MctB - PFAM28P - GREMLIN Contacts

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MctB - Copper transport outer membrane protein, MctB

PFAM:	PF11382	Sequences: MIDFRYHVVSLVAVFLALAIGIVLGSGLLGGGLVDGLEDQVDSLRAELDALRAQNDALQAQLAAADAFAAAVAPALVAGRLAGRRVAVVALPGADDDVVDAVTAALTDAGATVTGTVTLTDKFVDPDSADALDALAAQLLPGGALLPAGADLGERAGALLARALVTGGPAVTDGGATAVLAALADAGLLTVSGGPAGPADLVVVVTPGGGAAPPDAGATAAFLAGLAAGLAAAGVGAVVAGREGSAADGSAVAAVRADGALAAGVSTVDDVDTPAGRVALVLALAGQLAGGPGHYGVGPGADALLP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	306 (303)
Sequences:	2801 (2186)
Seq/√Len:	125.6
META:	0.794

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
106_L	111_A	10.493	1.00
55_N	58_L	6.027	1.00
11_L	14_V	4.848	1.00
68_F	72_V	4.755	1.00
48_L	51_L	3.266	1.00
51_L	55_N	3.190	1.00
72_V	76_L	3.119	1.00
87_A	199_A	3.021	1.00
7_H	10_S	2.844	1.00
54_Q	59_Q	2.839	1.00
62_L	65_A	2.717	1.00
279_A	305_L	2.565	1.00
239_V	255_V	2.488	1.00
87_A	115_G	2.398	1.00
132_L	136_A	2.322	1.00
77_V	281_V	2.265	1.00
86_V	201_L	2.188	1.00
250_S	255_V	2.187	1.00
77_V	105_A	2.172	1.00
204_V	227_A	2.049	1.00
88_V	103_T	2.047	1.00
94_A	205_V	1.994	1.00
7_H	14_V	1.930	1.00
231_A	287_Q	1.910	1.00
40_Q	45_R	1.906	1.00
79_G	82_A	1.894	1.00
37_L	40_Q	1.862	1.00
153_G	157_G	1.855	1.00
24_L	28_L	1.855	1.00
131_A	135_L	1.831	1.00
90_A	118_T	1.827	1.00
102_V	203_V	1.827	1.00
203_V	280_L	1.826	1.00
238_V	241_G	1.822	1.00
255_V	267_T	1.822	1.00
142_G	145_L	1.820	1.00
73_A	105_A	1.803	1.00
67_A	71_A	1.776	1.00
286_G	291_G	1.773	1.00
102_V	271_V	1.715	1.00
4_F	9_V	1.686	1.00
267_T	294_H	1.683	1.00
188_L	191_V	1.662	1.00
251_A	255_V	1.657	1.00
266_S	287_Q	1.623	1.00
236_G	241_G	1.614	1.00
44_L	48_L	1.602	1.00
26_S	29_L	1.580	1.00
135_L	138_Q	1.574	1.00
3_D	6_Y	1.563	1.00
10_S	14_V	1.529	1.00
84_R	200_D	1.508	1.00
87_A	202_V	1.506	1.00
255_V	261_L	1.506	1.00
33_L	36_G	1.499	1.00
4_F	8_V	1.498	1.00
251_A	254_A	1.496	1.00
26_S	30_G	1.487	1.00
70_A	274_P	1.479	1.00
161_A	229_G	1.464	1.00
6_Y	10_S	1.448	1.00
258_D	261_L	1.447	1.00
49_D	52_R	1.443	1.00
58_L	62_L	1.440	1.00
95_D	98_V	1.439	1.00
252_V	256_R	1.424	1.00
252_V	255_V	1.414	1.00
266_S	283_A	1.411	1.00
99_V	103_T	1.400	1.00
303_A	306_P	1.399	1.00
135_L	139_L	1.396	1.00
49_D	53_A	1.395	1.00
4_F	7_H	1.390	1.00
6_Y	9_V	1.388	1.00
68_F	278_V	1.375	1.00
15_F	18_L	1.363	1.00
91_L	223_L	1.351	1.00
114_T	199_A	1.341	1.00
