GREMLIN Database
RebB - Killing trait
PFAM: PF11747 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 68 (66)
Sequences: 1600 (959)
Seq/√Len: 118.0
META: 0.813

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
11_K15_E5.3791.00
2_T7_Q3.1511.00
57_G62_Y2.6541.00
27_A33_G2.3681.00
16_A22_G2.0731.00
45_Q48_I1.9691.00
28_T36_A1.9011.00
35_A40_V1.8841.00
30_Q37_H1.8561.00
28_T32_L1.7131.00
56_Q63_S1.7031.00
56_Q59_A1.6161.00
56_Q60_L1.6091.00
34_L37_H1.5661.00
2_T6_T1.5381.00
12_V18_A1.4081.00
59_A63_S1.3531.00
41_A44_Q1.3361.00
19_M23_N1.2420.99
53_A58_V1.2240.99
28_T31_A1.2050.99
32_L35_A1.1810.99
41_A47_N1.1370.99
25_Y29_A1.1270.99
21_M25_Y1.1160.99
42_A47_N1.1150.99
3_D6_T1.0680.98
34_L40_V1.0660.98
16_A25_Y1.0230.98
26_Q29_A1.0150.97
13_L18_A1.0140.97
26_Q62_Y1.0040.97
46_A50_A0.9810.97
49_T59_A0.9750.97
3_D14_G0.9360.96
32_L52_A0.9050.95
62_Y65_D0.9030.95
41_A49_T0.9000.95
29_A32_L0.8990.95
45_Q51_Q0.8980.95
19_M24_L0.8870.95
55_T59_A0.8710.94
32_L37_H0.8460.93
53_A57_G0.8450.93
6_T10_V0.8440.93
9_N12_V0.8240.92
31_A60_L0.8130.92
31_A37_H0.8120.91
24_L29_A0.7990.91
23_N26_Q0.7950.91
58_V61_L0.7850.90
53_A59_A0.7750.89
2_T10_V0.7560.88
36_A46_A0.7470.88
30_Q36_A0.7430.87
41_A45_Q0.7350.87
24_L36_A0.7340.87
31_A34_L0.7330.87
4_A15_E0.7330.87
21_M24_L0.7270.86
3_D7_Q0.7250.86
1_I7_Q0.7060.85
32_L36_A0.6920.83
12_V16_A0.6850.83
48_I53_A0.6780.82
19_M51_Q0.6710.82
42_A58_V0.6680.81
6_T20_A0.6620.81
14_G18_A0.6460.79
41_A46_A0.6350.78
39_A43_Q0.6330.78
13_L57_G0.6270.77
16_A21_M0.6200.76
42_A45_Q0.6140.75
30_Q34_L0.6030.74
45_Q54_T0.6000.74
24_L44_Q0.5910.73
23_N29_A0.5910.73
60_L66_T0.5880.72
28_T35_A0.5850.72
27_A31_A0.5840.72
6_T11_K0.5740.71
33_G50_A0.5690.70
51_Q55_T0.5670.70
44_Q48_I0.5660.69
60_L65_D0.5650.69
34_L49_T0.5600.69
14_G19_M0.5600.69
4_A10_V0.5590.69
1_I44_Q0.5550.68
20_A51_Q0.5530.68
6_T52_A0.5450.67
17_P24_L0.5320.65
31_A36_A0.5310.65
24_L32_L0.5290.64
23_N61_L0.5140.62
30_Q39_A0.5040.61
52_A56_Q0.5020.60
54_T58_V0.5000.60
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4b6iA 2 0.5147 1.5 0.904 Contact Map
2x4iA 2 0.6912 1.4 0.906 Contact Map
4dzdA 1 0.4559 1.2 0.909 Contact Map
3qrpA 1 0.4412 1 0.913 Contact Map
2y8yA 1 0.4412 1 0.913 Contact Map
2j85A 2 0.6912 0.9 0.917 Contact Map
2j6bA 2 0.6765 0.8 0.918 Contact Map
3dahA 5 0.5294 0.8 0.919 Contact Map
1dkuA 5 0.5147 0.6 0.925 Contact Map
4twbA 2 0.3382 0.6 0.927 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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