GREMLIN Database
DUF3301 - Protein of unknown function (DUF3301)
PFAM: PF11743 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 95 (93)
Sequences: 4221 (2824)
Seq/√Len: 292.9
META: 0.89

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
52_A62_R2.8071.00
54_D60_R2.6111.00
72_T75_N2.4131.00
48_R64_T2.2501.00
18_L21_R2.1761.00
54_D58_R2.1651.00
27_A88_V2.0931.00
47_R66_R2.0661.00
64_T82_V2.0621.00
29_R42_D1.9921.00
31_A91_V1.9761.00
30_R34_R1.9451.00
71_D75_N1.9391.00
50_R62_R1.9131.00
71_D77_R1.7951.00
12_A16_L1.7441.00
70_S75_N1.6831.00
13_W16_L1.6281.00
80_S92_E1.5801.00
52_A84_L1.5361.00
25_L42_D1.5171.00
30_R33_E1.4991.00
51_L59_L1.4911.00
41_D76_R1.4631.00
16_L19_R1.4571.00
26_A30_R1.4511.00
66_R78_Q1.3641.00
20_A83_L1.3521.00
21_R25_L1.3431.00
68_E78_Q1.3211.00
84_L89_E1.3031.00
53_R57_G1.2861.00
23_R26_A1.2541.00
37_L71_D1.2431.00
29_R33_E1.2411.00
62_R84_L1.2341.00
53_R59_L1.2261.00
28_A39_L1.2241.00
14_F17_S1.2141.00
9_A13_W1.1871.00
19_R22_E1.1841.00
31_A35_A1.1601.00
40_L76_R1.1141.00
25_L28_A1.1041.00
62_R82_V1.0961.00
3_L7_L1.0801.00
64_T80_S1.0701.00
28_A81_V1.0671.00
69_F94_P1.0461.00
25_L39_L1.0411.00
8_L12_A1.0321.00
37_L69_F1.0251.00
46_L49_L1.0131.00
62_R89_E1.0111.00
60_R84_L1.0041.00
70_S73_G1.0011.00
24_A81_V0.9951.00
25_L69_F0.9911.00
18_L22_E0.9751.00
4_L8_L0.9731.00
67_F79_G0.9531.00
39_L43_T0.9511.00
23_R86_R0.9351.00
27_A31_A0.9211.00
31_A34_R0.9021.00
26_A33_E0.8961.00
79_G93_L0.8641.00
23_R27_A0.8571.00
25_L29_R0.8471.00
81_V91_V0.8471.00
10_A14_F0.8411.00
27_A81_V0.8131.00
22_E44_V0.7880.99
63_R76_R0.7780.99
51_L61_L0.7540.99
59_L84_L0.7540.99
51_L65_Y0.7420.99
82_V90_S0.7380.99
21_R44_V0.7300.99
49_L61_L0.7250.99
24_A83_L0.7210.99
28_A46_L0.7100.99
9_A12_A0.7100.99
17_S63_R0.7030.99
21_R43_T0.7000.99
31_A93_L0.6970.99
14_F61_L0.6910.99
4_L16_L0.6790.98
32_C79_G0.6740.98
26_A29_R0.6720.98
35_A90_S0.6690.98
52_A89_E0.6640.98
33_E36_G0.6600.98
41_D44_V0.6550.98
41_D68_E0.6490.98
42_D68_E0.6420.98
69_F79_G0.6410.98
54_D57_G0.6350.97
31_A69_F0.6140.97
25_L43_T0.6110.97
10_A33_E0.6100.97
80_S90_S0.6090.97
45_A68_E0.6030.96
40_L63_R0.5990.96
17_S65_Y0.5960.96
2_L12_A0.5960.96
69_F93_L0.5940.96
38_Q42_D0.5780.96
13_W17_S0.5780.96
25_L65_Y0.5760.95
49_L64_T0.5710.95
20_A63_R0.5650.95
83_L88_V0.5640.95
22_E45_A0.5630.95
78_Q94_P0.5620.95
27_A30_R0.5610.95
42_D46_L0.5540.94
24_A88_V0.5540.94
11_A15_W0.5540.94
69_F77_R0.5500.94
66_R80_S0.5490.94
21_R41_D0.5410.94
39_L42_D0.5380.94
91_V94_P0.5380.94
41_D46_L0.5380.94
28_A44_V0.5370.93
45_A83_L0.5270.93
46_L65_Y0.5240.93
82_V89_E0.5220.92
39_L44_V0.5190.92
28_A37_L0.5190.92
63_R67_F0.5120.92
68_E73_G0.5100.92
41_D63_R0.5070.91
28_A91_V0.5060.91
21_R45_A0.5060.91
88_V91_V0.5040.91
74_D77_R0.5040.91
90_S94_P0.5020.91
69_F75_N0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2l2tA 2 0.2632 18.8 0.905 Contact Map
2jwaA 2 0.2421 13.7 0.911 Contact Map
2ks1B 1 0.2526 11.1 0.914 Contact Map
2l9uA 2 0.2632 8.7 0.918 Contact Map
2mfrA 1 0.3368 6.8 0.922 Contact Map
2fyfA 2 0.0632 6.2 0.923 Contact Map
1d3bA 1 0.6421 5.4 0.926 Contact Map
4rp9A 2 0.2737 5.3 0.926 Contact Map
3lb6C 1 0 5 0.927 Contact Map
1iijA 1 0.1895 4.6 0.928 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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