GREMLIN Database
KfrA_N - Plasmid replication region DNA-binding N-term
PFAM: PF11740 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 113 (110)
Sequences: 5159 (4079)
Seq/√Len: 388.9
META: 0.788

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
11_A27_E2.9791.00
15_E27_E2.8781.00
2_Y6_A2.6501.00
2_Y42_E2.5351.00
9_A43_W2.2491.00
22_D33_P2.1831.00
9_A40_L1.9891.00
5_V39_H1.9321.00
24_V40_L1.7971.00
37_S41_K1.7261.00
4_D30_T1.7241.00
106_L109_L1.7241.00
92_R96_E1.6811.00
88_L92_R1.6361.00
12_L17_E1.6351.00
39_H42_E1.6321.00
21_V33_P1.5971.00
17_E23_A1.5931.00
85_R89_E1.5661.00
105_E108_A1.5561.00
70_W73_A1.5061.00
94_A98_E1.4951.00
4_D7_A1.4831.00
99_L102_A1.4831.00
60_E64_E1.4301.00
11_A15_E1.3571.00
102_A106_L1.3421.00
105_E110_E1.3351.00
31_G36_I1.3331.00
99_L103_E1.3261.00
21_V37_S1.3131.00
13_L47_L1.3091.00
106_L110_E1.3011.00
92_R95_L1.2971.00
84_E88_L1.2911.00
89_E93_A1.2761.00
86_A90_A1.2711.00
87_A91_E1.2531.00
91_E94_A1.2061.00
80_R84_E1.1851.00
6_A39_H1.1821.00
24_V36_I1.1761.00
25_R36_I1.1501.00
38_R42_E1.1481.00
76_E79_A1.1361.00
6_A10_D1.1281.00
6_A43_W1.1121.00
96_E99_L1.0971.00
10_D43_W1.0851.00
98_E101_E1.0841.00
32_S35_T1.0811.00
71_E75_E1.0711.00
13_L19_P1.0701.00
59_P70_W1.0661.00
97_A101_E1.0471.00
84_E87_A1.0461.00
35_T39_H1.0351.00
6_A42_E1.0171.00
83_A87_A1.0141.00
25_R30_T1.0111.00
66_A69_L1.0101.00
89_E92_R1.0071.00
100_A104_A1.0021.00
2_Y39_H0.9951.00
19_P23_A0.9761.00
6_A46_E0.9621.00
81_L84_E0.9601.00
10_D14_A0.9581.00
25_R33_P0.9551.00
94_A97_A0.9511.00
95_L99_L0.9491.00
90_A94_A0.9461.00
65_A68_A0.9461.00
34_T38_R0.9441.00
74_L78_E0.9441.00
67_A71_E0.9431.00
61_E72_R0.9401.00
7_A11_A0.9381.00
42_E46_E0.9311.00
8_A12_L0.9251.00
3_E7_A0.9061.00
93_A97_A0.9061.00
100_A103_E0.9011.00
96_E100_A0.8881.00
69_L72_R0.8821.00
90_A93_A0.8761.00
82_A86_A0.8741.00
85_R88_L0.8741.00
103_E107_A0.8671.00
98_E103_E0.8661.00
22_D26_E0.8621.00
9_A24_V0.8621.00
68_A72_R0.8561.00
101_E105_E0.8521.00
91_E96_E0.8211.00
107_A111_A0.8171.00
28_L36_I0.8151.00
104_A108_A0.8031.00
8_A24_V0.7941.00
82_A85_R0.7881.00
21_V40_L0.7741.00
70_W74_L0.7721.00
18_R44_R0.7711.00
81_L88_L0.7681.00
31_G35_T0.7631.00
74_L80_R0.7541.00
95_L98_E0.7451.00
33_P37_S0.7371.00
43_W47_L0.7261.00
40_L44_R0.7171.00
102_A105_E0.7141.00
8_A27_E0.7071.00
88_L95_L0.6971.00
78_E82_A0.6961.00
72_R76_E0.6951.00
93_A96_E0.6951.00
40_L43_W0.6930.99
37_S44_R0.6870.99
104_A107_A0.6860.99
5_V36_I0.6760.99
79_A83_A0.6700.99
86_A89_E0.6620.99
70_W77_A0.6610.99
60_E63_A0.6590.99
16_G19_P0.6580.99
80_R83_A0.6580.99
59_P62_L0.6510.99
103_E106_L0.6460.99
4_D28_L0.6450.99
80_R85_R0.6420.99
61_E76_E0.6400.99
38_R41_K0.6380.99
9_A19_P0.6380.99
12_L15_E0.6380.99
97_A100_A0.6330.99
68_A71_E0.6270.99
47_L50_R0.6210.99
25_R31_G0.6100.99
84_E89_E0.6090.99
65_A72_R0.5990.99
98_E102_A0.5970.98
75_E79_A0.5940.98
20_T23_A0.5890.98
4_D39_H0.5790.98
20_T32_S0.5690.98
88_L91_E0.5670.98
33_P36_I0.5640.98
8_A28_L0.5600.98
42_E45_A0.5570.98
12_L24_V0.5520.98
82_A89_E0.5500.97
25_R29_G0.5480.97
73_A77_A0.5430.97
21_V34_T0.5430.97
105_E109_L0.5420.97
37_S70_W0.5290.97
101_E110_E0.5290.97
8_A11_A0.5270.97
21_V36_I0.5230.97
58_L63_A0.5210.96
11_A14_A0.5210.96
52_A56_A0.5060.96
98_E106_L0.5060.96
81_L85_R0.5040.96
28_L39_H0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ao9A 7 0.7876 63 0.811 Contact Map
2jn6A 1 0.7345 50.8 0.824 Contact Map
2elhA 1 0.5575 50.5 0.825 Contact Map
2rn7A 1 0.7257 46.6 0.828 Contact Map
2eh3A 2 0.9469 44.6 0.83 Contact Map
1k78A 1 0.3805 37.6 0.838 Contact Map
3or1C 1 0.531 36.6 0.839 Contact Map
2x48A 1 0.3451 35.9 0.84 Contact Map
3mvpA 2 0.9912 35.5 0.84 Contact Map
1sfuA 1 0.5575 34.3 0.841 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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