GREMLIN Database
DUF3347 - Protein of unknown function (DUF3347)
PFAM: PF11827 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 186 (180)
Sequences: 4278 (3539)
Seq/√Len: 263.8
META: 0.829

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
151_F162_Y4.5451.00
96_H100_M3.5001.00
88_M96_H3.4871.00
68_D71_K3.4061.00
134_Y149_Y3.2591.00
88_M100_M3.2521.00
150_Q185_V3.0161.00
127_E156_N2.7091.00
64_L72_A2.6751.00
69_A122_Q2.3861.00
150_Q170_I2.3781.00
56_A82_A2.2501.00
65_V180_L2.2071.00
67_D119_I2.2011.00
58_L147_L2.1781.00
171_K181_T2.1661.00
61_K126_F2.1561.00
67_D177_S2.0481.00
79_L110_A2.0401.00
84_K107_K2.0181.00
112_H121_H1.9741.00
127_E161_A1.9411.00
46_F49_Q1.9331.00
118_D121_H1.9331.00
26_H29_H1.9131.00
149_Y162_Y1.8861.00
56_A59_A1.8851.00
175_F180_L1.8571.00
54_L58_L1.7661.00
154_M179_M1.6631.00
59_A75_A1.6551.00
53_V86_V1.6371.00
127_E155_A1.6301.00
109_H132_D1.5411.00
112_H115_K1.4971.00
87_D90_L1.4691.00
76_A113_I1.4601.00
81_A85_K1.4561.00
62_D166_E1.4561.00
134_Y138_K1.4431.00
83_L106_L1.4331.00
171_K180_L1.4061.00
150_Q165_S1.3631.00
92_K95_A1.3541.00
56_A78_A1.3411.00
6_C10_G1.3311.00
98_V139_A1.3241.00
127_E159_K1.3191.00
69_A116_S1.3171.00
60_L75_A1.2991.00
158_N175_F1.2811.00
108_E112_H1.2721.00
105_D132_D1.2701.00
71_K74_K1.2311.00
60_L64_L1.2271.00
109_H125_H1.2261.00
112_H125_H1.2081.00
121_H124_E1.1961.00
7_Q15_M1.1881.00
156_N159_K1.1761.00
80_L111_E1.1751.00
58_L166_E1.1641.00
127_E131_E1.1551.00
106_L129_L1.1521.00
7_Q14_M1.1301.00
54_L147_L1.1261.00
151_F160_G1.1251.00
80_L114_A1.1241.00
61_K165_S1.1221.00
8_L14_M1.1011.00
78_A81_A1.0901.00
134_Y162_Y1.0861.00
71_K75_A1.0711.00
61_K150_Q1.0691.00
8_L13_S1.0601.00
152_C182_C1.0591.00
73_A122_Q1.0541.00
147_L164_L1.0511.00
75_A78_A1.0421.00
6_C15_M1.0391.00
11_K14_M1.0381.00
61_K65_V1.0341.00
46_F50_L1.0331.00
17_P20_G1.0301.00
70_K73_A1.0271.00
58_L61_K1.0201.00
25_G29_H1.0091.00
42_E45_A0.9981.00
60_L79_L0.9911.00
47_K50_L0.9911.00
121_H125_H0.9781.00
69_A118_D0.9671.00
98_V102_I0.9661.00
116_S121_H0.9571.00
6_C14_M0.9511.00
131_E135_D0.9501.00
77_K81_A0.9491.00
80_L110_A0.9471.00
25_G28_H0.9361.00
12_K15_M0.9301.00
53_V83_L0.9281.00
8_L15_M0.9271.00
133_L136_L0.9261.00
23_M26_H0.9201.00
13_S16_N0.9131.00
7_Q13_S0.9111.00
35_S38_M0.9091.00
103_L107_K0.9051.00
21_K24_T0.9041.00
46_F91_L0.9021.00
86_V99_W0.9001.00
10_G14_M0.8931.00
19_G25_G0.8891.00
28_H31_M0.8851.00
59_A78_A0.8841.00
111_E115_K0.8821.00
80_L84_K0.8811.00
20_G23_M0.8751.00
169_E181_T0.8751.00
12_K17_P0.8721.00
170_I185_V0.8681.00
132_D135_D0.8671.00
9_Q12_K0.8671.00
7_Q10_G0.8651.00
20_G25_G0.8501.00
155_A161_A0.8491.00
63_A71_K0.8420.99
165_S170_I0.8370.99
55_D59_A0.8300.99
77_K114_A0.8260.99
10_G13_S0.8190.99
27_E31_M0.8170.99
69_A119_I0.8170.99
50_L136_L0.8130.99
6_C9_Q0.8090.99
99_W103_L0.8060.99
153_P179_M0.8060.99
102_I105_D0.8040.99
31_M34_D0.8030.99
109_H128_M0.7970.99
161_A174_Y0.7900.99
113_I122_Q0.7890.99
