GREMLIN Database
DUF2894 - Protein of unknown function (DUF2894)
PFAM: PF11445 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 187 (181)
Sequences: 827 (685)
Seq/√Len: 50.9
META: 0.692

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
33_E36_R4.8351.00
17_F49_Y4.1291.00
32_G35_R3.0551.00
114_E122_R2.9741.00
5_R21_E2.8001.00
10_D17_F2.6591.00
170_Q173_L2.5541.00
27_A39_D2.3761.00
18_H21_E2.2901.00
84_H88_H2.1721.00
35_R39_D2.1651.00
151_H180_L2.1521.00
30_H34_A2.0881.00
74_R83_A2.0871.00
129_S132_Q1.9931.00
118_L150_S1.9931.00
180_L185_A1.9771.00
148_L181_W1.9681.00
14_P17_F1.9591.00
173_L180_L1.9150.99
49_Y148_L1.8960.99
22_A25_R1.8860.99
141_V155_H1.8550.99
174_S177_D1.8480.99
161_M172_F1.7960.99
16_R52_R1.7780.99
19_F45_L1.7760.99
10_D16_R1.7760.99
133_Q173_L1.7390.99
123_E170_Q1.7380.99
16_R45_L1.6930.99
157_S161_M1.6160.98
45_L155_H1.6130.98
60_A72_P1.5790.98
12_L53_L1.5450.97
20_I49_Y1.5420.97
135_R151_H1.5410.97
171_R180_L1.5280.97
18_H22_A1.5250.97
13_D52_R1.5240.97
125_W128_L1.5130.97
16_R49_Y1.4990.97
10_D49_Y1.4950.97
117_A143_E1.4920.97
120_Y124_T1.4890.97
124_T128_L1.4840.97
32_G39_D1.4680.96
150_S156_R1.3750.95
75_G79_A1.3390.94
150_S155_H1.3290.94
79_A82_V1.3130.93
167_D170_Q1.3090.93
91_A98_A1.2980.93
4_W10_D1.2920.93
80_E84_H1.2720.92
170_Q182_L1.2720.92
2_D6_A1.2700.92
157_S172_F1.2580.92
117_A144_N1.2490.91
27_A177_D1.2440.91
119_R151_H1.2340.91
91_A94_A1.2110.90
18_H23_L1.2070.90
91_A95_A1.2060.90
4_W119_R1.1860.89
62_A71_A1.1850.89
92_A97_A1.1840.89
99_A102_A1.1410.87
66_P69_A1.1230.86
132_Q162_R1.1210.86
4_W49_Y1.1180.86
172_F175_Y1.1080.85
157_S162_R1.0980.85
150_S154_V1.0980.85
48_A52_R1.0780.84
97_A100_A1.0740.84
121_F181_W1.0690.83
143_E152_H1.0690.83
157_S175_Y1.0540.82
79_A83_A1.0510.82
123_E141_V1.0410.82
124_T127_R1.0360.81
23_L38_L1.0330.81
120_Y132_Q1.0240.81
151_H171_R1.0080.80
133_Q140_Q1.0050.79
133_Q171_R0.9860.78
128_L173_L0.9790.78
82_V87_R0.9790.78
117_A167_D0.9780.77
122_R154_V0.9770.77
1_L6_A0.9750.77
67_A71_A0.9670.77
51_A134_L0.9620.76
19_F46_L0.9530.76
135_R141_V0.9520.76
45_L52_R0.9500.75
119_R171_R0.9500.75
75_G82_V0.9480.75
40_A44_A0.9470.75
150_S160_L0.9430.75
125_W148_L0.9380.74
98_A101_A0.9340.74
49_Y53_L0.9330.74
47_A51_A0.9280.74
119_R180_L0.9260.73
11_R67_A0.9260.73
93_A100_A0.9240.73
98_A102_A0.9140.72
20_I27_A0.9110.72
33_E173_L0.9100.72
60_A99_A0.9080.72
80_E182_L0.9070.72
47_A116_K0.9060.72
44_A80_E0.9050.72
121_F172_F0.9010.71
132_Q143_E0.8980.71
132_Q151_H0.8970.71
2_D27_A0.8900.70
157_S169_L0.8880.70
71_A74_R0.8880.70
1_L123_E0.8840.70
116_K180_L0.8820.70
121_F125_W0.8740.69
92_A96_A0.8730.69
25_R28_A0.8700.69
14_P143_E0.8690.69
100_A104_A0.8540.67
4_W9_A0.8500.67
60_A98_A0.8480.67
130_A184_Q0.8450.66
129_S138_L0.8400.66
131_E143_E0.8380.66
160_L173_L0.8370.66
94_A99_A0.8320.65
99_A103_A0.8310.65
160_L172_F0.8290.65
157_S164_L0.8270.65
133_Q155_H0.8260.65
27_A32_G0.8260.65
134_L171_R0.8200.64
129_S152_H0.8180.64
