GREMLIN Database
DctA-YdbH - Dicarboxylate transport
PFAM: PF11739 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 206 (198)
Sequences: 2968 (2185)
Seq/√Len: 155.3
META: 0.827

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
88_D110_R4.2581.00
142_N172_D4.1561.00
13_D38_P3.2581.00
36_S43_R2.8711.00
41_G71_E2.8001.00
73_L83_A2.7061.00
104_G153_D2.6691.00
47_E63_R2.6681.00
71_E74_A2.5961.00
134_D138_D2.5641.00
96_D99_G2.4381.00
63_R90_R2.3731.00
138_D141_E2.2711.00
84_T145_Y2.2391.00
167_D180_R2.2321.00
66_G110_R2.1441.00
174_L177_R2.1261.00
82_S116_R2.1091.00
68_D71_E2.0711.00
64_L67_L2.0451.00
41_G68_D1.9891.00
170_N176_G1.9581.00
43_R65_D1.9421.00
81_L117_Y1.9381.00
66_G88_D1.9221.00
146_D167_D1.9151.00
68_D86_T1.8351.00
45_S65_D1.7981.00
106_R149_S1.7301.00
94_V103_E1.7191.00
14_G37_W1.7091.00
136_A181_L1.5891.00
57_E96_D1.5831.00
113_G145_Y1.5821.00
59_R94_V1.5791.00
95_F100_V1.5721.00
59_R103_E1.5651.00
146_D169_K1.5621.00
104_G151_T1.5351.00
37_W44_L1.4661.00
165_R180_R1.4581.00
11_L37_W1.4541.00
108_A149_S1.4521.00
17_R33_E1.4451.00
69_L87_L1.4391.00
92_P153_D1.4321.00
5_I14_G1.4131.00
57_E94_V1.4121.00
61_T90_R1.4121.00
49_L60_L1.4061.00
143_F166_L1.3991.00
200_Y203_S1.3931.00
4_S10_P1.3701.00
38_P43_R1.3701.00
188_N191_Q1.3671.00
163_R184_N1.3641.00
179_I183_L1.3571.00
153_D163_R1.3571.00
31_R50_R1.3451.00
32_I49_L1.3311.00
91_L105_G1.3291.00
147_S167_D1.3281.00
107_L150_A1.3031.00
111_G115_L1.3021.00
70_A74_A1.2971.00
159_E186_E1.2941.00
106_R151_T1.2781.00
7_P10_P1.2471.00
161_V186_E1.2441.00
139_A173_V1.2391.00
86_T110_R1.2361.00
151_T163_R1.2331.00
6_N10_P1.2331.00
60_L93_L1.2241.00
47_E90_R1.2131.00
4_S12_T1.2081.00
111_G114_G1.2071.00
66_G86_T1.2031.00
188_N196_L1.1861.00
89_G107_L1.1791.00
39_F44_L1.1601.00
170_N174_L1.1501.00
164_L185_L1.1461.00
78_L81_L1.1361.00
46_L49_L1.1091.00
90_R106_R1.0970.99
174_L179_I1.0870.99
83_A109_A1.0810.99
52_D55_A1.0800.99
62_L93_L1.0780.99
17_R34_R1.0500.99
197_R200_Y1.0300.99
139_A179_I1.0240.99
19_Q31_R1.0120.99
130_N133_L1.0060.99
154_G190_P1.0050.99
85_G145_Y1.0030.99
135_L173_V0.9990.99
29_R52_D0.9980.99
197_R201_D0.9850.99
64_L107_L0.9840.99
109_A148_L0.9830.99
105_G184_N0.9810.99
114_G144_R0.9780.99
187_G192_L0.9770.99
68_D72_L0.9740.99
144_R171_P0.9710.99
119_G123_L0.9680.99
19_Q25_L0.9650.99
3_A13_D0.9630.99
120_E141_E0.9470.98
2_I14_G0.9410.98
36_S45_S0.9400.98
73_L76_L0.9330.98
31_R48_P0.9260.98
196_L199_G0.9260.98
14_G38_P0.9180.98
135_L179_I0.9080.98
191_Q197_R0.9000.98
118_D141_E0.8980.98
45_S63_R0.8860.98
173_V176_G0.8840.98
150_A164_L0.8820.97
170_N173_V0.8800.97
119_G122_A0.8790.97
133_L136_A0.8790.97
55_A58_R0.8720.97
109_A145_Y0.8710.97
103_E153_D0.8670.97
29_R50_R0.8580.97
135_L139_A0.8560.97
135_L138_D0.8550.97
182_N186_E0.8540.97
177_R188_N0.8430.97
16_I35_A0.8410.97
58_R95_F0.8370.97
188_N195_S0.8340.96
119_G137_F0.8320.96
115_L144_R0.8290.96
117_Y154_G0.8280.96
137_F143_F0.8220.96
35_A46_L0.8200.96
15_T36_S0.8180.96
115_L145_Y0.8160.96
183_L203_S0.8030.96
177_R180_R0.8030.96
87_L110_R0.7990.95
196_L203_S0.7990.95
158_G190_P0.7950.95
112_P115_L0.7950.95
187_G190_P0.7940.95
187_G200_Y0.7920.95
154_G160_L0.7900.95
131_P134_D0.7830.95
9_I12_T0.7800.95
80_G95_F0.7760.95
