ArsP_2 - PFAM28P - GREMLIN Contacts

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ArsP_2 - Putative, 10TM heavy-metal exporter

PFAM:	PF11449	Sequences: NTREIILESLSDAFLMITVFVAVMMLLIEYLNVLTKGRWSKLLKKSRWLQVLLAALLGATPGCGGAFAVVSLYTHGLVSFGALVATMIATSGDEAFVMLAMFPKTALLLFGILFVVGIISGYLVDKFHKKDFLRPKEEEHELEDEECCECEHEHEPLLNKLSNLSHLLWLLLLLPGLILGLLLAFQIDIDGLFGLGEGLITWIGLLGTLLSLFLWAVSPLLIGYFSVATVPDHFLEEHLWRHVAKETPFVFLWVFGALLVFELLVLFTGLDLEAWISSNGLLVLLIAVLIGLIPESGPHIIFVTLYASGLIPFSALLANSISQDGHALLPLLAESKKAALLAKLYNAIPALIVGYGLYFLF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	361 (351)
Sequences:	1254 (1027)
Seq/√Len:	54.8
META:	0.852

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
69_V	78_V	4.857	1.00
288_V	318_A	4.276	1.00
168_L	171_L	4.134	1.00
79_S	125_D	3.618	1.00
322_S	350_A	3.540	1.00
99_L	110_F	3.522	1.00
140_H	143_E	3.375	1.00
109_L	313_F	3.095	1.00
81_G	125_D	3.081	1.00
292_L	347_A	2.898	1.00
165_S	168_L	2.830	1.00
102_F	105_T	2.812	1.00
148_C	151_E	2.738	1.00
318_A	354_G	2.702	1.00
102_F	303_V	2.661	1.00
98_M	102_F	2.600	1.00
164_L	167_L	2.446	1.00
189_I	192_L	2.422	1.00
57_L	69_V	2.406	1.00
305_L	310_L	2.329	1.00
246_E	249_F	2.257	1.00
163_N	166_H	2.251	1.00
55_A	114_F	2.238	1.00
59_A	110_F	2.205	1.00
242_H	245_K	2.164	1.00
149_E	152_H	2.151	1.00
172_L	175_P	2.140	1.00
66_A	327_A	2.133	1.00
200_I	204_G	2.106	1.00
175_P	178_I	2.102	1.00
108_L	112_I	2.095	1.00
144_D	147_C	2.090	1.00
201_T	204_G	2.059	1.00
202_W	206_L	2.011	1.00
288_V	347_A	1.987	1.00
160_K	165_S	1.946	1.00
51_V	125_D	1.938	1.00
317_L	321_I	1.910	1.00
197_E	200_I	1.883	0.99
69_V	86_T	1.836	0.99
102_F	307_A	1.828	0.99
240_W	245_K	1.790	0.99
139_E	143_E	1.789	0.99
114_F	117_G	1.723	0.99
81_G	85_A	1.715	0.99
160_K	168_L	1.702	0.99
187_I	190_D	1.700	0.99
60_T	66_A	1.692	0.99
250_V	253_W	1.678	0.99
328_L	342_A	1.668	0.99
145_E	148_C	1.667	0.99
165_S	171_L	1.650	0.99
55_A	118_I	1.595	0.98
87_M	342_A	1.583	0.98
335_S	338_A	1.579	0.98
164_L	168_L	1.577	0.98
199_L	202_W	1.567	0.98
185_F	189_I	1.564	0.98
160_K	163_N	1.552	0.98
120_S	124_V	1.549	0.98
213_F	216_A	1.545	0.98
173_L	180_G	1.532	0.98
45_K	49_L	1.525	0.98
18_T	251_F	1.522	0.98
120_S	349_P	1.515	0.98
324_D	346_N	1.500	0.97
20_F	64_G	1.492	0.97
109_L	113_L	1.484	0.97
187_I	191_G	1.464	0.97
295_E	319_N	1.457	0.97
107_L	111_G	1.453	0.97
108_L	111_G	1.450	0.97
310_L	315_A	1.433	0.97
90_T	327_A	1.426	0.96
144_D	148_C	1.420	0.96
113_L	285_L	1.417	0.96
208_T	211_S	1.410	0.96
54_A	85_A	1.403	0.96
230_V	235_L	1.403	0.96
185_F	192_L	1.401	0.96
220_L	223_G	1.399	0.96
54_A	86_T	1.386	0.96
326_H	329_L	1.382	0.96
240_W	243_V	1.371	0.96
218_S	221_L	1.364	0.95
