DUF2894 - PFAM28P - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

DUF2894 - Protein of unknown function (DUF2894)

PFAM:	PF11445	Sequences: LDAWRARGADRLDPVRFHFIEALARRAAAHQGEARRLLDARLAALLAAYAARLERAAAAAAAAAAPAAAAAPARGPALAELVAHLARHAAAAAAAAAAAAAAAAPAAAAAAAPELKALRYFRETWSRLSAEQQLRQSLAQVPENAGPLNSHHLVHRSLSLMRELSPDYLQRFLSYVDALLWLEQANQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	187 (181)
Sequences:	827 (685)
Seq/√Len:	50.9
META:	0.692

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
33_E	36_R	4.835	1.00
17_F	49_Y	4.129	1.00
32_G	35_R	3.055	1.00
114_E	122_R	2.974	1.00
5_R	21_E	2.800	1.00
10_D	17_F	2.659	1.00
170_Q	173_L	2.554	1.00
27_A	39_D	2.376	1.00
18_H	21_E	2.290	1.00
84_H	88_H	2.172	1.00
35_R	39_D	2.165	1.00
151_H	180_L	2.152	1.00
30_H	34_A	2.088	1.00
74_R	83_A	2.087	1.00
129_S	132_Q	1.993	1.00
118_L	150_S	1.993	1.00
180_L	185_A	1.977	1.00
148_L	181_W	1.968	1.00
14_P	17_F	1.959	1.00
173_L	180_L	1.915	0.99
49_Y	148_L	1.896	0.99
22_A	25_R	1.886	0.99
141_V	155_H	1.855	0.99
174_S	177_D	1.848	0.99
161_M	172_F	1.796	0.99
16_R	52_R	1.778	0.99
19_F	45_L	1.776	0.99
10_D	16_R	1.776	0.99
133_Q	173_L	1.739	0.99
123_E	170_Q	1.738	0.99
16_R	45_L	1.693	0.99
157_S	161_M	1.616	0.98
45_L	155_H	1.613	0.98
60_A	72_P	1.579	0.98
12_L	53_L	1.545	0.97
20_I	49_Y	1.542	0.97
135_R	151_H	1.541	0.97
171_R	180_L	1.528	0.97
18_H	22_A	1.525	0.97
13_D	52_R	1.524	0.97
125_W	128_L	1.513	0.97
16_R	49_Y	1.499	0.97
10_D	49_Y	1.495	0.97
117_A	143_E	1.492	0.97
120_Y	124_T	1.489	0.97
124_T	128_L	1.484	0.97
32_G	39_D	1.468	0.96
150_S	156_R	1.375	0.95
75_G	79_A	1.339	0.94
150_S	155_H	1.329	0.94
79_A	82_V	1.313	0.93
167_D	170_Q	1.309	0.93
91_A	98_A	1.298	0.93
4_W	10_D	1.292	0.93
80_E	84_H	1.272	0.92
170_Q	182_L	1.272	0.92
2_D	6_A	1.270	0.92
157_S	172_F	1.258	0.92
117_A	144_N	1.249	0.91
27_A	177_D	1.244	0.91
119_R	151_H	1.234	0.91
91_A	94_A	1.211	0.90
18_H	23_L	1.207	0.90
91_A	95_A	1.206	0.90
4_W	119_R	1.186	0.89
62_A	71_A	1.185	0.89
92_A	97_A	1.184	0.89
99_A	102_A	1.141	0.87
66_P	69_A	1.123	0.86
132_Q	162_R	1.121	0.86
4_W	49_Y	1.118	0.86
172_F	175_Y	1.108	0.85
157_S	162_R	1.098	0.85
150_S	154_V	1.098	0.85
48_A	52_R	1.078	0.84
97_A	100_A	1.074	0.84
121_F	181_W	1.069	0.83
143_E	152_H	1.069	0.83
157_S	175_Y	1.054	0.82
79_A	83_A	1.051	0.82
123_E	141_V	1.041	0.82
124_T	127_R	1.036	0.81
23_L	38_L	1.033	0.81
