GREMLIN Database
ArsP_2 - Putative, 10TM heavy-metal exporter
PFAM: PF11449 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 361 (351)
Sequences: 1254 (1027)
Seq/√Len: 54.8
META: 0.852

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
69_V78_V4.8571.00
288_V318_A4.2761.00
168_L171_L4.1341.00
79_S125_D3.6181.00
322_S350_A3.5401.00
99_L110_F3.5221.00
140_H143_E3.3751.00
109_L313_F3.0951.00
81_G125_D3.0811.00
292_L347_A2.8981.00
165_S168_L2.8301.00
102_F105_T2.8121.00
148_C151_E2.7381.00
318_A354_G2.7021.00
102_F303_V2.6611.00
98_M102_F2.6001.00
164_L167_L2.4461.00
189_I192_L2.4221.00
57_L69_V2.4061.00
305_L310_L2.3291.00
246_E249_F2.2571.00
163_N166_H2.2511.00
55_A114_F2.2381.00
59_A110_F2.2051.00
242_H245_K2.1641.00
149_E152_H2.1511.00
172_L175_P2.1401.00
66_A327_A2.1331.00
200_I204_G2.1061.00
175_P178_I2.1021.00
108_L112_I2.0951.00
144_D147_C2.0901.00
201_T204_G2.0591.00
202_W206_L2.0111.00
288_V347_A1.9871.00
160_K165_S1.9461.00
51_V125_D1.9381.00
317_L321_I1.9101.00
197_E200_I1.8830.99
69_V86_T1.8360.99
102_F307_A1.8280.99
240_W245_K1.7900.99
139_E143_E1.7890.99
114_F117_G1.7230.99
81_G85_A1.7150.99
160_K168_L1.7020.99
187_I190_D1.7000.99
60_T66_A1.6920.99
250_V253_W1.6780.99
328_L342_A1.6680.99
145_E148_C1.6670.99
165_S171_L1.6500.99
55_A118_I1.5950.98
87_M342_A1.5830.98
335_S338_A1.5790.98
164_L168_L1.5770.98
199_L202_W1.5670.98
185_F189_I1.5640.98
160_K163_N1.5520.98
120_S124_V1.5490.98
213_F216_A1.5450.98
173_L180_G1.5320.98
45_K49_L1.5250.98
18_T251_F1.5220.98
120_S349_P1.5150.98
324_D346_N1.5000.97
20_F64_G1.4920.97
109_L113_L1.4840.97
187_I191_G1.4640.97
295_E319_N1.4570.97
107_L111_G1.4530.97
108_L111_G1.4500.97
310_L315_A1.4330.97
90_T327_A1.4260.96
144_D148_C1.4200.96
113_L285_L1.4170.96
208_T211_S1.4100.96
54_A85_A1.4030.96
230_V235_L1.4030.96
185_F192_L1.4010.96
220_L223_G1.3990.96
54_A86_T1.3860.96
326_H329_L1.3820.96
240_W243_V1.3710.96
218_S221_L1.3640.95
66_A86_T1.3540.95
32_N37_G1.3530.95
54_A69_V1.3520.95
272_L275_W1.3510.95
196_G200_I1.3430.95
166_H169_W1.3420.95
220_L224_Y1.3390.95
171_L181_L1.3310.95
251_F256_G1.3300.95
273_E277_S1.3290.95
343_K346_N1.3250.95
300_I303_V1.3240.95
151_E156_P1.3240.95
197_E201_T1.3190.95
192_L195_L1.3180.95
199_L203_I1.3150.94
253_W256_G1.3120.94
275_W279_N1.3090.94
55_A85_A1.3040.94
183_L187_I1.3040.94
202_W207_G1.3030.94
116_V120_S1.2960.94
345_Y349_P1.2930.94
66_A90_T1.2880.94
85_A121_G1.2870.94
216_A220_L1.2830.94
189_I193_F1.2730.93
350_A354_G1.2710.93
80_F342_A1.2700.93
254_V258_L1.2580.93
157_L160_K1.2560.93
347_A350_A1.2520.93
170_L177_L1.2390.92
317_L357_L1.2270.92
84_V346_N1.2250.92
160_K164_L1.2230.92
81_G258_L1.2210.92
339_A345_Y1.2130.92
244_A247_T1.2110.92
344_L353_V1.2080.92
251_F254_V1.2060.91
340_L344_L1.2060.91
271_D274_A1.2010.91
