GREMLIN Database
DUF3317 - Protein of unknown function (DUF3317)
PFAM: PF11779 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 54 (51)
Sequences: 534 (364)
Seq/√Len: 50.9
META: 0.309

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
12_E25_K5.7331.00
11_Y29_N4.6101.00
23_W27_L2.3491.00
6_R10_Q2.1281.00
7_K10_Q1.9240.99
3_W7_K1.8950.99
4_L8_Y1.7260.99
34_L44_Y1.6490.98
8_Y11_Y1.6290.98
21_E27_L1.4040.95
22_P26_F1.3510.94
10_Q18_Y1.3490.94
8_Y12_E1.1960.89
49_Q52_R1.1870.89
42_A48_P1.1830.89
16_G28_F1.1670.88
34_L37_S1.1400.87
15_F18_Y1.1100.86
19_M50_H1.0990.85
2_N5_Q1.0930.85
35_L40_L1.0220.80
13_V21_E1.0210.80
12_E21_E0.9680.77
10_Q14_T0.9360.74
42_A45_V0.9250.73
5_Q8_Y0.9110.72
2_N19_M0.9040.72
13_V29_N0.9010.71
32_L38_L0.8780.69
38_L42_A0.8630.68
36_L43_A0.8560.67
22_P30_S0.8320.65
17_L25_K0.8250.65
19_M46_Y0.8170.64
13_V18_Y0.8140.64
43_A50_H0.7990.62
33_L37_S0.7860.61
36_L44_Y0.7780.60
5_Q25_K0.7670.59
26_F35_L0.7640.59
26_F31_I0.7490.57
6_R38_L0.7390.56
33_L39_L0.7190.54
11_Y32_L0.7160.54
44_Y52_R0.6960.52
38_L44_Y0.6910.51
31_I41_Y0.6870.51
35_L39_L0.6820.50
11_Y17_L0.6710.49
11_Y49_Q0.6650.48
8_Y35_L0.6540.47
32_L51_I0.6480.47
8_Y36_L0.6480.47
26_F40_L0.6360.45
8_Y29_N0.6260.44
36_L52_R0.6100.43
5_Q23_W0.6070.42
6_R9_Y0.5930.41
22_P40_L0.5900.41
19_M39_L0.5860.40
30_S41_Y0.5860.40
3_W28_F0.5640.38
37_S50_H0.5610.38
13_V36_L0.5500.37
32_L49_Q0.5480.37
16_G19_M0.5470.37
17_L29_N0.5300.35
5_Q14_T0.5290.35
42_A46_Y0.5210.34
31_I40_L0.5180.34
44_Y51_I0.5160.34
28_F42_A0.5090.33
16_G20_L0.5060.33
10_Q28_F0.5060.33
14_T25_K0.5050.33
16_G48_P0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2kixA 3 0.5741 5.1 0.869 Contact Map
4q6xA 1 0.463 3.2 0.881 Contact Map
2kogA 1 0.5926 2.9 0.884 Contact Map
3mk7B 1 0.6111 2.6 0.887 Contact Map
2zxeB 1 0.6296 1.6 0.899 Contact Map
3wguB 1 1 1.4 0.903 Contact Map
3ixzB 1 0.6111 1.4 0.903 Contact Map
2l16A 1 0.6111 1.3 0.905 Contact Map
2mn6B 2 0.5926 1.2 0.906 Contact Map
3spcA 3 0.9074 1 0.912 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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