GREMLIN Database
DUF3293 - Protein of unknown function (DUF3293)
PFAM: PF11697 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 73 (73)
Sequences: 6399 (5145)
Seq/√Len: 602.2
META: 0.932

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
26_E67_R2.9831.00
26_E68_F2.5171.00
11_L19_R2.1531.00
4_W20_N2.1401.00
20_N51_F2.1351.00
4_W49_P1.9711.00
24_E51_F1.9551.00
12_S15_E1.8981.00
56_I61_A1.8031.00
57_S60_E1.8031.00
32_L53_V1.6621.00
7_R69_G1.6531.00
13_D17_A1.6481.00
24_E28_R1.6301.00
35_L54_L1.6071.00
8_S71_N1.6071.00
37_G50_S1.5691.00
24_E36_P1.5441.00
27_L51_F1.5311.00
3_A20_N1.4871.00
58_R62_I1.4661.00
11_L15_E1.4361.00
41_D45_S1.3351.00
30_L60_E1.3141.00
26_E30_L1.2911.00
65_G73_I1.2901.00
37_G52_L1.2781.00
7_R71_N1.2641.00
24_E34_F1.2401.00
19_R69_G1.2071.00
19_R22_R1.2021.00
28_R34_F1.1881.00
20_N24_E1.1591.00
40_R44_G1.1371.00
2_T20_N1.1301.00
27_L53_V1.1151.00
3_A23_L1.1151.00
20_N36_P1.0981.00
34_F51_F1.0791.00
20_N49_P1.0671.00
8_S46_W0.9791.00
38_E47_P0.9661.00
62_I65_G0.9631.00
41_D44_G0.9451.00
62_I66_R0.9361.00
22_R26_E0.9231.00
30_L64_L0.9081.00
25_A29_A0.8961.00
39_G50_S0.8561.00
32_L56_I0.8511.00
38_E49_P0.8501.00
31_G34_F0.8411.00
53_V56_I0.8341.00
60_E63_A0.8331.00
17_A49_P0.8311.00
18_A22_R0.8181.00
27_L64_L0.8181.00
32_L60_E0.7861.00
21_A24_E0.7831.00
40_R47_P0.7761.00
34_F54_L0.7581.00
20_N50_S0.7541.00
15_E19_R0.7531.00
4_W17_A0.7501.00
63_A67_R0.7451.00
35_L52_L0.7421.00
26_E29_A0.7321.00
46_W72_A0.7291.00
57_S61_A0.7261.00
21_A25_A0.7161.00
56_I60_E0.7051.00
23_L68_F0.7041.00
27_L34_F0.6731.00
22_R67_R0.6631.00
23_L64_L0.6611.00
2_T50_S0.6571.00
1_I53_V0.6531.00
4_W13_D0.6521.00
5_N16_N0.6461.00
46_W52_L0.6431.00
62_I73_I0.6371.00
61_A73_I0.6351.00
15_E18_A0.6221.00
22_R25_A0.6151.00
46_W71_N0.6131.00
23_L65_G0.6051.00
22_R68_F0.5991.00
18_A21_A0.5921.00
61_A65_G0.5861.00
44_G47_P0.5851.00
8_S11_L0.5771.00
41_D46_W0.5721.00
14_A18_A0.5601.00
65_G72_A0.5581.00
38_E50_S0.5550.99
31_G53_V0.5550.99
27_L32_L0.5520.99
17_A21_A0.5510.99
39_G47_P0.5500.99
7_R11_L0.5460.99
41_D47_P0.5440.99
59_E63_A0.5360.99
64_L68_F0.5350.99
36_P49_P0.5270.99
6_P11_L0.5260.99
10_P44_G0.5080.99
37_G55_G0.5010.99
56_I64_L0.5000.99
30_L67_R0.5000.99
42_P46_W0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qlcA 1 0.7123 61 0.809 Contact Map
1g03A 1 0.6438 20.6 0.854 Contact Map
4ph2A 1 0.5616 14 0.865 Contact Map
3d64A 4 0.8493 9.5 0.875 Contact Map
3tgoC 2 0 9.3 0.875 Contact Map
3l21A 5 0.9315 6.7 0.883 Contact Map
4bjuA 1 0.726 6.4 0.884 Contact Map
4oe7A 3 0.9315 6.1 0.885 Contact Map
3cprA 3 0.9315 6 0.885 Contact Map
4dppA 3 0.9315 5.9 0.886 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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