GREMLIN Database
DUF2877 - Protein of unknown function (DUF2877)
PFAM: PF11392 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 109 (108)
Sequences: 5316 (4171)
Seq/√Len: 401.4
META: 0.916

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
21_A64_A5.2441.00
11_S100_D4.1151.00
15_F107_L3.4881.00
22_A105_L2.8791.00
91_L99_A2.7231.00
68_L105_L2.3111.00
68_L101_L2.2801.00
8_L51_I2.0911.00
54_A58_A2.0541.00
64_A69_H2.0091.00
90_L102_L2.0031.00
19_L108_G1.8461.00
70_A89_R1.8431.00
17_A59_A1.8331.00
45_A53_A1.8211.00
22_A108_G1.7571.00
65_S101_L1.7141.00
65_S93_I1.6301.00
67_P93_I1.6111.00
87_L102_L1.5921.00
53_A57_R1.5521.00
72_L105_L1.5271.00
58_A63_E1.5171.00
9_T14_D1.4771.00
15_F103_A1.4371.00
1_L12_G1.3331.00
6_P11_S1.3111.00
37_A41_L1.3031.00
44_A53_A1.2751.00
11_S96_T1.2471.00
21_A68_L1.2441.00
69_H73_A1.2351.00
51_I55_L1.2351.00
79_D82_A1.2041.00
35_L39_A1.1911.00
46_G53_A1.1871.00
17_A21_A1.1771.00
56_L59_A1.1701.00
79_D83_L1.1031.00
20_L60_A1.0991.00
17_A55_L1.0941.00
71_L90_L1.0841.00
18_G22_A1.0821.00
17_A64_A1.0791.00
74_A86_A1.0741.00
45_A57_R1.0571.00
66_E70_A1.0541.00
49_T53_A1.0501.00
55_L58_A1.0381.00
57_R61_R1.0301.00
36_A41_L1.0171.00
48_T52_S0.9941.00
58_A61_R0.9941.00
90_L93_I0.9931.00
36_A40_L0.9861.00
38_A42_A0.9841.00
33_A36_A0.9611.00
43_A46_G0.9571.00
33_A37_A0.9471.00
14_D97_S0.9441.00
37_A40_L0.9411.00
47_R53_A0.9261.00
14_D94_G0.9091.00
55_L65_S0.8971.00
101_L105_L0.8961.00
71_L105_L0.8941.00
17_A101_L0.8861.00
22_A26_L0.8841.00
21_A69_H0.8811.00
55_L101_L0.8551.00
3_G7_G0.8521.00
6_P100_D0.8521.00
30_A33_A0.8371.00
64_A68_L0.8361.00
15_F19_L0.8251.00
71_L102_L0.8221.00
86_A89_R0.8201.00
2_I56_L0.8171.00
15_F100_D0.8111.00
74_A83_L0.8041.00
25_A72_L0.7971.00
94_G97_S0.7891.00
68_L90_L0.7871.00
18_G101_L0.7791.00
50_A54_A0.7771.00
52_S56_L0.7521.00
21_A72_L0.7461.00
11_S15_F0.7411.00
6_P96_T0.7401.00
88_A92_A0.7401.00
80_P89_R0.7351.00
70_A86_A0.7311.00
33_A39_A0.7311.00
21_A59_A0.7301.00
50_A53_A0.7281.00
2_I46_G0.7251.00
52_S55_L0.7201.00
81_D85_A0.7191.00
20_L24_R0.7111.00
39_A42_A0.7101.00
103_A107_L0.7061.00
25_A73_A0.7031.00
9_T52_S0.7031.00
84_A88_A0.6991.00
55_L68_L0.6901.00
17_A68_L0.6871.00
19_L69_H0.6861.00
9_T94_G0.6851.00
9_T97_S0.6760.99
87_L91_L0.6740.99
85_A89_R0.6540.99
89_R92_A0.6510.99
55_L63_E0.6500.99
24_R64_A0.6430.99
94_G98_G0.6310.99
51_I64_A0.6290.99
22_A100_D0.6280.99
17_A56_L0.6230.99
4_L55_L0.6210.99
21_A105_L0.6180.99
54_A57_R0.6170.99
75_L78_G0.6150.99
38_A41_L0.6150.99
8_L93_I0.6150.99
66_E69_H0.6060.99
26_L76_A0.6060.99
25_A69_H0.5990.99
64_A101_L0.5970.99
19_L23_L0.5910.99
24_R62_G0.5910.99
93_I96_T0.5860.98
7_G10_P0.5810.98
22_A72_L0.5780.98
2_I45_A0.5780.98
25_A29_P0.5760.98
2_I68_L0.5720.98
47_R50_A0.5710.98
28_R31_A0.5700.98
100_D103_A0.5670.98
36_A39_A0.5650.98
84_A87_L0.5610.98
11_S99_A0.5560.98
73_A77_A0.5530.98
96_T100_D0.5530.98
77_A82_A0.5490.98
82_A86_A0.5480.98
8_L49_T0.5480.98
6_P16_L0.5390.97
71_L86_A0.5390.97
65_S90_L0.5380.97
45_A60_A0.5320.97
51_I54_A0.5300.97
32_A36_A0.5290.97
34_A38_A0.5280.97
85_A92_A0.5260.97
23_L34_A0.5240.97
81_D84_A0.5240.97
68_L102_L0.5230.97
73_A88_A0.5230.97
60_A63_E0.5070.96
51_I100_D0.5000.96
11_S95_H0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3e1hA 2 0.9174 25.4 0.897 Contact Map
1ee0A 2 0.9541 25 0.897 Contact Map
2p0uA 2 0.9358 24.2 0.897 Contact Map
3awkA 2 0.9358 20.5 0.901 Contact Map
3a5rA 2 0.9725 18 0.903 Contact Map
3wxyA 2 0.9633 17.8 0.903 Contact Map
4jaqD 2 0.9817 17.4 0.904 Contact Map
3wd8A 2 0.9358 16.9 0.905 Contact Map
1xesA 2 0.945 16.7 0.905 Contact Map
3euoA 2 0.9174 16.4 0.905 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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