GREMLIN Database
DUF3311 - Protein of unknown function (DUF3311)
PFAM: PF11755 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 61 (54)
Sequences: 8645 (4575)
Seq/√Len: 622.6
META: 0.905

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
20_V23_L3.1431.00
46_A50_R2.8701.00
24_L32_W2.6061.00
13_W16_F2.4971.00
32_W36_L2.3621.00
39_L43_L1.7401.00
17_Y29_F1.6861.00
33_Y37_W1.6221.00
47_L51_L1.6101.00
2_L6_P1.5521.00
8_F11_L1.4991.00
29_F33_Y1.4851.00
50_R53_R1.4621.00
10_A33_Y1.4441.00
39_L42_A1.4211.00
10_A37_W1.3261.00
42_A46_A1.2691.00
19_R22_P1.2621.00
45_T49_Y1.2031.00
41_T45_T1.1631.00
22_P29_F1.1461.00
45_T48_V1.1421.00
19_R29_F1.1191.00
53_R56_R1.0991.00
30_F34_Q1.0901.00
23_L32_W1.0521.00
17_Y30_F1.0271.00
38_V45_T1.0231.00
36_L40_L1.0221.00
27_L35_L0.9731.00
48_V52_T0.9531.00
45_T52_T0.9221.00
46_A49_Y0.9161.00
6_P11_L0.8711.00
38_V41_T0.8491.00
9_V37_W0.8421.00
43_L47_L0.8401.00
11_L16_F0.8381.00
8_F12_L0.8331.00
5_I44_L0.8281.00
11_L37_W0.8271.00
14_V18_N0.8181.00
3_L6_P0.8141.00
13_W17_Y0.8111.00
44_L47_L0.7741.00
52_T55_R0.7561.00
37_W40_L0.7381.00
31_Y41_T0.7331.00
12_L16_F0.7261.00
2_L5_I0.7021.00
23_L26_G0.7001.00
9_V12_L0.6971.00
25_F35_L0.6921.00
17_Y31_Y0.6871.00
23_L27_L0.6841.00
16_F33_Y0.6771.00
39_L46_A0.6771.00
37_W44_L0.6611.00
49_Y53_R0.6541.00
9_V13_W0.6501.00
35_L38_V0.6481.00
51_L55_R0.6461.00
43_L46_A0.6441.00
6_P41_T0.6311.00
14_V17_Y0.6231.00
10_A34_Q0.6181.00
36_L39_L0.6161.00
49_Y55_R0.5861.00
41_T47_L0.5821.00
31_Y38_V0.5531.00
30_F35_L0.5481.00
17_Y22_P0.5440.99
18_N35_L0.5410.99
42_A47_L0.5400.99
15_P18_N0.5300.99
35_L39_L0.5260.99
34_Q38_V0.5160.99
10_A38_V0.5120.99
17_Y33_Y0.5100.99
22_P32_W0.5050.99
40_L43_L0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4httA 1 0.6557 7.4 0.857 Contact Map
4p02A 1 0.9508 6.2 0.862 Contact Map
4b4aA 1 0.6557 6 0.863 Contact Map
4uc1A 3 0.8689 5.6 0.865 Contact Map
2a65A 2 1 4.7 0.87 Contact Map
2xq2A 2 0.9672 4.3 0.872 Contact Map
3dh4A 3 0.9672 4.2 0.873 Contact Map
4c7rA 3 0.918 3.4 0.878 Contact Map
4ogqG 1 0.6066 3.4 0.879 Contact Map
2mgyA 1 0.9508 3.3 0.88 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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