DUF3326 - PFAM28P - GREMLIN Contacts

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DUF3326 - Protein of unknown function (DUF3326)

PFAM:	PF11805	Sequences: TAVLIVPTGIGAEIGGYAGDALPVARLLASVCDRLITHPNVVNAADLYWMPPNALYVEGYALDRFAMGTWGLQPVRQNRIGLVLDAGIEPELRLRHLNAADAARATLGLDITDYVVTDAPLGVELRYSESGASWGTIENPDSLLRAAEKLIGEAGATAIAVVARFPDDVDSEALQNYRQGEGVDPLGGVEAVISHLISREFQIPCAHAPALEPLPLDGVVDPRAAAEEISYTFLPCVLKGLSRAPQIVTDPSAMSRPGDITADDVDALVIPAGALGGLPVLAALEQGIPVIAVRENKTVLQVTPEALGIKVIEVENYLEAAGVLAALRAGISPESLR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	337 (335)
Sequences:	747 (530)
Seq/√Len:	29.0
META:	0.74

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
82_L	100_A	6.666	1.00
314_V	323_V	5.288	1.00
6_V	21_A	5.271	1.00
2_A	32_C	5.168	1.00
294_R	315_E	4.864	1.00
208_A	237_V	4.398	1.00
73_Q	259_D	4.266	1.00
122_G	138_E	4.001	1.00
51_P	54_A	3.708	1.00
4_L	24_V	3.545	1.00
25_A	35_L	3.475	1.00
64_R	69_T	3.432	1.00
148_E	201_F	3.374	1.00
2_A	324_L	3.184	1.00
5_I	62_L	3.178	1.00
31_V	325_A	2.970	1.00
151_I	203_I	2.842	1.00
25_A	41_V	2.726	1.00
83_V	197_I	2.686	1.00
61_A	247_I	2.637	1.00
102_A	226_A	2.595	0.99
71_G	261_T	2.567	0.99
97_L	101_D	2.281	0.99
318_L	333_P	2.268	0.99
2_A	269_V	2.240	0.98
118_D	145_R	2.201	0.98
27_L	321_A	2.175	0.98
140_P	196_L	2.121	0.98
157_T	163_A	2.090	0.97
305_E	313_E	2.027	0.97
321_A	325_A	2.000	0.97
294_R	313_E	1.976	0.96
110_D	332_S	1.968	0.96
124_E	138_E	1.964	0.96
37_T	54_A	1.957	0.96
81_G	150_L	1.904	0.96
70_W	247_I	1.888	0.95
289_P	327_L	1.881	0.95
32_C	35_L	1.872	0.95
64_R	202_Q	1.856	0.95
147_A	197_I	1.801	0.94
83_V	146_A	1.793	0.94
58_E	195_H	1.751	0.93
3_V	265_V	1.747	0.93
28_L	321_A	1.704	0.92
303_T	306_A	1.701	0.92
53_N	78_N	1.689	0.92
4_L	25_A	1.681	0.92
28_L	269_V	1.679	0.92
162_V	233_F	1.678	0.92
82_L	234_L	1.670	0.91
29_A	35_L	1.663	0.91
157_T	161_V	1.662	0.91
270_I	290_V	1.661	0.91
112_T	156_A	1.654	0.91
270_I	280_V	1.628	0.90
34_R	74_P	1.605	0.90
13_E	297_K	1.571	0.89
107_L	235_P	1.563	0.88
100_A	111_I	1.547	0.88
148_E	200_E	1.537	0.87
121_L	142_S	1.514	0.87
273_G	298_T	1.507	0.86
267_A	324_L	1.500	0.86
80_I	189_V	1.496	0.86
71_G	248_V	1.488	0.86
14_I	24_V	1.486	0.86
38_H	41_V	1.471	0.85
170_D	182_G	1.467	0.85
10_I	274_A	1.461	0.85
128_S	134_W	1.452	0.84
84_L	96_H	1.437	0.84
278_L	282_A	1.430	0.83
111_I	156_A	1.430	0.83
332_S	335_S	1.397	0.82
269_V	321_A	1.391	0.81
174_L	177_Y	1.377	0.81
90_P	94_L	1.377	0.81
78_N	246_Q	1.368	0.80
85_D	232_T	1.361	0.80
65_F	265_V	1.333	0.79
174_L	178_R	1.325	0.78
