GREMLIN Database
DUF3333 - Domain of unknown function (DUF3333)
PFAM: PF11812 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 152 (148)
Sequences: 5161 (3900)
Seq/√Len: 320.6
META: 0.867

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
52_D129_T3.3241.00
50_T129_T2.8831.00
50_T131_W2.8271.00
116_M123_L2.7881.00
30_A34_G2.6581.00
55_F128_V2.4491.00
16_A19_L2.3361.00
94_G97_D2.3161.00
13_R17_Y2.1811.00
47_T142_L2.0511.00
34_G38_S2.0461.00
86_R102_Y2.0041.00
10_A13_R1.9881.00
23_A27_L1.9751.00
37_V41_Y1.9261.00
9_A13_R1.8981.00
54_T57_P1.8311.00
81_V105_V1.8071.00
35_S39_K1.7711.00
20_A24_L1.7221.00
68_D71_A1.7171.00
16_A20_A1.6951.00
84_A88_A1.6911.00
83_A87_A1.6511.00
111_F115_D1.5901.00
82_R102_Y1.5691.00
116_M120_D1.5671.00
19_L23_A1.5141.00
12_R15_R1.5131.00
49_I134_A1.5111.00
41_Y45_T1.4841.00
147_D150_L1.4771.00
27_L31_F1.4651.00
54_T127_T1.4471.00
47_T134_A1.4301.00
112_Q133_P1.4231.00
78_R110_A1.4091.00
24_L28_F1.3941.00
140_M145_R1.3861.00
116_M130_V1.3851.00
114_R118_L1.3711.00
42_S45_T1.3671.00
86_R98_K1.3581.00
11_E14_F1.3431.00
134_A138_V1.3161.00
13_R16_A1.3121.00
117_V123_L1.3071.00
5_K9_A1.2921.00
123_L126_T1.2751.00
117_V124_I1.2681.00
139_D143_K1.2671.00
8_Y12_R1.2561.00
15_R19_L1.2451.00
61_D67_R1.2421.00
120_D123_L1.2271.00
33_L37_V1.2221.00
48_Y131_W1.2191.00
116_M128_V1.2171.00
98_K102_Y1.2051.00
78_R82_R1.1831.00
29_L33_L1.1831.00
4_L8_Y1.1711.00
72_L77_Y1.1661.00
10_A17_Y1.1601.00
52_D127_T1.1591.00
55_F116_M1.1481.00
51_L84_A1.1421.00
63_D66_P1.1401.00
45_T48_Y1.1311.00
97_D100_A1.1301.00
141_Y148_R1.1241.00
115_D119_A1.1221.00
26_L30_A1.1061.00
79_G83_A1.0991.00
55_F123_L1.0821.00
76_D79_G1.0571.00
22_I26_L1.0431.00
57_P125_G1.0311.00
85_L105_V1.0221.00
56_D59_V1.0171.00
20_A23_A1.0161.00
61_D64_G0.9991.00
48_Y133_P0.9951.00
34_G37_V0.9921.00
69_P73_A0.9721.00
62_P67_R0.9671.00
92_V101_L0.9661.00
59_V79_G0.9421.00
17_Y20_A0.9391.00
38_S42_S0.9391.00
55_F60_L0.9311.00
77_Y117_V0.9281.00
112_Q116_M0.9261.00
100_A103_G0.9151.00
59_V83_A0.9141.00
83_A86_R0.9091.00
54_T87_A0.9051.00
138_V142_L0.9021.00
40_G44_F0.8961.00
120_D126_T0.8951.00
25_A29_L0.8851.00
95_R98_K0.8841.00
38_S41_Y0.8831.00
89_F92_V0.8821.00
73_A118_L0.8721.00
52_D56_D0.8611.00
12_R16_A0.8581.00
66_P71_A0.8521.00
81_V109_A0.8401.00
115_D118_L0.8351.00
69_P118_L0.8331.00
53_V84_A0.8121.00
28_F32_L0.8091.00
47_T139_D0.8031.00
122_S126_T0.8031.00
66_P69_P0.7991.00
53_V81_V0.7991.00
55_F130_V0.7971.00