132_Q135_L0.7720.95
37_W154_G0.7720.95
198_L202_L0.7700.94
127_A130_N0.7660.94
143_F170_N0.7660.94
109_A113_G0.7650.94
40_L75_L0.7620.94
174_L187_G0.7600.94
176_G180_R0.7570.94
121_A124_A0.7540.94
143_F174_L0.7520.94
191_Q194_R0.7510.94
185_L193_L0.7480.94
89_G150_A0.7470.94
76_L187_G0.7470.94
14_G154_G0.7430.93
167_D178_P0.7400.93
174_L180_R0.7400.93
40_L67_L0.7400.93
154_G158_G0.7370.93
3_A12_T0.7330.93
177_R187_G0.7280.93
159_E188_N0.7220.92
136_A158_G0.7210.92
116_R142_N0.7200.92
76_L150_A0.7170.92
2_I5_I0.7160.92
88_D108_A0.7150.92
196_L200_Y0.7140.92
188_N192_L0.7140.92
171_P177_R0.7070.92
66_G147_S0.7030.91
169_K176_G0.7030.91
51_L62_L0.6970.91
69_L83_A0.6970.91
144_R170_N0.6940.91
19_Q33_E0.6900.91
94_V101_R0.6880.90
199_G203_S0.6880.90
194_R202_L0.6850.90
16_I34_R0.6830.90
32_I35_A0.6790.90
152_L162_L0.6770.90
191_Q200_Y0.6740.90
170_N175_A0.6660.89
136_A179_I0.6630.89
92_P182_N0.6610.89
186_E197_R0.6560.88
10_P40_L0.6560.88
173_V177_R0.6540.88
133_L166_L0.6510.88
4_S7_P0.6430.87
79_E181_L0.6410.87
119_G124_A0.6340.87
56_E97_G0.6310.86
25_L29_R0.6280.86
61_T94_V0.6280.86
187_G197_R0.6270.86
65_D90_R0.6180.85
173_V179_I0.6180.85
63_R82_S0.6150.85
28_G52_D0.6120.85
91_L102_I0.6080.84
91_L161_V0.6080.84
142_N171_P0.6040.84
169_K174_L0.6040.84
164_L183_L0.6000.83
51_L58_R0.5980.83
177_R186_E0.5980.83
89_G109_A0.5940.83
14_G18_F0.5940.83
194_R197_R0.5910.82
136_A143_F0.5870.82
187_G198_L0.5870.82
125_A129_S0.5850.82
70_A98_G0.5850.82
189_L202_L0.5820.82
14_G39_F0.5820.82
47_E61_T0.5800.81
144_R169_K0.5770.81
67_L196_L0.5750.81
11_L14_G0.5730.81
119_G141_E0.5730.81
190_P193_L0.5720.80
87_L183_L0.5710.80
116_R120_E0.5700.80
140_L148_L0.5700.80
134_D184_N0.5690.80
179_I187_G0.5690.80
189_L193_L0.5690.80
183_L188_N0.5690.80
10_P131_P0.5650.80
41_G86_T0.5650.80
169_K175_A0.5650.80
180_R183_L0.5630.79
122_A137_F0.5610.79
42_G67_L0.5600.79
101_R156_L0.5570.79
16_I32_I0.5560.79
15_T34_R0.5560.79
150_A158_G0.5520.78
157_D190_P0.5510.78
138_D173_V0.5500.78
70_A82_S0.5500.78
189_L196_L0.5450.77
91_L152_L0.5440.77
177_R202_L0.5430.77
10_P15_T0.5430.77
74_A82_S0.5400.77
104_G108_A0.5360.76
197_R203_S0.5330.76
194_R201_D0.5250.75
190_P197_R0.5240.74
24_L60_L0.5230.74
198_L201_D0.5220.74
109_A147_S0.5210.74
15_T56_E0.5200.74
187_G191_Q0.5200.74
139_A143_F0.5190.74
50_R59_R0.5180.74
29_R59_R0.5170.73
182_N193_L0.5170.73
74_A79_E0.5160.73
41_G105_G0.5150.73
26_P29_R0.5150.73
77_G122_A0.5130.73
165_R182_N0.5130.73
16_I107_L0.5120.73
150_A157_D0.5120.73
117_Y137_F0.5110.73
155_D159_E0.5070.72
102_I182_N0.5060.72
171_P176_G0.5060.72
37_W62_L0.5030.71
39_F67_L0.5020.71
56_E162_L0.5020.71
13_D104_G0.5010.71
55_A96_D0.5010.71
136_A140_L0.5010.71
102_I181_L0.5000.71
143_F181_L0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2xmxA 1 0.4175 10.6 0.94 Contact Map
4jtmA 2 0.3204 8.2 0.943 Contact Map
1yycA 1 0.5583 2.9 0.954 Contact Map
2ekfA 1 0.2087 2.8 0.954 Contact Map
2oplA 2 0.7087 2.7 0.955 Contact Map
1hekA 1 0.1408 2.5 0.956 Contact Map
2ru9A 1 0.1893 2.5 0.956 Contact Map
3vz9B 1 0.3495 2.4 0.956 Contact Map
2ywqA 1 0.3641 2.1 0.958 Contact Map
2qifA 2 0.2961 2 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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