268_L	280_V	1.323	0.78
158_A	206_A	1.312	0.77
99_A	229_I	1.299	0.77
304_P	313_E	1.292	0.76
156_A	161_V	1.288	0.76
155_G	161_V	1.280	0.76
197_I	205_C	1.279	0.76
79_R	112_T	1.260	0.74
156_A	163_A	1.249	0.74
281_L	291_I	1.248	0.74
23_P	105_A	1.244	0.74
319_E	322_G	1.244	0.74
4_L	22_L	1.241	0.73
144_L	201_F	1.240	0.73
49_W	239_K	1.235	0.73
36_I	159_I	1.235	0.73
18_A	23_P	1.232	0.73
83_V	147_A	1.231	0.73
283_A	288_I	1.228	0.73
18_A	21_A	1.223	0.72
328_R	332_S	1.207	0.71
34_R	55_L	1.206	0.71
212_E	233_F	1.190	0.70
31_V	321_A	1.185	0.70
179_Q	219_V	1.183	0.70
272_A	294_R	1.180	0.69
180_G	224_A	1.179	0.69
155_G	163_A	1.171	0.69
206_A	237_V	1.171	0.69
18_A	45_A	1.159	0.68
80_I	263_D	1.155	0.68
128_S	201_F	1.154	0.68
295_E	318_L	1.147	0.67
174_L	214_L	1.134	0.66
272_A	292_A	1.131	0.66
232_T	235_P	1.127	0.66
3_V	283_A	1.126	0.66
300_L	311_V	1.123	0.66
6_V	163_A	1.122	0.65
62_L	65_F	1.119	0.65
184_D	230_S	1.111	0.65
157_T	246_Q	1.099	0.64
197_I	223_R	1.099	0.64
324_L	328_R	1.088	0.63
92_L	95_R	1.085	0.63
211_L	232_T	1.083	0.63
101_D	219_V	1.080	0.62
198_S	203_I	1.078	0.62
22_L	159_I	1.072	0.62
221_D	289_P	1.071	0.62
50_M	239_K	1.050	0.60
316_N	319_E	1.048	0.60
225_A	231_Y	1.046	0.60
78_N	157_T	1.035	0.59
248_V	259_D	1.031	0.59
133_S	147_A	1.029	0.59
100_A	222_P	1.021	0.58
322_G	326_A	1.021	0.58
86_A	116_V	1.020	0.58
44_A	106_T	1.016	0.58
99_A	236_C	1.013	0.57
198_S	247_I	1.011	0.57
234_L	237_V	1.009	0.57
120_P	233_F	1.007	0.57
50_M	54_A	1.005	0.57
292_A	311_V	0.986	0.55
123_V	193_I	0.984	0.55
87_G	122_G	0.984	0.55
172_E	176_N	0.982	0.55
208_A	234_L	0.978	0.55
9_G	16_G	0.978	0.55
9_G	15_G	0.978	0.55
63_D	150_L	0.978	0.55
322_G	330_G	0.978	0.55
323_V	332_S	0.975	0.55
304_P	307_L	0.972	0.54
48_Y	239_K	0.969	0.54
300_L	303_T	0.969	0.54
174_L	211_L	0.965	0.54
53_N	298_T	0.965	0.54
98_N	101_D	0.964	0.54
139_N	142_S	0.953	0.53
318_L	323_V	0.953	0.53
162_V	232_T	0.942	0.52
314_V	320_A	0.938	0.52
312_I	327_L	0.935	0.51
148_E	243_R	0.935	0.51
139_N	225_A	0.934	0.51
38_H	62_L	0.934	0.51
80_I	110_D	0.931	0.51
28_L	324_L	0.922	0.50
325_A	333_P	0.921	0.50
60_Y	198_S	0.918	0.50
105_A	229_I	0.913	0.50
119_A	139_N	0.912	0.50
13_E	50_M	0.909	0.49
137_I	189_V	0.906	0.49
213_P	231_Y	0.890	0.48
211_L	233_F	0.889	0.48
161_V	193_I	0.888	0.48
74_P	80_I	0.888	0.48
67_M	194_S	0.887	0.48
110_D	252_S	0.884	0.47
7_P	16_G	0.883	0.47
7_P	15_G	0.883	0.47
139_N	297_K	0.879	0.47
284_L	290_V	0.871	0.46
252_S	334_E	0.871	0.46
315_E	331_I	0.868	0.46
90_P	324_L	0.868	0.46
