GREMLIN Database
DUF3341 - Protein of unknown function (DUF3341)
PFAM: PF11821 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 170 (167)
Sequences: 16028 (9191)
Seq/√Len: 711.3
META: 0.969

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
66_F87_F3.2661.00
57_G107_G2.8121.00
157_R161_E2.7261.00
54_V108_A2.7171.00
68_L72_T2.6721.00
9_D12_A2.5211.00
62_A100_T2.5011.00
7_F163_L2.3811.00
158_A162_S2.3591.00
70_W87_F2.2951.00
112_M116_N2.2541.00
20_L28_M2.2031.00
63_L67_L1.9721.00
106_L110_F1.9621.00
64_G67_L1.9051.00
8_D166_E1.9051.00
53_I107_G1.8701.00
158_A161_E1.8541.00
64_G103_F1.8441.00
20_L159_F1.8301.00
71_W76_D1.7851.00
60_T64_G1.7661.00
62_A96_T1.7421.00
155_E158_A1.6831.00
65_G99_L1.6811.00
53_I115_L1.6601.00
56_I60_T1.6531.00
154_E158_A1.6431.00
19_K22_A1.6311.00
152_D155_E1.6271.00
54_V104_A1.6251.00
31_Y143_C1.6181.00
8_D12_A1.5951.00
109_V113_L1.5601.00
4_L125_V1.5551.00
19_K23_A1.5391.00
69_Q96_T1.5341.00
19_K162_S1.5021.00
153_A157_R1.4751.00
60_T103_F1.4731.00
135_A141_F1.4541.00
28_M43_L1.4261.00
15_A18_R1.4061.00
110_F114_A1.4011.00
70_W74_V1.3991.00
72_T76_D1.3971.00
122_Y127_N1.3781.00
21_R44_G1.3701.00
18_R22_A1.3441.00
154_E157_R1.3321.00
133_R138_D1.3291.00
8_D139_R1.3191.00
144_I156_T1.3141.00
97_F101_V1.3131.00
6_E141_F1.3071.00
139_R166_E1.3011.00
52_L56_I1.3011.00
73_S92_F1.2931.00
159_F163_L1.2861.00
55_L59_L1.2591.00
150_K155_E1.2381.00
30_A39_L1.2371.00
5_A165_A1.2361.00
66_F96_T1.2181.00
64_G99_L1.2071.00
23_A155_E1.1971.00
15_A19_K1.1951.00
6_E139_R1.1621.00
57_G103_F1.1541.00
17_A30_A1.1521.00
99_L103_F1.1431.00
21_R26_R1.1421.00
18_R42_A1.1091.00
133_R139_R1.1031.00
65_G69_Q1.0981.00
13_L30_A1.0871.00
12_A15_A1.0861.00
109_V112_M1.0841.00
53_I111_G1.0801.00
80_N84_K1.0781.00
49_R52_L1.0761.00
11_D15_A1.0751.00
156_T159_F1.0601.00
13_L142_L1.0541.00
14_L38_G1.0471.00
130_R167_E1.0381.00
27_R147_D1.0361.00
65_G95_I1.0281.00
40_D45_L1.0191.00
50_L54_V1.0151.00
17_A43_L1.0091.00
69_Q92_F0.9931.00
57_G111_G0.9911.00
21_R42_A0.9901.00
62_A66_F0.9901.00
34_F140_F0.9801.00
2_G143_C0.9731.00
20_L142_L0.9721.00
125_V128_V0.9701.00
58_G104_A0.9551.00
107_G111_G0.9511.00
59_L63_L0.9481.00
19_K163_L0.9471.00
123_H126_F0.9421.00
20_L144_I0.9421.00
66_F70_W0.9221.00
117_G120_R0.9201.00
66_F89_W0.9171.00
53_I57_G0.9021.00
17_A42_A0.8881.00
74_V87_F0.8841.00
87_F92_F0.8811.00
68_L71_W0.8811.00
133_R137_D0.8741.00
17_A39_L0.8741.00
57_G61_G0.8701.00
70_W75_I0.8691.00
64_G68_L0.8491.00
156_T160_L0.8471.00
103_F107_G0.8471.00
11_D14_L0.8461.00
17_A21_R0.8411.00
80_N86_L0.8241.00
49_R115_L0.8211.00
32_S36_V0.8211.00
38_G41_E0.8201.00
131_F141_F0.8121.00
13_L140_F0.8111.00
23_A159_F0.8061.00
111_G115_L0.8041.00
27_R145_E0.8021.00
