GREMLIN Database
RP-C_C - Replication protein C C-terminal region
PFAM: PF11800 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 205 (204)
Sequences: 2000 (1504)
Seq/√Len: 105.3
META: 0.623

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
53_S60_E5.5181.00
113_E168_E4.5201.00
185_R188_R4.0771.00
142_I163_V3.8901.00
78_S81_E3.8031.00
113_E116_D3.5351.00
182_G186_K2.8161.00
146_A178_G2.7971.00
149_E188_R2.6421.00
145_S149_E2.6091.00
54_A61_R2.5641.00
103_P106_L2.3751.00
13_V16_L2.2511.00
192_F197_M2.2351.00
57_S60_E2.1781.00
197_M200_A2.0721.00
17_P20_A2.0381.00
175_S178_G2.0241.00
162_A197_M1.9771.00
151_C156_P1.9341.00
148_E152_E1.9231.00
110_A202_L1.9181.00
22_L26_E1.9141.00
182_G185_R1.8651.00
147_W159_A1.8271.00
8_R38_E1.8231.00
117_Y154_M1.7931.00
13_V17_P1.7871.00
166_I180_L1.7811.00
118_A132_A1.7771.00
137_R143_S1.7621.00
143_S146_A1.7501.00
117_Y167_L1.7061.00
6_E10_R1.6681.00
82_Q85_K1.6441.00
15_R31_E1.5911.00
21_T24_E1.5881.00
67_N141_G1.5881.00
7_A11_A1.5881.00
34_A38_E1.5801.00
29_L33_E1.4841.00
106_L202_L1.4761.00
193_S196_P1.4741.00
54_A57_S1.4721.00
3_E7_A1.4571.00
107_V129_L1.4101.00
5_L39_V1.4101.00
169_R173_I1.4061.00
104_L129_L1.4051.00
114_I136_V1.3991.00
102_F195_G1.3961.00
114_I164_A1.3611.00
151_C159_A1.3581.00
194_L197_M1.3541.00
137_R147_W1.3460.99
165_C197_M1.3430.99
192_F196_P1.3300.99
146_A177_G1.3110.99
106_L198_L1.3030.99
36_R40_L1.2780.99
114_I129_L1.2700.99
87_A90_P1.2690.99
78_S83_G1.2550.99
165_C201_L1.2530.99
8_R15_R1.2500.99
178_G181_R1.2450.99
9_Y13_V1.2320.99
148_E151_C1.1990.99
150_A180_L1.1890.99
163_V166_I1.1830.99
70_S73_E1.1690.99
61_R66_S1.1670.99
76_P82_Q1.1660.99
143_S178_G1.1650.98
6_E9_Y1.1560.98
106_L110_A1.1510.98
196_P200_A1.1420.98
183_L197_M1.1340.98
33_E37_E1.1320.98
140_L166_I1.1260.98
199_M202_L1.1260.98
107_V110_A1.1180.98
63_I66_S1.1020.98
159_A163_V1.0940.98
130_M160_A1.0940.98
146_A180_L1.0940.98
169_R172_H1.0870.98
149_E181_R1.0780.97
10_R13_V1.0630.97
165_C173_I1.0630.97
134_V151_C1.0610.97
10_R14_A1.0600.97
62_H66_S1.0600.97
77_S80_K1.0580.97
5_L8_R1.0560.97
153_V188_R1.0340.97
84_A87_A1.0320.97
150_A181_R1.0220.97
91_E94_A1.0120.96
179_Y183_L1.0010.96
146_A181_R0.9970.96
70_S75_E0.9970.96
138_P163_V0.9970.96
3_E11_A0.9900.96
183_L193_S0.9830.96
92_P95_E0.9780.96
147_W163_V0.9760.96
196_P199_M0.9650.95
166_I173_I0.9620.95
12_L31_E0.9620.95
44_E47_L0.9620.95
129_L161_I0.9500.95
7_A10_R0.9490.95
53_S61_R0.9480.95
112_P164_A0.9350.94
109_R202_L0.9320.94
195_G199_M0.9310.94
89_E92_P0.9280.94
130_M151_C0.9250.94
162_A192_F0.9190.94
128_D131_A0.9000.93
192_F200_A0.8900.93
16_L27_A0.8830.92
82_Q87_A0.8800.92
78_S87_A0.8780.92
177_G181_R0.8730.92
77_S83_G0.8620.92
200_A203_R0.8550.91
133_A159_A0.8520.91
170_A173_I0.8480.91
190_G194_L0.8460.91
124_R128_D0.8420.91
183_L192_F0.8400.90
180_L183_L0.8330.90
104_L108_L0.8300.90
111_C139_M0.8280.90
16_L22_L0.8280.90
175_S180_L0.8230.90
197_M201_L0.8210.89
149_E184_T0.8180.89
82_Q88_A0.8150.89
168_E179_Y0.8140.89
102_F198_L0.8140.89
198_L202_L0.8130.89
193_S197_M0.8130.89
58_Q66_S0.8120.89
154_M180_L0.8080.89
192_F199_M0.8030.88
79_E83_G0.7950.88
7_A14_A0.7930.88
77_S81_E0.7880.87
114_I118_A0.7850.87
154_M187_A0.7850.87
111_C167_L0.7820.87
62_H67_N0.7700.86
108_L123_I0.7660.86
59_N62_H0.7660.86
91_E95_E0.7620.86
