GREMLIN Database
DUF3189 - Protein of unknown function (DUF3189)
PFAM: PF11385 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 147 (145)
Sequences: 738 (615)
Seq/√Len: 51.1
META: 0.709

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
6_C13_S4.5651.00
28_R34_E3.9791.00
4_Y20_H3.6431.00
15_V131_T3.4041.00
3_I52_L2.9201.00
110_G123_G2.6611.00
25_P28_R2.6311.00
57_T63_E2.5331.00
42_D124_R2.3241.00
129_K132_R2.3131.00
26_E146_K2.1921.00
30_P135_Y2.1611.00
115_R124_R2.1491.00
107_M131_T2.0701.00
129_K133_K1.9971.00
106_L133_K1.8740.99
23_L39_P1.8410.99
106_L129_K1.7860.99
19_I24_L1.7730.99
110_G130_G1.7360.99
54_F65_Y1.7210.99
49_I70_R1.7050.99
76_V79_A1.6830.98
135_Y139_V1.6560.98
17_A55_M1.6250.98
69_R73_G1.5980.98
8_G11_H1.5430.97
59_E146_K1.5240.97
113_L122_I1.5110.97
134_A137_N1.4990.97
132_R136_P1.4710.96
55_M66_T1.4590.96
2_I95_L1.4250.96
123_G130_G1.4200.96
11_H42_D1.4180.96
42_D111_G1.4150.95
58_D62_N1.4010.95
25_P135_Y1.3830.95
54_F57_T1.3650.95
8_G111_G1.3290.94
10_T44_L1.3290.94
7_Y68_G1.3280.94
100_L108_R1.2830.92
32_K128_V1.2460.91
44_L49_I1.2440.91
41_F127_V1.2180.90
16_A142_V1.2140.90
111_G114_S1.1830.89
113_L119_L1.1820.89
29_I132_R1.1620.88
16_A138_I1.1530.88
6_C9_G1.1410.87
26_E143_E1.1410.87
131_T134_A1.1350.87
63_E68_G1.1330.87
52_L70_R1.1240.86
97_V141_L1.1100.86
15_V35_I1.1080.86
97_V145_V1.1060.85
19_I30_P1.1010.85
52_L107_M1.0940.85
114_S123_G1.0740.84
120_V124_R1.0730.84
90_P140_K1.0680.83
8_G12_S1.0670.83
8_G13_S1.0410.82
112_F117_L1.0350.81
102_T141_L1.0170.80
113_L126_L1.0160.80
99_T102_T1.0000.79
19_I135_Y0.9950.79
11_H114_S0.9860.78
107_M127_V0.9850.78
13_S19_I0.9780.78
136_P143_E0.9740.77
12_S103_V0.9720.77
42_D114_S0.9650.77
83_L86_I0.9580.76
79_A82_S0.9430.75
127_V131_T0.9420.75
136_P140_K0.9400.75
12_S107_M0.9360.74
12_S99_T0.9290.74
114_S124_R0.9270.74
42_D120_V0.9140.73
67_L76_V0.9110.72
77_E81_K0.9070.72
62_N121_S0.9040.72
18_A23_L0.9010.72
11_H124_R0.8980.71
104_N130_G0.8920.71
85_E93_E0.8730.69
103_V111_G0.8720.69
115_R120_V0.8640.68
111_G123_G0.8630.68
5_H96_F0.8570.68
83_L87_L0.8500.67
77_E96_F0.8500.67
64_V105_L0.8490.67
18_A55_M0.8450.67
22_G59_E0.8390.66
45_T48_D0.8350.66
40_Y55_M0.8270.65
122_I140_K0.8200.64
36_L128_V0.8130.64
114_S125_P0.8130.64
14_V66_T0.8070.63
37_N143_E0.8040.63
85_E144_E0.7940.62
9_G13_S0.7910.61
38_L67_L0.7850.61
78_P93_E0.7660.59
104_N107_M0.7620.59
42_D130_G0.7610.58
128_V132_R0.7600.58
