RP-C_C - PFAM28P - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

RP-C_C - Replication protein C C-terminal region

PFAM:	PF11800	Sequences: DWEALEARYRALVARLPRSATLEELEALLDELEALREEVLNLLETHLKTENMSANESQNERHIQNSNPESISESEPSSEKEQGAKPAAEPEPNAEPEEQKAFPLGLVLRACPEIADYAPGGGIRSWRDLMAAAVVVRPMLGISPSAWEEACEVMGPENAAIAVACILERAGHINSPGGYLRGLTRKARAGEFSLGPMLMALLRAN	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	205 (204)
Sequences:	2000 (1504)
Seq/√Len:	105.3
META:	0.623

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
53_S	60_E	5.518	1.00
113_E	168_E	4.520	1.00
185_R	188_R	4.077	1.00
142_I	163_V	3.890	1.00
78_S	81_E	3.803	1.00
113_E	116_D	3.535	1.00
182_G	186_K	2.816	1.00
146_A	178_G	2.797	1.00
149_E	188_R	2.642	1.00
145_S	149_E	2.609	1.00
54_A	61_R	2.564	1.00
103_P	106_L	2.375	1.00
13_V	16_L	2.251	1.00
192_F	197_M	2.235	1.00
57_S	60_E	2.178	1.00
197_M	200_A	2.072	1.00
17_P	20_A	2.038	1.00
175_S	178_G	2.024	1.00
162_A	197_M	1.977	1.00
151_C	156_P	1.934	1.00
148_E	152_E	1.923	1.00
110_A	202_L	1.918	1.00
22_L	26_E	1.914	1.00
182_G	185_R	1.865	1.00
147_W	159_A	1.827	1.00
8_R	38_E	1.823	1.00
117_Y	154_M	1.793	1.00
13_V	17_P	1.787	1.00
166_I	180_L	1.781	1.00
118_A	132_A	1.777	1.00
137_R	143_S	1.762	1.00
143_S	146_A	1.750	1.00
117_Y	167_L	1.706	1.00
6_E	10_R	1.668	1.00
82_Q	85_K	1.644	1.00
15_R	31_E	1.591	1.00
21_T	24_E	1.588	1.00
67_N	141_G	1.588	1.00
7_A	11_A	1.588	1.00
34_A	38_E	1.580	1.00
29_L	33_E	1.484	1.00
106_L	202_L	1.476	1.00
193_S	196_P	1.474	1.00
54_A	57_S	1.472	1.00
3_E	7_A	1.457	1.00
107_V	129_L	1.410	1.00
5_L	39_V	1.410	1.00
169_R	173_I	1.406	1.00
104_L	129_L	1.405	1.00
114_I	136_V	1.399	1.00
102_F	195_G	1.396	1.00
114_I	164_A	1.361	1.00
151_C	159_A	1.358	1.00
194_L	197_M	1.354	1.00
137_R	147_W	1.346	0.99
165_C	197_M	1.343	0.99
192_F	196_P	1.330	0.99
146_A	177_G	1.311	0.99
106_L	198_L	1.303	0.99
36_R	40_L	1.278	0.99
114_I	129_L	1.270	0.99
87_A	90_P	1.269	0.99
78_S	83_G	1.255	0.99
165_C	201_L	1.253	0.99
8_R	15_R	1.250	0.99
178_G	181_R	1.245	0.99
9_Y	13_V	1.232	0.99
148_E	151_C	1.199	0.99
150_A	180_L	1.189	0.99
163_V	166_I	1.183	0.99
70_S	73_E	1.169	0.99
61_R	66_S	1.167	0.99
76_P	82_Q	1.166	0.99
143_S	178_G	1.165	0.98
6_E	9_Y	1.156	0.98
106_L	110_A	1.151	0.98
196_P	200_A	1.142	0.98
183_L	197_M	1.134	0.98
33_E	37_E	1.132	0.98
140_L	166_I	1.126	0.98
199_M	202_L	1.126	0.98
107_V	110_A	1.118	0.98
63_I	66_S	1.102	0.98
159_A	163_V	1.094	0.98
130_M	160_A	1.094	0.98
146_A	180_L	1.094	0.98
169_R	172_H	1.087	0.98
149_E	181_R	1.078	0.97
10_R	13_V	1.063	0.97
165_C	173_I	1.063	0.97
134_V	151_C	1.061	0.97
10_R	14_A	1.060	0.97
