GREMLIN Database
Thoc2 - Transcription- and export-related complex subunit
PFAM: PF11732 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 76 (76)
Sequences: 529 (380)
Seq/√Len: 43.6
META: 0.554

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
21_E58_R4.4891.00
17_L48_C4.1561.00
21_E52_A3.4691.00
60_R72_L2.7211.00
9_P44_V2.6181.00
10_L33_A2.1551.00
45_L50_L2.1471.00
47_Y51_E2.0950.99
64_D67_N1.9940.99
62_K67_N1.9060.99
1_L37_L1.7850.98
21_E29_P1.5680.96
55_N58_R1.5160.95
37_L42_Y1.4550.94
67_N70_Q1.4300.93
13_F25_N1.3890.92
33_A47_Y1.3820.92
2_A8_N1.3790.92
17_L28_E1.3660.92
62_K66_T1.3320.91
13_F45_L1.3130.90
29_P38_T1.2620.88
56_P59_S1.2350.87
71_W75_L1.1800.84
62_K70_Q1.1720.84
25_N72_L1.1500.83
31_V50_L1.1210.81
27_I53_L1.0920.79
23_Y76_A1.0290.75
69_S72_L1.0200.75
34_L42_Y1.0180.74
5_A41_G1.0060.74
52_A61_L0.9840.72
37_L41_G0.9830.72
6_H38_T0.9690.71
40_L48_C0.9480.69
52_A58_R0.9400.68
32_E55_N0.9360.68
2_A10_L0.9300.68
15_V18_N0.9220.67
65_G71_W0.9100.66
12_V27_I0.8800.63
20_I27_I0.8550.61
6_H47_Y0.8520.61
50_L54_S0.8500.61
63_E68_I0.8360.59
14_D29_P0.8330.59
16_I32_E0.8320.59
20_I67_N0.8300.59
26_L55_N0.8220.58
28_E49_L0.8100.57
4_L12_V0.8000.56
35_K69_S0.7820.54
57_G61_L0.7770.54
2_A34_L0.7770.54
24_D47_Y0.7760.54
5_A8_N0.7740.53
18_N24_D0.7660.53
23_Y65_G0.7600.52
6_H37_L0.7560.52
31_V56_P0.7560.52
47_Y59_S0.7550.52
56_P61_L0.7520.51
56_P70_Q0.7490.51
46_T57_G0.7380.50
70_Q73_Q0.7320.49
25_N74_S0.7260.49
3_K15_V0.7200.48
70_Q76_A0.7150.48
72_L76_A0.7130.48
14_D18_N0.7080.47
61_L68_I0.7030.47
30_V44_V0.7000.46
26_L42_Y0.6980.46
15_V19_Q0.6910.45
24_D74_S0.6910.45
52_A72_L0.6880.45
68_I75_L0.6880.45
27_I41_G0.6830.45
9_P36_Y0.6810.45
31_V74_S0.6750.44
51_E74_S0.6720.44
35_K64_D0.6710.44
14_D50_L0.6610.43
21_E32_E0.6590.42
14_D73_Q0.6320.40
22_S25_N0.6180.39
27_I40_L0.6110.38
17_L46_T0.6100.38
11_I44_V0.6090.38
34_L37_L0.6080.38
61_L66_T0.6070.38
59_S70_Q0.5980.37
68_I74_S0.5930.36
33_A49_L0.5890.36
69_S75_L0.5890.36
13_F39_P0.5850.36
2_A5_A0.5830.36
51_E54_S0.5830.36
14_D26_L0.5830.36
25_N33_A0.5770.35
10_L44_V0.5690.34
63_E66_T0.5660.34
11_I31_V0.5630.34
59_S76_A0.5520.33
19_Q26_L0.5430.32
12_V46_T0.5400.32
7_S36_Y0.5330.31
20_I39_P0.5320.31
44_V49_L0.5290.31
41_G62_K0.5110.30
8_N61_L0.5100.29
67_N74_S0.5080.29
4_L39_P0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3nftA 2 0.3816 24.9 0.885 Contact Map
2j0oA 1 0.3289 21.4 0.888 Contact Map
3ohwB 1 0.6447 15.6 0.895 Contact Map
3l6xA 1 0.8947 13.5 0.898 Contact Map
3osjA 1 0.6447 13.4 0.898 Contact Map
2ky4A 1 0.7895 8.2 0.907 Contact Map
3nphB 1 0.6447 7.3 0.909 Contact Map
3pruC 1 0.8026 6.9 0.91 Contact Map
4wisA 2 0.6974 6.8 0.911 Contact Map
3b40A 1 0.2632 6.1 0.913 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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