GREMLIN Database
DUF3348 - Protein of unknown function (DUF3348)
PFAM: PF11828 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 246 (246)
Sequences: 724 (573)
Seq/√Len: 36.6
META: 0.699

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
185_R222_D4.7161.00
185_R188_R4.1571.00
221_K224_Q3.8161.00
206_P209_W3.3311.00
204_D209_W3.2841.00
43_D46_D3.2571.00
123_R127_L2.9611.00
15_L46_D2.9131.00
73_E246_R2.7981.00
75_E78_R2.7951.00
41_W171_E2.7901.00
76_C235_L2.7011.00
178_V226_V2.3471.00
218_A221_K2.3431.00
22_L226_V2.2610.99
183_E187_E2.2150.99
44_W51_S2.1970.99
117_F124_Y2.1930.99
239_E243_E2.1590.99
142_L238_V2.1360.99
120_Y183_E2.1050.99
235_L238_V2.0670.99
127_L130_A2.0490.99
75_E141_R2.0280.99
41_W170_R2.0180.99
175_L233_V1.9870.98
124_Y223_M1.9470.98
129_R172_R1.9250.98
241_L244_A1.9170.98
34_L76_C1.9090.98
46_D135_I1.8820.98
230_E234_R1.8660.98
234_R237_P1.7830.97
189_L219_F1.7810.97
135_I238_V1.7410.96
193_H197_L1.7350.96
161_A167_L1.6980.96
51_S54_L1.6700.95
226_V238_V1.6630.95
15_L43_D1.6580.95
43_D129_R1.5920.94
33_S42_L1.5790.94
170_R174_L1.5660.93
15_L158_A1.5570.93
131_M135_I1.5500.93
43_D55_N1.5380.93
80_R135_I1.5330.93
81_A85_Q1.5330.93
100_I103_P1.5310.93
117_F122_Q1.5280.93
12_G154_A1.5270.92
219_F222_D1.5230.92
45_T51_S1.5200.92
242_L245_L1.4760.91
54_L116_D1.4690.91
49_A120_Y1.4390.90
142_L235_L1.4230.90
8_T25_A1.4170.89
197_L213_G1.4140.89
190_R215_W1.4080.89
79_V138_L1.3930.89
171_E174_L1.3910.88
162_V165_Q1.3880.88
11_S14_A1.3790.88
163_M236_Q1.3720.88
20_A28_P1.3700.88
234_R240_G1.3680.88
201_Q204_D1.3570.87
88_A224_Q1.3510.87
90_D93_A1.3450.87
13_S34_L1.3420.87
84_A228_L1.3380.86
53_A162_V1.3370.86
41_W174_L1.2990.85
142_L146_L1.2860.84
237_P240_G1.2760.84
153_L217_D1.2700.83
79_V147_A1.2550.83
209_W214_A1.2420.82
44_W136_G1.2360.82
203_A207_A1.2300.81
46_D52_A1.2220.81
83_L231_L1.2220.81
135_I232_D1.2210.81
237_P241_L1.2200.81
237_P244_A1.2130.80
230_E240_G1.1970.79
43_D183_E1.1900.79
149_R153_L1.1730.78
3_Q14_A1.1730.78
91_P123_R1.1690.78
18_L24_D1.1640.78
183_E224_Q1.1290.75
84_A88_A1.1280.75
189_L218_A1.1240.75
11_S15_L1.1210.75
132_E169_A1.1160.74
227_L230_E1.1080.74
99_R103_P1.1040.74
48_I132_E1.1030.74
171_E175_L1.0950.73
165_Q211_Q1.0910.73
25_A62_A1.0880.73
48_I52_A1.0860.72
18_L42_L1.0750.72
197_L202_A1.0700.71
2_T5_P1.0690.71
39_S84_A1.0690.71
82_A240_G1.0610.71
48_I141_R1.0550.70
2_T6_P1.0500.70
230_E237_P1.0390.69
44_W154_A1.0390.69
39_S233_V1.0320.68
151_P223_M1.0250.68
200_A208_A1.0130.67
44_W130_A1.0070.67
117_F157_A1.0040.66
205_D209_W1.0040.66
240_G243_E0.9980.66
153_L180_A0.9980.66
46_D55_N0.9960.66
12_G16_V0.9940.66