62_H	66_S	1.060	0.97
77_S	80_K	1.058	0.97
5_L	8_R	1.056	0.97
153_V	188_R	1.034	0.97
84_A	87_A	1.032	0.97
150_A	181_R	1.022	0.97
91_E	94_A	1.012	0.96
179_Y	183_L	1.001	0.96
146_A	181_R	0.997	0.96
70_S	75_E	0.997	0.96
138_P	163_V	0.997	0.96
3_E	11_A	0.990	0.96
183_L	193_S	0.983	0.96
92_P	95_E	0.978	0.96
147_W	163_V	0.976	0.96
196_P	199_M	0.965	0.95
166_I	173_I	0.962	0.95
12_L	31_E	0.962	0.95
44_E	47_L	0.962	0.95
129_L	161_I	0.950	0.95
7_A	10_R	0.949	0.95
53_S	61_R	0.948	0.95
112_P	164_A	0.935	0.94
109_R	202_L	0.932	0.94
195_G	199_M	0.931	0.94
89_E	92_P	0.928	0.94
130_M	151_C	0.925	0.94
162_A	192_F	0.919	0.94
128_D	131_A	0.900	0.93
192_F	200_A	0.890	0.93
16_L	27_A	0.883	0.92
82_Q	87_A	0.880	0.92
78_S	87_A	0.878	0.92
177_G	181_R	0.873	0.92
77_S	83_G	0.862	0.92
200_A	203_R	0.855	0.91
133_A	159_A	0.852	0.91
170_A	173_I	0.848	0.91
190_G	194_L	0.846	0.91
124_R	128_D	0.842	0.91
183_L	192_F	0.840	0.90
180_L	183_L	0.833	0.90
104_L	108_L	0.830	0.90
111_C	139_M	0.828	0.90
16_L	22_L	0.828	0.90
175_S	180_L	0.823	0.90
197_M	201_L	0.821	0.89
149_E	184_T	0.818	0.89
82_Q	88_A	0.815	0.89
168_E	179_Y	0.814	0.89
102_F	198_L	0.814	0.89
198_L	202_L	0.813	0.89
193_S	197_M	0.813	0.89
58_Q	66_S	0.812	0.89
154_M	180_L	0.808	0.89
192_F	199_M	0.803	0.88
79_E	83_G	0.795	0.88
7_A	14_A	0.793	0.88
77_S	81_E	0.788	0.87
114_I	118_A	0.785	0.87
154_M	187_A	0.785	0.87
111_C	167_L	0.782	0.87
62_H	67_N	0.770	0.86
108_L	123_I	0.766	0.86
59_N	62_H	0.766	0.86
91_E	95_E	0.762	0.86
52_M	60_E	0.753	0.85
87_A	93_N	0.750	0.85
16_L	19_S	0.744	0.84
77_S	82_Q	0.742	0.84
140_L	167_L	0.742	0.84
26_E	30_D	0.742	0.84
55_N	66_S	0.737	0.84
9_Y	25_L	0.734	0.83
114_I	132_A	0.732	0.83
88_A	92_P	0.731	0.83
136_V	139_M	0.728	0.83
15_R	19_S	0.726	0.83
3_E	14_A	0.725	0.83
8_R	12_L	0.723	0.82
4_A	8_R	0.721	0.82
88_A	93_N	0.718	0.82
114_I	133_A	0.717	0.82
147_W	165_C	0.717	0.82
92_P	96_P	0.716	0.82
154_M	184_T	0.715	0.82
69_E	73_E	0.712	0.82
184_T	192_F	0.711	0.81
77_S	89_E	0.708	0.81
183_L	200_A	0.708	0.81
31_E	35_L	0.700	0.80
153_V	184_T	0.699	0.80
28_L	33_E	0.697	0.80
130_M	157_E	0.692	0.80
4_A	7_A	0.690	0.79
32_L	155_G	0.688	0.79
30_D	34_A	0.686	0.79
3_E	8_R	0.683	0.79
87_A	95_E	0.682	0.79
108_L	115_A	0.679	0.78
173_I	179_Y	0.673	0.78
81_E	87_A	0.671	0.78
90_P	93_N	0.670	0.77
89_E	94_A	0.665	0.77
139_M	142_I	0.663	0.77
88_A	95_E	0.658	0.76
175_S	181_R	0.654	0.76
141_G	178_G	0.654	0.76
88_A	94_A	0.653	0.76
193_S	200_A	0.653	0.76
86_P	89_E	0.650	0.75
58_Q	61_R	0.645	0.75
126_W	164_A	0.645	0.75
86_P	94_A	0.644	0.75
103_P	169_R	0.641	0.74
164_A	175_S	0.640	0.74
82_Q	91_E	0.640	0.74
30_D	49_T	0.639	0.74
