
418_V	422_T	0.701	0.46
56_P	60_Q	0.701	0.46
14_A	22_Q	0.700	0.46
267_L	272_L	0.700	0.46
168_I	189_A	0.700	0.46
507_E	522_V	0.700	0.46
14_A	81_L	0.699	0.46
251_T	265_L	0.698	0.46
462_S	487_D	0.696	0.46
163_K	385_S	0.696	0.46
256_Q	273_R	0.695	0.46
10_G	19_L	0.695	0.46
29_A	32_S	0.694	0.46
108_A	229_A	0.694	0.46
99_P	304_P	0.693	0.45
257_Q	260_G	0.692	0.45
38_A	51_S	0.690	0.45
436_G	439_D	0.690	0.45
492_L	496_E	0.688	0.45
198_A	201_T	0.688	0.45
142_L	427_G	0.687	0.45
340_L	348_L	0.686	0.45
113_D	465_D	0.686	0.45
7_V	375_G	0.685	0.45
355_D	359_W	0.682	0.44
7_V	10_G	0.681	0.44
140_A	380_L	0.678	0.44
270_D	325_A	0.678	0.44
254_Q	259_Q	0.677	0.44
199_I	385_S	0.676	0.44
437_W	448_G	0.675	0.44
101_L	366_L	0.675	0.44
271_G	487_D	0.674	0.44
382_V	385_S	0.673	0.44
73_A	77_E	0.673	0.44
348_L	419_T	0.672	0.43
401_A	485_Y	0.671	0.43
339_Q	484_F	0.670	0.43
167_I	474_A	0.670	0.43
304_P	307_T	0.670	0.43
51_S	106_T	0.669	0.43
108_A	260_G	0.669	0.43
323_L	365_A	0.668	0.43
52_L	55_D	0.666	0.43
470_Q	517_I	0.665	0.43
134_D	209_L	0.664	0.43
408_V	413_L	0.662	0.43
7_V	37_A	0.662	0.43
38_A	167_I	0.660	0.42
509_P	525_A	0.658	0.42
298_K	383_E	0.656	0.42
95_K	350_L	0.655	0.42
69_E	73_A	0.655	0.42
476_L	485_Y	0.655	0.42
240_L	443_V	0.651	0.41
52_L	58_Q	0.651	0.41
309_A	364_F	0.650	0.41
445_A	450_A	0.650	0.41
245_G	517_I	0.650	0.41
506_A	528_D	0.650	0.41
409_S	422_T	0.650	0.41
83_D	89_S	0.649	0.41
400_L	403_S	0.649	0.41
8_L	156_D	0.649	0.41
378_G	446_T	0.649	0.41
501_P	510_A	0.647	0.41
471_A	474_A	0.647	0.41
238_A	270_D	0.646	0.41
342_A	454_A	0.646	0.41
189_A	193_K	0.646	0.41
42_V	234_N	0.644	0.41
103_G	316_L	0.644	0.41
213_P	217_A	0.643	0.41
17_Y	22_Q	0.642	0.41
524_S	531_T	0.640	0.40
8_L	44_A	0.640	0.40
439_D	447_S	0.640	0.40
83_D	183_D	0.640	0.40
252_L	257_Q	0.639	0.40
18_W	22_Q	0.638	0.40
513_L	525_A	0.638	0.40
158_E	166_T	0.637	0.40
153_G	323_L	0.637	0.40
266_G	303_L	0.635	0.40
41_F	54_T	0.634	0.40
105_V	256_Q	0.634	0.40
299_L	310_A	0.633	0.40
78_L	101_L	0.632	0.40
323_L	368_L	0.632	0.40
11_L	14_A	0.631	0.40
362_G	383_E	0.631	0.40
239_A	436_G	0.631	0.40
261_L	272_L	0.630	0.40
146_K	153_G	0.630	0.40
4_A	520_L	0.629	0.39
368_L	391_E	0.628	0.39
359_W	393_T	0.628	0.39
498_Q	503_L	0.626	0.39
263_A	356_L	0.626	0.39
492_L	514_L	0.625	0.39
271_G	435_H	0.625	0.39
97_I	194_V	0.624	0.39
272_L	404_Q	0.624	0.39
376_P	379_V	0.623	0.39
509_P	519_S	0.623	0.39
30_G	33_L	0.622	0.39
414_G	418_V	0.621	0.39
280_V	283_L	0.621	0.39
498_Q	521_G	0.621	0.39
