GREMLIN Database
DUF3021 - Protein of unknown function (DUF3021)
PFAM: PF11457 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 130 (128)
Sequences: 2251 (1916)
Seq/√Len: 169.4
META: 0.662

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
73_F105_I4.6271.00
8_I45_G4.1721.00
77_L101_F3.9631.00
63_W67_K3.7831.00
72_H108_Y2.5521.00
58_F108_Y2.4821.00
84_A90_F2.3371.00
9_L13_G2.2131.00
121_K125_K2.1741.00
114_I118_Y2.1381.00
50_L79_V1.9051.00
65_L69_T1.8091.00
12_I15_G1.7971.00
65_L68_Q1.7501.00
124_K128_E1.6641.00
63_W71_I1.6571.00
37_V41_I1.6481.00
67_K71_I1.5961.00
118_Y122_E1.5491.00
43_L87_F1.5481.00
6_L10_I1.5291.00
120_K124_K1.5281.00
54_A75_I1.5121.00
40_Q44_S1.5061.00
12_I16_L1.4991.00
8_I11_G1.4961.00
64_S68_Q1.4451.00
38_L41_I1.4431.00
95_G99_I1.4311.00
64_S67_K1.4041.00
66_L69_T1.3931.00
9_L12_I1.3881.00
121_K124_K1.3581.00
4_I49_A1.3171.00
60_I63_W1.3171.00
97_I101_F1.3081.00
93_S96_G1.2821.00
76_T80_V1.2781.00
94_L97_I1.2771.00
53_L56_L1.2751.00
69_T112_W1.2691.00
110_I114_I1.2501.00
94_L98_L1.2351.00
13_G17_I1.2051.00
36_A40_Q1.2041.00
122_E126_I1.2021.00
77_L104_F1.2011.00
119_Y122_E1.1891.00
82_P86_L1.1851.00
13_G16_L1.1431.00
43_L83_L1.1411.00
33_E36_A1.1381.00
58_F72_H1.1311.00
77_L105_I1.1221.00
22_I26_F1.0981.00
7_G13_G1.0741.00
8_I12_I1.0721.00
119_Y123_A1.0580.99
51_F76_T1.0480.99
67_K70_L1.0470.99
72_H112_W1.0430.99
76_T104_F1.0420.99
21_I25_F1.0400.99
7_G12_I1.0400.99
37_V40_Q1.0220.99
11_G15_G1.0200.99
118_Y128_E0.9920.99
102_L106_V0.9740.99
73_F112_W0.9570.99
96_G100_F0.9530.99
4_I7_G0.9520.99
38_L42_L0.9510.99
117_L121_K0.9370.99
89_W112_W0.9230.99
84_A89_W0.9220.99
37_V44_S0.9110.98
47_I51_F0.8910.98
25_F28_G0.8910.98
126_I129_K0.8760.98
48_G52_G0.8510.98
83_L87_F0.8410.97
19_T23_S0.8380.97
7_G16_L0.8330.97
10_I14_I0.8320.97
18_I22_I0.8300.97
95_G98_L0.8260.97
44_S48_G0.8220.97
3_R7_G0.8200.97
72_H111_I0.8140.97
75_I79_V0.8100.97
51_F80_V0.8070.97
97_I100_F0.8060.97
47_I80_V0.7980.96
117_L120_K0.7950.96
5_L13_G0.7930.96
52_G55_S0.7910.96
70_L74_L0.7870.96
16_L41_I0.7840.96
39_L48_G0.7750.96
21_I26_F0.7750.96
113_L117_L0.7700.96
85_Y92_L0.7690.96
54_A76_T0.7650.96
62_K67_K0.7640.95
66_L70_L0.7590.95
28_G32_L0.7540.95
20_I23_S0.7520.95
48_G87_F0.7510.95
50_L54_A0.7470.95
127_N130_L0.7460.95
81_L101_F0.7400.95
65_L112_W0.7380.95
85_Y90_F0.7310.94
83_L90_F0.7250.94
115_F118_Y0.7240.94
63_W68_Q0.7170.94
73_F104_F0.7140.94
7_G11_G0.7080.93
115_F119_Y0.6990.93
74_L78_A0.6980.93
42_L46_L0.6960.93
57_I68_Q0.6960.93
57_I71_I0.6940.93
73_F101_F0.6920.92
10_I13_G0.6880.92
80_V84_A0.6830.92
72_H76_T0.6780.92
34_L38_L0.6760.92
6_L9_L0.6760.92
79_V83_L0.6750.92
36_A43_L0.6750.92
15_G44_S0.6720.91
70_L83_L0.6680.91
84_A100_F0.6670.91
101_F105_I0.6630.91
23_S28_G0.6590.91
55_S112_W0.6590.91
17_I20_I0.6590.91
3_R6_L0.6590.91
12_I45_G0.6540.90
55_S125_K0.6520.90
76_T108_Y0.6470.90
111_I119_Y0.6440.90
60_I68_Q0.6420.89
58_F69_T0.6410.89
19_T27_G0.6400.89
17_I24_L0.6390.89
100_F107_I0.6370.89
123_A127_N0.6330.89
99_I102_L0.6250.88
16_L19_T0.6170.87
85_Y96_G0.6170.87
20_I31_Y0.6150.87
116_Y120_K0.6110.87
40_Q43_L0.6090.87
106_V110_I0.6090.87
105_I110_I0.6040.86
76_T115_F0.6030.86
28_G31_Y0.5990.86
78_A82_P0.5930.85
14_I17_I0.5910.85
75_I78_A0.5890.85
19_T31_Y0.5860.85
22_I27_G0.5850.85
111_I115_F0.5730.83
5_L9_L0.5710.83
123_A126_I0.5690.83
68_Q112_W0.5680.83
29_G32_L0.5670.83
45_G51_F0.5630.82
21_I38_L0.5620.82
37_V43_L0.5620.82
23_S33_E0.5620.82
23_S29_G0.5610.82
74_L95_G0.5590.82
33_E39_L0.5570.82
52_G109_L0.5570.82
17_I41_I0.5510.81
91_P96_G0.5450.80
51_F73_F0.5440.80
16_L20_I0.5360.79
76_T119_Y0.5360.79
8_I14_I0.5310.78
106_V128_E0.5260.78
70_L95_G0.5220.77
103_I123_A0.5210.77
47_I109_L0.5130.76
12_I17_I0.5120.76
66_L83_L0.5090.76
96_G99_I0.5050.75
41_I45_G0.5020.75
49_A52_G0.5000.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2rddB 1 0.2692 14.1 0.876 Contact Map
4lz6A 1 0.9538 9.5 0.885 Contact Map
4ev6A 3 0.4923 7.4 0.891 Contact Map
4i0uA 4 0.4769 6.5 0.894 Contact Map
4pypA 1 0.8692 6.4 0.894 Contact Map
4av3A 2 0.9923 6 0.895 Contact Map
3w4tA 1 0.9077 4.8 0.9 Contact Map
1pw4A 1 0.9385 4.2 0.903 Contact Map
3mktA 1 0.9692 3.9 0.904 Contact Map
3pjzA 2 0.5231 3.4 0.907 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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