GREMLIN Database
DUF2798 - Protein of unknown function (DUF2798)
PFAM: PF11391 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 59 (58)
Sequences: 6212 (4012)
Seq/√Len: 526.7
META: 0.816

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_P43_P3.3421.00
20_L29_R2.2701.00
8_S34_W2.2621.00
17_L22_F2.0731.00
25_G29_R2.0071.00
52_V56_V1.9981.00
4_S38_W1.8651.00
4_S42_F1.6441.00
23_G29_R1.5301.00
14_V40_V1.5221.00
49_A53_R1.5101.00
51_L54_R1.4451.00
9_F31_L1.4191.00
15_A19_N1.3801.00
16_T20_L1.3731.00
11_M15_A1.3641.00
38_W42_F1.3501.00
2_I52_V1.3311.00
28_A32_K1.3201.00
7_M11_M1.3001.00
35_L39_P1.2991.00
31_L35_L1.2771.00
45_V49_A1.2581.00
27_L31_L1.2291.00
18_I32_K1.1991.00
18_I36_I1.1891.00
20_L23_G1.1851.00
13_G30_W1.1701.00
43_P47_L1.0671.00
53_R57_A1.0651.00
8_S41_A1.0531.00
3_M49_A1.0511.00
7_M41_A1.0461.00
44_T48_V1.0321.00
9_F34_W1.0281.00
25_G28_A1.0031.00
6_L48_V0.9841.00
1_L42_F0.9661.00
10_I44_T0.9491.00
54_R58_R0.9431.00
32_K36_I0.9271.00
51_L55_L0.9241.00
42_F46_L0.8911.00
4_S8_S0.8901.00
24_P28_A0.8861.00
17_L26_F0.8591.00
3_M45_V0.8291.00
13_G38_W0.7751.00
32_K35_L0.7591.00
13_G17_L0.7521.00
30_W38_W0.7441.00
2_I56_V0.7221.00
21_G25_G0.7091.00
15_A33_A0.7011.00
15_A18_I0.6971.00
13_G26_F0.6771.00
9_F13_G0.6661.00
14_V18_I0.6561.00
12_S30_W0.6501.00
19_N24_P0.6491.00
11_M41_A0.6371.00
2_I6_L0.6291.00
19_N33_A0.6281.00
7_M15_A0.6171.00
5_G38_W0.6111.00
50_P54_R0.6111.00
29_R32_K0.5991.00
16_T26_F0.5840.99
37_A49_A0.5830.99
8_S15_A0.5790.99
54_R57_A0.5770.99
31_L34_W0.5760.99
15_A45_V0.5760.99
15_A37_A0.5730.99
5_G34_W0.5620.99
20_L25_G0.5600.99
6_L51_L0.5540.99
46_L49_A0.5450.99
19_N29_R0.5440.99
28_A31_L0.5440.99
24_P27_L0.5430.99
12_S15_A0.5400.99
2_I55_L0.5240.99
19_N32_K0.5220.99
8_S45_V0.5090.98
33_A37_A0.5080.98
10_I45_V0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4il3A 1 1 14.2 0.809 Contact Map
4aw6A 2 1 8.7 0.827 Contact Map
3w9iA 3 0.9831 6 0.838 Contact Map
4k0jA 3 0.9831 5.5 0.842 Contact Map
4mt1A 3 0.9831 5 0.845 Contact Map
4pd6A 3 0.8814 4.7 0.846 Contact Map
4dx5A 3 0.9831 3.6 0.854 Contact Map
3ne5A 3 0.9322 3.6 0.855 Contact Map
4j72A 2 0.5424 3.2 0.859 Contact Map
4u4vA 1 0.8814 1.6 0.879 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0039 seconds.