66_A	86_T	1.354	0.95
32_N	37_G	1.353	0.95
54_A	69_V	1.352	0.95
272_L	275_W	1.351	0.95
196_G	200_I	1.343	0.95
166_H	169_W	1.342	0.95
220_L	224_Y	1.339	0.95
171_L	181_L	1.331	0.95
251_F	256_G	1.330	0.95
273_E	277_S	1.329	0.95
343_K	346_N	1.325	0.95
300_I	303_V	1.324	0.95
151_E	156_P	1.324	0.95
197_E	201_T	1.319	0.95
192_L	195_L	1.318	0.95
199_L	203_I	1.315	0.94
253_W	256_G	1.312	0.94
275_W	279_N	1.309	0.94
55_A	85_A	1.304	0.94
183_L	187_I	1.304	0.94
202_W	207_G	1.303	0.94
116_V	120_S	1.296	0.94
345_Y	349_P	1.293	0.94
66_A	90_T	1.288	0.94
85_A	121_G	1.287	0.94
216_A	220_L	1.283	0.94
189_I	193_F	1.273	0.93
350_A	354_G	1.271	0.93
80_F	342_A	1.270	0.93
254_V	258_L	1.258	0.93
157_L	160_K	1.256	0.93
347_A	350_A	1.252	0.93
170_L	177_L	1.239	0.92
317_L	357_L	1.227	0.92
84_V	346_N	1.225	0.92
160_K	164_L	1.223	0.92
81_G	258_L	1.221	0.92
339_A	345_Y	1.213	0.92
244_A	247_T	1.211	0.92
344_L	353_V	1.208	0.92
251_F	254_V	1.206	0.91
340_L	344_L	1.206	0.91
271_D	274_A	1.201	0.91
303_V	307_A	1.197	0.91
173_L	176_G	1.192	0.91
212_L	215_W	1.176	0.90
239_L	242_H	1.171	0.90
203_I	207_G	1.170	0.90
146_E	149_E	1.170	0.90
251_F	255_F	1.166	0.90
188_D	193_F	1.162	0.90
84_V	124_V	1.156	0.90
169_W	184_A	1.155	0.90
165_S	169_W	1.152	0.89
198_G	201_T	1.152	0.89
248_P	251_F	1.152	0.89
188_D	191_G	1.146	0.89
241_R	245_K	1.139	0.89
188_D	192_L	1.138	0.89
148_C	153_E	1.129	0.88
186_Q	189_I	1.115	0.88
80_F	328_L	1.114	0.88
111_G	115_V	1.108	0.88
209_L	213_F	1.106	0.87
313_F	317_L	1.105	0.87
74_T	250_V	1.098	0.87
336_K	339_A	1.096	0.87
199_L	204_G	1.095	0.87
152_H	157_L	1.094	0.87
138_E	141_E	1.089	0.87
280_G	283_V	1.086	0.86
333_A	336_K	1.083	0.86
171_L	174_L	1.080	0.86
234_F	242_H	1.074	0.86
346_N	349_P	1.070	0.86
216_A	219_P	1.065	0.85
217_V	220_L	1.065	0.85
176_G	179_L	1.051	0.85
219_P	222_I	1.049	0.85
197_E	202_W	1.048	0.84
313_F	316_L	1.045	0.84
163_N	169_W	1.042	0.84
48_W	122_Y	1.037	0.84
81_G	124_V	1.037	0.84
211_S	216_A	1.033	0.84
186_Q	190_D	1.031	0.83
94_E	295_E	1.025	0.83
167_L	175_P	1.025	0.83
150_C	153_E	1.021	0.83
339_A	343_K	1.021	0.83
104_K	108_L	1.021	0.83
235_L	238_H	1.021	0.83
167_L	170_L	1.019	0.83
337_K	341_L	1.014	0.82
149_E	153_E	1.010	0.82
16_M	258_L	1.006	0.82
22_A	117_G	0.995	0.81
234_F	240_W	0.995	0.81
240_W	244_A	0.994	0.81
91_S	98_M	0.993	0.81
91_S	346_N	0.991	0.81
233_H	238_H	0.989	0.81
51_V	122_Y	0.987	0.81
220_L	225_F	0.980	0.80
324_D	328_L	0.977	0.80
239_L	243_V	0.976	0.80
215_W	219_P	0.971	0.80
222_I	225_F	0.970	0.80
31_L	34_L	0.967	0.79
208_T	212_L	0.967	0.79
53_L	57_L	0.961	0.79
54_A	82_A	0.956	0.79
167_L	171_L	0.955	0.78
170_L	180_G	0.952	0.78
176_G	180_G	0.949	0.78
263_L	266_L	0.940	0.77