120_Y	132_Q	1.024	0.81
151_H	171_R	1.008	0.80
133_Q	140_Q	1.005	0.79
133_Q	171_R	0.986	0.78
128_L	173_L	0.979	0.78
82_V	87_R	0.979	0.78
117_A	167_D	0.978	0.77
122_R	154_V	0.977	0.77
1_L	6_A	0.975	0.77
67_A	71_A	0.967	0.77
51_A	134_L	0.962	0.76
19_F	46_L	0.953	0.76
135_R	141_V	0.952	0.76
45_L	52_R	0.950	0.75
119_R	171_R	0.950	0.75
75_G	82_V	0.948	0.75
40_A	44_A	0.947	0.75
150_S	160_L	0.943	0.75
125_W	148_L	0.938	0.74
98_A	101_A	0.934	0.74
49_Y	53_L	0.933	0.74
47_A	51_A	0.928	0.74
119_R	180_L	0.926	0.73
11_R	67_A	0.926	0.73
93_A	100_A	0.924	0.73
98_A	102_A	0.914	0.72
20_I	27_A	0.911	0.72
33_E	173_L	0.910	0.72
60_A	99_A	0.908	0.72
80_E	182_L	0.907	0.72
47_A	116_K	0.906	0.72
44_A	80_E	0.905	0.72
121_F	172_F	0.901	0.71
132_Q	143_E	0.898	0.71
132_Q	151_H	0.897	0.71
2_D	27_A	0.890	0.70
157_S	169_L	0.888	0.70
71_A	74_R	0.888	0.70
1_L	123_E	0.884	0.70
116_K	180_L	0.882	0.70
121_F	125_W	0.874	0.69
92_A	96_A	0.873	0.69
25_R	28_A	0.870	0.69
14_P	143_E	0.869	0.69
100_A	104_A	0.854	0.67
4_W	9_A	0.850	0.67
60_A	98_A	0.848	0.67
130_A	184_Q	0.845	0.66
129_S	138_L	0.840	0.66
131_E	143_E	0.838	0.66
160_L	173_L	0.837	0.66
94_A	99_A	0.832	0.65
99_A	103_A	0.831	0.65
160_L	172_F	0.829	0.65
157_S	164_L	0.827	0.65
133_Q	155_H	0.826	0.65
27_A	32_G	0.826	0.65
134_L	171_R	0.820	0.64
129_S	152_H	0.818	0.64
73_A	76_P	0.818	0.64
38_L	115_L	0.807	0.63
10_D	175_Y	0.800	0.62
132_Q	170_Q	0.792	0.61
121_F	150_S	0.790	0.61
78_L	82_V	0.788	0.61
152_H	158_L	0.782	0.60
7_R	37_L	0.768	0.59
118_L	122_R	0.767	0.59
181_W	185_A	0.762	0.58
124_T	144_N	0.761	0.58
64_A	68_A	0.761	0.58
12_L	52_R	0.758	0.58
149_N	165_S	0.755	0.58
37_L	41_R	0.749	0.57
134_L	143_E	0.748	0.57
137_S	155_H	0.744	0.57
73_A	165_S	0.740	0.56
133_Q	141_V	0.738	0.56
132_Q	152_H	0.736	0.56
138_L	178_A	0.736	0.56
13_D	19_F	0.732	0.55
125_W	150_S	0.727	0.55
19_F	52_R	0.724	0.55
118_L	133_Q	0.723	0.54
157_S	160_L	0.721	0.54
121_F	151_H	0.720	0.54
155_H	159_S	0.720	0.54
19_F	34_A	0.718	0.54
62_A	66_P	0.717	0.54
66_P	75_G	0.712	0.53
134_L	162_R	0.710	0.53
5_R	20_I	0.709	0.53
141_V	151_H	0.707	0.53
115_L	125_W	0.696	0.52
138_L	155_H	0.694	0.51
149_N	154_V	0.690	0.51
151_H	185_A	0.685	0.51
96_A	100_A	0.684	0.50
164_L	186_N	0.684	0.50
27_A	35_R	0.680	0.50
128_L	135_R	0.675	0.49
57_A	60_A	0.670	0.49
12_L	49_Y	0.668	0.49
165_S	171_R	0.661	0.48
151_H	159_S	0.655	0.47