104_L138_V0.7971.00
23_A26_L0.7911.00
53_V80_L0.7901.00
137_D140_M0.7841.00
32_L36_I0.7741.00
82_R86_R0.7721.00
25_A28_F0.7691.00
40_G45_T0.7630.99
22_I25_A0.7460.99
93_T97_D0.7360.99
63_D71_A0.7330.99
113_L130_V0.7290.99
95_R99_R0.7260.99
57_P67_R0.7240.99
113_L132_L0.7230.99
112_Q115_D0.7210.99
26_L33_L0.7190.99
59_V75_A0.7150.99
85_L88_A0.7090.99
64_G67_R0.7040.99
11_E15_R0.7040.99
92_V97_D0.6970.99
85_L101_L0.6960.99
5_K8_Y0.6920.99
140_M144_G0.6890.99
55_F117_V0.6880.99
81_V110_A0.6860.99
63_D67_R0.6840.99
48_Y52_D0.6830.99
146_I150_L0.6770.99
66_P70_E0.6750.99
46_Q133_P0.6740.99
3_R6_R0.6730.99
138_V141_Y0.6670.99
128_V131_W0.6660.99
32_L39_K0.6650.99
123_L128_V0.6640.99
89_F101_L0.6630.99
71_A75_A0.6550.98
60_L67_R0.6510.98
73_A114_R0.6500.98
82_R95_R0.6500.98
28_F31_F0.6430.98
67_R71_A0.6410.98
134_A142_L0.6370.98
71_A74_T0.6360.98
64_G71_A0.6340.98
87_A127_T0.6320.98
6_R9_A0.6290.98
60_L75_A0.6250.98
141_Y147_D0.6250.98
6_R10_A0.6230.98
29_L55_F0.6220.98
28_F35_S0.6200.98
107_S135_S0.6200.98
94_G99_R0.6180.98
47_T138_V0.6170.98
63_D68_D0.6160.98
18_G22_I0.6140.98
72_L75_A0.6120.98
55_F132_L0.6070.97
136_D140_M0.6070.97
107_S136_D0.6060.97
135_S140_M0.5940.97
60_L80_L0.5920.97
81_V113_L0.5840.97
70_E74_T0.5840.97
92_V98_K0.5810.97
69_P124_I0.5810.97
33_L36_I0.5800.97
59_V80_L0.5780.97
94_G98_K0.5750.96
8_Y14_F0.5710.96
20_A27_L0.5650.96
51_L132_L0.5650.96
53_V130_V0.5640.96
60_L71_A0.5610.96
3_R33_L0.5600.96
16_A23_A0.5580.96
49_I105_V0.5560.96
141_Y150_L0.5560.96
21_A25_A0.5550.96
113_L116_M0.5550.96
5_K12_R0.5500.95
42_S145_R0.5450.95
109_A132_L0.5410.95
93_T96_R0.5400.95
22_I32_L0.5400.95
79_G82_R0.5360.95
141_Y146_I0.5330.95
72_L118_L0.5310.95
52_D88_A0.5290.94
69_P72_L0.5210.94
132_L135_S0.5200.94
61_D71_A0.5200.94
112_Q132_L0.5090.93
66_P72_L0.5070.93
9_A12_R0.5060.93
135_S138_V0.5060.93
31_F34_G0.5060.93
93_T98_K0.5040.93
8_Y11_E0.5030.93
121_P124_I0.5010.93
89_F105_V0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2m8rA 1 0.2566 11.7 0.941 Contact Map
2w3zA 1 0.4868 7.7 0.945 Contact Map
4ud4A 1 0.5 6.8 0.946 Contact Map
3j00Z 1 0.6382 5.9 0.948 Contact Map
2kogA 1 0.2632 5.6 0.949 Contact Map
3owqA 1 0.3684 4.4 0.951 Contact Map
2adlA 2 0.4737 4 0.952 Contact Map
1p3qQ 2 0.3553 4 0.952 Contact Map
3k6qA 2 0.5461 3.7 0.953 Contact Map
3hd7A 1 0.2632 3.6 0.953 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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