12_G	520_L	0.620	0.39
181_V	411_L	0.620	0.39
139_R	143_Q	0.619	0.39
125_G	212_S	0.618	0.38
436_G	447_S	0.618	0.38
240_L	395_A	0.618	0.38
388_A	392_A	0.618	0.38
145_L	307_T	0.617	0.38
327_L	417_T	0.616	0.38
340_L	518_R	0.615	0.38
51_S	54_T	0.614	0.38
68_P	72_A	0.614	0.38
451_L	456_A	0.614	0.38
189_A	441_D	0.614	0.38
460_G	466_S	0.613	0.38
104_E	363_E	0.612	0.38
433_A	438_L	0.612	0.38
446_T	456_A	0.612	0.38
268_E	472_A	0.611	0.38
217_A	358_S	0.611	0.38
205_G	464_A	0.609	0.38
504_K	508_L	0.608	0.38
179_A	182_G	0.608	0.38
350_L	359_W	0.608	0.38
344_L	348_L	0.607	0.37
95_K	522_V	0.606	0.37
206_G	349_G	0.606	0.37
313_G	469_F	0.606	0.37
502_A	511_K	0.604	0.37
135_P	367_A	0.603	0.37
466_S	470_Q	0.600	0.37
407_S	436_G	0.599	0.37
12_G	444_F	0.599	0.37
307_T	341_L	0.599	0.37
50_V	231_A	0.599	0.37
494_L	498_Q	0.598	0.37
13_G	20_L	0.598	0.37
88_D	158_E	0.598	0.37
51_S	267_L	0.597	0.37
110_L	437_W	0.596	0.36
235_V	478_S	0.596	0.36
29_A	48_L	0.596	0.36
190_N	422_T	0.595	0.36
107_L	146_K	0.594	0.36
33_L	344_L	0.593	0.36
38_A	46_A	0.593	0.36
504_K	512_P	0.593	0.36
319_L	325_A	0.592	0.36
435_H	442_V	0.592	0.36
93_Y	100_W	0.592	0.36
512_P	518_R	0.591	0.36
6_V	461_N	0.591	0.36
226_R	299_L	0.590	0.36
45_D	60_Q	0.590	0.36
358_S	376_P	0.590	0.36
320_W	483_Y	0.590	0.36
460_G	467_P	0.589	0.36
455_L	477_P	0.589	0.36
236_P	240_L	0.588	0.36
50_V	133_K	0.586	0.36
142_L	179_A	0.586	0.36
412_T	425_Q	0.584	0.35
60_Q	227_L	0.583	0.35
334_A	429_L	0.581	0.35
52_L	295_V	0.580	0.35
31_G	35_P	0.580	0.35
217_A	439_D	0.580	0.35
475_S	521_G	0.578	0.35
401_A	405_G	0.578	0.35
66_G	72_A	0.577	0.35
312_S	482_G	0.577	0.35
365_A	370_P	0.577	0.35
92_D	188_I	0.577	0.35
110_L	113_D	0.576	0.35
152_A	338_D	0.576	0.35
105_V	321_Q	0.576	0.35
126_Y	276_A	0.574	0.35
40_K	352_L	0.573	0.34
6_V	11_L	0.571	0.34
13_G	23_S	0.571	0.34
57_D	103_G	0.571	0.34
72_A	414_G	0.570	0.34
501_P	507_E	0.570	0.34
364_F	448_G	0.568	0.34
167_I	438_L	0.568	0.34
199_I	203_Q	0.567	0.34
522_V	527_S	0.567	0.34
115_D	403_S	0.566	0.34
42_V	198_A	0.565	0.34
64_Q	167_I	0.565	0.34
421_W	501_P	0.565	0.34
154_A	170_G	0.565	0.34
103_G	308_L	0.564	0.34
310_A	365_A	0.564	0.34
356_L	396_K	0.563	0.34
107_L	305_A	0.562	0.34
444_F	455_L	0.562	0.34
307_T	450_A	0.562	0.34
137_K	223_P	0.561	0.33
131_A	359_W	0.561	0.33
200_D	377_G	0.560	0.33
46_A	49_Y	0.560	0.33
349_G	386_D	0.560	0.33
519_S	527_S	0.560	0.33
184_D	492_L	0.560	0.33
63_R	75_D	0.559	0.33
266_G	273_R	0.559	0.33
216_Q	345_K	0.558	0.33
420_A	426_G	0.558	0.33