80_L107_K0.7890.99
54_L137_V0.7860.99
155_A174_Y0.7840.99
29_H32_M0.7660.99
34_D37_E0.7610.99
160_G175_F0.7570.99
33_G38_M0.7490.99
7_Q11_K0.7470.99
67_D180_L0.7440.99
107_K111_E0.7440.99
59_A71_K0.7430.99
120_E178_K0.7420.99
151_F155_A0.7380.99
178_K181_T0.7310.99
49_Q52_A0.7300.99
65_V165_S0.7200.98
14_M17_P0.7150.98
53_V79_L0.7150.98
62_D65_V0.7100.98
56_A75_A0.7080.98
22_T25_G0.7010.98
170_I183_G0.7000.98
53_V133_L0.6990.98
88_M103_L0.6950.98
79_L129_L0.6930.98
64_L67_D0.6920.98
27_E30_D0.6910.98
12_K16_N0.6910.98
8_L11_K0.6870.98
69_A73_A0.6850.98
19_G22_T0.6840.98
30_D33_G0.6800.98
16_N21_K0.6780.98
13_S17_P0.6760.98
12_K18_E0.6730.97
8_L12_K0.6720.97
63_A72_A0.6610.97
6_C16_N0.6580.97
8_L16_N0.6560.97
32_M36_S0.6510.97
113_I129_L0.6510.97
20_G24_T0.6510.97
29_H33_G0.6500.97
151_F184_E0.6480.97
24_T27_E0.6480.97
112_H116_S0.6440.97
97_K101_K0.6430.97
137_V164_L0.6430.97
176_G179_M0.6350.96
74_K78_A0.6340.96
26_H30_D0.6320.96
110_A114_A0.6310.96
17_P22_T0.6290.96
142_T147_L0.6280.96
104_E108_E0.6250.96
119_I123_R0.6240.96
155_A160_G0.6220.96
149_Y185_V0.6210.96
17_P21_K0.6140.96
37_E40_M0.6110.96
137_V142_T0.6080.95
91_L99_W0.6070.95
93_G97_K0.6060.95
67_D72_A0.6040.95
79_L106_L0.6030.95
148_Y165_S0.5980.95
36_S40_M0.5950.95
167_E171_K0.5940.95
165_S185_V0.5930.95
63_A75_A0.5930.95
130_S134_Y0.5910.95
72_A122_Q0.5900.95
22_T26_H0.5880.95
19_G24_T0.5860.94
67_D123_R0.5820.94
18_E21_K0.5780.94
19_G29_H0.5770.94
154_M180_L0.5770.94
19_G26_H0.5760.94
111_E114_A0.5710.94
91_L95_A0.5710.94
86_V91_L0.5650.93
11_K15_M0.5610.93
77_K80_L0.5600.93
34_D38_M0.5600.93
126_F130_S0.5570.93
60_L113_I0.5570.93
78_A82_A0.5560.93
150_Q167_E0.5550.93
32_M40_M0.5550.93
19_G28_H0.5540.93
120_E124_E0.5510.92
134_Y137_V0.5500.92
16_N19_G0.5500.92
9_Q15_M0.5490.92
12_K19_G0.5490.92
7_Q12_K0.5460.92
96_H99_W0.5420.92
47_K51_K0.5410.92
19_G23_M0.5410.92
14_M20_G0.5350.91
18_E22_T0.5340.91
17_P25_G0.5330.91
109_H112_H0.5320.91
60_L76_A0.5310.91
33_G36_S0.5280.91
38_M41_K0.5220.90
176_G180_L0.5220.90
99_W140_F0.5220.90
156_N160_G0.5210.90
108_E125_H0.5200.90
102_I135_D0.5170.90
28_H32_M0.5170.90
93_G96_H0.5150.90
74_K77_K0.5140.90
57_Y61_K0.5130.90
175_F178_K0.5100.89
23_M27_E0.5100.89
106_L109_H0.5100.89
27_E33_G0.5090.89
132_D136_L0.5080.89
9_Q13_S0.5080.89
105_D109_H0.5070.89
51_K55_D0.5060.89
125_H128_M0.5020.89
67_D176_G0.5010.88
76_A122_Q0.5000.88
22_T30_D0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1j7nA 2 0.9462 31.4 0.936 Contact Map
1xfxA 1 0.9086 18.1 0.943 Contact Map
1y6dA 1 0.5591 15.8 0.944 Contact Map
4h8sA 2 0.5323 15.8 0.944 Contact Map
1sr2A 1 0.6237 12.6 0.947 Contact Map
3iqtA 1 0.6129 11.1 0.948 Contact Map
4l8tA 1 0.4247 11 0.948 Contact Map
1s05A 1 0.5699 6.9 0.952 Contact Map
3l6aA 1 0.7043 6.4 0.953 Contact Map
4jeaA 4 0.5054 6 0.954 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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