303_V307_A1.1970.91
173_L176_G1.1920.91
212_L215_W1.1760.90
239_L242_H1.1710.90
203_I207_G1.1700.90
146_E149_E1.1700.90
251_F255_F1.1660.90
188_D193_F1.1620.90
84_V124_V1.1560.90
169_W184_A1.1550.90
165_S169_W1.1520.89
198_G201_T1.1520.89
248_P251_F1.1520.89
188_D191_G1.1460.89
241_R245_K1.1390.89
188_D192_L1.1380.89
148_C153_E1.1290.88
186_Q189_I1.1150.88
80_F328_L1.1140.88
111_G115_V1.1080.88
209_L213_F1.1060.87
313_F317_L1.1050.87
74_T250_V1.0980.87
336_K339_A1.0960.87
199_L204_G1.0950.87
152_H157_L1.0940.87
138_E141_E1.0890.87
280_G283_V1.0860.86
333_A336_K1.0830.86
171_L174_L1.0800.86
234_F242_H1.0740.86
346_N349_P1.0700.86
216_A219_P1.0650.85
217_V220_L1.0650.85
176_G179_L1.0510.85
219_P222_I1.0490.85
197_E202_W1.0480.84
313_F316_L1.0450.84
163_N169_W1.0420.84
48_W122_Y1.0370.84
81_G124_V1.0370.84
211_S216_A1.0330.84
186_Q190_D1.0310.83
94_E295_E1.0250.83
167_L175_P1.0250.83
150_C153_E1.0210.83
339_A343_K1.0210.83
104_K108_L1.0210.83
235_L238_H1.0210.83
167_L170_L1.0190.83
337_K341_L1.0140.82
149_E153_E1.0100.82
16_M258_L1.0060.82
22_A117_G0.9950.81
234_F240_W0.9950.81
240_W244_A0.9940.81
91_S98_M0.9930.81
91_S346_N0.9910.81
233_H238_H0.9890.81
51_V122_Y0.9870.81
220_L225_F0.9800.80
324_D328_L0.9770.80
239_L243_V0.9760.80
215_W219_P0.9710.80
222_I225_F0.9700.80
31_L34_L0.9670.79
208_T212_L0.9670.79
53_L57_L0.9610.79
54_A82_A0.9560.79
167_L171_L0.9550.78
170_L180_G0.9520.78
176_G180_G0.9490.78
263_L266_L0.9400.77
168_L175_P0.9390.77
285_L289_L0.9380.77
203_I206_L0.9370.77
36_K41_K0.9350.77
171_L185_F0.9330.77
162_S165_S0.9280.76
195_L199_L0.9220.76
271_D276_I0.9220.76
306_Y313_F0.9170.76
139_E142_L0.9090.75
183_L189_I0.9060.75
189_I200_I0.9040.75
112_I317_L0.8950.74
169_W174_L0.8950.74
148_C152_H0.8930.74
346_N350_A0.8910.73
299_H319_N0.8880.73
69_V85_A0.8850.73
91_S295_E0.8850.73
97_V300_I0.8830.73
205_L209_L0.8820.73
200_I203_I0.8790.72
162_S169_W0.8720.72
281_L355_Y0.8690.72
169_W176_G0.8680.71
122_Y125_D0.8680.71
178_I185_F0.8670.71
168_L172_L0.8660.71
44_K71_S0.8620.71
123_L289_L0.8620.71
85_A124_V0.8580.71
230_V234_F0.8570.71
215_W218_S0.8560.70
56_L60_T0.8540.70
206_L209_L0.8540.70
59_A117_G0.8530.70
56_L114_F0.8460.70
136_K139_E0.8410.69
236_E240_W0.8400.69
230_V233_H0.8400.69
161_L165_S0.8400.69
234_F239_L0.8400.69
202_W205_L0.8390.69
283_V287_A0.8380.69
349_P353_V0.8370.69
81_G117_G0.8340.68
101_M307_A0.8330.68
303_V316_L0.8320.68
230_V242_H0.8320.68
169_W173_L0.8250.68
257_A261_F0.8250.68
136_K140_H0.8250.68
83_L335_S0.8250.68
124_V130_K0.8210.67
233_H239_L0.8200.67
253_W257_A0.8180.67
214_L218_S0.8170.67
295_E326_H0.8140.67
56_L270_L0.8130.66
219_P224_Y0.8090.66
272_L276_I0.8060.66
172_L178_I0.8050.66
51_V81_G0.8050.66
116_V321_I0.8050.66
258_L261_F0.8030.65
161_L164_L0.7990.65
200_I206_L0.7980.65
9_S126_K0.7980.65