168_L	175_P	0.939	0.77
285_L	289_L	0.938	0.77
203_I	206_L	0.937	0.77
36_K	41_K	0.935	0.77
171_L	185_F	0.933	0.77
162_S	165_S	0.928	0.76
195_L	199_L	0.922	0.76
271_D	276_I	0.922	0.76
306_Y	313_F	0.917	0.76
139_E	142_L	0.909	0.75
183_L	189_I	0.906	0.75
189_I	200_I	0.904	0.75
112_I	317_L	0.895	0.74
169_W	174_L	0.895	0.74
148_C	152_H	0.893	0.74
346_N	350_A	0.891	0.73
299_H	319_N	0.888	0.73
69_V	85_A	0.885	0.73
91_S	295_E	0.885	0.73
97_V	300_I	0.883	0.73
205_L	209_L	0.882	0.73
200_I	203_I	0.879	0.72
162_S	169_W	0.872	0.72
281_L	355_Y	0.869	0.72
169_W	176_G	0.868	0.71
122_Y	125_D	0.868	0.71
178_I	185_F	0.867	0.71
168_L	172_L	0.866	0.71
44_K	71_S	0.862	0.71
123_L	289_L	0.862	0.71
85_A	124_V	0.858	0.71
230_V	234_F	0.857	0.71
215_W	218_S	0.856	0.70
56_L	60_T	0.854	0.70
206_L	209_L	0.854	0.70
59_A	117_G	0.853	0.70
56_L	114_F	0.846	0.70
136_K	139_E	0.841	0.69
236_E	240_W	0.840	0.69
230_V	233_H	0.840	0.69
161_L	165_S	0.840	0.69
234_F	239_L	0.840	0.69
202_W	205_L	0.839	0.69
283_V	287_A	0.838	0.69
349_P	353_V	0.837	0.69
81_G	117_G	0.834	0.68
101_M	307_A	0.833	0.68
303_V	316_L	0.832	0.68
230_V	242_H	0.832	0.68
169_W	173_L	0.825	0.68
257_A	261_F	0.825	0.68
136_K	140_H	0.825	0.68
83_L	335_S	0.825	0.68
124_V	130_K	0.821	0.67
233_H	239_L	0.820	0.67
253_W	257_A	0.818	0.67
214_L	218_S	0.817	0.67
295_E	326_H	0.814	0.67
56_L	270_L	0.813	0.66
219_P	224_Y	0.809	0.66
272_L	276_I	0.806	0.66
172_L	178_I	0.805	0.66
51_V	81_G	0.805	0.66
116_V	321_I	0.805	0.66
258_L	261_F	0.803	0.65
161_L	164_L	0.799	0.65
200_I	206_L	0.798	0.65
9_S	126_K	0.798	0.65
17_I	21_V	0.797	0.65
29_E	32_N	0.796	0.65
221_L	224_Y	0.795	0.65
159_N	168_L	0.794	0.65
211_S	214_L	0.791	0.64
64_G	295_E	0.790	0.64
276_I	279_N	0.789	0.64
169_W	175_P	0.787	0.64
105_T	108_L	0.786	0.64
354_G	358_Y	0.785	0.64
264_L	267_F	0.784	0.64
175_P	186_Q	0.783	0.64
70_V	83_L	0.783	0.64
20_F	66_A	0.783	0.64
132_F	135_P	0.782	0.63
292_L	304_T	0.781	0.63
323_Q	331_L	0.781	0.63
247_T	251_F	0.777	0.63
10_L	13_A	0.776	0.63
204_G	207_G	0.770	0.62
98_M	303_V	0.770	0.62
84_V	90_T	0.768	0.62
64_G	327_A	0.765	0.62
171_L	176_G	0.765	0.62
195_L	198_G	0.764	0.62
115_V	337_K	0.764	0.62
217_V	221_L	0.762	0.61
219_P	223_G	0.761	0.61
183_L	186_Q	0.757	0.61
288_V	292_L	0.757	0.61
62_G	65_G	0.757	0.61
166_H	171_L	0.756	0.61
33_V	37_G	0.755	0.61
84_V	91_S	0.753	0.60
223_G	226_S	0.748	0.60
163_N	168_L	0.745	0.60
214_L	217_V	0.744	0.60
334_E	338_A	0.743	0.59
157_L	168_L	0.742	0.59
218_S	222_I	0.740	0.59
286_I	290_I	0.738	0.59
52_L	118_I	0.736	0.59
270_L	286_I	0.735	0.59
51_V	117_G	0.733	0.58
239_L	244_A	0.730	0.58
103_P	309_G	0.729	0.58
109_L	306_Y	0.729	0.58