125_L	228_E	0.863	0.46
158_A	241_L	0.859	0.45
262_A	288_I	0.858	0.45
26_R	242_S	0.855	0.45
325_A	329_A	0.854	0.45
44_A	236_C	0.853	0.45
206_A	241_L	0.852	0.45
23_P	31_V	0.847	0.45
160_A	170_D	0.846	0.44
268_L	333_P	0.842	0.44
29_A	51_P	0.840	0.44
208_A	232_T	0.840	0.44
64_R	86_A	0.835	0.44
27_L	269_V	0.834	0.44
17_Y	223_R	0.833	0.43
26_R	107_L	0.833	0.43
294_R	314_V	0.832	0.43
79_R	155_G	0.832	0.43
137_I	167_D	0.831	0.43
122_G	136_T	0.824	0.43
6_V	27_L	0.824	0.43
8_T	15_G	0.823	0.43
8_T	16_G	0.823	0.43
22_L	106_T	0.822	0.43
83_V	117_T	0.822	0.43
78_N	298_T	0.820	0.42
186_L	230_S	0.818	0.42
294_R	335_S	0.817	0.42
36_I	57_V	0.817	0.42
30_S	329_A	0.813	0.42
33_D	53_N	0.811	0.42
295_E	333_P	0.807	0.42
323_V	333_P	0.805	0.41
133_S	184_D	0.805	0.41
93_R	97_L	0.804	0.41
333_P	336_L	0.804	0.41
264_D	269_V	0.799	0.41
211_L	214_L	0.798	0.41
284_L	309_I	0.798	0.41
275_L	280_V	0.797	0.41
189_V	229_I	0.793	0.40
217_D	269_V	0.790	0.40
46_D	230_S	0.789	0.40
6_V	22_L	0.787	0.40
76_R	239_K	0.782	0.40
179_Q	260_I	0.777	0.39
86_A	118_D	0.775	0.39
256_R	335_S	0.772	0.39
173_A	177_Y	0.772	0.39
325_A	332_S	0.770	0.39
62_L	264_D	0.767	0.39
101_D	104_R	0.767	0.39
61_A	70_W	0.764	0.38
149_K	326_A	0.762	0.38
79_R	243_R	0.760	0.38
48_Y	125_L	0.760	0.38
268_L	283_A	0.758	0.38
83_V	220_V	0.758	0.38
315_E	318_L	0.755	0.38
128_S	265_V	0.753	0.37
257_P	269_V	0.752	0.37
277_G	305_E	0.750	0.37
96_H	211_L	0.745	0.37
165_F	210_A	0.745	0.37
158_A	237_V	0.745	0.37
80_I	321_A	0.744	0.37
149_K	301_Q	0.743	0.37
12_A	298_T	0.742	0.37
10_I	312_I	0.742	0.37
168_D	186_L	0.739	0.36
38_H	222_P	0.735	0.36
6_V	219_V	0.735	0.36
113_D	156_A	0.735	0.36
202_Q	249_T	0.734	0.36
291_I	314_V	0.734	0.36
32_C	328_R	0.733	0.36
295_E	315_E	0.732	0.36
214_L	257_P	0.731	0.36
90_P	121_L	0.730	0.36
67_M	278_L	0.729	0.36
119_A	306_A	0.727	0.36
43_N	56_Y	0.724	0.35
276_G	292_A	0.722	0.35
283_A	289_P	0.718	0.35
83_V	201_F	0.714	0.35
80_I	301_Q	0.714	0.35
95_R	228_E	0.713	0.35
26_R	331_I	0.711	0.34
161_V	197_I	0.711	0.34
165_F	184_D	0.708	0.34
56_Y	59_G	0.708	0.34
78_N	295_E	0.706	0.34
82_L	111_I	0.704	0.34
180_G	233_F	0.702	0.34
317_Y	320_A	0.702	0.34
177_Y	233_F	0.699	0.34
272_A	298_T	0.698	0.34
80_I	84_L	0.698	0.34
182_G	216_L	0.695	0.33
52_P	145_R	0.692	0.33
185_P	206_A	0.692	0.33
160_A	163_A	0.688	0.33
55_L	78_N	0.688	0.33
4_L	38_H	0.685	0.33
4_L	35_L	0.683	0.33
29_A	304_P	0.681	0.32
140_P	193_I	0.679	0.32
295_E	301_Q	0.678	0.32
290_V	310_K	0.678	0.32
83_V	143_L	0.675	0.32
27_L	30_S	0.675	0.32
