GREMLIN Database
DUF3323 - Protein of unknown function N-terminus (DUF3323)
PFAM: PF11796 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 209 (206)
Sequences: 1586 (1319)
Seq/√Len: 91.9
META: 0.717

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
139_V147_R4.7211.00
66_R71_E4.5221.00
67_D70_A4.4641.00
133_R147_R4.1251.00
169_L191_A4.1111.00
153_H156_D4.0201.00
196_D199_S3.8861.00
144_L193_V3.7801.00
54_R58_E3.4451.00
139_V144_L3.1681.00
35_S38_D2.9791.00
40_D44_R2.7221.00
151_D159_T2.5481.00
79_W110_R2.5051.00
10_L32_L2.4971.00
10_L18_L2.4111.00
155_L165_V2.3601.00
170_A178_P2.2631.00
57_L62_G2.1701.00
158_G163_T2.1371.00
4_T33_R2.1321.00
130_V155_L2.0751.00
11_T14_E2.0631.00
149_T161_L2.0611.00
198_L203_L2.0241.00
85_A121_R2.0061.00
52_G55_E1.9731.00
180_D183_E1.9511.00
40_D52_G1.8651.00
173_A191_A1.8231.00
127_A161_L1.8091.00
83_F124_L1.8091.00
165_V188_W1.8071.00
80_A84_A1.7861.00
204_V207_L1.7351.00
149_T155_L1.7351.00
157_D184_R1.7291.00
133_R148_V1.7271.00
125_R129_R1.7261.00
86_L100_L1.7251.00
146_A152_A1.5991.00
131_L166_L1.5981.00
131_L168_A1.5841.00
41_A45_R1.5471.00
127_A165_V1.5161.00
10_L15_R1.4731.00
103_L107_G1.4681.00
87_R101_A1.4661.00
51_S55_E1.4390.99
73_A77_A1.4260.99
130_V165_V1.4160.99
17_A21_L1.3850.99
152_A156_D1.3750.99
74_A78_A1.3710.99
188_W193_V1.2910.99
70_A74_A1.2770.99
6_T33_R1.2560.99
79_W120_A1.2470.98
162_G166_L1.2270.98
169_L187_L1.2230.98
10_L20_G1.1980.98
122_R126_Q1.1960.98
24_R38_D1.1940.98
55_E59_A1.1840.98
199_S203_L1.1820.98
19_A25_P1.1580.98
76_A80_A1.1080.97
14_E57_L1.0790.96
142_A206_G1.0780.96
178_P187_L1.0770.96
178_P183_E1.0700.96
130_V144_L1.0650.96
158_G162_G1.0600.96
104_R107_G1.0560.96
21_L39_L1.0480.96
79_W152_A1.0420.95
68_R71_E1.0400.95
141_L144_L1.0300.95
58_E64_P1.0260.95
22_L34_V1.0230.95
6_T31_S1.0230.95
83_F104_R1.0220.95
10_L19_A1.0130.95
42_A57_L0.9990.94
135_P138_G0.9870.94
195_V200_S0.9840.94
152_A201_T0.9800.94
24_R29_G0.9480.92
185_R203_L0.9450.92
142_A199_S0.9410.92
152_A200_S0.9400.92
126_Q149_T0.9360.92
19_A22_L0.9310.92
15_R29_G0.9280.92
138_G192_G0.9250.92
43_L162_G0.9200.91
144_L148_V0.9130.91
183_E187_L0.9130.91
16_R20_G0.9100.91
69_A73_A0.9090.91
11_T19_A0.9070.91
172_L178_P0.9000.90
94_P97_A0.8950.90
108_L194_L0.8910.90
140_P197_D0.8760.89
185_R197_D0.8750.89
108_L163_T0.8680.89
7_L14_E0.8650.89
188_W203_L0.8640.88
161_L165_V0.8630.88
87_R97_A0.8560.88
149_T154_A0.8550.88
162_G188_W0.8450.87
196_D200_S0.8430.87
193_V208_P0.8400.87
189_A194_L0.8400.87
110_R113_A0.8340.87
108_L112_L0.8270.86
126_Q161_L0.8250.86
19_A28_P0.8250.86
116_D119_A0.8240.86
185_R198_L0.8180.86
22_L42_A0.8180.86
18_L32_L0.8170.86
133_R144_L0.8170.86
15_R28_P0.8120.85
143_V147_R0.8100.85
55_E58_E0.8090.85
140_P144_L0.8040.85
103_L106_D0.8040.85
50_G55_E0.8010.84
56_A62_G0.7970.84
116_D121_R0.7960.84
4_T35_S0.7920.84
169_L173_A0.7890.84
185_R189_A0.7880.83
181_A206_G0.7860.83
12_P76_A0.7850.83
146_A203_L0.7800.83
96_L198_L0.7750.82
53_L57_L0.7710.82
153_H199_S0.7650.82
155_L169_L0.7640.81
34_V38_D0.7630.81
16_R74_A0.7610.81
46_S152_A0.7570.81
57_L201_T0.7540.81
83_F106_D0.7530.81
189_A195_V0.7500.80
107_G111_R0.7490.80
139_V193_V0.7480.80
141_L193_V0.7480.80
185_R195_V0.7430.80
123_L161_L0.7430.80
22_L29_G0.7400.79
126_Q154_A0.7380.79
36_L53_L0.7380.79
6_T10_L0.7380.79
90_L143_V0.7380.79
75_E114_R0.7360.79
153_H196_D0.7360.79