17_I21_V0.7970.65
29_E32_N0.7960.65
221_L224_Y0.7950.65
159_N168_L0.7940.65
211_S214_L0.7910.64
64_G295_E0.7900.64
276_I279_N0.7890.64
169_W175_P0.7870.64
105_T108_L0.7860.64
354_G358_Y0.7850.64
264_L267_F0.7840.64
175_P186_Q0.7830.64
70_V83_L0.7830.64
20_F66_A0.7830.64
132_F135_P0.7820.63
292_L304_T0.7810.63
323_Q331_L0.7810.63
247_T251_F0.7770.63
10_L13_A0.7760.63
204_G207_G0.7700.62
98_M303_V0.7700.62
84_V90_T0.7680.62
64_G327_A0.7650.62
171_L176_G0.7650.62
195_L198_G0.7640.62
115_V337_K0.7640.62
217_V221_L0.7620.61
219_P223_G0.7610.61
183_L186_Q0.7570.61
288_V292_L0.7570.61
62_G65_G0.7570.61
166_H171_L0.7560.61
33_V37_G0.7550.61
84_V91_S0.7530.60
223_G226_S0.7480.60
163_N168_L0.7450.60
214_L217_V0.7440.60
334_E338_A0.7430.59
157_L168_L0.7420.59
218_S222_I0.7400.59
286_I290_I0.7380.59
52_L118_I0.7360.59
270_L286_I0.7350.59
51_V117_G0.7330.58
239_L244_A0.7300.58
103_P309_G0.7290.58
109_L306_Y0.7290.58
114_F118_I0.7280.58
135_P141_E0.7280.58
147_C152_H0.7270.58
206_L210_L0.7270.58
179_L182_L0.7260.58
141_E144_D0.7230.57
333_A339_A0.7230.57
342_A346_N0.7220.57
168_L173_L0.7190.57
221_L226_S0.7190.57
20_F90_T0.7190.57
171_L175_P0.7160.57
212_L218_S0.7140.56
106_A110_F0.7130.56
233_H237_E0.7120.56
249_F254_V0.7100.56
184_A187_I0.7100.56
29_E333_A0.7080.56
59_A66_A0.7060.56
163_N170_L0.7050.55
212_L217_V0.7050.55
242_H247_T0.7000.55
144_D149_E0.6990.55
318_A321_I0.6970.55
196_G206_L0.6970.55
308_S313_F0.6950.54
30_Y37_G0.6940.54
187_I192_L0.6930.54
290_I351_L0.6900.54
284_L315_A0.6880.54
239_L245_K0.6860.53
183_L188_D0.6860.53
196_G204_G0.6800.53
91_S324_D0.6790.53
32_N35_T0.6760.52
169_W172_L0.6760.52
206_L217_V0.6750.52
22_A51_V0.6750.52
252_L256_G0.6740.52
225_F233_H0.6740.52
22_A328_L0.6730.52
51_V90_T0.6720.52
150_C156_P0.6700.52
185_F188_D0.6690.52
38_R41_K0.6550.50
197_E204_G0.6550.50
20_F86_T0.6540.50
185_F191_G0.6530.50
326_H343_K0.6530.50
16_M97_V0.6520.50
160_K169_W0.6520.50
20_F40_S0.6490.49
168_L186_Q0.6490.49
343_K350_A0.6470.49
27_L88_I0.6460.49
348_I352_I0.6460.49
9_S13_A0.6460.49
137_E143_E0.6410.49
91_S319_N0.6410.49
167_L172_L0.6400.48
196_G201_T0.6390.48
21_V24_M0.6350.48
255_F259_L0.6320.48
157_L161_L0.6320.48
224_Y231_P0.6310.48
195_L200_I0.6310.48
236_E239_L0.6300.47
50_Q125_D0.6270.47
255_F258_L0.6260.47
180_G184_A0.6250.47
158_L161_L0.6240.47
53_L288_V0.6230.47
288_V307_A0.6230.47
47_R125_D0.6220.47
223_G227_V0.6220.47
29_E33_V0.6210.46
195_L202_W0.6210.46
316_L357_L0.6190.46
113_L329_L0.6180.46
29_E74_T0.6180.46
31_L181_L0.6160.46
259_L263_L0.6160.46
168_L178_I0.6150.46
151_E154_H0.6140.46
184_A190_D0.6140.46
197_E205_L0.6140.46
27_L39_W0.6120.46
40_S74_T0.6120.46
115_V118_I0.6110.45
56_L311_I0.6050.45
356_G359_F0.6050.45
207_G214_L0.6030.45
160_K167_L0.6030.45
225_F229_T0.6030.45
171_L192_L0.6020.44
