Myb_Cef - PFAM28P - GREMLIN Contacts

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Myb_Cef - pre-mRNA splicing factor component

PFAM:	PF11831	Sequences: TPNPVLATPFRTGGGVGATPGRGGATPLRTPLRDNLAINPEDGQLVGDTPRDEKLRQKAARRQLRAGLASLPKPKNEYELVLPEEEEEDEEEDEEAEELSEEDAADRDARERAEREAEEEAELKRRSQVVQRGLPRPAVVDLDALRKSLSSPDNDSVPLTDLQPAEELIAKEMATLLAHDAIKYPLKKKPGTAQHLPGGKAPPLEEFSDEELAEARELIAAEMAVVKGGMGHGELSLE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	238 (223)
Sequences:	526 (407)
Seq/√Len:	27.2
META:	0.232

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
112_R	116_E	5.765	1.00
102_E	110_R	5.358	1.00
116_E	120_E	3.932	1.00
123_L	126_R	3.684	1.00
34_D	39_N	3.658	1.00
125_R	209_D	3.323	1.00
208_S	211_E	3.269	1.00
75_K	81_V	3.186	1.00
124_K	131_Q	3.037	1.00
115_R	119_E	2.977	1.00
113_A	117_A	2.702	1.00
77_E	81_V	2.513	0.99
117_A	120_E	2.469	0.99
3_N	6_L	2.441	0.99
217_E	221_A	2.441	0.99
207_F	211_E	2.371	0.99
114_E	118_E	2.319	0.98
214_E	218_L	2.300	0.98
128_Q	131_Q	2.283	0.98
118_E	121_A	2.262	0.98
136_R	185_P	2.219	0.98
218_L	221_A	2.105	0.97
33_R	39_N	1.991	0.96
129_V	177_L	1.934	0.95
76_N	81_V	1.861	0.94
198_G	202_P	1.752	0.92
104_A	108_D	1.743	0.92
34_D	38_I	1.717	0.91
204_L	207_F	1.703	0.91
165_A	168_L	1.675	0.90
28_L	106_D	1.663	0.90
26_T	92_E	1.645	0.89
115_R	118_E	1.643	0.89
165_A	169_I	1.624	0.89
108_D	125_R	1.616	0.88
1_T	4_P	1.602	0.88
111_E	115_R	1.587	0.87
109_A	113_A	1.585	0.87
67_G	118_E	1.582	0.87
1_T	6_L	1.541	0.86
36_L	39_N	1.532	0.85
126_R	184_Y	1.525	0.85
104_A	107_R	1.520	0.85
112_R	115_R	1.509	0.85
129_V	181_A	1.506	0.84
124_K	209_D	1.485	0.84
128_Q	132_R	1.475	0.83
230_M	233_G	1.434	0.81
213_A	217_E	1.410	0.80
63_Q	207_F	1.409	0.80
192_T	207_F	1.353	0.77
209_D	216_R	1.339	0.77
226_V	230_M	1.333	0.76
119_E	184_Y	1.329	0.76
38_I	68_L	1.303	0.75
141_D	146_R	1.301	0.74
162_L	219_I	1.292	0.74
38_I	174_A	1.285	0.74
25_A	220_A	1.282	0.73
119_E	122_E	1.257	0.72
25_A	28_L	1.248	0.71
67_G	184_Y	1.232	0.70
227_K	232_H	1.230	0.70
53_E	56_R	1.229	0.70
38_I	61_R	1.222	0.70
38_I	173_M	1.195	0.68
215_A	222_E	1.189	0.67
102_E	107_R	1.187	0.67
65_R	119_E	1.168	0.66
123_L	179_H	1.165	0.66
21_G	130_V	1.155	0.65
78_Y	82_L	1.152	0.65
166_E	170_A	1.147	0.65
226_V	232_H	1.144	0.64
78_Y	127_S	1.142	0.64
106_D	109_A	1.140	0.64
67_G	126_R	1.126	0.63
159_L	170_A	1.119	0.63
65_R	95_E	1.118	0.63
21_G	24_G	1.109	0.62
47_G	219_I	1.096	0.61
87_E	210_E	1.086	0.60
125_R	206_E	1.086	0.60
4_P	7_A	1.077	0.60
6_L	10_F	1.076	0.60
147_K	150_S	1.064	0.59
2_P	6_L	1.063	0.59
38_I	202_P	1.060	0.58
229_G	232_H	1.059	0.58
76_N	130_V	1.053	0.58
166_E	213_A	1.051	0.58
118_E	126_R	1.047	0.57
127_S	220_A	1.047	0.57
85_E	124_K	1.034	0.56
101_E	138_A	1.028	0.56
105_A	109_A	1.026	0.56
13_G	18_A	1.021	0.56
119_E	126_R	1.020	0.55
60_A	63_Q	1.020	0.55
92_E	95_E	1.017	0.55
67_G	119_E	1.010	0.55
107_R	110_R	0.996	0.54