73_A76_P0.8180.64
38_L115_L0.8070.63
10_D175_Y0.8000.62
132_Q170_Q0.7920.61
121_F150_S0.7900.61
78_L82_V0.7880.61
152_H158_L0.7820.60
7_R37_L0.7680.59
118_L122_R0.7670.59
181_W185_A0.7620.58
124_T144_N0.7610.58
64_A68_A0.7610.58
12_L52_R0.7580.58
149_N165_S0.7550.58
37_L41_R0.7490.57
134_L143_E0.7480.57
137_S155_H0.7440.57
73_A165_S0.7400.56
133_Q141_V0.7380.56
132_Q152_H0.7360.56
138_L178_A0.7360.56
13_D19_F0.7320.55
125_W150_S0.7270.55
19_F52_R0.7240.55
118_L133_Q0.7230.54
157_S160_L0.7210.54
121_F151_H0.7200.54
155_H159_S0.7200.54
19_F34_A0.7180.54
62_A66_P0.7170.54
66_P75_G0.7120.53
134_L162_R0.7100.53
5_R20_I0.7090.53
141_V151_H0.7070.53
115_L125_W0.6960.52
138_L155_H0.6940.51
149_N154_V0.6900.51
151_H185_A0.6850.51
96_A100_A0.6840.50
164_L186_N0.6840.50
27_A35_R0.6800.50
128_L135_R0.6750.49
57_A60_A0.6700.49
12_L49_Y0.6680.49
165_S171_R0.6610.48
151_H159_S0.6550.47
9_A53_L0.6530.47
135_R183_E0.6530.47
11_R35_R0.6510.47
79_A139_A0.6490.47
151_H155_H0.6440.46
114_E118_L0.6420.46
64_A71_A0.6350.45
141_V148_L0.6330.45
143_E159_S0.6320.45
138_L141_V0.6310.45
80_E87_R0.6310.45
140_Q175_Y0.6300.45
182_L185_A0.6300.45
168_Y172_F0.6300.45
94_A102_A0.6290.45
156_R177_D0.6280.45
41_R183_E0.6260.44
60_A64_A0.6180.44
142_P152_H0.6140.43
153_L157_S0.6120.43
129_S144_N0.6080.43
124_T154_V0.6000.42
117_A129_S0.5960.41
84_H139_A0.5950.41
151_H173_L0.5940.41
8_G17_F0.5930.41
97_A103_A0.5930.41
21_E50_A0.5880.41
125_W134_L0.5870.40
86_A102_A0.5850.40
132_Q159_S0.5830.40
140_Q151_H0.5820.40
116_K167_D0.5800.40
66_P103_A0.5800.40
152_H178_A0.5790.40
139_A143_E0.5790.40
66_P70_A0.5770.40
67_A80_E0.5760.39
49_Y161_M0.5760.39
93_A97_A0.5740.39
1_L4_W0.5730.39
174_S178_A0.5720.39
140_Q173_L0.5700.39
92_A95_A0.5690.39
99_A105_P0.5690.39
4_W151_H0.5670.39
40_A50_A0.5650.38
60_A71_A0.5640.38
79_A86_A0.5550.37
125_W133_Q0.5530.37
2_D7_R0.5530.37
60_A175_Y0.5490.37
1_L128_L0.5490.37
18_H44_A0.5460.36
58_A72_P0.5460.36
31_Q118_L0.5460.36
131_E181_W0.5450.36
154_V176_V0.5450.36
64_A73_A0.5430.36
66_P74_R0.5430.36
19_F41_R0.5430.36
59_A68_A0.5410.36
17_F46_L0.5410.36
168_Y175_Y0.5380.36
155_H167_D0.5370.36
164_L173_L0.5350.35
2_D110_A0.5340.35
130_A150_S0.5290.35
46_L49_Y0.5280.35
24_A133_Q0.5220.34
117_A130_A0.5220.34
23_L144_N0.5200.34
98_A103_A0.5150.34
121_F126_S0.5140.33
71_A75_G0.5130.33
62_A100_A0.5130.33
70_A98_A0.5120.33
111_A115_L0.5110.33
47_A50_A0.5090.33
30_H118_L0.5070.33
162_R181_W0.5070.33
2_D131_E0.5040.33
86_A160_L0.5010.32
24_A42_L0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1zg3A 2 0.4011 5.6 0.959 Contact Map
2qfaC 1 0.1872 4.8 0.96 Contact Map
3lstA 2 0.3529 4.2 0.961 Contact Map
3dp7A 2 0.3904 3.7 0.962 Contact Map
4z2yA 2 0.3529 3.6 0.962 Contact Map
4wxhA 2 0.3904 3.6 0.962 Contact Map
1gk7A 1 0.1604 3.4 0.963 Contact Map
3r3jA 5 0.369 3.3 0.963 Contact Map
2r3sA 4 0.3636 3.2 0.963 Contact Map
4u1qA 2 0.3636 3.1 0.963 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.007 seconds.