99_A	228_E	0.675	0.32
117_T	235_P	0.674	0.32
99_A	235_P	0.669	0.32
165_F	170_D	0.667	0.31
6_V	12_A	0.667	0.31
153_E	290_V	0.667	0.31
38_H	47_L	0.667	0.31
183_V	232_T	0.666	0.31
85_D	162_V	0.664	0.31
248_V	312_I	0.662	0.31
183_V	233_F	0.661	0.31
85_D	222_P	0.660	0.31
57_V	72_L	0.660	0.31
137_I	192_V	0.659	0.31
73_Q	162_V	0.657	0.31
142_S	145_R	0.656	0.31
89_E	164_R	0.656	0.31
6_V	9_G	0.655	0.31
42_V	94_L	0.655	0.31
263_D	268_L	0.653	0.30
18_A	180_G	0.653	0.30
36_I	262_A	0.653	0.30
63_D	194_S	0.652	0.30
107_L	331_I	0.651	0.30
48_Y	184_D	0.650	0.30
203_I	297_K	0.649	0.30
18_A	233_F	0.649	0.30
185_P	299_V	0.646	0.30
226_A	235_P	0.646	0.30
262_A	286_Q	0.646	0.30
192_V	244_A	0.646	0.30
2_A	321_A	0.643	0.30
61_A	198_S	0.642	0.30
6_V	262_A	0.642	0.30
256_R	259_D	0.641	0.30
44_A	47_L	0.636	0.29
195_H	281_L	0.635	0.29
117_T	121_L	0.634	0.29
3_V	66_A	0.634	0.29
71_G	259_D	0.634	0.29
96_H	184_D	0.634	0.29
275_L	311_V	0.634	0.29
84_L	93_R	0.633	0.29
168_D	171_S	0.632	0.29
256_R	328_R	0.630	0.29
288_I	327_L	0.630	0.29
85_D	201_F	0.629	0.29
272_A	304_P	0.628	0.29
38_H	237_V	0.625	0.29
29_A	246_Q	0.625	0.29
306_A	310_K	0.624	0.29
118_D	290_V	0.624	0.29
177_Y	183_V	0.622	0.28
326_A	334_E	0.621	0.28
229_I	236_C	0.619	0.28
149_K	323_V	0.618	0.28
45_A	66_A	0.617	0.28
137_I	273_G	0.614	0.28
38_H	44_A	0.614	0.28
78_N	103_A	0.613	0.28
276_G	281_L	0.612	0.28
186_L	211_L	0.610	0.28
17_Y	84_L	0.607	0.28
249_T	262_A	0.606	0.27
278_L	283_A	0.605	0.27
280_V	290_V	0.605	0.27
248_V	321_A	0.605	0.27
154_A	161_V	0.604	0.27
166_P	170_D	0.603	0.27
270_I	281_L	0.602	0.27
45_A	184_D	0.601	0.27
137_I	145_R	0.600	0.27
37_T	267_A	0.600	0.27
248_V	251_P	0.599	0.27
200_E	294_R	0.599	0.27
83_V	150_L	0.599	0.27
91_E	236_C	0.599	0.27
76_R	197_I	0.599	0.27
148_E	312_I	0.597	0.27
98_N	187_G	0.595	0.27
105_A	335_S	0.593	0.27
42_V	236_C	0.593	0.27
15_G	20_D	0.593	0.27
16_G	20_D	0.593	0.27
17_Y	81_G	0.590	0.26
102_A	105_A	0.588	0.26
154_A	163_A	0.587	0.26
6_V	14_I	0.586	0.26
203_I	287_G	0.586	0.26
41_V	44_A	0.586	0.26
47_L	61_A	0.585	0.26
221_D	288_I	0.585	0.26
226_A	229_I	0.584	0.26
89_E	214_L	0.583	0.26
67_M	282_A	0.582	0.26
144_L	200_E	0.582	0.26
134_W	192_V	0.580	0.26
184_D	235_P	0.579	0.26
184_D	279_P	0.578	0.26
101_D	242_S	0.577	0.26
97_L	219_V	0.577	0.26
38_H	71_G	0.577	0.26
18_A	226_A	0.576	0.26
46_D	184_D	0.574	0.26
121_L	167_D	0.574	0.26
4_L	28_L	0.572	0.25
229_I	261_T	0.571	0.25
79_R	148_E	0.571	0.25
42_V	46_D	0.570	0.25
129_E	305_E	0.570	0.25
111_I	114_Y	0.569	0.25
101_D	235_P	0.569	0.25