100_L103_V0.7590.58
136_P139_V0.7580.58
69_R107_M0.7550.58
38_L98_D0.7530.58
16_A99_T0.7510.57
103_V107_M0.7460.57
88_G140_K0.7380.56
17_A66_T0.7360.56
94_I105_L0.7340.56
111_G124_R0.7330.56
37_N91_E0.7320.55
67_L90_P0.7310.55
10_T83_L0.7310.55
80_L84_L0.7290.55
46_K75_L0.7260.55
19_I29_I0.7240.55
28_R31_T0.7220.54
4_Y12_S0.7190.54
17_A29_I0.7190.54
64_V72_A0.7180.54
42_D103_V0.7180.54
75_L87_L0.7150.54
5_H70_R0.7120.53
2_I97_V0.7090.53
6_C11_H0.7030.53
94_I109_I0.7000.52
77_E109_I0.6990.52
40_Y53_I0.6980.52
80_L91_E0.6860.51
18_A38_L0.6770.50
37_N144_E0.6750.50
104_N134_A0.6740.49
122_I125_P0.6730.49
42_D115_R0.6700.49
45_T118_G0.6640.48
9_G107_M0.6540.47
9_G41_F0.6500.47
47_K144_E0.6500.47
4_Y58_D0.6470.47
8_G114_S0.6450.46
20_H64_V0.6440.46
6_C12_S0.6420.46
2_I78_P0.6420.46
52_L72_A0.6380.46
48_D51_K0.6370.46
18_A65_Y0.6350.45
21_L112_F0.6300.45
4_Y56_G0.6290.45
115_R123_G0.6190.44
5_H69_R0.6150.43
6_C21_L0.6080.43
111_G115_R0.6070.43
3_I6_C0.6050.42
76_V93_E0.6040.42
15_V126_L0.6020.42
44_L66_T0.6010.42
61_G74_K0.6000.42
83_L90_P0.5950.41
9_G68_G0.5940.41
28_R135_Y0.5930.41
11_H111_G0.5910.41
64_V101_P0.5910.41
69_R127_V0.5800.40
12_S114_S0.5780.40
5_H73_G0.5650.38
78_P122_I0.5650.38
82_S87_L0.5650.38
35_I81_K0.5610.38
20_H65_Y0.5590.38
140_K143_E0.5570.38
84_L89_I0.5570.38
10_T100_L0.5570.38
11_H130_G0.5570.38
120_V138_I0.5530.37
103_V131_T0.5490.37
110_G114_S0.5480.37
7_Y11_H0.5470.37
13_S114_S0.5470.37
30_P139_V0.5460.37
2_I104_N0.5430.36
73_G80_L0.5360.36
21_L55_M0.5350.36
105_L109_I0.5310.35
13_S42_D0.5230.34
140_K144_E0.5220.34
75_L143_E0.5210.34
26_E139_V0.5210.34
126_L140_K0.5200.34
31_T59_E0.5180.34
82_S100_L0.5170.34
11_H123_G0.5170.34
33_E60_E0.5120.33
60_E120_V0.5110.33
28_R37_N0.5080.33
81_K140_K0.5070.33
33_E37_N0.5070.33
107_M130_G0.5060.33
53_I67_L0.5040.33
7_Y70_R0.5030.33
14_V55_M0.5020.32
42_D108_R0.5020.32
94_I117_L0.5010.32
60_E85_E0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1uarA 1 0.3265 32.9 0.92 Contact Map
1urhA 1 0.2381 31.6 0.92 Contact Map
3hzuA 2 0.3537 29.2 0.922 Contact Map
3d1pA 1 0.3197 23.9 0.925 Contact Map
2m6rA 1 0.8095 21.8 0.926 Contact Map
4rb5B 1 0.7551 20.7 0.927 Contact Map
3aayA 1 0.3333 19.8 0.928 Contact Map
2isbA 1 0.415 19.2 0.928 Contact Map
1jbiA 1 0.4558 18 0.929 Contact Map
1xhjA 1 0.5578 14.9 0.932 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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