GREMLIN Database
DUF3297 - Protein of unknown function (DUF3297)
PFAM: PF11730 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 71 (71)
Sequences: 3420 (635)
Seq/√Len: 75.4
META: 0.923

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
48_A51_T3.1591.00
27_N66_K2.7051.00
24_I69_P2.5791.00
9_R57_N2.3901.00
16_A19_E2.3881.00
39_V69_P2.3631.00
7_D57_N2.3551.00
52_L55_K2.3201.00
29_V33_N2.1811.00
45_R62_K1.9711.00
15_A19_E1.9331.00
46_V63_L1.8461.00
20_R71_F1.8341.00
17_V21_G1.7711.00
51_T59_L1.7261.00
28_G66_K1.6451.00
35_E47_A1.4990.99
45_R60_T1.4150.99
17_V20_R1.4070.99
25_R68_E1.4000.99
52_L57_N1.3940.99
34_V44_V1.3260.98
26_F44_V1.2500.97
51_T55_K1.2340.97
49_G60_T1.2270.97
13_Y19_E1.2060.96
17_V71_F1.1720.96
7_D35_E1.0960.94
27_N64_K1.0890.94
33_N61_I1.0810.93
6_V18_L1.0320.92
24_I30_E1.0280.92
24_I46_V1.0200.91
6_V35_E0.9620.89
29_V32_T0.9450.88
33_N46_V0.9450.88
14_D18_L0.9390.88
50_K59_L0.9350.87
14_D17_V0.9320.87
53_D57_N0.9110.86
3_R38_C0.8810.84
31_R63_L0.8620.83
26_F31_R0.8520.82
48_A61_I0.8500.82
35_E57_N0.8450.81
42_G64_K0.8260.80
47_A52_L0.8140.79
66_K69_P0.8040.78
24_I27_N0.8030.78
66_K70_Y0.7970.77
3_R12_H0.7910.77
47_A58_P0.7830.76
55_K59_L0.7390.72
14_D20_R0.7390.72
35_E45_R0.7380.72
58_P63_L0.7350.72
18_L21_G0.7270.71
5_S15_A0.7250.70
47_A60_T0.7140.69
3_R17_V0.7130.69
2_D38_C0.7120.69
48_A60_T0.7100.69
30_E70_Y0.7070.69
44_V63_L0.7010.68
52_L58_P0.6890.67
31_R46_V0.6800.66
6_V13_Y0.6760.65
25_R70_Y0.6760.65
47_A50_K0.6740.65
48_A52_L0.6730.65
59_L64_K0.6710.65
33_N38_C0.6670.64
5_S47_A0.6660.64
7_D10_S0.6570.63
28_G31_R0.6380.61
6_V17_V0.6380.61
18_L22_V0.6220.59
14_D69_P0.6090.57
30_E47_A0.6050.57
46_V61_I0.6010.56
5_S11_P0.5960.55
6_V22_V0.5950.55
26_F63_L0.5930.55
39_V67_V0.5910.55
50_K53_D0.5870.54
32_T49_G0.5720.52
49_G52_L0.5690.52
40_S60_T0.5670.52
19_E35_E0.5610.51
6_V9_R0.5610.51
8_P13_Y0.5590.51
29_V55_K0.5590.51
1_P4_L0.5570.51
24_I29_V0.5560.50
22_V32_T0.5540.50
44_V64_K0.5530.50
2_D40_S0.5490.50
3_R40_S0.5410.49
30_E34_V0.5380.48
35_E38_C0.5340.48
38_C44_V0.5300.47
14_D21_G0.5170.46
18_L55_K0.5150.45
42_G55_K0.5140.45
13_Y16_A0.5090.45
13_Y27_N0.5000.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3e59A 1 0.662 11.9 0.931 Contact Map
2hzmB 1 0.2817 11.4 0.931 Contact Map
1ky9A 5 0.8169 10.6 0.932 Contact Map
4bjpA 2 0.3099 10.5 0.932 Contact Map
3eopA 1 0.8873 10 0.933 Contact Map
1lcyA 3 0.9014 9.7 0.933 Contact Map
3pv2A 6 0.8451 9.1 0.934 Contact Map
1ng7A 2 0.7183 8.7 0.935 Contact Map
4aw7A 1 0.9014 7.7 0.936 Contact Map
2vmhA 1 0.507 7.3 0.937 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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