37_A	41_E	0.995	0.54
127_S	176_L	0.988	0.53
123_L	127_S	0.986	0.53
125_R	208_S	0.982	0.53
175_T	219_I	0.981	0.53
167_E	170_A	0.979	0.52
12_T	16_V	0.978	0.52
77_E	193_A	0.959	0.51
85_E	162_L	0.957	0.51
169_I	177_L	0.956	0.51
71_L	103_D	0.948	0.50
84_E	211_E	0.947	0.50
13_G	22_R	0.944	0.50
168_L	185_P	0.941	0.49
18_A	47_G	0.940	0.49
132_R	166_E	0.930	0.49
216_R	220_A	0.923	0.48
81_V	132_R	0.923	0.48
167_E	171_K	0.921	0.48
97_E	100_S	0.919	0.48
107_R	125_R	0.912	0.47
41_E	226_V	0.902	0.47
114_E	221_A	0.901	0.46
68_L	232_H	0.896	0.46
64_L	179_H	0.895	0.46
6_L	126_R	0.892	0.46
125_R	216_R	0.886	0.45
77_E	204_L	0.884	0.45
29_R	125_R	0.883	0.45
177_L	184_Y	0.880	0.45
58_K	219_I	0.878	0.45
68_L	73_K	0.872	0.44
4_P	176_L	0.868	0.44
64_L	140_V	0.861	0.43
200_K	205_E	0.855	0.43
48_D	59_A	0.854	0.43
26_T	29_R	0.853	0.43
116_E	218_L	0.849	0.43
108_D	141_D	0.848	0.43
69_A	129_V	0.847	0.42
118_E	125_R	0.847	0.42
132_R	220_A	0.846	0.42
225_V	229_G	0.845	0.42
192_T	196_L	0.844	0.42
13_G	41_E	0.842	0.42
52_D	94_E	0.838	0.42
130_V	153_D	0.836	0.42
87_E	112_R	0.835	0.42
60_A	66_A	0.831	0.41
49_T	52_D	0.825	0.41
31_P	102_E	0.825	0.41
16_V	19_T	0.824	0.41
153_D	164_P	0.822	0.41
94_E	210_E	0.818	0.40
77_E	178_A	0.813	0.40
120_E	124_K	0.811	0.40
179_H	217_E	0.810	0.40
131_Q	214_E	0.808	0.40
43_G	61_R	0.807	0.40
205_E	221_A	0.803	0.39
94_E	97_E	0.797	0.39
106_D	216_R	0.794	0.39
15_G	18_A	0.786	0.38
81_V	122_E	0.786	0.38
103_D	135_P	0.781	0.38
142_L	174_A	0.780	0.38
19_T	22_R	0.777	0.37
62_R	174_A	0.777	0.37
176_L	204_L	0.768	0.37
191_G	195_H	0.768	0.37
33_R	38_I	0.766	0.37
214_E	220_A	0.765	0.37
112_R	219_I	0.764	0.36
193_A	231_G	0.762	0.36
141_D	144_A	0.762	0.36
130_V	185_P	0.760	0.36
44_Q	207_F	0.756	0.36
8_T	36_L	0.754	0.36
77_E	202_P	0.754	0.36
75_K	132_R	0.751	0.36
15_G	21_G	0.749	0.35
75_K	128_Q	0.747	0.35
68_L	135_P	0.746	0.35
78_Y	109_A	0.743	0.35
82_L	85_E	0.742	0.35
138_A	177_L	0.740	0.35
70_S	213_A	0.740	0.35
58_K	124_K	0.739	0.35
63_Q	128_Q	0.739	0.35
79_E	115_R	0.735	0.34
166_E	177_L	0.733	0.34
130_V	136_R	0.733	0.34
166_E	212_L	0.723	0.34
106_D	186_L	0.723	0.34
78_Y	219_I	0.722	0.34
12_T	211_E	0.719	0.33
34_D	82_L	0.715	0.33
68_L	111_E	0.714	0.33
226_V	229_G	0.712	0.33
44_Q	224_A	0.710	0.33
35_N	132_R	0.707	0.33
84_E	130_V	0.707	0.33
42_D	105_A	0.706	0.32
139_V	165_A	0.705	0.32
103_D	134_L	0.705	0.32
166_E	190_P	0.703	0.32
68_L	171_K	0.702	0.32
162_L	204_L	0.702	0.32
121_A	126_R	0.701	0.32
117_A	121_A	0.698	0.32
121_A	209_D	0.695	0.32
15_G	98_E	0.693	0.32
116_E	124_K	0.693	0.32
64_L	135_P	0.690	0.31
107_R	111_E	0.689	0.31
32_L	69_A	0.689	0.31
61_R	209_D	0.688	0.31
100_S	106_D	0.687	0.31
79_E	125_R	0.686	0.31
146_R	167_E	0.686	0.31
170_A	174_A	0.684	0.31
171_K	175_T	0.683	0.31
209_D	213_A	0.683	0.31
98_E	101_E	0.682	0.31
12_T	44_Q	0.682	0.31
54_K	171_K	0.677	0.31
96_A	114_E	0.676	0.31