145_R	215_P	0.568	0.25
29_A	32_C	0.568	0.25
85_D	211_L	0.568	0.25
32_C	73_Q	0.567	0.25
159_I	192_V	0.567	0.25
163_A	170_D	0.566	0.25
143_L	229_I	0.566	0.25
202_Q	265_V	0.566	0.25
88_I	208_A	0.565	0.25
64_R	159_I	0.564	0.25
9_G	12_A	0.564	0.25
156_A	162_V	0.563	0.25
131_G	276_G	0.561	0.25
174_L	236_C	0.560	0.25
54_A	83_V	0.555	0.24
252_S	335_S	0.554	0.24
307_L	314_V	0.554	0.24
260_I	264_D	0.553	0.24
11_G	210_A	0.553	0.24
129_E	306_A	0.553	0.24
160_A	165_F	0.552	0.24
25_A	234_L	0.552	0.24
25_A	80_I	0.551	0.24
318_L	329_A	0.551	0.24
67_M	290_V	0.551	0.24
70_W	118_D	0.550	0.24
252_S	256_R	0.549	0.24
97_L	331_I	0.549	0.24
102_A	229_I	0.548	0.24
97_L	138_E	0.548	0.24
278_L	298_T	0.548	0.24
116_V	246_Q	0.548	0.24
79_R	181_E	0.547	0.24
220_V	224_A	0.547	0.24
203_I	246_Q	0.546	0.24
81_G	117_T	0.546	0.24
186_L	220_V	0.546	0.24
77_Q	231_Y	0.545	0.24
96_H	210_A	0.545	0.24
160_A	166_P	0.545	0.24
98_N	219_V	0.544	0.24
47_L	107_L	0.543	0.24
314_V	317_Y	0.543	0.24
32_C	324_L	0.541	0.24
16_G	19_G	0.541	0.24
15_G	19_G	0.541	0.24
4_L	268_L	0.539	0.24
156_A	302_V	0.538	0.23
101_D	222_P	0.538	0.23
169_V	182_G	0.538	0.23
120_P	180_G	0.536	0.23
45_A	226_A	0.536	0.23
200_E	246_Q	0.534	0.23
161_V	170_D	0.533	0.23
113_D	116_V	0.531	0.23
25_A	29_A	0.530	0.23
313_E	331_I	0.529	0.23
254_M	261_T	0.528	0.23
258_G	264_D	0.527	0.23
197_I	253_A	0.525	0.23
216_L	224_A	0.524	0.23
37_T	281_L	0.523	0.23
253_A	257_P	0.523	0.23
217_D	224_A	0.523	0.23
70_W	198_S	0.522	0.23
279_P	283_A	0.521	0.23
122_G	139_N	0.519	0.22
129_E	148_E	0.516	0.22
160_A	237_V	0.516	0.22
89_E	118_D	0.515	0.22
141_D	148_E	0.515	0.22
159_I	167_D	0.515	0.22
114_Y	139_N	0.514	0.22
149_K	269_V	0.512	0.22
197_I	336_L	0.512	0.22
57_V	61_A	0.510	0.22
279_P	282_A	0.509	0.22
301_Q	334_E	0.509	0.22
13_E	17_Y	0.508	0.22
2_A	31_V	0.507	0.22
253_A	256_R	0.507	0.22
126_R	136_T	0.506	0.22
162_V	165_F	0.506	0.22
27_L	31_V	0.506	0.22
103_A	248_V	0.504	0.22
149_K	181_E	0.503	0.22
37_T	243_R	0.500	0.21

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4ry0A	1	0.7033	24.4	0.978	Contact Map
3ojcA	4	0.6231	21.6	0.978	Contact Map
1tv5A	3	0.5875	19.1	0.979	Contact Map
3l6uA	2	0.6944	17.6	0.979	Contact Map
2fvyA	1	0.727	17.2	0.979	Contact Map
2rjoA	1	0.724	16.6	0.98	Contact Map
2hqbA	1	0.6677	15.3	0.98	Contact Map
2ioyA	1	0.6914	14.2	0.98	Contact Map
2dgdA	4	0.6083	14	0.98	Contact Map
2x7xA	2	0.6914	13.4	0.98	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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