GREMLIN Database
DUF3018 - Protein of unknown function (DUF3018)
PFAM: PF11455 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 64 (61)
Sequences: 4423 (2456)
Seq/√Len: 314.5
META: 0.949

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
6_A10_R2.6091.00
34_E37_R2.4001.00
5_R9_E2.2671.00
34_E38_Q2.1941.00
11_L18_P2.1871.00
36_R40_L2.1431.00
35_A39_S2.0561.00
54_F58_V1.7741.00
7_H11_L1.7701.00
52_Q56_D1.6531.00
7_H10_R1.6141.00
37_R41_A1.5681.00
26_T31_F1.5411.00
17_R27_R1.5411.00
19_V23_V1.4951.00
50_E54_F1.3571.00
4_V7_H1.3391.00
47_H51_D1.3351.00
2_E5_R1.3341.00
9_E13_A1.2871.00
6_A9_E1.2751.00
48_E52_Q1.2731.00
49_A53_A1.2451.00
52_Q55_I1.2431.00
51_D55_I1.2321.00
39_S43_A1.2131.00
11_L14_Q1.2121.00
48_E51_D1.1671.00
45_S48_E1.1511.00
51_D58_V1.1161.00
31_F35_A1.1091.00
2_E6_A1.0131.00
17_R26_T0.9611.00
30_G33_A0.9501.00
10_R14_Q0.9291.00
11_L16_L0.9191.00
46_P50_E0.9101.00
55_I59_S0.9011.00
8_R15_G0.8881.00
44_A47_H0.8621.00
51_D54_F0.8581.00
15_G22_W0.8511.00
45_S51_D0.8481.00
29_P33_A0.8471.00
12_R20_Q0.8451.00
59_S62_D0.8281.00
44_A48_E0.8211.00
55_I61_W0.8191.00
47_H50_E0.8171.00
30_G34_E0.8161.00
44_A49_A0.7991.00
11_L20_Q0.7931.00
42_V46_P0.7871.00
12_R18_P0.7851.00
36_R39_S0.7741.00
19_V22_W0.7680.99
42_V48_E0.7530.99
21_I24_P0.7430.99
3_R6_A0.7330.99
18_P21_I0.7260.99
46_P49_A0.7250.99
33_A36_R0.7130.99
8_R20_Q0.6930.99
34_E41_A0.6810.99
2_E9_E0.6760.99
3_R7_H0.6630.98
38_Q42_V0.6490.98
40_L44_A0.6470.98
32_A36_R0.6300.98
55_I58_V0.6250.98
28_S31_F0.6220.98
2_E13_A0.6210.98
45_S49_A0.6040.97
57_A61_W0.5960.97
17_R20_Q0.5940.97
53_A57_A0.5940.97
48_E55_I0.5930.97
4_V11_L0.5910.97
3_R10_R0.5810.96
42_V51_D0.5660.96
35_A43_A0.5590.96
7_H20_Q0.5540.95
29_P32_A0.5390.95
16_L24_P0.5370.95
26_T35_A0.5240.94
12_R15_G0.5210.94
4_V20_Q0.5210.94
40_L43_A0.5170.93
29_P37_R0.5130.93
22_W31_F0.5070.93
56_D59_S0.5020.92
17_R23_V0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4mijA 1 0.875 11 0.877 Contact Map
4ekfA 1 0.9375 9.3 0.881 Contact Map
3r3pA 3 0.6875 9.3 0.881 Contact Map
4n8yA 1 0.8438 7.5 0.886 Contact Map
4ovrA 1 0.8438 6.7 0.889 Contact Map
4n4jA 3 0.875 6.2 0.891 Contact Map
4p1lA 1 0.875 6.1 0.891 Contact Map
4xfeA 1 0.8438 5.9 0.892 Contact Map
3kfwX 4 0.9688 5.8 0.892 Contact Map
4ay3A 2 0.3438 5.7 0.892 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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