42_L49_L0.6010.44
175_P184_A0.5990.44
152_H160_K0.5990.44
198_G202_W0.5970.44
27_L100_A0.5970.44
83_L331_L0.5970.44
169_W183_L0.5950.44
330_P333_A0.5950.44
288_V322_S0.5940.44
98_M101_M0.5920.43
167_L180_G0.5920.43
213_F220_L0.5910.43
134_R209_L0.5900.43
236_E242_H0.5880.43
173_L177_L0.5880.43
276_I310_L0.5880.43
191_G195_L0.5880.43
30_Y34_L0.5870.43
80_F128_H0.5870.43
351_L354_G0.5870.43
147_C150_C0.5860.43
267_F270_L0.5860.43
16_M85_A0.5830.42
161_L166_H0.5820.42
225_F228_A0.5820.42
202_W210_L0.5810.42
43_L115_V0.5790.42
207_G210_L0.5790.42
210_L214_L0.5770.42
105_T303_V0.5750.42
208_T219_P0.5720.41
200_I207_G0.5710.41
242_H246_E0.5710.41
127_F260_V0.5710.41
152_H155_E0.5710.41
41_K45_K0.5710.41
112_I340_L0.5700.41
225_F230_V0.5700.41
159_N163_N0.5660.41
232_D235_L0.5660.41
126_K136_K0.5650.41
279_N290_I0.5610.40
190_D193_F0.5570.40
60_T69_V0.5570.40
136_K141_E0.5550.40
168_L188_D0.5540.39
56_L59_A0.5530.39
159_N165_S0.5520.39
47_R81_G0.5510.39
201_T206_L0.5500.39
168_L185_F0.5490.39
322_S342_A0.5490.39
137_E140_H0.5480.39
99_L306_Y0.5480.39
91_S95_A0.5470.39
151_E340_L0.5470.39
188_D195_L0.5470.39
106_A118_I0.5470.39
228_A231_P0.5460.39
144_D152_H0.5460.39
177_L180_G0.5460.39
148_C156_P0.5450.39
91_S328_L0.5440.38
130_K139_E0.5440.38
334_E339_A0.5430.38
201_T205_L0.5430.38
24_M64_G0.5420.38
169_W185_F0.5410.38
219_P225_F0.5410.38
131_D139_E0.5410.38
116_V293_I0.5400.38
196_G199_L0.5380.38
25_M28_I0.5370.38
237_E241_R0.5350.37
108_L123_L0.5340.37
71_S83_L0.5340.37
135_P138_E0.5320.37
175_P181_L0.5310.37
346_N354_G0.5310.37
171_L187_I0.5310.37
119_I122_Y0.5290.37
333_A345_Y0.5290.37
58_G63_C0.5270.37
30_Y35_T0.5260.37
19_V301_I0.5260.37
62_G92_G0.5250.36
22_A327_A0.5250.36
54_A78_V0.5240.36
47_R85_A0.5210.36
106_A113_L0.5210.36
354_G357_L0.5180.36
151_E157_L0.5170.36
192_L196_G0.5170.36
196_G202_W0.5150.36
114_F293_I0.5130.35
184_A188_D0.5120.35
108_L306_Y0.5120.35
221_L225_F0.5120.35
172_L203_I0.5110.35
183_L191_G0.5110.35
64_G90_T0.5110.35
269_G319_N0.5110.35
117_G125_D0.5090.35
306_Y314_S0.5070.35
280_G315_A0.5070.35
136_K143_E0.5060.35
204_G214_L0.5060.35
315_A326_H0.5060.35
194_G197_E0.5030.34
126_K352_I0.5020.34
20_F68_A0.5020.34
143_E146_E0.5020.34
25_M29_E0.5010.34
264_L270_L0.5000.34
216_A340_L0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2xq2A 2 0.5097 17 0.974 Contact Map
2ksrA 1 0.3102 14.4 0.975 Contact Map
2b2hA 3 0.3961 10.2 0.977 Contact Map
3dh4A 3 0.4432 10 0.977 Contact Map
3b9wA 3 0.3767 8 0.978 Contact Map
4n7wA 2 0.2355 6.9 0.978 Contact Map
3vouA 4 0.3463 6.3 0.979 Contact Map
4ltoA 3 0.2992 6.1 0.979 Contact Map
4h33A 3 0.2382 5.9 0.979 Contact Map
4he8J 1 0.3352 5.7 0.979 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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