GREMLIN Database
DUF2897 - Protein of unknown function (DUF2897)
PFAM: PF11446 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 54 (52)
Sequences: 685 (470)
Seq/√Len: 65.2
META: 0.699

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
48_Q52_E3.0461.00
35_D39_K2.6911.00
39_K43_K2.5401.00
6_W10_V2.1881.00
5_A8_I2.1071.00
9_I13_L1.8611.00
17_V21_L1.8281.00
3_W7_L1.7601.00
38_L42_K1.7070.99
44_R47_E1.5370.99
13_L16_I1.5300.99
16_I19_G1.3860.98
45_N49_D1.3630.97
19_G25_Y1.2950.96
26_S29_M1.2440.95
37_V40_R1.1860.94
19_G22_L1.1710.94
5_A9_I1.1280.92
38_L45_N1.1260.92
8_I15_V1.1160.92
13_L17_V1.1130.92
31_M34_S1.0940.91
11_L14_G1.0640.90
41_A45_N1.0620.90
37_V41_A1.0580.90
33_L37_V1.0300.88
18_G24_R1.0070.87
43_K46_R0.9970.87
50_A53_K0.9890.86
48_Q53_K0.9650.85
21_L25_Y0.9440.84
47_E51_K0.9430.84
18_G25_Y0.9210.82
40_R43_K0.9070.81
24_R30_K0.8910.80
9_I12_V0.8870.80
46_R49_D0.8560.77
38_L44_R0.8500.77
36_E40_R0.8390.76
41_A44_R0.8340.75
4_Y20_L0.8190.74
12_V25_Y0.7850.71
14_G22_L0.7830.71
38_L41_A0.7830.71
9_I16_I0.7770.70
7_L10_V0.7680.69
4_Y7_L0.7610.68
2_P5_A0.7480.67
15_V19_G0.7420.66
27_A30_K0.7410.66
47_E50_A0.7280.65
27_A51_K0.7200.64
6_W26_S0.7130.63
48_Q51_K0.7040.62
12_V19_G0.6860.60
20_L46_R0.6740.59
3_W10_V0.6730.59
15_V25_Y0.6670.58
27_A49_D0.6650.58
40_R44_R0.6620.58
22_L28_K0.6450.56
2_P13_L0.6300.54
42_K45_N0.6290.54
43_K47_E0.6210.53
45_N48_Q0.6010.51
8_I12_V0.5910.49
2_P6_W0.5890.49
43_K49_D0.5890.49
23_L28_K0.5870.49
36_E44_R0.5790.48
23_L41_A0.5580.46
11_L25_Y0.5530.45
46_R52_E0.5520.45
18_G34_S0.5470.44
11_L32_P0.5420.44
33_L41_A0.5140.40
34_S39_K0.5070.40
6_W14_G0.5000.39
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mk7C 2 0.9074 40.4 0.804 Contact Map
2k21A 1 0.963 27.3 0.821 Contact Map
5a2fA 1 0 26.2 0.822 Contact Map
2mi2A 1 0.9815 22.3 0.828 Contact Map
2l16A 1 0.6481 13 0.846 Contact Map
1scfA 4 0 11.9 0.848 Contact Map
2m8rA 1 0.4074 11.3 0.849 Contact Map
2ls4A 1 0.4444 11 0.85 Contact Map
4ij3C 1 0 10.5 0.852 Contact Map
2m0qA 1 0.9444 9.6 0.854 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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