9_A	53_L	0.653	0.47
135_R	183_E	0.653	0.47
11_R	35_R	0.651	0.47
79_A	139_A	0.649	0.47
151_H	155_H	0.644	0.46
114_E	118_L	0.642	0.46
64_A	71_A	0.635	0.45
141_V	148_L	0.633	0.45
143_E	159_S	0.632	0.45
138_L	141_V	0.631	0.45
80_E	87_R	0.631	0.45
140_Q	175_Y	0.630	0.45
182_L	185_A	0.630	0.45
168_Y	172_F	0.630	0.45
94_A	102_A	0.629	0.45
156_R	177_D	0.628	0.45
41_R	183_E	0.626	0.44
60_A	64_A	0.618	0.44
142_P	152_H	0.614	0.43
153_L	157_S	0.612	0.43
129_S	144_N	0.608	0.43
124_T	154_V	0.600	0.42
117_A	129_S	0.596	0.41
84_H	139_A	0.595	0.41
151_H	173_L	0.594	0.41
8_G	17_F	0.593	0.41
97_A	103_A	0.593	0.41
21_E	50_A	0.588	0.41
125_W	134_L	0.587	0.40
86_A	102_A	0.585	0.40
132_Q	159_S	0.583	0.40
140_Q	151_H	0.582	0.40
116_K	167_D	0.580	0.40
66_P	103_A	0.580	0.40
152_H	178_A	0.579	0.40
139_A	143_E	0.579	0.40
66_P	70_A	0.577	0.40
67_A	80_E	0.576	0.39
49_Y	161_M	0.576	0.39
93_A	97_A	0.574	0.39
1_L	4_W	0.573	0.39
174_S	178_A	0.572	0.39
140_Q	173_L	0.570	0.39
92_A	95_A	0.569	0.39
99_A	105_P	0.569	0.39
4_W	151_H	0.567	0.39
40_A	50_A	0.565	0.38
60_A	71_A	0.564	0.38
79_A	86_A	0.555	0.37
125_W	133_Q	0.553	0.37
2_D	7_R	0.553	0.37
60_A	175_Y	0.549	0.37
1_L	128_L	0.549	0.37
18_H	44_A	0.546	0.36
58_A	72_P	0.546	0.36
31_Q	118_L	0.546	0.36
131_E	181_W	0.545	0.36
154_V	176_V	0.545	0.36
64_A	73_A	0.543	0.36
66_P	74_R	0.543	0.36
19_F	41_R	0.543	0.36
59_A	68_A	0.541	0.36
17_F	46_L	0.541	0.36
168_Y	175_Y	0.538	0.36
155_H	167_D	0.537	0.36
164_L	173_L	0.535	0.35
2_D	110_A	0.534	0.35
130_A	150_S	0.529	0.35
46_L	49_Y	0.528	0.35
24_A	133_Q	0.522	0.34
117_A	130_A	0.522	0.34
23_L	144_N	0.520	0.34
98_A	103_A	0.515	0.34
121_F	126_S	0.514	0.33
71_A	75_G	0.513	0.33
62_A	100_A	0.513	0.33
70_A	98_A	0.512	0.33
111_A	115_L	0.511	0.33
47_A	50_A	0.509	0.33
30_H	118_L	0.507	0.33
162_R	181_W	0.507	0.33
2_D	131_E	0.504	0.33
86_A	160_L	0.501	0.32
24_A	42_L	0.500	0.32

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1zg3A	2	0.4011	5.6	0.959	Contact Map
2qfaC	1	0.1872	4.8	0.96	Contact Map
3lstA	2	0.3529	4.2	0.961	Contact Map
3dp7A	2	0.3904	3.7	0.962	Contact Map
4z2yA	2	0.3529	3.6	0.962	Contact Map
4wxhA	2	0.3904	3.6	0.962	Contact Map
1gk7A	1	0.1604	3.4	0.963	Contact Map
3r3jA	5	0.369	3.3	0.963	Contact Map
2r3sA	4	0.3636	3.2	0.963	Contact Map
4u1qA	2	0.3636	3.1	0.963	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0069 seconds.