GREMLIN Database
Myb_Cef - pre-mRNA splicing factor component
PFAM: PF11831 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 238 (223)
Sequences: 526 (407)
Seq/√Len: 27.2
META: 0.232

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
112_R116_E5.7651.00
102_E110_R5.3581.00
116_E120_E3.9321.00
123_L126_R3.6841.00
34_D39_N3.6581.00
125_R209_D3.3231.00
208_S211_E3.2691.00
75_K81_V3.1861.00
124_K131_Q3.0371.00
115_R119_E2.9771.00
113_A117_A2.7021.00
77_E81_V2.5130.99
117_A120_E2.4690.99
3_N6_L2.4410.99
217_E221_A2.4410.99
207_F211_E2.3710.99
114_E118_E2.3190.98
214_E218_L2.3000.98
128_Q131_Q2.2830.98
118_E121_A2.2620.98
136_R185_P2.2190.98
218_L221_A2.1050.97
33_R39_N1.9910.96
129_V177_L1.9340.95
76_N81_V1.8610.94
198_G202_P1.7520.92
104_A108_D1.7430.92
34_D38_I1.7170.91
204_L207_F1.7030.91
165_A168_L1.6750.90
28_L106_D1.6630.90
26_T92_E1.6450.89
115_R118_E1.6430.89
165_A169_I1.6240.89
108_D125_R1.6160.88
1_T4_P1.6020.88
111_E115_R1.5870.87
109_A113_A1.5850.87
67_G118_E1.5820.87
1_T6_L1.5410.86
36_L39_N1.5320.85
126_R184_Y1.5250.85
104_A107_R1.5200.85
112_R115_R1.5090.85
129_V181_A1.5060.84
124_K209_D1.4850.84
128_Q132_R1.4750.83
230_M233_G1.4340.81
213_A217_E1.4100.80
63_Q207_F1.4090.80
192_T207_F1.3530.77
209_D216_R1.3390.77
226_V230_M1.3330.76
119_E184_Y1.3290.76
38_I68_L1.3030.75
141_D146_R1.3010.74
162_L219_I1.2920.74
38_I174_A1.2850.74
25_A220_A1.2820.73
119_E122_E1.2570.72
25_A28_L1.2480.71
67_G184_Y1.2320.70
227_K232_H1.2300.70
53_E56_R1.2290.70
38_I61_R1.2220.70
38_I173_M1.1950.68
215_A222_E1.1890.67
102_E107_R1.1870.67
65_R119_E1.1680.66
123_L179_H1.1650.66
21_G130_V1.1550.65
78_Y82_L1.1520.65
166_E170_A1.1470.65
226_V232_H1.1440.64
78_Y127_S1.1420.64
106_D109_A1.1400.64
67_G126_R1.1260.63
159_L170_A1.1190.63
65_R95_E1.1180.63
21_G24_G1.1090.62
47_G219_I1.0960.61
87_E210_E1.0860.60
125_R206_E1.0860.60
4_P7_A1.0770.60
6_L10_F1.0760.60
147_K150_S1.0640.59
2_P6_L1.0630.59
38_I202_P1.0600.58
229_G232_H1.0590.58
76_N130_V1.0530.58
166_E213_A1.0510.58
118_E126_R1.0470.57
127_S220_A1.0470.57
85_E124_K1.0340.56
101_E138_A1.0280.56
105_A109_A1.0260.56
13_G18_A1.0210.56
119_E126_R1.0200.55
60_A63_Q1.0200.55
92_E95_E1.0170.55
67_G119_E1.0100.55
107_R110_R0.9960.54
37_A41_E0.9950.54
127_S176_L0.9880.53
123_L127_S0.9860.53
125_R208_S0.9820.53
175_T219_I0.9810.53
167_E170_A0.9790.52
12_T16_V0.9780.52
77_E193_A0.9590.51
85_E162_L0.9570.51
