GREMLIN Database
DUF3019 - Protein of unknown function (DUF3019)
PFAM: PF11456 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 102 (102)
Sequences: 847 (664)
Seq/√Len: 65.8
META: 0.78

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
36_Y70_R2.8751.00
35_L47_W2.7671.00
90_Y101_R2.7531.00
3_V81_A2.7471.00
11_L18_Y2.6801.00
3_V23_I2.4391.00
61_S65_L2.4361.00
37_I67_F2.3491.00
25_W53_G2.3261.00
87_W101_R2.2261.00
5_P8_C2.1231.00
68_Q77_V2.0941.00
87_W90_Y1.9231.00
47_W53_G1.8891.00
96_R101_R1.7251.00
25_W47_W1.7221.00
11_L87_W1.6050.99
14_G18_Y1.5350.99
66_T80_S1.5250.99
1_L79_A1.5250.99
88_V101_R1.4950.99
98_R101_R1.4850.99
33_Y78_L1.4750.98
83_V98_R1.4340.98
57_Y67_F1.4150.98
11_L14_G1.3960.98
25_W69_L1.3680.97
33_Y61_S1.3650.97
4_K26_Q1.3630.97
53_G69_L1.3260.97
67_F83_V1.3080.97
8_C17_C1.3040.97
30_A51_S1.2870.96
3_V83_V1.2830.96
50_A53_G1.2620.96
40_R64_D1.2200.95
96_R99_P1.2120.95
7_L11_L1.2020.95
45_R53_G1.1900.94
37_I40_R1.1860.94
27_S33_Y1.1830.94
24_S82_K1.1460.93
71_D85_V1.1430.93
14_G87_W1.1370.93
68_Q80_S1.1370.93
5_P17_C1.1240.92
15_Q18_Y1.0940.91
32_S53_G1.0600.90
61_S102_L1.0540.90
45_R52_S1.0430.89
59_L67_F1.0310.89
93_R96_R1.0210.88
29_E78_L0.9830.86
1_L37_I0.9410.84
94_R99_P0.9120.82
84_E94_R0.9030.81
37_I65_L0.8970.81
25_W46_C0.8950.80
6_R10_A0.8940.80
44_L67_F0.8800.79
98_R102_L0.8750.79
31_G71_D0.8710.79
59_L85_V0.8700.79
86_A102_L0.8510.77
6_R16_T0.8390.76
22_R54_S0.8270.75
59_L83_V0.8230.75
59_L92_Y0.8200.74
92_Y98_R0.8190.74
72_P76_Q0.8140.74
27_S47_W0.8130.74
28_P48_E0.8050.73
15_Q98_R0.7990.72
18_Y101_R0.7990.72
3_V21_V0.7970.72
18_Y87_W0.7960.72
66_T82_K0.7930.72
94_R101_R0.7870.71
3_V73_D0.7740.70
93_R101_R0.7730.70
2_T24_S0.7710.70
71_D74_S0.7640.69
19_T83_V0.7600.69
45_R71_D0.7590.69
64_D82_K0.7580.68
91_K96_R0.7560.68
22_R29_E0.7540.68
10_A87_W0.7530.68
26_Q51_S0.7500.68
59_L101_R0.7450.67
23_I67_F0.7410.67
39_D73_D0.7360.66
21_V43_P0.7260.65
19_T81_A0.7250.65
26_Q69_L0.7210.65
58_E101_R0.7210.65
75_G83_V0.7170.64
13_Q18_Y0.7140.64
10_A14_G0.7130.64
10_A32_S0.7060.63
7_L85_V0.6970.62
55_Y63_E0.6940.62
50_A56_S0.6940.62
56_S74_S0.6930.61
85_V97_R0.6840.60
36_Y68_Q0.6800.60
22_R56_S0.6800.60
15_Q19_T0.6560.57
17_C34_C0.6520.57
13_Q19_T0.6490.56
60_E78_L0.6400.55
89_A92_Y0.6370.55
4_K37_I0.6370.55
70_R77_V0.6360.55
5_P34_C0.6280.54
93_R99_P0.6260.54
60_E85_V0.6260.54
8_C34_C0.6240.54
93_R97_R0.6230.53
12_R22_R0.6200.53
21_V36_Y0.6200.53
71_D76_Q0.6200.53
1_L7_L0.6140.52
95_R100_W0.6080.52
59_L88_V0.5970.50
12_R15_Q0.5950.50
3_V6_R0.5880.49
20_T58_E0.5840.49
64_D84_E0.5840.49
16_T60_E0.5830.49
33_Y68_Q0.5820.49
15_Q20_T0.5760.48
92_Y95_R0.5730.48
32_S71_D0.5720.47
88_V102_L0.5650.47
7_L87_W0.5640.46
34_C100_W0.5630.46
97_R102_L0.5550.45
46_C94_R0.5530.45
11_L78_L0.5510.45
21_V92_Y0.5480.45
59_L65_L0.5460.44
38_S94_R0.5440.44
25_W98_R0.5420.44
31_G73_D0.5390.44
20_T56_S0.5330.43
27_S71_D0.5220.42
48_E78_L0.5180.41
25_W78_L0.5120.40
7_L101_R0.5110.40
30_A75_G0.5090.40
61_S83_V0.5000.39
3_V11_L0.5000.39
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4lk4A 1 0.5294 17.4 0.895 Contact Map
2kr0A 1 0.8431 5 0.918 Contact Map
3w5mA 1 0.8039 2.9 0.927 Contact Map
4jjnK 1 0.2549 2.7 0.928 Contact Map
2ifsA 1 0.7549 2.3 0.931 Contact Map
2bc4A 2 0.3725 2 0.933 Contact Map
2eeaA 1 0.8922 2 0.933 Contact Map
1iakA 1 0.2549 1.8 0.935 Contact Map
2d7oA 1 0.951 1.7 0.936 Contact Map
2wv9A 1 0.1961 1.6 0.936 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0135 seconds.