52_M60_E0.7530.85
87_A93_N0.7500.85
16_L19_S0.7440.84
77_S82_Q0.7420.84
140_L167_L0.7420.84
26_E30_D0.7420.84
55_N66_S0.7370.84
9_Y25_L0.7340.83
114_I132_A0.7320.83
88_A92_P0.7310.83
136_V139_M0.7280.83
15_R19_S0.7260.83
3_E14_A0.7250.83
8_R12_L0.7230.82
4_A8_R0.7210.82
88_A93_N0.7180.82
114_I133_A0.7170.82
147_W165_C0.7170.82
92_P96_P0.7160.82
154_M184_T0.7150.82
69_E73_E0.7120.82
184_T192_F0.7110.81
77_S89_E0.7080.81
183_L200_A0.7080.81
31_E35_L0.7000.80
153_V184_T0.6990.80
28_L33_E0.6970.80
130_M157_E0.6920.80
4_A7_A0.6900.79
32_L155_G0.6880.79
30_D34_A0.6860.79
3_E8_R0.6830.79
87_A95_E0.6820.79
108_L115_A0.6790.78
173_I179_Y0.6730.78
81_E87_A0.6710.78
90_P93_N0.6700.77
89_E94_A0.6650.77
139_M142_I0.6630.77
88_A95_E0.6580.76
175_S181_R0.6540.76
141_G178_G0.6540.76
88_A94_A0.6530.76
193_S200_A0.6530.76
86_P89_E0.6500.75
58_Q61_R0.6450.75
126_W164_A0.6450.75
86_P94_A0.6440.75
103_P169_R0.6410.74
164_A175_S0.6400.74
82_Q91_E0.6400.74
30_D49_T0.6390.74
76_P81_E0.6380.74
13_V26_E0.6350.74
85_K88_A0.6340.73
139_M167_L0.6310.73
143_S175_S0.6300.73
172_H179_Y0.6300.73
78_S93_N0.6300.73
83_G93_N0.6300.73
122_G171_G0.6230.72
8_R21_T0.6220.72
117_Y170_A0.6180.72
77_S84_A0.6170.71
106_L199_M0.6160.71
11_A15_R0.6150.71
8_R11_A0.6150.71
150_A184_T0.6120.71
133_A147_W0.6110.71
50_E56_E0.6110.71
111_C161_I0.6090.70
3_E10_R0.6080.70
12_L16_L0.6020.70
54_A65_N0.6000.69
168_E200_A0.5960.69
127_R131_A0.5930.68
131_A144_P0.5920.68
125_S128_D0.5920.68
136_V167_L0.5900.68
125_S130_M0.5890.68
68_P71_I0.5880.68
119_P165_C0.5840.67
31_E34_A0.5830.67
106_L194_L0.5830.67
144_P148_E0.5800.67
182_G189_A0.5790.67
9_Y17_P0.5780.67
77_S87_A0.5780.67
16_L28_L0.5740.66
71_I74_S0.5730.66
100_K158_N0.5700.65
76_P83_G0.5690.65
9_Y14_A0.5690.65
12_L40_L0.5660.65
90_P95_E0.5640.65
9_Y39_V0.5630.65
40_L43_L0.5610.64
75_E78_S0.5570.64
111_C168_E0.5510.63
9_Y40_L0.5510.63
65_N103_P0.5510.63
144_P156_P0.5500.63
162_A193_S0.5500.63
64_Q68_P0.5500.63
119_P122_G0.5490.63
105_G109_R0.5460.62
62_H65_N0.5450.62
84_A97_E0.5430.62
14_A17_P0.5420.62
17_P27_A0.5420.62
150_A159_A0.5410.61
154_M157_E0.5410.61
111_C173_I0.5390.61
103_P111_C0.5340.60
28_L31_E0.5320.60
9_Y19_S0.5320.60
161_I164_A0.5320.60
76_P79_E0.5300.60
9_Y12_L0.5250.59
94_A97_E0.5240.59
154_M162_A0.5240.59
161_I196_P0.5220.59
17_P28_L0.5210.59
146_A173_I0.5190.58
150_A154_M0.5180.58
128_D179_Y0.5180.58
2_W39_V0.5160.58
183_L186_K0.5160.58
77_S88_A0.5160.58
191_E195_G0.5130.57
7_A15_R0.5130.57
104_L168_E0.5120.57
82_Q98_E0.5120.57
171_G174_N0.5110.57
28_L32_L0.5110.57
169_R179_Y0.5110.57
69_E72_S0.5100.57
154_M159_A0.5100.57
162_A182_G0.5080.57
76_P86_P0.5080.57
85_K89_E0.5060.56
83_G86_P0.5050.56
74_S83_G0.5050.56
191_E194_L0.5040.56
4_A27_A0.5030.56
12_L15_R0.5010.56
78_S88_A0.5010.56
38_E43_L0.5000.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3p9aA 4 0.5561 12.7 0.942 Contact Map
1vw1A 5 0.5951 9 0.946 Contact Map
4p9fA 1 0.439 7.2 0.948 Contact Map
4mnuA 2 0.2634 4.6 0.952 Contact Map
3ihuA 1 0.4341 4.5 0.953 Contact Map
4ie5A 1 0.439 4.5 0.953 Contact Map
4mf9A 1 0.5268 4 0.954 Contact Map
2xc7A 1 0.4098 3.7 0.955 Contact Map
3sqiA 1 0 3.4 0.956 Contact Map
3k8pD 1 0.2341 3.4 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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