114_F	118_I	0.728	0.58
135_P	141_E	0.728	0.58
147_C	152_H	0.727	0.58
206_L	210_L	0.727	0.58
179_L	182_L	0.726	0.58
141_E	144_D	0.723	0.57
333_A	339_A	0.723	0.57
342_A	346_N	0.722	0.57
168_L	173_L	0.719	0.57
221_L	226_S	0.719	0.57
20_F	90_T	0.719	0.57
171_L	175_P	0.716	0.57
212_L	218_S	0.714	0.56
106_A	110_F	0.713	0.56
233_H	237_E	0.712	0.56
249_F	254_V	0.710	0.56
184_A	187_I	0.710	0.56
29_E	333_A	0.708	0.56
59_A	66_A	0.706	0.56
163_N	170_L	0.705	0.55
212_L	217_V	0.705	0.55
242_H	247_T	0.700	0.55
144_D	149_E	0.699	0.55
318_A	321_I	0.697	0.55
196_G	206_L	0.697	0.55
308_S	313_F	0.695	0.54
30_Y	37_G	0.694	0.54
187_I	192_L	0.693	0.54
290_I	351_L	0.690	0.54
284_L	315_A	0.688	0.54
239_L	245_K	0.686	0.53
183_L	188_D	0.686	0.53
196_G	204_G	0.680	0.53
91_S	324_D	0.679	0.53
32_N	35_T	0.676	0.52
169_W	172_L	0.676	0.52
206_L	217_V	0.675	0.52
22_A	51_V	0.675	0.52
252_L	256_G	0.674	0.52
225_F	233_H	0.674	0.52
22_A	328_L	0.673	0.52
51_V	90_T	0.672	0.52
150_C	156_P	0.670	0.52
185_F	188_D	0.669	0.52
38_R	41_K	0.655	0.50
197_E	204_G	0.655	0.50
20_F	86_T	0.654	0.50
185_F	191_G	0.653	0.50
326_H	343_K	0.653	0.50
16_M	97_V	0.652	0.50
160_K	169_W	0.652	0.50
20_F	40_S	0.649	0.49
168_L	186_Q	0.649	0.49
343_K	350_A	0.647	0.49
27_L	88_I	0.646	0.49
348_I	352_I	0.646	0.49
9_S	13_A	0.646	0.49
137_E	143_E	0.641	0.49
91_S	319_N	0.641	0.49
167_L	172_L	0.640	0.48
196_G	201_T	0.639	0.48
21_V	24_M	0.635	0.48
255_F	259_L	0.632	0.48
157_L	161_L	0.632	0.48
224_Y	231_P	0.631	0.48
195_L	200_I	0.631	0.48
236_E	239_L	0.630	0.47
50_Q	125_D	0.627	0.47
255_F	258_L	0.626	0.47
180_G	184_A	0.625	0.47
158_L	161_L	0.624	0.47
53_L	288_V	0.623	0.47
288_V	307_A	0.623	0.47
47_R	125_D	0.622	0.47
223_G	227_V	0.622	0.47
29_E	33_V	0.621	0.46
195_L	202_W	0.621	0.46
316_L	357_L	0.619	0.46
113_L	329_L	0.618	0.46
29_E	74_T	0.618	0.46
31_L	181_L	0.616	0.46
259_L	263_L	0.616	0.46
168_L	178_I	0.615	0.46
151_E	154_H	0.614	0.46
184_A	190_D	0.614	0.46
197_E	205_L	0.614	0.46
27_L	39_W	0.612	0.46
40_S	74_T	0.612	0.46
115_V	118_I	0.611	0.45
56_L	311_I	0.605	0.45
356_G	359_F	0.605	0.45
207_G	214_L	0.603	0.45
160_K	167_L	0.603	0.45
225_F	229_T	0.603	0.45
171_L	192_L	0.602	0.44
42_L	49_L	0.601	0.44
175_P	184_A	0.599	0.44
152_H	160_K	0.599	0.44
198_G	202_W	0.597	0.44
27_L	100_A	0.597	0.44
83_L	331_L	0.597	0.44
169_W	183_L	0.595	0.44
330_P	333_A	0.595	0.44
288_V	322_S	0.594	0.44
98_M	101_M	0.592	0.43
167_L	180_G	0.592	0.43
213_F	220_L	0.591	0.43
134_R	209_L	0.590	0.43
236_E	242_H	0.588	0.43
173_L	177_L	0.588	0.43
276_I	310_L	0.588	0.43
191_G	195_L	0.588	0.43
30_Y	34_L	0.587	0.43
80_F	128_H	0.587	0.43
351_L	354_G	0.587	0.43
147_C	150_C	0.586	0.43
267_F	270_L	0.586	0.43