148_D151_F0.7991.00
71_W75_I0.7951.00
85_P88_S0.7941.00
48_S51_P0.7901.00
69_Q95_I0.7861.00
106_L109_V0.7861.00
130_R133_R0.7851.00
71_W74_V0.7671.00
37_H40_D0.7661.00
67_L70_W0.7581.00
3_L157_R0.7521.00
58_G100_T0.7491.00
88_S92_F0.7471.00
113_L119_P0.7451.00
4_L128_V0.7421.00
129_P132_D0.7381.00
6_E135_A0.7381.00
14_L18_R0.7311.00
57_G106_L0.7301.00
78_P86_L0.7261.00
10_P36_V0.7171.00
41_E44_G0.7131.00
42_A45_L0.7131.00
16_A163_L0.7081.00
105_A109_V0.7011.00
3_L156_T0.6981.00
28_M142_L0.6951.00
93_I97_F0.6931.00
6_E130_R0.6891.00
59_L62_A0.6871.00
25_Y156_T0.6831.00
36_V39_L0.6761.00
13_L16_A0.6711.00
94_P100_T0.6691.00
23_A162_S0.6661.00
73_S79_L0.6591.00
46_K49_R0.6581.00
54_V107_G0.6581.00
10_P14_L0.6571.00
6_E167_E0.6561.00
30_A142_L0.6541.00
40_D43_L0.6501.00
14_L42_A0.6491.00
108_A112_M0.6481.00
4_L143_C0.6441.00
159_F162_S0.6431.00
89_W93_I0.6421.00
10_P34_F0.6421.00
47_R52_L0.6371.00
81_I86_L0.6371.00
29_D45_L0.6361.00
73_S86_L0.6351.00
95_I99_L0.6331.00
17_A142_L0.6291.00
13_L39_L0.6231.00
132_D169_E0.6221.00
160_L165_A0.6211.00
32_S35_P0.6211.00
25_Y159_F0.6171.00
161_E165_A0.6161.00
36_V140_F0.6141.00
10_P38_G0.6141.00
60_T63_L0.6111.00
20_L23_A0.6111.00
103_F106_L0.6101.00
67_L71_W0.6101.00
33_P39_L0.6031.00
90_P95_I0.6011.00
47_R51_P0.5971.00
98_E102_L0.5951.00
85_P90_P0.5931.00
93_I96_T0.5841.00
98_E101_V0.5811.00
62_A104_A0.5801.00
50_L108_A0.5791.00
128_V169_E0.5791.00
32_S39_L0.5791.00
13_L32_S0.5781.00
61_G65_G0.5761.00
165_A168_V0.5761.00
65_G96_T0.5741.00
18_R21_R0.5731.00
68_L99_L0.5731.00
88_S91_A0.5711.00
61_G103_F0.5661.00
149_P152_D0.5651.00
21_R28_M0.5641.00
94_P98_E0.5631.00
90_P93_I0.5631.00
72_T95_I0.5581.00
65_G97_F0.5571.00
56_I63_L0.5571.00
13_L17_A0.5551.00
72_T79_L0.5521.00
60_T107_G0.5521.00
60_T67_L0.5491.00
56_I107_G0.5491.00
4_L141_F0.5481.00
57_G60_T0.5451.00
66_F93_I0.5451.00
33_P36_V0.5441.00
30_A43_L0.5431.00
91_A94_P0.5421.00
91_A95_I0.5411.00
73_S88_S0.5361.00
114_A117_G0.5361.00
70_W73_S0.5341.00
49_R53_I0.5311.00
50_L111_G0.5301.00
6_E166_E0.5291.00
17_A28_M0.5291.00
31_Y131_F0.5281.00
129_P169_E0.5241.00
132_D139_R0.5191.00
38_G44_G0.5181.00
150_K156_T0.5141.00
65_G68_L0.5040.99
13_L139_R0.5020.99
151_F156_T0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1x60A 1 0.1941 28.5 0.929 Contact Map
1utaA 1 0.3588 28.5 0.929 Contact Map
4i0uA 4 0.5941 11.3 0.941 Contact Map
4ev6A 3 0.6059 10.6 0.942 Contact Map
3a9sA 5 0.9529 10.1 0.942 Contact Map
2lfvA 1 0.2353 9.3 0.943 Contact Map
4fp1A 5 0.6353 8.9 0.943 Contact Map
2qrrA 2 0.2 7.2 0.946 Contact Map
3ju3A 4 0.5588 7 0.946 Contact Map
1gccA 1 0.2176 6.9 0.946 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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