GREMLIN Database
DUF3263 - Protein of unknown function (DUF3263)
PFAM: PF11662 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 74 (72)
Sequences: 3492 (1865)
Seq/√Len: 219.8
META: 0.841

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
14_R55_D3.7941.00
13_E23_K2.8871.00
3_S6_D2.8651.00
11_D54_Y2.7481.00
52_L60_R2.5731.00
47_D66_R2.0121.00
6_D48_R2.0091.00
23_K39_Y1.9261.00
4_E8_A1.9231.00
37_R40_Q1.9061.00
12_F31_F1.8871.00
5_R41_L1.8321.00
37_R41_L1.7931.00
27_I35_P1.7441.00
6_D41_L1.7111.00
33_L41_L1.6331.00
7_R54_Y1.5801.00
15_Q30_R1.5481.00
25_Q29_E1.5341.00
8_A30_R1.4211.00
46_I62_L1.2691.00
9_I45_L1.1831.00
11_D55_D1.1461.00
67_D70_R1.1391.00
12_F26_A1.1261.00
4_E7_R1.1171.00
55_D58_L1.1161.00
44_A48_R1.1141.00
24_E35_P1.1101.00
38_Y42_L1.0771.00
9_I41_L1.0411.00
60_R69_R1.0321.00
9_I31_F1.0281.00
43_N46_I1.0201.00
47_D63_R1.0101.00
41_L44_A1.0011.00
43_N66_R0.9951.00
28_R34_S0.9831.00
68_A72_A0.9391.00
5_R8_A0.9140.99
13_E38_Y0.8880.99
7_R11_D0.8870.99
45_L51_A0.8800.99
60_R70_R0.8710.99
17_W20_A0.8710.99
26_A29_E0.8500.99
67_D71_R0.8420.99
51_A59_V0.8310.99
57_L64_R0.8310.99
60_R63_R0.8300.99
45_L48_R0.8280.99
9_I12_F0.7940.98
6_D45_L0.7890.98
19_Y30_R0.7770.98
28_R32_G0.7730.98
68_A71_R0.7680.98
51_A54_Y0.7520.98
58_L62_L0.7450.98
57_L60_R0.7440.98
24_E43_N0.7420.98
28_R35_P0.7410.98
9_I33_L0.7390.97
59_V62_L0.7310.97
16_W19_Y0.7160.97
10_L59_V0.7090.97
40_Q44_A0.6920.96
15_Q18_R0.6880.96
40_Q43_N0.6830.96
19_Y22_A0.6700.96
30_R70_R0.6680.95
22_A25_Q0.6610.95
33_L37_R0.6560.95
5_R9_I0.6510.95
10_L58_L0.6460.95
49_P53_A0.6460.95
26_A30_R0.6410.94
65_L69_R0.6370.94
33_L38_Y0.6340.94
43_N47_D0.6340.94
46_I65_L0.6270.94
13_E39_Y0.6230.93
39_Y43_N0.6030.92
23_K38_Y0.6030.92
20_A68_A0.6000.92
48_R51_A0.5900.92
65_L70_R0.5860.91
8_A12_F0.5780.91
40_Q62_L0.5760.91
18_R36_T0.5760.91
65_L68_A0.5750.90
32_G37_R0.5750.90
16_W20_A0.5750.90
48_R54_Y0.5720.90
24_E28_R0.5600.89
63_R67_D0.5580.89
59_V66_R0.5530.89
56_P60_R0.5390.87
18_R57_L0.5350.87
16_W47_D0.5270.86
69_R72_A0.5240.86
21_G27_I0.5230.86
46_I66_R0.5230.86
52_L59_V0.5200.86
27_I39_Y0.5190.85
19_Y36_T0.5180.85
46_I58_L0.5140.85
32_G53_A0.5080.84
16_W57_L0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3k2zA 2 0.8108 29.3 0.854 Contact Map
4un1B 1 1 26.8 0.857 Contact Map
1ku3A 1 0.7297 24.1 0.86 Contact Map
3eyiA 1 0.6892 23.8 0.86 Contact Map
4nqwA 1 0.6757 20.9 0.864 Contact Map
4un1A 1 1 20.8 0.864 Contact Map
1u5tA 1 0.7973 19.6 0.866 Contact Map
4ou0A 1 0.8514 19.6 0.866 Contact Map
4g6dA 1 0.7027 18.9 0.867 Contact Map
1l9zH 1 0.8649 18.4 0.868 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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