GREMLIN Database
DUF3262 - Protein of unknown function (DUF3262)
PFAM: PF11660 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 77 (75)
Sequences: 693 (486)
Seq/√Len: 56.2
META: 0.665

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
37_G65_A6.1831.00
41_L62_A3.3561.00
44_A61_V3.2421.00
12_A36_W3.2291.00
2_T5_Q2.5991.00
24_L28_I2.0181.00
40_A65_A2.0161.00
21_L25_I2.0151.00
45_Y49_A1.9861.00
64_R71_V1.8711.00
63_V67_L1.7980.99
30_F73_G1.7540.99
6_L18_P1.5090.98
44_A58_F1.4070.96
24_L27_G1.3570.96
40_A76_L1.2940.94
58_F70_L1.2840.94
22_S26_A1.2590.94
16_F24_L1.2120.92
46_R50_E1.2100.92
29_V76_L1.1910.91
10_Q13_S1.1850.91
40_A49_A1.1790.91
46_R49_A1.1650.91
21_L46_R1.1560.90
9_F39_W1.1320.89
5_Q36_W1.1040.88
51_G75_F1.1040.88
2_T6_L1.0850.87
8_A61_V1.0790.87
46_R51_G1.0620.86
25_I32_L1.0450.85
20_A70_L1.0050.83
37_G68_L0.9890.82
16_F21_L0.9580.80
34_L38_A0.9500.79
17_T20_A0.9470.79
42_L46_R0.9460.79
34_L69_L0.9160.76
44_A71_V0.9080.76
56_R59_L0.8990.75
58_F75_F0.8960.75
9_F72_L0.8890.74
3_A63_V0.8820.74
69_L72_L0.8790.73
31_A48_W0.8760.73
19_A66_V0.8720.73
33_L57_D0.8690.73
41_L66_V0.8640.72
36_W45_Y0.8620.72
26_A64_R0.8540.71
10_Q17_T0.8450.70
21_L76_L0.8310.69
29_V66_V0.8310.69
3_A6_L0.8300.69
40_A44_A0.8280.69
9_F21_L0.8260.69
33_L68_L0.8000.66
51_G67_L0.7860.65
14_G29_V0.7820.64
32_L71_V0.7750.64
40_A47_G0.7740.64
58_F69_L0.7690.63
7_A10_Q0.7530.61
26_A65_A0.7500.61
47_G53_L0.7250.59
47_G61_V0.7200.58
6_L59_L0.7130.57
62_A71_V0.7110.57
54_S63_V0.7090.57
30_F70_L0.6930.55
43_T46_R0.6700.53
3_A7_A0.6650.52
48_W69_L0.6580.51
21_L63_V0.6470.50
6_L62_A0.6380.49
4_A19_A0.6360.49
2_T50_E0.6360.49
37_G69_L0.6350.49
30_F34_L0.6270.48
19_A38_A0.6260.48
22_S68_L0.6230.48
8_A12_A0.6080.46
46_R67_L0.6010.45
1_M4_A0.5980.45
18_P47_G0.5970.45
52_R76_L0.5850.43
52_R55_L0.5680.42
4_A7_A0.5630.41
32_L57_D0.5550.40
5_Q39_W0.5520.40
7_A20_A0.5390.39
35_L53_L0.5350.38
43_T50_E0.5330.38
45_Y48_W0.5310.38
18_P39_W0.5310.38
70_L74_F0.5300.38
21_L34_L0.5260.37
55_L63_V0.5260.37
2_T12_A0.5230.37
38_A56_R0.5200.37
25_I60_G0.5180.36
14_G39_W0.5180.36
36_W64_R0.5170.36
49_A54_S0.5160.36
31_A45_Y0.5130.36
46_R63_V0.5100.36
19_A50_E0.5100.36
48_W51_G0.5060.35
21_L58_F0.5050.35
13_S20_A0.5040.35
4_A17_T0.5000.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ayfA 2 0.987 18 0.844 Contact Map
4hw9A 3 0.7013 7.1 0.87 Contact Map
3ox6A 2 0.8312 3.6 0.887 Contact Map
1s6jA 1 0.8182 3.2 0.89 Contact Map
4mzjA 1 0.7922 2.9 0.893 Contact Map
2gsmB 1 0.974 2.8 0.893 Contact Map
5ajiA 3 0.8052 2.6 0.895 Contact Map
1v54B 1 0.987 2.4 0.897 Contact Map
2kogA 1 0.5325 2.4 0.897 Contact Map
2pmyA 4 0.8182 2.3 0.898 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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