84_A93_A0.9930.65
13_S119_P0.9900.65
57_S61_A0.9890.65
102_L105_P0.9820.65
53_A82_A0.9660.63
44_W121_R0.9650.63
17_R21_R0.9440.61
117_F225_S0.9420.61
121_R175_L0.9370.61
48_I243_E0.9250.60
68_A145_A0.9240.60
122_Q127_L0.9240.60
13_S127_L0.9220.60
90_D123_R0.9200.59
52_A183_E0.9200.59
71_A224_Q0.9120.59
122_Q130_A0.9090.59
159_L172_R0.9040.58
9_A12_G0.8980.58
23_A26_D0.8940.57
186_F219_F0.8900.57
48_I133_T0.8850.56
162_V178_V0.8840.56
15_L19_L0.8820.56
5_P10_F0.8800.56
98_R118_A0.8800.56
156_L244_A0.8780.56
146_L164_E0.8750.56
126_A172_R0.8700.55
1_M4_A0.8680.55
72_E141_R0.8670.55
187_E221_K0.8660.55
128_Q230_E0.8660.55
213_G216_L0.8650.55
80_R163_M0.8640.55
169_A235_L0.8610.54
76_C239_E0.8530.54
13_S243_E0.8510.54
115_A213_G0.8470.53
36_E161_A0.8450.53
235_L239_E0.8430.53
216_L242_L0.8360.52
235_L240_G0.8360.52
47_A171_E0.8330.52
123_R165_Q0.8320.52
10_F161_A0.8250.51
16_V24_D0.8240.51
15_L144_A0.8240.51
62_A200_A0.8240.51
128_Q143_R0.8240.51
234_R241_L0.8220.51
80_R186_F0.8110.50
5_P70_A0.8080.50
130_A183_E0.8070.50
43_D170_R0.8000.49
23_A177_T0.7990.49
143_R160_D0.7980.49
216_L219_F0.7960.49
101_P109_A0.7960.49
231_L234_R0.7930.48
23_A135_I0.7930.48
204_D210_A0.7930.48
60_A67_A0.7910.48
13_S35_A0.7910.48
121_R181_L0.7870.48
52_A238_V0.7840.48
76_C93_A0.7830.48
44_W236_Q0.7830.48
51_S130_A0.7790.47
61_A188_R0.7770.47
20_A134_A0.7740.47
225_S236_Q0.7680.46
84_A159_L0.7680.46
151_P175_L0.7660.46
187_E224_Q0.7640.46
21_R34_L0.7620.46
32_Q236_Q0.7580.45
36_E183_E0.7550.45
44_W54_L0.7450.44
97_R102_L0.7450.44
1_M6_P0.7440.44
98_R119_P0.7400.44
53_A99_R0.7390.44
35_A165_Q0.7390.44
32_Q37_R0.7380.44
51_S121_R0.7340.43
126_A152_A0.7320.43
11_S132_E0.7320.43
227_L234_R0.7320.43
220_R243_E0.7310.43
172_R240_G0.7290.43
15_L132_E0.7280.43
81_A194_Q0.7260.43
77_A123_R0.7230.42
41_W131_M0.7230.42
150_S178_V0.7190.42
120_Y124_Y0.7140.42
39_S122_Q0.7130.42
197_L200_A0.7100.41
30_S177_T0.7080.41
142_L145_A0.7080.41
42_L166_A0.7060.41
201_Q206_P0.7050.41
123_R190_R0.7030.41
46_D132_E0.7000.40
58_P113_A0.6950.40
76_C238_V0.6940.40
204_D208_A0.6890.39
3_Q42_L0.6870.39
12_G155_R0.6850.39
61_A97_R0.6840.39
201_Q210_A0.6830.39
126_A132_E0.6820.39
197_L204_D0.6780.39
140_G164_E0.6780.39
166_A232_D0.6770.38
33_S47_A0.6770.38
132_E236_Q0.6760.38
41_W47_A0.6750.38
198_A203_A0.6730.38
3_Q48_I0.6710.38
159_L216_L0.6710.38
132_E144_A0.6700.38
9_A20_A0.6690.38
74_A110_P0.6690.38
78_R242_L0.6680.38
13_S69_G0.6670.38
240_G244_A0.6660.38
142_L242_L0.6660.38
205_D208_A0.6660.38
4_A14_A0.6640.37
12_G21_R0.6610.37
170_R173_R0.6590.37
77_A91_P0.6590.37
20_A24_D0.6540.37
9_A43_D0.6530.37
221_K225_S0.6530.37
