GREMLIN Database
DUF3339 - Protein of unknown function (DUF3339)
PFAM: PF11820 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 67 (65)
Sequences: 632 (300)
Seq/√Len: 37.2
META: 0.481

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
40_S43_S4.8591.00
8_L66_I4.0691.00
24_Q43_S3.3081.00
29_S38_Q3.0211.00
10_A55_F2.6571.00
24_Q40_S2.0150.99
54_L58_L2.0030.99
50_V54_L1.7650.97
31_G38_Q1.5570.94
12_V36_N1.5370.93
5_G11_V1.4490.91
27_G32_V1.3990.89
12_V16_L1.3590.88
7_V11_V1.3420.87
24_Q36_N1.3090.86
51_F59_L1.2460.83
13_L17_L1.2380.82
21_L44_I1.2250.82
25_L53_L1.2050.81
27_G33_E1.1950.80
2_A29_S1.1640.78
23_L48_A1.1610.78
5_G10_A1.1520.77
55_F59_L1.1480.77
10_A42_A1.1190.75
21_L43_S1.1160.75
21_L24_Q1.0900.73
28_K58_L1.0530.71
41_G57_I1.0120.68
11_V65_H1.0070.67
11_V15_V1.0020.67
16_L53_L0.9810.65
39_T44_I0.9780.65
15_V33_E0.9730.65
28_K38_Q0.9710.64
37_M56_A0.9680.64
52_F56_A0.9560.63
24_Q37_M0.9450.62
3_D6_P0.9220.60
48_A66_I0.9090.59
18_S63_G0.9080.59
32_V45_L0.8840.57
6_P10_A0.8710.56
24_Q30_R0.8600.55
9_V49_L0.8510.54
38_Q53_L0.8020.50
56_A66_I0.7970.49
10_A50_V0.7850.48
41_G52_F0.7810.48
12_V15_V0.7790.48
5_G63_G0.7710.47
52_F61_A0.7700.47
15_V37_M0.7280.43
51_F55_F0.7250.43
22_L46_V0.7250.43
17_L48_A0.7130.42
12_V26_P0.7090.42
16_L54_L0.6810.39
49_L62_I0.6730.39
5_G13_L0.6730.39
4_W50_V0.6670.38
11_V22_L0.6660.38
18_S45_L0.6630.38
30_R33_E0.6600.38
22_L48_A0.6570.37
7_V53_L0.6490.37
25_L57_I0.6490.37
18_S39_T0.6400.36
43_S57_I0.6330.35
13_L32_V0.6220.35
14_F17_L0.6180.34
26_P36_N0.6040.33
2_A63_G0.6000.33
30_R34_F0.5950.32
26_P60_L0.5950.32
45_L66_I0.5940.32
23_L37_M0.5900.32
25_L46_V0.5870.32
10_A56_A0.5860.32
14_F20_G0.5860.32
9_V27_G0.5790.31
63_G66_I0.5760.31
42_A48_A0.5720.31
11_V28_K0.5720.31
36_N56_A0.5650.30
24_Q38_Q0.5580.30
21_L30_R0.5540.29
2_A53_L0.5520.29
22_L54_L0.5300.28
16_L62_I0.5230.27
31_G37_M0.5200.27
22_L28_K0.5180.27
24_Q28_K0.5120.26
38_Q61_A0.5120.26
58_L64_V0.5110.26
10_A49_L0.5080.26
7_V10_A0.5040.26
7_V41_G0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4hygA 3 0.9104 3.2 0.912 Contact Map
1kqfC 3 0.8955 3.1 0.913 Contact Map
3i94A 1 0.5821 1.8 0.923 Contact Map
2l9uA 2 0.4328 1.6 0.926 Contact Map
4huqT 1 0.2836 1.2 0.931 Contact Map
4ltoA 3 0.3731 1.2 0.932 Contact Map
3wu2Z 1 0.3731 1.1 0.932 Contact Map
2m0jB 1 0.1493 1.1 0.934 Contact Map
4cbcA 3 0.3582 0.9 0.937 Contact Map
3rceA 1 0.4328 0.9 0.937 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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