GREMLIN Database
DUF3329 - Domain of unknown function (DUF3329)
PFAM: PF11808 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 86 (82)
Sequences: 7869 (5865)
Seq/√Len: 647.7
META: 0.902

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
25_A28_A2.6191.00
63_G71_F2.6021.00
27_A31_L2.4341.00
46_Y50_R2.1021.00
78_Q81_N2.0651.00
49_L53_R2.0181.00
51_W61_P1.9931.00
81_N84_R1.8831.00
26_P29_A1.7581.00
25_A29_A1.7031.00
16_A29_A1.6951.00
68_G72_A1.6761.00
36_L40_W1.6701.00
37_Y41_H1.6441.00
44_Q47_R1.6211.00
48_L74_L1.5941.00
34_L38_L1.5791.00
31_L34_L1.5551.00
23_F29_A1.5321.00
40_W44_Q1.5111.00
48_L71_F1.5081.00
4_R7_L1.4381.00
26_P30_L1.4061.00
18_L22_L1.3871.00
44_Q63_G1.3661.00
45_L66_L1.3591.00
43_R47_R1.3341.00
28_A31_L1.3171.00
4_R8_R1.3171.00
49_L73_R1.3141.00
37_Y42_L1.2961.00
39_A43_R1.2931.00
23_F26_P1.2801.00
53_R73_R1.2781.00
13_L34_L1.2501.00
77_L81_N1.2331.00
12_L16_A1.1801.00
20_G28_A1.1661.00
20_G25_A1.1581.00
72_A75_Y1.1391.00
7_L11_L1.1271.00
38_L42_L1.0811.00
12_L33_G1.0771.00
18_L21_L1.0511.00
27_A30_L1.0341.00
77_L80_R1.0311.00
5_E8_R1.0201.00
8_R12_L1.0121.00
17_L26_P1.0021.00
49_L69_E0.9801.00
40_W43_R0.9351.00
72_A76_R0.9301.00
16_A33_G0.9281.00
7_L10_A0.9231.00
19_L23_F0.9101.00
11_L15_A0.9061.00
32_L36_L0.9031.00
17_L21_L0.8491.00
5_E37_Y0.8421.00
48_L70_V0.8291.00
63_G68_G0.8281.00
51_W55_P0.8231.00
67_W70_V0.8151.00
10_A13_L0.8061.00
6_L10_A0.7941.00
37_Y40_W0.7941.00
41_H44_Q0.7911.00
19_L27_A0.7881.00
45_L70_V0.7781.00
17_L20_G0.7781.00
20_G24_G0.7711.00
54_G57_R0.7631.00
20_G26_P0.7621.00
49_L70_V0.7531.00
21_L25_A0.7511.00
46_Y49_L0.7511.00
21_L24_G0.7451.00
82_R85_K0.7401.00
20_G23_F0.7251.00
45_L49_L0.7231.00
43_R64_S0.7201.00
28_A32_L0.6901.00
47_R69_E0.6851.00
21_L29_A0.6791.00
37_Y66_L0.6621.00
21_L26_P0.6551.00
41_H67_W0.6521.00
46_Y66_L0.6461.00
17_L30_L0.6311.00
13_L17_L0.6281.00
74_L81_N0.6141.00
56_R59_P0.6131.00
76_R80_R0.6101.00
60_P77_L0.5951.00
9_L12_L0.5931.00
41_H45_L0.5881.00
42_L66_L0.5831.00
50_R54_G0.5791.00
67_W71_F0.5781.00
43_R46_Y0.5751.00
35_L39_A0.5721.00
63_G67_W0.5711.00
62_E72_A0.5651.00
43_R69_E0.5631.00
5_E9_L0.5531.00
58_A82_R0.5521.00
72_A79_R0.5481.00
64_S68_G0.5471.00
54_G58_A0.5471.00
44_Q71_F0.5471.00
73_R77_L0.5391.00
71_F75_Y0.5350.99
81_N85_K0.5340.99
24_G27_A0.5290.99
41_H70_V0.5250.99
52_L73_R0.5200.99
71_F78_Q0.5150.99
8_R11_L0.5130.99
55_P58_A0.5090.99
69_E73_R0.5080.99
29_A33_G0.5070.99
71_F74_L0.5050.99
73_R85_K0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2m20A 2 0.6395 30.9 0.828 Contact Map
4c7rA 3 0.9884 10.7 0.861 Contact Map
2j69A 1 0.9884 5 0.881 Contact Map
3pjsK 4 0.8721 4.8 0.881 Contact Map
1ji6A 1 0.7326 4.3 0.884 Contact Map
1wazA 1 0.5 4.2 0.885 Contact Map
4ry2A 2 0.9884 3.6 0.889 Contact Map
2mgyA 1 0.7907 3.3 0.89 Contact Map
3effK 4 0.9302 3 0.892 Contact Map
4lxjA 1 0.8837 2.9 0.894 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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