213_A	225_V	0.674	0.30
140_V	145_L	0.668	0.30
66_A	210_E	0.666	0.30
85_E	108_D	0.664	0.30
56_R	60_A	0.661	0.30
129_V	186_L	0.655	0.29
163_Q	173_M	0.654	0.29
106_D	148_S	0.653	0.29
111_E	206_E	0.647	0.29
182_I	198_G	0.647	0.29
88_E	110_R	0.640	0.28
61_R	104_A	0.640	0.28
179_H	220_A	0.637	0.28
40_P	43_G	0.634	0.28
68_L	71_L	0.632	0.28
29_R	112_R	0.632	0.28
72_P	215_A	0.631	0.28
229_G	233_G	0.631	0.28
46_V	60_A	0.631	0.28
7_A	49_T	0.629	0.28
67_G	123_L	0.629	0.28
227_K	230_M	0.627	0.27
80_L	146_R	0.625	0.27
15_G	19_T	0.623	0.27
67_G	76_N	0.621	0.27
123_L	133_G	0.619	0.27
51_R	115_R	0.615	0.27
124_K	171_K	0.614	0.27
19_T	144_A	0.613	0.27
148_S	151_S	0.613	0.27
115_R	124_K	0.612	0.27
69_A	177_L	0.610	0.26
101_E	104_A	0.607	0.26
80_L	129_V	0.605	0.26
104_A	169_I	0.601	0.26
98_E	115_R	0.595	0.26
79_E	108_D	0.594	0.26
113_A	116_E	0.593	0.25
72_P	180_D	0.592	0.25
70_S	147_K	0.591	0.25
69_A	88_E	0.589	0.25
178_A	181_A	0.589	0.25
87_E	106_D	0.588	0.25
176_L	192_T	0.587	0.25
130_V	220_A	0.583	0.25
3_N	34_D	0.583	0.25
54_K	177_L	0.583	0.25
122_E	209_D	0.582	0.25
155_D	163_Q	0.582	0.25
36_L	105_A	0.581	0.25
119_E	123_L	0.579	0.25
76_N	80_L	0.579	0.25
35_N	70_S	0.574	0.24
79_E	130_V	0.574	0.24
17_G	23_G	0.573	0.24
214_E	217_E	0.573	0.24
35_N	62_R	0.571	0.24
111_E	210_E	0.569	0.24
43_G	219_I	0.567	0.24
113_A	121_A	0.567	0.24
170_A	204_L	0.566	0.24
105_A	141_D	0.566	0.24
162_L	168_L	0.562	0.24
50_P	63_Q	0.562	0.24
161_D	204_L	0.562	0.24
66_A	148_S	0.561	0.24
67_G	182_I	0.561	0.24
14_G	17_G	0.560	0.24
44_Q	48_D	0.560	0.24
106_D	185_P	0.558	0.24
21_G	44_Q	0.557	0.23
144_A	169_I	0.555	0.23
53_E	68_L	0.553	0.23
82_L	113_A	0.553	0.23
10_F	182_I	0.552	0.23
130_V	196_L	0.549	0.23
140_V	165_A	0.543	0.23
108_D	174_A	0.539	0.22
80_L	200_K	0.538	0.22
193_A	204_L	0.536	0.22
70_S	206_E	0.533	0.22
214_E	223_M	0.531	0.22
71_L	134_L	0.531	0.22
72_P	103_D	0.531	0.22
3_N	38_I	0.529	0.22
77_E	111_E	0.527	0.22
197_P	212_L	0.526	0.22
144_A	219_I	0.525	0.22
105_A	168_L	0.524	0.22
62_R	112_R	0.522	0.22
14_G	112_R	0.518	0.21
114_E	146_R	0.516	0.21
86_E	109_A	0.516	0.21
121_A	217_E	0.516	0.21
37_A	171_K	0.516	0.21
168_L	194_Q	0.514	0.21
27_P	31_P	0.511	0.21
119_E	155_D	0.509	0.21
47_G	50_P	0.507	0.21
177_L	223_M	0.506	0.21
40_P	75_K	0.505	0.21
190_P	195_H	0.504	0.21
169_I	197_P	0.503	0.21
16_V	87_E	0.501	0.21
17_G	22_R	0.500	0.21

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2b19A	1	0.105	7.5	0.962	Contact Map
3tjyA	1	0.0798	5.6	0.964	Contact Map
2dyjA	1	0.3235	2.6	0.97	Contact Map
3whjA	2	0.2521	2.5	0.97	Contact Map
4mjzA	2	0.2647	2.5	0.97	Contact Map
3rrwA	1	0.4034	2.4	0.97	Contact Map
3utmC	1	0.0756	2.3	0.97	Contact Map
3czuB	1	0.1597	2	0.971	Contact Map
1g8eA	2	0.1849	2	0.971	Contact Map
3i71A	3	0.1092	2	0.971	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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