GREMLIN Database
DUF3310 - Protein of unknwon function (DUF3310)
PFAM: PF11753 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 60 (56)
Sequences: 21088 (11397)
Seq/√Len: 1523.0
META: 0.979

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
17_V40_W2.5281.00
56_I60_D2.5111.00
30_F33_G2.3961.00
14_P40_W2.3371.00
49_L53_K2.0121.00
19_E31_C1.7301.00
30_F34_N1.5551.00
15_I57_W1.5141.00
42_A52_L1.5021.00
9_K44_K1.4911.00
18_I33_G1.4731.00
42_A48_P1.4351.00
55_A59_L1.4141.00
32_L42_A1.4071.00
34_N37_K1.4001.00
35_A59_L1.3771.00
2_N57_W1.3741.00
12_I20_A1.3271.00
39_I55_A1.2641.00
12_I17_V1.2441.00
26_E29_G1.2051.00
15_I31_C1.1901.00
34_N58_Y1.1761.00
35_A39_I1.1601.00
26_E32_L1.1401.00
11_G20_A1.1391.00
3_H57_W1.1161.00
29_G32_L1.1031.00
17_V21_N1.0891.00
46_G50_E1.0871.00
10_G44_K1.0711.00
39_I59_L1.0681.00
46_G51_D1.0031.00
32_L43_G0.9941.00
57_W60_D0.9921.00
35_A55_A0.9881.00
19_E27_F0.9771.00
43_G48_P0.9601.00
21_N40_W0.9501.00
50_E53_K0.9341.00
47_G50_E0.9331.00
14_P18_I0.9291.00
25_E28_L0.9291.00
53_K56_I0.9051.00
18_I36_I0.8701.00
14_P36_I0.8591.00
49_L56_I0.8471.00
56_I59_L0.8381.00
21_N36_I0.8031.00
36_I40_W0.7831.00
4_P57_W0.7271.00
43_G51_D0.7211.00
13_E16_D0.7161.00
27_F31_C0.7101.00
47_G51_D0.7091.00
37_K58_Y0.7051.00
3_H13_E0.7011.00
35_A56_I0.6871.00
10_G40_W0.6591.00
34_N38_Y0.6561.00
12_I16_D0.6381.00
32_L48_P0.6311.00
52_L59_L0.6131.00
15_I30_F0.6061.00
18_I30_F0.6021.00
29_G33_G0.6011.00
15_I19_E0.5921.00
28_L32_L0.5921.00
17_V36_I0.5911.00
10_G20_A0.5881.00
43_G47_G0.5861.00
17_V20_A0.5851.00
3_H8_K0.5791.00
10_G14_P0.5791.00
43_G46_G0.5751.00
9_K12_I0.5651.00
38_Y58_Y0.5411.00
5_S8_K0.5331.00
30_F58_Y0.5281.00
26_E43_G0.5221.00
30_F37_K0.5191.00
8_K11_G0.5171.00
8_K44_K0.5031.00
31_C58_Y0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3j9oB 7 0.9333 6.9 0.867 Contact Map
4wz9A 2 0.9167 5.8 0.872 Contact Map
1z5hA 3 0.9167 5.8 0.872 Contact Map
2d73A 2 0.8833 5.7 0.872 Contact Map
3b34A 1 0.9167 4.7 0.877 Contact Map
4qhpA 1 0.9167 4.3 0.879 Contact Map
5aj3G 1 1 4.2 0.88 Contact Map
4kx7A 1 0.9167 4.1 0.881 Contact Map
2yd0A 1 0.9 4 0.882 Contact Map
2dvkA 2 0.2 3.7 0.884 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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