GREMLIN Database
DUF2589 - Protein of unknown function (DUF2589)
PFAM: PF11655 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 169 (164)
Sequences: 1976 (1595)
Seq/√Len: 124.5
META: 0.839

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
82_E149_K5.1571.00
86_D147_K5.0271.00
84_D147_K4.6011.00
88_D145_H4.4711.00
81_D151_K4.2841.00
13_A83_V3.5571.00
84_D149_K2.9891.00
86_D145_H2.8651.00
55_D59_G2.5621.00
3_E15_E2.4521.00
110_E119_S2.2011.00
46_P66_E2.1961.00
34_D38_D2.0701.00
34_D39_G2.0031.00
26_D30_E1.9621.00
14_V20_A1.8981.00
50_T62_E1.8771.00
18_A23_A1.8671.00
47_F51_R1.7781.00
113_G117_P1.7121.00
79_R153_D1.6951.00
48_T66_E1.6691.00
32_G70_L1.6671.00
55_D58_G1.6601.00
50_T60_E1.6431.00
50_T66_E1.5691.00
22_Q26_D1.5581.00
13_A80_I1.5211.00
79_R151_K1.4971.00
36_D39_G1.4951.00
111_A114_G1.4861.00
48_T62_E1.4791.00
2_L7_G1.4421.00
56_G59_G1.4231.00
11_N15_E1.4211.00
81_D149_K1.4061.00
111_A117_P1.4031.00
6_I148_V1.3991.00
28_I32_G1.3561.00
87_F146_V1.3241.00
83_V150_A1.3211.00
155_P160_A1.3151.00
34_D37_D1.3051.00
89_M142_A1.2981.00
13_A150_A1.2941.00
156_P163_L1.2821.00
160_A164_D1.2741.00
102_D127_K1.2601.00
50_T64_T1.2471.00
82_E147_K1.2140.99
157_E160_A1.2110.99
35_K38_D1.2110.99
35_K39_G1.2090.99
161_R164_D1.2000.99
48_T64_T1.2000.99
157_E161_R1.1840.99
45_V51_R1.1710.99
156_P159_L1.1620.99
114_G117_P1.1590.99
91_V142_A1.1520.99
46_P64_T1.1450.99
39_G42_T1.1310.99
44_M66_E1.1310.99
112_S115_W1.1270.99
5_L144_Y1.1150.99
4_D8_G1.1120.99
138_T141_S1.0980.99
72_L162_L1.0940.99
74_P152_Q1.0920.99
44_M47_F1.0850.99
2_L89_M1.0790.99
110_E118_V1.0790.99
9_P144_Y1.0430.98
46_P51_R1.0340.98
3_E119_S1.0310.98
74_P79_R1.0260.98
92_K123_S1.0160.98
123_S127_K1.0140.98
54_P58_G1.0110.98
51_R63_V1.0100.98
24_T76_P1.0060.98
113_G116_G0.9980.98
88_D143_K0.9960.98
82_E151_K0.9890.97
132_R139_D0.9790.97
53_V61_E0.9780.97
129_E132_R0.9540.97
100_S127_K0.9530.97
111_A116_G0.9520.97
90_E143_K0.9500.97
15_E19_Q0.9380.97
11_N19_Q0.9300.96
24_T77_S0.9260.96
21_A24_T0.9240.96
24_T32_G0.9200.96
118_V124_V0.9150.96
108_S121_K0.9100.96
151_K154_E0.9090.96
122_G125_S0.8840.95
79_R152_Q0.8740.95
46_P49_Y0.8740.95
24_T27_F0.8720.95
140_N143_K0.8600.94
36_D40_T0.8570.94
47_F53_V0.8430.94
13_A17_Q0.8420.94
25_V73_V0.8390.94
54_P57_D0.8310.93
53_V56_G0.8210.93
157_E164_D0.8210.93
139_D143_K0.8180.93
96_S137_K0.8080.92
5_L89_M0.7980.92
17_Q166_L0.7910.92
11_N91_V0.7860.91
1_P4_D0.7840.91
126_S130_S0.7780.91
7_G14_V0.7770.91
24_T28_I0.7750.91
7_G10_L0.7710.90
127_K130_S0.7600.90
34_D42_T0.7590.90
28_I75_I0.7570.90
103_S107_A0.7510.89
124_V127_K0.7500.89
43_R47_F0.7370.88
79_R154_E0.7350.88
19_Q22_Q0.7330.88
7_G12_A0.7320.88
161_R166_L0.7310.88
