GREMLIN Database
DUF3307 - Protein of unknown function (DUF3307)
PFAM: PF11750 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 124 (106)
Sequences: 7874 (6379)
Seq/√Len: 619.5
META: 0.887

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_A72_F3.9721.00
43_A68_F3.7591.00
74_I97_L3.7341.00
70_S101_T3.6491.00
19_D23_K2.9531.00
14_F91_F2.5461.00
18_T21_M2.5311.00
12_A42_H2.4311.00
12_A45_L2.2691.00
6_L99_L2.2451.00
88_W92_L2.1821.00
63_L67_I1.8661.00
36_L72_F1.8481.00
10_L15_V1.6491.00
11_L16_L1.6131.00
11_L15_V1.5641.00
76_W80_R1.5471.00
89_L92_L1.4801.00
35_L39_A1.4631.00
20_W24_N1.4571.00
42_H46_T1.4371.00
39_A68_F1.4341.00
21_M41_I1.4261.00
74_I101_T1.3721.00
30_H76_W1.3541.00
8_A12_A1.3481.00
28_K31_K1.3411.00
50_L54_G1.3391.00
8_A46_T1.3181.00
43_A64_A1.3181.00
24_N34_G1.2971.00
20_W37_L1.2591.00
102_L105_I1.2391.00
12_A41_I1.2031.00
87_F92_L1.1521.00
66_L70_S1.1441.00
88_W91_F1.1351.00
51_L54_G1.1321.00
24_N31_K1.1301.00
24_N28_K1.1211.00
22_A25_K1.1121.00
66_L105_I1.0791.00
77_L81_L1.0731.00
99_L102_L1.0661.00
101_T105_I1.0491.00
16_L41_I1.0121.00
49_L53_L1.0111.00
77_L97_L1.0031.00
19_D22_A1.0021.00
85_K89_L0.9891.00
7_L96_L0.9771.00
59_S62_L0.9731.00
35_L72_F0.9691.00
13_D94_D0.9661.00
47_L64_A0.9551.00
17_Q25_K0.9371.00
29_G76_W0.9361.00
2_L103_L0.9341.00
21_M24_N0.9331.00
48_L52_L0.9171.00
67_I105_I0.9111.00
35_L76_W0.9071.00
64_A67_I0.8991.00
92_L96_L0.8961.00
21_M37_L0.8911.00
24_N27_K0.8791.00
67_I102_L0.8761.00
42_H45_L0.8541.00
67_I101_T0.8521.00
75_D94_D0.8451.00
51_L55_F0.8411.00
70_S74_I0.8341.00
93_L97_L0.8311.00
77_L80_R0.8241.00
86_N89_L0.8241.00
2_L106_A0.8231.00
30_H34_G0.8121.00
28_K73_L0.8041.00
4_L8_A0.8011.00
81_L90_L0.7981.00
29_G80_R0.7931.00
83_K87_F0.7901.00
87_F90_L0.7891.00
49_L52_L0.7881.00
99_L103_L0.7711.00
20_W31_K0.7661.00
61_W65_L0.7601.00
72_F76_W0.7601.00
8_A45_L0.7591.00
56_D59_S0.7511.00
64_A68_F0.7381.00
61_W64_A0.7341.00
60_A64_A0.7341.00
73_L77_L0.7311.00
36_L39_A0.7301.00
63_L105_I0.7261.00
62_L65_L0.7231.00
3_L6_L0.7231.00
82_K86_N0.7201.00
20_W23_K0.7141.00
24_N30_H0.7101.00
48_L53_L0.6991.00
9_H13_D0.6861.00
17_Q94_D0.6781.00
69_V73_L0.6771.00
49_L54_G0.6771.00
84_K87_F0.6691.00
53_L56_D0.6641.00
60_A63_L0.6631.00
82_K85_K0.6611.00
66_L101_T0.6581.00
83_K86_N0.6511.00
18_T22_A0.6491.00
10_L99_L0.6431.00
23_K27_K0.6411.00
22_A79_L0.6361.00
71_H75_D0.6351.00
10_L14_F0.6331.00
42_H67_I0.6321.00
101_T104_L0.6311.00
83_K88_W0.6301.00
89_L93_L0.6241.00
12_A15_V0.6231.00
87_F91_F0.6201.00
43_A46_T0.6191.00
20_W34_G0.6181.00
26_G79_L0.6041.00
10_L93_L0.6021.00
39_A43_A0.5901.00
73_L76_W0.5831.00
50_L53_L0.5831.00
2_L6_L0.5811.00
93_L96_L0.5761.00
25_K79_L0.5761.00
40_L44_L0.5731.00
12_A16_L0.5731.00
39_A42_H0.5661.00
85_K91_F0.5581.00
85_K88_W0.5561.00
21_M25_K0.5491.00
63_L66_L0.5460.99
14_F95_Q0.5380.99
82_K90_L0.5360.99
86_N90_L0.5360.99
5_L102_L0.5340.99
62_L66_L0.5310.99
6_L10_L0.5300.99
85_K90_L0.5270.99
14_F92_L0.5150.99
5_L46_T0.5120.99
37_L40_L0.5120.99
83_K90_L0.5100.99
82_K87_F0.5090.99
104_L108_W0.5060.99
75_D78_K0.5030.99
6_L96_L0.5020.99
42_H50_L0.5000.99
78_K94_D0.5000.99
21_M31_K0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tx3A 2 0.6371 31.1 0.87 Contact Map
1vsy5 1 0.8548 1.8 0.928 Contact Map
2ls4A 1 0.1613 1.7 0.929 Contact Map
1emzA 1 0.1694 0.7 0.945 Contact Map
3wu2L 1 0.1371 0.5 0.949 Contact Map
3nd0A 2 0.2177 0.5 0.95 Contact Map
3vbcA 1 0.3468 0.5 0.95 Contact Map
3wmiB 1 0.1048 0.4 0.953 Contact Map
3ar4A 1 0.6774 0.4 0.954 Contact Map
1v54M 1 0.3387 0.4 0.954 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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