16_M	85_A	0.583	0.42
161_L	166_H	0.582	0.42
225_F	228_A	0.582	0.42
202_W	210_L	0.581	0.42
43_L	115_V	0.579	0.42
207_G	210_L	0.579	0.42
210_L	214_L	0.577	0.42
105_T	303_V	0.575	0.42
208_T	219_P	0.572	0.41
200_I	207_G	0.571	0.41
242_H	246_E	0.571	0.41
127_F	260_V	0.571	0.41
152_H	155_E	0.571	0.41
41_K	45_K	0.571	0.41
112_I	340_L	0.570	0.41
225_F	230_V	0.570	0.41
159_N	163_N	0.566	0.41
232_D	235_L	0.566	0.41
126_K	136_K	0.565	0.41
279_N	290_I	0.561	0.40
190_D	193_F	0.557	0.40
60_T	69_V	0.557	0.40
136_K	141_E	0.555	0.40
168_L	188_D	0.554	0.39
56_L	59_A	0.553	0.39
159_N	165_S	0.552	0.39
47_R	81_G	0.551	0.39
201_T	206_L	0.550	0.39
168_L	185_F	0.549	0.39
322_S	342_A	0.549	0.39
137_E	140_H	0.548	0.39
99_L	306_Y	0.548	0.39
91_S	95_A	0.547	0.39
151_E	340_L	0.547	0.39
188_D	195_L	0.547	0.39
106_A	118_I	0.547	0.39
228_A	231_P	0.546	0.39
144_D	152_H	0.546	0.39
177_L	180_G	0.546	0.39
148_C	156_P	0.545	0.39
91_S	328_L	0.544	0.38
130_K	139_E	0.544	0.38
334_E	339_A	0.543	0.38
201_T	205_L	0.543	0.38
24_M	64_G	0.542	0.38
169_W	185_F	0.541	0.38
219_P	225_F	0.541	0.38
131_D	139_E	0.541	0.38
116_V	293_I	0.540	0.38
196_G	199_L	0.538	0.38
25_M	28_I	0.537	0.38
237_E	241_R	0.535	0.37
108_L	123_L	0.534	0.37
71_S	83_L	0.534	0.37
135_P	138_E	0.532	0.37
175_P	181_L	0.531	0.37
346_N	354_G	0.531	0.37
171_L	187_I	0.531	0.37
119_I	122_Y	0.529	0.37
333_A	345_Y	0.529	0.37
58_G	63_C	0.527	0.37
30_Y	35_T	0.526	0.37
19_V	301_I	0.526	0.37
62_G	92_G	0.525	0.36
22_A	327_A	0.525	0.36
54_A	78_V	0.524	0.36
47_R	85_A	0.521	0.36
106_A	113_L	0.521	0.36
354_G	357_L	0.518	0.36
151_E	157_L	0.517	0.36
192_L	196_G	0.517	0.36
196_G	202_W	0.515	0.36
114_F	293_I	0.513	0.35
184_A	188_D	0.512	0.35
108_L	306_Y	0.512	0.35
221_L	225_F	0.512	0.35
172_L	203_I	0.511	0.35
183_L	191_G	0.511	0.35
64_G	90_T	0.511	0.35
269_G	319_N	0.511	0.35
117_G	125_D	0.509	0.35
306_Y	314_S	0.507	0.35
280_G	315_A	0.507	0.35
136_K	143_E	0.506	0.35
204_G	214_L	0.506	0.35
315_A	326_H	0.506	0.35
194_G	197_E	0.503	0.34
126_K	352_I	0.502	0.34
20_F	68_A	0.502	0.34
143_E	146_E	0.502	0.34
25_M	29_E	0.501	0.34
264_L	270_L	0.500	0.34
216_A	340_L	0.500	0.34

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2xq2A	2	0.5097	17	0.974	Contact Map
2ksrA	1	0.3102	14.4	0.975	Contact Map
2b2hA	3	0.3961	10.2	0.977	Contact Map
3dh4A	3	0.4432	10	0.977	Contact Map
3b9wA	3	0.3767	8	0.978	Contact Map
4n7wA	2	0.2355	6.9	0.978	Contact Map
3vouA	4	0.3463	6.3	0.979	Contact Map
4ltoA	3	0.2992	6.1	0.979	Contact Map
4h33A	3	0.2382	5.9	0.979	Contact Map
4he8J	1	0.3352	5.7	0.979	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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