76_P	81_E	0.638	0.74
13_V	26_E	0.635	0.74
85_K	88_A	0.634	0.73
139_M	167_L	0.631	0.73
143_S	175_S	0.630	0.73
172_H	179_Y	0.630	0.73
78_S	93_N	0.630	0.73
83_G	93_N	0.630	0.73
122_G	171_G	0.623	0.72
8_R	21_T	0.622	0.72
117_Y	170_A	0.618	0.72
77_S	84_A	0.617	0.71
106_L	199_M	0.616	0.71
11_A	15_R	0.615	0.71
8_R	11_A	0.615	0.71
150_A	184_T	0.612	0.71
133_A	147_W	0.611	0.71
50_E	56_E	0.611	0.71
111_C	161_I	0.609	0.70
3_E	10_R	0.608	0.70
12_L	16_L	0.602	0.70
54_A	65_N	0.600	0.69
168_E	200_A	0.596	0.69
127_R	131_A	0.593	0.68
131_A	144_P	0.592	0.68
125_S	128_D	0.592	0.68
136_V	167_L	0.590	0.68
125_S	130_M	0.589	0.68
68_P	71_I	0.588	0.68
119_P	165_C	0.584	0.67
31_E	34_A	0.583	0.67
106_L	194_L	0.583	0.67
144_P	148_E	0.580	0.67
182_G	189_A	0.579	0.67
9_Y	17_P	0.578	0.67
77_S	87_A	0.578	0.67
16_L	28_L	0.574	0.66
71_I	74_S	0.573	0.66
100_K	158_N	0.570	0.65
76_P	83_G	0.569	0.65
9_Y	14_A	0.569	0.65
12_L	40_L	0.566	0.65
90_P	95_E	0.564	0.65
9_Y	39_V	0.563	0.65
40_L	43_L	0.561	0.64
75_E	78_S	0.557	0.64
111_C	168_E	0.551	0.63
9_Y	40_L	0.551	0.63
65_N	103_P	0.551	0.63
144_P	156_P	0.550	0.63
162_A	193_S	0.550	0.63
64_Q	68_P	0.550	0.63
119_P	122_G	0.549	0.63
105_G	109_R	0.546	0.62
62_H	65_N	0.545	0.62
84_A	97_E	0.543	0.62
14_A	17_P	0.542	0.62
17_P	27_A	0.542	0.62
150_A	159_A	0.541	0.61
154_M	157_E	0.541	0.61
111_C	173_I	0.539	0.61
103_P	111_C	0.534	0.60
28_L	31_E	0.532	0.60
9_Y	19_S	0.532	0.60
161_I	164_A	0.532	0.60
76_P	79_E	0.530	0.60
9_Y	12_L	0.525	0.59
94_A	97_E	0.524	0.59
154_M	162_A	0.524	0.59
161_I	196_P	0.522	0.59
17_P	28_L	0.521	0.59
146_A	173_I	0.519	0.58
150_A	154_M	0.518	0.58
128_D	179_Y	0.518	0.58
2_W	39_V	0.516	0.58
183_L	186_K	0.516	0.58
77_S	88_A	0.516	0.58
191_E	195_G	0.513	0.57
7_A	15_R	0.513	0.57
104_L	168_E	0.512	0.57
82_Q	98_E	0.512	0.57
171_G	174_N	0.511	0.57
28_L	32_L	0.511	0.57
169_R	179_Y	0.511	0.57
69_E	72_S	0.510	0.57
154_M	159_A	0.510	0.57
162_A	182_G	0.508	0.57
76_P	86_P	0.508	0.57
85_K	89_E	0.506	0.56
83_G	86_P	0.505	0.56
74_S	83_G	0.505	0.56
191_E	194_L	0.504	0.56
4_A	27_A	0.503	0.56
12_L	15_R	0.501	0.56
78_S	88_A	0.501	0.56
38_E	43_L	0.500	0.56

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3p9aA	4	0.5561	12.7	0.942	Contact Map
1vw1A	5	0.5951	9	0.946	Contact Map
4p9fA	1	0.439	7.2	0.948	Contact Map
4mnuA	2	0.2634	4.6	0.952	Contact Map
3ihuA	1	0.4341	4.5	0.953	Contact Map
4ie5A	1	0.439	4.5	0.953	Contact Map
4mf9A	1	0.5268	4	0.954	Contact Map
2xc7A	1	0.4098	3.7	0.955	Contact Map
3sqiA	1	0	3.4	0.956	Contact Map
3k8pD	1	0.2341	3.4	0.956	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0074 seconds.