GREMLIN Database
DUF3306 - Protein of unknown function (DUF3306)
PFAM: PF11748 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 121 (117)
Sequences: 5539 (4733)
Seq/√Len: 437.5
META: 0.891

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
109_D112_I5.6531.00
11_R14_R3.6891.00
95_K98_A3.0191.00
108_L112_I2.6511.00
66_P69_S2.4901.00
70_L74_S2.4821.00
105_F112_I2.3871.00
60_D63_T2.2291.00
59_F63_T2.2001.00
7_S11_R2.0681.00
16_E19_A2.0491.00
9_R13_A2.0381.00
86_E89_R2.0211.00
86_E90_R2.0061.00
106_D112_I2.0041.00
65_P69_S1.9801.00
76_F96_L1.9361.00
117_D120_P1.7711.00
105_F109_D1.7631.00
20_P23_A1.7571.00
107_G112_I1.6971.00
18_E21_E1.6661.00
70_L76_F1.6651.00
110_D113_D1.6591.00
16_E21_E1.5961.00
78_A82_P1.5911.00
113_D117_D1.5261.00
77_S81_A1.5041.00
91_A95_K1.4881.00
65_P68_E1.4571.00
67_I91_A1.4501.00
106_D109_D1.4201.00
111_Y115_Y1.3401.00
8_R12_E1.3181.00
17_A20_P1.3111.00
71_T74_S1.2461.00
113_D118_P1.2411.00
59_F62_A1.1821.00
85_P97_W1.1621.00
19_A22_P1.1601.00
94_R98_A1.1551.00
76_F95_K1.1531.00
71_T76_F1.1521.00
87_E91_A1.1271.00
1_G4_S1.1151.00
105_F108_L1.1111.00
113_D116_T1.0691.00
112_I115_Y1.0611.00
64_L67_I1.0211.00
36_A39_A1.0201.00
27_E30_A1.0111.00
72_A99_D0.9961.00
28_A31_P0.9711.00
55_A58_A0.9691.00
65_P80_L0.9591.00
32_P35_A0.9521.00
41_A48_A0.9461.00
104_V109_D0.9461.00
7_S10_K0.9451.00
109_D113_D0.9331.00
42_A47_P0.9291.00
35_A38_A0.9251.00
108_L115_Y0.9241.00
62_A84_V0.9231.00
71_T75_D0.9211.00
61_P64_L0.9141.00
85_P90_R0.8961.00
9_R12_E0.8941.00
18_E23_A0.8821.00
106_D111_Y0.8731.00
102_F105_F0.8661.00
41_A47_P0.8621.00
57_P60_D0.8591.00
96_L102_F0.8491.00
34_A37_P0.8491.00
75_D78_A0.8451.00
42_A46_A0.8391.00
105_F110_D0.8391.00
39_A42_A0.8381.00
34_A40_A0.8231.00
99_D105_F0.8141.00
66_P91_A0.8081.00
40_A43_A0.7951.00
36_A43_A0.7911.00
80_L89_R0.7881.00
105_F113_D0.7871.00
102_F106_D0.7861.00
45_A48_A0.7851.00
29_A32_P0.7841.00
31_P34_A0.7781.00
58_A61_P0.7781.00
87_E90_R0.7671.00
30_A33_A0.7531.00
37_P40_A0.7511.00
81_A85_P0.7511.00
16_E20_P0.7481.00
44_A50_A0.7461.00
107_G113_D0.7401.00
39_A44_A0.7381.00
4_S8_R0.7371.00
43_A47_P0.7331.00
70_L75_D0.7291.00
104_V107_G0.7171.00
65_P78_A0.7131.00
116_T119_D0.7101.00
81_A89_R0.7071.00
110_D116_T0.7061.00
47_P50_A0.7051.00
98_A103_N0.7031.00
2_F5_R0.6941.00
33_A44_A0.6881.00
89_R93_L0.6791.00
29_A34_A0.6761.00
39_A48_A0.6751.00
76_F80_L0.6741.00
42_A49_A0.6661.00
23_A28_A0.6611.00
78_A81_A0.6571.00
33_A36_A0.6551.00
8_R11_R0.6530.99
110_D115_Y0.6520.99
58_A62_A0.6480.99
101_A104_V0.6390.99
38_A41_A0.6360.99
47_P51_A0.6350.99
98_A102_F0.6310.99
94_R119_D0.6260.99
104_V113_D0.6220.99
103_N109_D0.6170.99
27_E31_P0.6150.99
67_I88_L0.6150.99
61_P85_P0.6110.99
46_A50_A0.6090.99
38_A51_A0.6060.99
41_A50_A0.6060.99
80_L110_D0.6040.99
2_F13_A0.6020.99
71_T86_E0.5990.99
60_D64_L0.5980.99
105_F111_Y0.5930.99
37_P42_A0.5880.99
106_D113_D0.5850.99
1_G73_D0.5790.99
28_A32_P0.5760.99
30_A34_A0.5720.99
24_A29_A0.5690.99
79_F88_L0.5670.99
21_E24_A0.5670.99
90_R105_F0.5650.99
72_A101_A0.5600.98
97_W118_P0.5560.98
72_A102_F0.5520.98
53_A56_E0.5520.98
107_G115_Y0.5480.98
17_A45_A0.5480.98
97_W104_V0.5450.98
98_A101_A0.5450.98
86_E91_A0.5360.98
44_A48_A0.5360.98
108_L111_Y0.5340.98
97_W101_A0.5300.98
63_T85_P0.5270.98
74_S77_S0.5220.98
72_A80_L0.5220.98
85_P93_L0.5180.97
73_D78_A0.5150.97
35_A42_A0.5140.97
35_A48_A0.5140.97
88_L91_A0.5130.97
101_A110_D0.5110.97
29_A33_A0.5060.97
34_A42_A0.5060.97
54_P58_A0.5030.97
33_A39_A0.5010.97
35_A43_A0.5000.97
17_A21_E0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pzqA 2 0.1818 8 0.929 Contact Map
2pifA 2 0.3306 3.2 0.941 Contact Map
3n5mA 4 0.3719 3.2 0.942 Contact Map
3echC 1 0.1983 2.6 0.944 Contact Map
4zgjA 2 0.3388 2.5 0.945 Contact Map
1k8rB 1 0.438 2.4 0.945 Contact Map
4i6yA 2 0.3884 2.4 0.945 Contact Map
3winD 1 0.124 2.3 0.946 Contact Map
4ayoA 1 0.2727 2.3 0.946 Contact Map
3ismC 1 0.4959 2.3 0.946 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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