144_Y157_E0.7300.88
109_A118_V0.7290.88
125_S128_K0.7260.88
45_V49_Y0.7240.88
24_T29_K0.7160.87
122_G127_K0.7160.87
111_A115_W0.7160.87
2_L13_A0.7080.86
16_A80_I0.7070.86
71_T156_P0.7040.86
91_V144_Y0.7030.86
101_T106_S0.6960.85
88_D141_S0.6940.85
17_Q80_I0.6920.85
77_S146_V0.6910.85
52_P73_V0.6910.85
14_V23_A0.6870.85
78_L83_V0.6860.85
106_S109_A0.6840.84
9_P12_A0.6830.84
112_S116_G0.6770.84
63_V162_L0.6760.84
163_L167_E0.6740.84
2_L5_L0.6720.83
26_D78_L0.6720.83
91_V140_N0.6700.83
111_A118_V0.6690.83
158_G163_L0.6690.83
14_V76_P0.6650.83
27_F76_P0.6630.83
52_P60_E0.6580.82
124_V128_K0.6570.82
17_Q24_T0.6520.81
4_D11_N0.6410.80
132_R138_T0.6410.80
15_E23_A0.6400.80
6_I87_F0.6390.80
80_I148_V0.6390.80
45_V53_V0.6350.80
98_K129_E0.6310.79
118_V126_S0.6260.79
110_E115_W0.6260.79
104_S127_K0.6250.79
71_T167_E0.6220.78
77_S85_I0.6180.78
113_G119_S0.6150.78
81_D152_Q0.6140.77
4_D19_Q0.6130.77
85_I148_V0.6100.77
49_Y53_V0.6090.77
89_M144_Y0.6060.77
155_P163_L0.6040.76
25_V29_K0.6030.76
20_A23_A0.5990.76
7_G21_A0.5980.76
37_D57_D0.5940.75
1_P9_P0.5920.75
102_D106_S0.5880.74
123_S129_E0.5860.74
144_Y155_P0.5860.74
10_L150_A0.5850.74
9_P32_G0.5850.74
13_A85_I0.5840.74
141_S157_E0.5790.73
112_S117_P0.5740.73
101_T112_S0.5740.73
36_D45_V0.5730.72
48_T52_P0.5700.72
7_G51_R0.5700.72
10_L165_I0.5690.72
7_G11_N0.5620.71
11_N16_A0.5610.71
38_D45_V0.5590.71
23_A80_I0.5590.71
80_I85_I0.5560.70
60_E63_V0.5550.70
20_A78_L0.5520.70
50_T53_V0.5510.70
77_S150_A0.5490.69
27_F75_I0.5460.69
21_A152_Q0.5460.69
37_D40_T0.5460.69
8_G12_A0.5460.69
44_M49_Y0.5460.69
70_L158_G0.5430.68
88_D142_A0.5410.68
67_V72_L0.5400.68
67_V162_L0.5370.68
1_P13_A0.5370.68
118_V123_S0.5360.67
28_I45_V0.5350.67
49_Y52_P0.5330.67
9_P165_I0.5320.67
90_E141_S0.5300.67
11_N18_A0.5300.67
2_L146_V0.5300.67
119_S122_G0.5280.66
25_V161_R0.5280.66
110_E121_K0.5220.65
121_K127_K0.5200.65
102_D105_A0.5180.65
5_L77_S0.5170.65
38_D42_T0.5160.65
33_F67_V0.5150.64
20_A74_P0.5150.64
84_D146_V0.5130.64
23_A27_F0.5130.64
70_L87_F0.5120.64
113_G120_V0.5110.64
12_A81_D0.5100.64
34_D41_E0.5080.63
14_V31_V0.5070.63
165_I168_K0.5040.63
18_A32_G0.5030.63
45_V65_L0.5000.62
10_L27_F0.5000.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3eojA 3 0.3905 8.5 0.929 Contact Map
2ot3A 1 0.4675 6.3 0.933 Contact Map
2l32A 1 0.1538 4.9 0.936 Contact Map
1xkmA 2 0.1124 3.9 0.94 Contact Map
2izyA 5 0.1006 3.7 0.94 Contact Map
4hrsA 2 0.1598 3 0.943 Contact Map
2k5pA 1 0.1538 2.7 0.944 Contact Map
4anoA 1 0.2959 2.3 0.946 Contact Map
2lvwA 2 0.2012 2.2 0.947 Contact Map
4wyqB 1 0.1893 2.2 0.947 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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