GREMLIN Database
DUF2933 - Protein of unknown function (DUF2933)
PFAM: PF11666 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 52 (50)
Sequences: 4092 (2834)
Seq/√Len: 400.7
META: 0.897

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
15_H18_H3.2891.00
9_F13_T2.9671.00
12_L16_R2.7061.00
24_P27_L2.4801.00
29_L32_P2.1731.00
22_A26_L1.8881.00
10_F14_E1.7391.00
23_L27_L1.6801.00
16_R19_V1.5731.00
13_T19_V1.4741.00
2_G34_M1.4251.00
38_M41_G1.4021.00
35_H39_H1.3961.00
13_T16_R1.2821.00
33_L36_L1.1801.00
46_G50_G1.1421.00
3_F7_A1.1301.00
9_F21_G1.1261.00
14_E17_A1.1231.00
39_H42_H1.0941.00
10_F17_A1.0801.00
35_H38_M1.0531.00
34_M37_F1.0101.00
10_F15_H0.9811.00
16_R20_L0.9391.00
2_G6_I0.9391.00
20_L24_P0.9391.00
45_H48_H0.9351.00
37_F41_G0.9311.00
11_L14_E0.9151.00
36_L40_G0.9061.00
20_L23_L0.9051.00
4_L8_G0.8971.00
13_T17_A0.8961.00
26_L30_A0.8501.00
6_I14_E0.8451.00
2_G5_A0.8281.00
47_G50_G0.8281.00
6_I10_F0.7901.00
8_G19_V0.7821.00
1_L4_L0.7741.00
28_L35_H0.7691.00
28_L39_H0.7541.00
43_G47_G0.7521.00
11_L15_H0.7511.00
30_A33_L0.7441.00
11_L16_R0.7311.00
21_G24_P0.7271.00
9_F20_L0.7101.00
44_G48_H0.7001.00
27_L30_A0.6941.00
28_L31_C0.6861.00
43_G46_G0.6790.99
31_C35_H0.6720.99
34_M38_M0.6640.99
1_L5_A0.6520.99
9_F27_L0.6480.99
9_F17_A0.6460.99
6_I9_F0.6380.99
3_F10_F0.6220.99
1_L9_F0.6040.99
1_L13_T0.5950.99
12_L20_L0.5950.99
37_F40_G0.5870.98
28_L43_G0.5850.98
35_H42_H0.5830.98
21_G25_Y0.5800.98
13_T25_Y0.5760.98
31_C34_M0.5750.98
32_P36_L0.5700.98
44_G47_G0.5590.98
12_L22_A0.5450.98
29_L33_L0.5120.96
21_G26_L0.5020.96
16_R29_L0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4cylA 1 0 4.1 0.855 Contact Map
2mmuA 1 0.6538 3.2 0.863 Contact Map
4bxhA 3 0 2.9 0.866 Contact Map
4kppA 1 0.9808 2.9 0.866 Contact Map
2rddB 1 0.6346 2.8 0.867 Contact Map
2xq2A 2 0.7308 2.7 0.868 Contact Map
4ry2A 2 0.9615 2.6 0.869 Contact Map
1q55A 2 0.0385 2.5 0.87 Contact Map
4a82A 2 0.9038 2.2 0.874 Contact Map
4xtrG 1 0 2.1 0.875 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0047 seconds.