GREMLIN Database
DUF3288 - Protein of unknown function (DUF3288)
PFAM: PF11691 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 89 (86)
Sequences: 642 (351)
Seq/√Len: 37.8
META: 0.794

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
34_I51_E4.2511.00
7_Y45_D4.1771.00
1_D44_R3.1371.00
27_L68_T2.9111.00
44_R47_Q2.4861.00
65_F68_T2.1330.99
31_A68_T2.0630.99
15_D18_L2.0220.99
25_L29_E1.9900.99
80_S83_D1.9400.98
60_T63_E1.9270.98
40_F43_A1.8930.98
79_G84_T1.6770.96
16_S26_D1.6200.95
80_S85_S1.5020.93
79_G83_D1.4240.90
78_Y81_G1.4150.90
23_E26_D1.4080.90
59_L67_K1.3940.89
11_R45_D1.3400.87
67_K70_A1.3350.87
43_A50_L1.2770.85
76_D83_D1.2670.84
22_P57_W1.2630.84
15_D49_D1.2170.82
11_R49_D1.2140.82
82_F86_E1.1980.81
27_L40_F1.1750.79
30_L53_I1.1590.79
27_L59_L1.1510.78
25_L46_I1.1400.77
45_D49_D1.1220.76
58_G62_E1.1140.76
81_G84_T1.1050.75
16_S20_E1.0950.74
19_A39_G1.0940.74
59_L63_E1.0630.72
76_D82_F1.0370.70
7_Y39_G1.0320.70
76_D84_T1.0320.70
29_E72_H1.0130.68
71_I80_S1.0030.68
68_T71_I0.9910.67
8_A28_V0.9760.66
54_L63_E0.9190.61
80_S84_T0.9180.61
10_D37_Y0.9110.60
17_L57_W0.8900.58
83_D86_E0.8860.58
13_I50_L0.8790.57
51_E63_E0.8740.57
13_I17_L0.8670.56
20_E26_D0.8600.56
34_I61_E0.8500.55
82_F85_S0.8470.55
72_H78_Y0.8420.54
27_L41_P0.8410.54
3_T50_L0.8380.54
61_E65_F0.8360.54
76_D79_G0.8350.53
77_V83_D0.8090.51
75_G82_F0.8000.50
30_L60_T0.7970.50
70_A73_A0.7940.50
7_Y80_S0.7930.50
76_D80_S0.7900.49
72_H75_G0.7740.48
38_Q65_F0.7690.48
79_G82_F0.7680.48
48_N52_K0.7630.47
60_T74_N0.7600.47
78_Y83_D0.7600.47
35_I38_Q0.7590.47
38_Q61_E0.7560.46
7_Y15_D0.7550.46
18_L53_I0.7540.46
52_K56_F0.7510.46
17_L22_P0.7310.44
58_G86_E0.7230.44
42_G47_Q0.7230.44
50_L65_F0.7210.43
72_H77_V0.7200.43
75_G78_Y0.7180.43
76_D81_G0.7160.43
6_L9_T0.7140.43
39_G47_Q0.7120.43
18_L29_E0.7010.42
21_E74_N0.6980.41
79_G86_E0.6910.41
29_E32_R0.6840.40
74_N77_V0.6790.40
9_T12_D0.6670.39
62_E74_N0.6610.38
7_Y49_D0.6520.37
34_I65_F0.6520.37
25_L30_L0.6510.37
14_V50_L0.6480.37
30_L54_L0.6470.37
35_I65_F0.6430.37
30_L65_F0.6420.37
29_E43_A0.6380.36
2_Q5_P0.6360.36
63_E66_E0.6320.36
46_I65_F0.6320.36
26_D32_R0.6130.34
1_D71_I0.6100.34
14_V17_L0.6000.33
18_L49_D0.5860.32
17_L30_L0.5810.32
21_E26_D0.5810.32
23_E73_A0.5760.31
74_N86_E0.5720.31
24_D39_G0.5700.31
14_V33_L0.5680.31
49_D52_K0.5620.30
35_I44_R0.5610.30
43_A47_Q0.5540.30
55_K85_S0.5500.29
50_L69_R0.5450.29
54_L68_T0.5440.29
16_S19_A0.5400.29
68_T72_H0.5360.28
46_I61_E0.5280.28
24_D41_P0.5210.27
13_I16_S0.5170.27
6_L80_S0.5140.27
14_V49_D0.5060.26
77_V85_S0.5050.26
12_D85_S0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1qsaA 1 0.9438 13.3 0.927 Contact Map
4ch7A 1 0.6629 12 0.928 Contact Map
1q2fA 1 0.3596 10 0.931 Contact Map
4g9qA 3 0.6292 8.7 0.932 Contact Map
4lwlA 1 0.8427 8.6 0.933 Contact Map
4g55A 1 0.4045 7.9 0.934 Contact Map
1yubA 1 0.4944 7.6 0.934 Contact Map
1f6vA 1 0.6404 7 0.935 Contact Map
1vt0M 4 0.8315 6.1 0.937 Contact Map
2ggtA 1 0.6517 6.1 0.937 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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