167_R170_A0.7330.79
127_A155_L0.7310.79
90_L96_L0.7300.78
107_G112_L0.7230.78
132_A168_A0.7220.78
155_L188_W0.7220.78
25_P28_P0.7140.77
187_L191_A0.7140.77
131_L169_L0.7140.77
9_D30_A0.7140.77
185_R202_V0.7090.76
143_V166_L0.7080.76
185_R188_W0.7070.76
94_P157_D0.7070.76
165_V169_L0.7040.76
49_A62_G0.7040.76
14_E100_L0.7020.76
198_L201_T0.6940.75
6_T206_G0.6920.75
177_P183_E0.6920.75
9_D32_L0.6910.75
155_L207_L0.6910.75
203_L206_G0.6880.74
6_T143_V0.6870.74
121_R125_R0.6820.74
129_R132_A0.6810.74
154_A161_L0.6800.73
60_L124_L0.6760.73
142_A146_A0.6760.73
116_D120_A0.6740.73
142_A196_D0.6670.72
107_G113_A0.6640.72
6_T16_R0.6640.72
15_R19_A0.6600.71
188_W192_G0.6580.71
82_L117_P0.6560.71
79_W83_F0.6550.71
109_L116_D0.6480.70
121_R124_L0.6470.70
174_G177_P0.6470.70
96_L99_W0.6460.70
40_D46_S0.6430.69
126_Q129_R0.6420.69
197_D201_T0.6420.69
14_E200_S0.6390.69
74_A77_A0.6310.68
27_R33_R0.6310.68
202_V207_L0.6310.68
141_L202_V0.6290.68
6_T22_L0.6270.67
14_E29_G0.6250.67
164_L193_V0.6240.67
44_R52_G0.6230.67
171_A179_A0.6210.67
40_D51_S0.6190.66
48_F56_A0.6160.66
2_G37_A0.6160.66
3_G36_L0.6130.66
57_L191_A0.6110.65
201_T204_V0.6090.65
130_V161_L0.6080.65
99_W168_A0.6060.65
57_L134_L0.6060.65
102_K105_G0.6000.64
73_A76_A0.5990.64
36_L101_A0.5980.64
166_L184_R0.5970.64
170_A175_L0.5970.64
104_R202_V0.5960.63
5_V180_D0.5960.63
35_S142_A0.5940.63
140_P162_G0.5900.63
143_V200_S0.5850.62
72_R84_A0.5840.62
153_H189_A0.5810.61
133_R139_V0.5810.61
72_R134_L0.5790.61
97_A132_A0.5770.61
82_L124_L0.5770.61
185_R193_V0.5760.61
96_L110_R0.5760.61
72_R176_P0.5760.61
13_E183_E0.5760.61
19_A24_R0.5720.60
184_R195_V0.5690.60
58_E63_G0.5690.60
181_A184_R0.5680.60
19_A27_R0.5670.60
140_P198_L0.5670.60
30_A35_S0.5650.59
154_A171_A0.5640.59
148_V155_L0.5640.59
76_A187_L0.5630.59
40_D58_E0.5620.59
70_A73_A0.5620.59
166_L187_L0.5620.59
195_V205_L0.5560.58
93_R96_L0.5530.58
197_D205_L0.5530.58
42_A48_F0.5530.58
84_A175_L0.5500.57
145_A165_V0.5490.57
63_G67_D0.5490.57
39_L159_T0.5480.57
15_R18_L0.5460.57
167_R171_A0.5450.57
133_R191_A0.5430.56
17_A43_L0.5420.56
127_A130_V0.5410.56
82_L113_A0.5400.56
129_R133_R0.5400.56
80_A119_A0.5390.56
8_T34_V0.5380.56
62_G65_L0.5380.56
122_R125_R0.5370.55
123_L160_P0.5360.55
26_P113_A0.5330.55
66_R74_A0.5320.55
43_L53_L0.5320.55
39_L158_G0.5320.55
41_A80_A0.5310.55
102_K106_D0.5280.54
148_V197_D0.5280.54
7_L148_V0.5270.54
69_A129_R0.5260.54
84_A179_A0.5240.54
12_P16_R0.5240.54
162_G165_V0.5220.53
4_T36_L0.5180.53
7_L59_A0.5180.53
28_P73_A0.5180.53
26_P66_R0.5160.53
146_A163_T0.5150.52
185_R200_S0.5120.52
49_A56_A0.5120.52
116_D169_L0.5120.52
7_L92_A0.5110.52
130_V188_W0.5100.52
130_V168_A0.5080.51
140_P143_V0.5060.51
140_P163_T0.5060.51
29_G37_A0.5060.51
14_E18_L0.5040.51
181_A194_L0.5030.51
45_R190_R0.5030.51
161_L188_W0.5030.51
151_D187_L0.5000.50
48_F165_V0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ixmA 1 0.8469 35.4 0.936 Contact Map
2ixnA 1 0.8373 28.9 0.939 Contact Map
2ixoA 1 0.8995 22.1 0.942 Contact Map
3i5gC 1 0.7033 21.4 0.943 Contact Map
2l6aA 1 0.4306 19.8 0.944 Contact Map
1w7jB 1 0.5359 19.4 0.944 Contact Map
4qbdB 1 0.6938 19.4 0.944 Contact Map
3j04B 1 0.6364 17.5 0.945 Contact Map
2jnfA 1 0.6699 15.8 0.946 Contact Map
3qvsA 2 0.3589 15.5 0.946 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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