GREMLIN Database
DUF3343 - Protein of unknown function (DUF3343)
PFAM: PF11823 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 69 (66)
Sequences: 7511 (5498)
Seq/√Len: 676.7
META: 0.884

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
2_Y47_L2.5471.00
45_F53_V2.5101.00
31_V42_A2.3601.00
49_D52_A2.2661.00
50_L54_E2.2261.00
4_I45_F2.1991.00
29_I44_R1.7711.00
46_P49_D1.7281.00
15_A57_L1.7191.00
15_A43_L1.7121.00
55_R59_E1.6021.00
19_L53_V1.5081.00
8_S11_H1.4851.00
18_L60_A1.4801.00
22_A56_L1.4691.00
16_E20_K1.4501.00
26_V43_L1.4301.00
6_F15_A1.3911.00
24_I52_A1.3881.00
7_H65_E1.3231.00
7_H11_H1.2891.00
52_A55_R1.2601.00
3_V29_I1.2521.00
45_F50_L1.2111.00
16_E26_V1.1621.00
54_E58_E1.1571.00
25_P49_D1.0911.00
19_L43_L1.0801.00
2_Y45_F1.0751.00
22_A52_A1.0571.00
14_R18_L1.0521.00
28_L41_L1.0251.00
33_R36_S1.0251.00
33_R38_G1.0141.00
12_A38_G1.0131.00
56_L60_A1.0131.00
9_T41_L1.0061.00
18_L22_A0.9821.00
19_L26_V0.9731.00
56_L59_E0.9581.00
51_E54_E0.9431.00
18_L21_E0.9391.00
31_V40_G0.9391.00
5_T31_V0.9271.00
38_G41_L0.9231.00
22_A59_E0.9161.00
29_I42_A0.9141.00
51_E55_R0.9081.00
12_A41_L0.8701.00
22_A60_A0.8691.00
20_K26_V0.8111.00
11_H14_R0.8081.00
7_H63_E0.7911.00
18_L56_L0.7811.00
57_L64_P0.7721.00
19_L45_F0.7691.00
25_P46_P0.7681.00
9_T13_L0.7601.00
12_A28_L0.7571.00
10_H38_G0.7551.00
9_T30_P0.7421.00
24_I56_L0.7401.00
31_V37_S0.7381.00
11_H63_E0.7321.00
4_I57_L0.7191.00
47_L50_L0.7171.00
30_P41_L0.7161.00
10_H41_L0.7161.00
54_E67_I0.7151.00
28_L43_L0.7111.00
52_A56_L0.6901.00
4_I64_P0.6871.00
55_R58_E0.6861.00
4_I53_V0.6771.00
10_H13_L0.6611.00
17_K21_E0.6591.00
24_I53_V0.6571.00
64_P67_I0.6471.00
24_I49_D0.6401.00
5_T42_A0.6311.00
15_A19_L0.6301.00
19_L24_I0.6291.00
27_R44_R0.6231.00
14_R17_K0.6191.00
10_H14_R0.6191.00
58_E61_G0.6181.00
6_F12_A0.6121.00
9_T12_A0.6081.00
32_P35_I0.5861.00
13_L16_E0.5851.00
4_I67_I0.5631.00
2_Y50_L0.5621.00
5_T10_H0.5541.00
36_S40_G0.5541.00
21_E60_A0.5321.00
32_P42_A0.5241.00
5_T35_I0.5110.99
45_F49_D0.5090.99
5_T38_G0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2hfvA 1 0.9855 59.1 0.783 Contact Map
2gqcA 1 0.913 47.1 0.798 Contact Map
2lepA 1 0.8986 46 0.799 Contact Map
4w4mA 1 0.8841 37 0.81 Contact Map
4hddA 6 0.913 34.5 0.813 Contact Map
3j6da 3 0.8116 31.2 0.817 Contact Map
2l69A 1 1 28.5 0.821 Contact Map
1vr9A 1 0 24.5 0.826 Contact Map
4o9uB 2 0.7971 20.7 0.833 Contact Map
1djlA 1 0.7971 15.5 0.841 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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