169_I177_L0.9560.51
71_L103_D0.9480.50
84_E211_E0.9470.50
13_G22_R0.9440.50
168_L185_P0.9410.49
18_A47_G0.9400.49
132_R166_E0.9300.49
216_R220_A0.9230.48
81_V132_R0.9230.48
167_E171_K0.9210.48
97_E100_S0.9190.48
107_R125_R0.9120.47
41_E226_V0.9020.47
114_E221_A0.9010.46
68_L232_H0.8960.46
64_L179_H0.8950.46
6_L126_R0.8920.46
125_R216_R0.8860.45
77_E204_L0.8840.45
29_R125_R0.8830.45
177_L184_Y0.8800.45
58_K219_I0.8780.45
68_L73_K0.8720.44
4_P176_L0.8680.44
64_L140_V0.8610.43
200_K205_E0.8550.43
48_D59_A0.8540.43
26_T29_R0.8530.43
116_E218_L0.8490.43
108_D141_D0.8480.43
69_A129_V0.8470.42
118_E125_R0.8470.42
132_R220_A0.8460.42
225_V229_G0.8450.42
192_T196_L0.8440.42
13_G41_E0.8420.42
52_D94_E0.8380.42
130_V153_D0.8360.42
87_E112_R0.8350.42
60_A66_A0.8310.41
49_T52_D0.8250.41
31_P102_E0.8250.41
16_V19_T0.8240.41
153_D164_P0.8220.41
94_E210_E0.8180.40
77_E178_A0.8130.40
120_E124_K0.8110.40
179_H217_E0.8100.40
131_Q214_E0.8080.40
43_G61_R0.8070.40
205_E221_A0.8030.39
94_E97_E0.7970.39
106_D216_R0.7940.39
15_G18_A0.7860.38
81_V122_E0.7860.38
103_D135_P0.7810.38
142_L174_A0.7800.38
19_T22_R0.7770.37
62_R174_A0.7770.37
176_L204_L0.7680.37
191_G195_H0.7680.37
33_R38_I0.7660.37
214_E220_A0.7650.37
112_R219_I0.7640.36
193_A231_G0.7620.36
141_D144_A0.7620.36
130_V185_P0.7600.36
44_Q207_F0.7560.36
8_T36_L0.7540.36
77_E202_P0.7540.36
75_K132_R0.7510.36
15_G21_G0.7490.35
75_K128_Q0.7470.35
68_L135_P0.7460.35
78_Y109_A0.7430.35
82_L85_E0.7420.35
138_A177_L0.7400.35
70_S213_A0.7400.35
58_K124_K0.7390.35
63_Q128_Q0.7390.35
79_E115_R0.7350.34
166_E177_L0.7330.34
130_V136_R0.7330.34
166_E212_L0.7230.34
106_D186_L0.7230.34
78_Y219_I0.7220.34
12_T211_E0.7190.33
34_D82_L0.7150.33
68_L111_E0.7140.33
226_V229_G0.7120.33
44_Q224_A0.7100.33
35_N132_R0.7070.33
84_E130_V0.7070.33
42_D105_A0.7060.32
139_V165_A0.7050.32
103_D134_L0.7050.32
166_E190_P0.7030.32
68_L171_K0.7020.32
162_L204_L0.7020.32
121_A126_R0.7010.32
117_A121_A0.6980.32
121_A209_D0.6950.32
15_G98_E0.6930.32
116_E124_K0.6930.32
64_L135_P0.6900.31
107_R111_E0.6890.31
32_L69_A0.6890.31
61_R209_D0.6880.31
100_S106_D0.6870.31
79_E125_R0.6860.31
146_R167_E0.6860.31
170_A174_A0.6840.31
171_K175_T0.6830.31
209_D213_A0.6830.31
98_E101_E0.6820.31
12_T44_Q0.6820.31
54_K171_K0.6770.31
96_A114_E0.6760.31
213_A225_V0.6740.30
140_V145_L0.6680.30
66_A210_E0.6660.30
85_E108_D0.6640.30
56_R60_A0.6610.30
129_V186_L0.6550.29