87_I235_L0.6530.37
149_R162_V0.6480.36
60_A135_I0.6450.36
204_D207_A0.6430.36
42_L52_A0.6390.35
79_V131_M0.6370.35
15_L240_G0.6350.35
44_W123_R0.6340.35
47_A51_S0.6330.35
123_R126_A0.6320.35
74_A240_G0.6300.35
117_F219_F0.6300.35
105_P197_L0.6300.35
123_R163_M0.6290.35
34_L233_V0.6290.35
146_L238_V0.6290.35
66_R70_A0.6270.34
139_R157_A0.6270.34
88_A178_V0.6250.34
198_A201_Q0.6230.34
89_A137_A0.6210.34
10_F23_A0.6200.34
181_L224_Q0.6180.34
124_Y222_D0.6160.34
27_V30_S0.6150.33
33_S144_A0.6150.33
46_D137_A0.6140.33
164_E171_E0.6130.33
10_F15_L0.6130.33
202_A205_D0.6130.33
94_A216_L0.6120.33
146_L178_V0.6090.33
209_W213_G0.6070.33
193_H225_S0.6070.33
42_L46_D0.6070.33
46_D91_P0.6050.33
55_N135_I0.6020.32
194_Q199_D0.5990.32
41_W175_L0.5990.32
112_D213_G0.5950.32
120_Y214_A0.5950.32
2_T162_V0.5940.32
16_V23_A0.5920.32
56_G155_R0.5920.32
6_P141_R0.5920.32
126_A184_K0.5910.32
44_W166_A0.5880.31
184_K224_Q0.5870.31
49_A59_P0.5810.31
125_L157_A0.5780.31
153_L223_M0.5740.30
150_S193_H0.5730.30
234_R244_A0.5700.30
130_A137_A0.5690.30
32_Q179_P0.5690.30
95_A120_Y0.5690.30
26_D196_A0.5680.30
75_E189_L0.5650.30
42_L161_A0.5640.30
130_A166_A0.5620.29
13_S122_Q0.5600.29
184_K225_S0.5600.29
88_A228_L0.5590.29
189_L216_L0.5590.29
18_L225_S0.5580.29
23_A42_L0.5560.29
78_R145_A0.5550.29
12_G24_D0.5550.29
203_A208_A0.5540.29
31_R34_L0.5540.29
75_E134_A0.5540.29
153_L189_L0.5530.29
37_R178_V0.5510.29
124_Y179_P0.5500.29
140_G154_A0.5490.29
89_A185_R0.5490.29
39_S176_A0.5480.28
43_D150_S0.5460.28
65_A68_A0.5460.28
63_P88_A0.5450.28
124_Y219_F0.5440.28
8_T18_L0.5400.28
5_P11_S0.5400.28
100_I127_L0.5390.28
75_E79_V0.5370.28
46_D236_Q0.5360.28
21_R124_Y0.5360.28
122_Q172_R0.5320.27
195_A199_D0.5310.27
163_M239_E0.5310.27
48_I236_Q0.5300.27
7_R10_F0.5290.27
74_A82_A0.5280.27
141_R190_R0.5260.27
206_P210_A0.5250.27
99_R104_A0.5230.27
193_H215_W0.5230.27
147_A153_L0.5230.27
113_A240_G0.5170.26
97_R101_P0.5140.26
15_L135_I0.5130.26
82_A201_Q0.5120.26
48_I51_S0.5110.26
11_S34_L0.5080.26
18_L21_R0.5070.26
160_D241_L0.5060.26
133_T184_K0.5040.25
139_R215_W0.5020.25
12_G219_F0.5000.25
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2h58A 1 0.2276 4.5 0.97 Contact Map
2jd3A 2 0.2114 4.2 0.971 Contact Map
4ozqA 1 0.2276 2.7 0.973 Contact Map
1zeeA 3 0.1341 2 0.975 Contact Map
2ys9A 1 0.2561 1.9 0.975 Contact Map
4rg9S 1 0.0732 1.8 0.976 Contact Map
4n6cA 1 0.5732 1.7 0.976 Contact Map
3hglA 1 0.313 1.6 0.976 Contact Map
4g78A 1 0.4878 1.5 0.977 Contact Map
3eabG 1 0.1179 1.5 0.977 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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