GREMLIN Database
DUF3302 - Protein of unknown function (DUF3302)
PFAM: PF11742 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 77 (65)
Sequences: 3339 (1193)
Seq/√Len: 147.9
META: 0.95

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
3_Y7_V3.4061.00
45_L60_A3.1321.00
32_K43_H2.2491.00
42_I66_T1.9531.00
15_V19_V1.7231.00
28_G39_A1.6681.00
7_V11_V1.5491.00
4_F8_V1.5461.00
34_R40_D1.4781.00
21_V25_I1.4611.00
32_K39_A1.4051.00
46_G49_S1.3741.00
4_F7_V1.3731.00
36_H63_W1.3661.00
52_F55_V1.3241.00
28_G46_G1.3051.00
40_D43_H1.3041.00
30_I34_R1.2811.00
55_V58_P1.2781.00
48_L61_W1.2381.00
6_L10_I1.1961.00
26_L30_I1.1811.00
24_H47_W1.1801.00
57_W61_W1.1721.00
18_A22_L1.1521.00
44_V61_W1.1481.00
30_I65_Y1.1471.00
18_A21_V1.1290.99
49_S60_A1.1260.99
38_Q66_T1.1210.99
38_Q42_I1.0980.99
12_V21_V1.0890.99
12_V16_A1.0710.99
39_A43_H1.0600.99
44_V65_Y1.0460.99
45_L59_L1.0450.99
17_I21_V1.0390.99
24_H46_G1.0370.99
8_V12_V1.0320.99
48_L57_W1.0070.99
25_I29_K0.9970.99
6_L9_L0.9910.99
11_V15_V0.9820.99
20_F24_H0.9800.99
22_L26_L0.9720.98
41_A63_W0.9630.98
49_S58_P0.9630.98
50_L53_G0.9490.98
51_F65_Y0.9220.98
29_K32_K0.9080.98
22_L29_K0.9060.98
14_A18_A0.8980.97
45_L56_L0.8970.97
20_F50_L0.8860.97
16_A19_V0.8690.97
34_R65_Y0.8630.97
50_L57_W0.8450.96
30_I33_K0.8440.96
24_H50_L0.8410.96
9_L13_P0.8220.96
19_V22_L0.8010.95
56_L59_L0.7890.94
28_G32_K0.7790.94
23_L26_L0.7670.94
35_N39_A0.7640.93
45_L58_P0.7440.93
32_K35_N0.7380.92
19_V23_L0.7300.92
4_F11_V0.7290.92
6_L52_F0.7260.92
43_H47_W0.7100.91
49_S54_G0.6950.90
38_Q48_L0.6800.89
3_Y6_L0.6750.88
20_F46_G0.6580.87
41_A50_L0.6540.87
25_I46_G0.6510.87
29_K33_K0.6430.86
27_P31_A0.6400.86
2_D6_L0.6390.86
39_A46_G0.6250.84
19_V56_L0.6230.84
47_W51_F0.5980.82
26_L65_Y0.5940.81
2_D17_I0.5890.81
5_A15_V0.5840.80
16_A20_F0.5820.80
28_G44_V0.5570.77
26_L29_K0.5550.77
2_D8_V0.5510.76
48_L53_G0.5310.74
18_A26_L0.5300.73
37_P41_A0.5280.73
12_V17_I0.5200.72
49_S55_V0.5170.72
8_V11_V0.5120.71
61_W65_Y0.5040.70
33_K66_T0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2wswA 3 0.6104 5 0.91 Contact Map
4p02B 1 0.3636 3.1 0.919 Contact Map
4tllB 2 0.3636 2.6 0.922 Contact Map
1wazA 1 0.3506 1.9 0.927 Contact Map
4c7rA 3 0.961 1.9 0.928 Contact Map
4gb7A 1 0.3247 1.8 0.928 Contact Map
2mofA 1 0.5325 1.7 0.929 Contact Map
1pi7A 1 0.2468 1.6 0.93 Contact Map
3ne5A 3 0.8701 1.6 0.931 Contact Map
4ccfA 3 0 1.5 0.932 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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