163_Q173_M0.6540.29
106_D148_S0.6530.29
111_E206_E0.6470.29
182_I198_G0.6470.29
88_E110_R0.6400.28
61_R104_A0.6400.28
179_H220_A0.6370.28
40_P43_G0.6340.28
68_L71_L0.6320.28
29_R112_R0.6320.28
72_P215_A0.6310.28
229_G233_G0.6310.28
46_V60_A0.6310.28
7_A49_T0.6290.28
67_G123_L0.6290.28
227_K230_M0.6270.27
80_L146_R0.6250.27
15_G19_T0.6230.27
67_G76_N0.6210.27
123_L133_G0.6190.27
51_R115_R0.6150.27
124_K171_K0.6140.27
19_T144_A0.6130.27
148_S151_S0.6130.27
115_R124_K0.6120.27
69_A177_L0.6100.26
101_E104_A0.6070.26
80_L129_V0.6050.26
104_A169_I0.6010.26
98_E115_R0.5950.26
79_E108_D0.5940.26
113_A116_E0.5930.25
72_P180_D0.5920.25
70_S147_K0.5910.25
69_A88_E0.5890.25
178_A181_A0.5890.25
87_E106_D0.5880.25
176_L192_T0.5870.25
130_V220_A0.5830.25
3_N34_D0.5830.25
54_K177_L0.5830.25
122_E209_D0.5820.25
155_D163_Q0.5820.25
36_L105_A0.5810.25
119_E123_L0.5790.25
76_N80_L0.5790.25
35_N70_S0.5740.24
79_E130_V0.5740.24
17_G23_G0.5730.24
214_E217_E0.5730.24
35_N62_R0.5710.24
111_E210_E0.5690.24
43_G219_I0.5670.24
113_A121_A0.5670.24
170_A204_L0.5660.24
105_A141_D0.5660.24
162_L168_L0.5620.24
50_P63_Q0.5620.24
161_D204_L0.5620.24
66_A148_S0.5610.24
67_G182_I0.5610.24
14_G17_G0.5600.24
44_Q48_D0.5600.24
106_D185_P0.5580.24
21_G44_Q0.5570.23
144_A169_I0.5550.23
53_E68_L0.5530.23
82_L113_A0.5530.23
10_F182_I0.5520.23
130_V196_L0.5490.23
140_V165_A0.5430.23
108_D174_A0.5390.22
80_L200_K0.5380.22
193_A204_L0.5360.22
70_S206_E0.5330.22
214_E223_M0.5310.22
71_L134_L0.5310.22
72_P103_D0.5310.22
3_N38_I0.5290.22
77_E111_E0.5270.22
197_P212_L0.5260.22
144_A219_I0.5250.22
105_A168_L0.5240.22
62_R112_R0.5220.22
14_G112_R0.5180.21
114_E146_R0.5160.21
86_E109_A0.5160.21
121_A217_E0.5160.21
37_A171_K0.5160.21
168_L194_Q0.5140.21
27_P31_P0.5110.21
119_E155_D0.5090.21
47_G50_P0.5070.21
177_L223_M0.5060.21
40_P75_K0.5050.21
190_P195_H0.5040.21
169_I197_P0.5030.21
16_V87_E0.5010.21
17_G22_R0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2b19A 1 0.105 7.5 0.962 Contact Map
3tjyA 1 0.0798 5.6 0.964 Contact Map
2dyjA 1 0.3235 2.6 0.97 Contact Map
3whjA 2 0.2521 2.5 0.97 Contact Map
4mjzA 2 0.2647 2.5 0.97 Contact Map
3rrwA 1 0.4034 2.4 0.97 Contact Map
3utmC 1 0.0756 2.3 0.97 Contact Map
3czuB 1 0.1597 2 0.971 Contact Map
1g8eA 2 0.1849 2 0.971 Contact Map
3i71A 3 0.1092 2 0.971 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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