128_L	407_S	0.557	0.33
7_V	22_Q	0.557	0.33
20_L	94_E	0.557	0.33
227_L	369_V	0.556	0.33
93_Y	235_V	0.555	0.33
187_L	401_A	0.554	0.33
301_S	306_D	0.553	0.33
394_L	477_P	0.552	0.33
134_D	330_N	0.551	0.33
109_V	470_Q	0.551	0.33
306_D	371_G	0.551	0.33
320_W	364_F	0.549	0.32
124_P	253_A	0.548	0.32
239_A	243_W	0.548	0.32
45_D	212_S	0.547	0.32
252_L	337_L	0.547	0.32
499_L	505_L	0.547	0.32
221_Q	474_A	0.547	0.32
141_F	476_L	0.546	0.32
310_A	420_A	0.546	0.32
293_E	361_D	0.545	0.32
136_A	349_G	0.544	0.32
101_L	133_K	0.544	0.32
415_G	423_S	0.541	0.32
305_A	373_G	0.541	0.32
463_L	518_R	0.541	0.32
127_L	263_A	0.540	0.32
284_D	430_A	0.540	0.32
7_V	15_A	0.539	0.32
163_K	217_A	0.539	0.32
210_A	264_S	0.538	0.32
515_D	518_R	0.537	0.31
71_Q	167_I	0.537	0.31
389_A	406_L	0.534	0.31
140_A	192_P	0.531	0.31
439_D	442_V	0.531	0.31
97_I	390_A	0.530	0.31
210_A	352_L	0.529	0.31
467_P	471_A	0.529	0.31
59_W	131_A	0.528	0.31
423_S	426_G	0.528	0.31
93_Y	408_V	0.528	0.31
305_A	334_A	0.527	0.31
59_W	62_L	0.525	0.30
517_I	520_L	0.525	0.30
193_K	196_E	0.524	0.30
4_A	7_V	0.524	0.30
143_Q	256_Q	0.523	0.30
129_V	135_P	0.522	0.30
397_L	458_K	0.522	0.30
270_D	351_D	0.521	0.30
293_E	310_A	0.520	0.30
527_S	531_T	0.520	0.30
129_V	195_L	0.519	0.30
51_S	209_L	0.518	0.30
54_T	66_G	0.517	0.30
78_L	439_D	0.517	0.30
402_A	409_S	0.517	0.30
3_A	407_S	0.517	0.30
123_Q	195_L	0.517	0.30
478_S	486_L	0.516	0.30
435_H	483_Y	0.515	0.30
523_T	526_G	0.515	0.30
272_L	388_A	0.514	0.30
163_K	414_G	0.514	0.30
63_R	314_G	0.513	0.30
166_T	307_T	0.512	0.29
19_L	26_A	0.512	0.29
307_T	310_A	0.512	0.29
118_A	176_G	0.511	0.29
5_A	312_S	0.511	0.29
425_Q	428_P	0.511	0.29
213_P	240_L	0.510	0.29
345_K	484_F	0.509	0.29
260_G	266_G	0.509	0.29
42_V	138_A	0.509	0.29
137_K	179_A	0.507	0.29
515_D	526_G	0.506	0.29
503_L	508_L	0.506	0.29
169_S	520_L	0.505	0.29
287_L	454_A	0.505	0.29
411_L	424_P	0.504	0.29
53_S	446_T	0.504	0.29
13_G	16_A	0.502	0.29
198_A	262_A	0.501	0.29
188_I	452_A	0.501	0.29
264_S	478_S	0.500	0.28

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1s7qA	1	0	12.1	0.972	Contact Map
4um9B	2	0	4.6	0.976	Contact Map
1spfA	1	0.0389	4.1	0.977	Contact Map
2q13A	2	0.1481	3.7	0.977	Contact Map
2lxtC	1	0.063	3.5	0.978	Contact Map
1jbwA	1	0.1111	3.1	0.978	Contact Map
3j1rA	5	0.0426	3	0.979	Contact Map
1kdxB	1	0.0519	2.9	0.979	Contact Map
2jwaA	2	0.0519	2.9	0.979	Contact Map
2ks1B	1	0.0537	2.5	0.979	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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