96_D	100_D	1.336	1.00
161_A	230_L	1.327	1.00
15_F	20_I	1.321	1.00
22_I	27_G	1.311	1.00
193_G	196_A	1.304	1.00
274_P	277_R	1.291	1.00
105_A	281_V	1.291	1.00
270_D	273_T	1.277	1.00
65_A	69_A	1.266	1.00
142_G	146_L	1.262	1.00
202_V	230_L	1.252	1.00
7_H	11_L	1.251	1.00
89_V	202_V	1.250	1.00
131_A	136_A	1.249	1.00
123_F	132_L	1.248	1.00
80_R	285_A	1.245	1.00
104_A	108_D	1.239	1.00
181_A	185_D	1.234	0.99
156_A	183_L	1.228	0.99
103_T	116_T	1.228	0.99
100_D	104_A	1.224	0.99
298_G	301_A	1.215	0.99
6_Y	14_V	1.208	0.99
106_L	203_V	1.202	0.99
302_D	306_P	1.193	0.99
10_S	13_A	1.187	0.99
165_V	234_G	1.187	0.99
85_R	112_T	1.187	0.99
43_S	47_E	1.184	0.99
34_V	38_E	1.176	0.99
73_A	77_V	1.173	0.99
132_L	135_L	1.167	0.99
225_G	229_G	1.161	0.99
122_K	128_S	1.152	0.99
12_V	16_L	1.147	0.99
14_V	17_A	1.144	0.99
36_G	40_Q	1.140	0.99
134_A	137_A	1.139	0.99
11_L	15_F	1.139	0.99
130_D	133_D	1.138	0.99
272_D	276_G	1.136	0.99
204_V	230_L	1.134	0.99
50_A	54_Q	1.123	0.99
105_A	278_V	1.122	0.99
53_A	57_A	1.110	0.99
34_V	37_L	1.101	0.99
163_A	179_V	1.099	0.99
201_L	284_L	1.092	0.99
69_A	278_V	1.091	0.99
59_Q	63_A	1.089	0.99
266_S	292_P	1.084	0.99
249_G	253_A	1.077	0.99
116_T	120_T	1.074	0.99
285_A	289_A	1.073	0.99
151_D	154_E	1.063	0.98
68_F	76_L	1.062	0.98
21_G	25_G	1.060	0.98
10_S	15_F	1.058	0.98
85_R	114_T	1.046	0.98
269_D	301_A	1.045	0.98
98_V	271_V	1.044	0.98
58_L	61_Q	1.037	0.98
163_A	178_A	1.036	0.98
2_I	9_V	1.035	0.98
241_G	250_S	1.023	0.98
34_V	41_V	1.023	0.98
41_V	44_L	1.020	0.98
297_V	304_L	1.019	0.98
250_S	253_A	1.018	0.98
266_S	293_G	1.013	0.98
7_H	13_A	1.011	0.98
219_T	223_L	1.009	0.98
247_A	250_S	1.008	0.98
48_L	55_N	1.006	0.98
125_D	128_S	0.999	0.98
46_A	50_A	0.994	0.98
292_P	295_Y	0.993	0.98
91_L	119_L	0.992	0.98
134_A	138_Q	0.987	0.98
28_L	31_G	0.976	0.97
117_V	195_P	0.967	0.97
249_G	255_V	0.966	0.97
44_L	47_E	0.960	0.97
19_A	27_G	0.959	0.97
212_A	216_A	0.958	0.97
268_V	279_A	0.958	0.97
98_V	101_A	0.955	0.97
240_A	271_V	0.951	0.97
131_A	138_Q	0.951	0.97
2_I	16_L	0.947	0.97
174_G	177_T	0.944	0.97
117_V	189_L	0.939	0.97
223_L	227_A	0.937	0.97
224_A	228_A	0.933	0.97
46_A	49_D	0.921	0.96
270_D	279_A	0.915	0.96
255_V	258_D	0.914	0.96
89_V	226_L	0.913	0.96
102_V	280_L	0.912	0.96
85_R	200_D	0.908	0.96
184_A	191_V	0.908	0.96
78_A	82_A	0.907	0.96
159_L	179_V	0.907	0.96
119_L	123_F	0.905	0.96
47_E	50_A	0.899	0.96
92_P	118_T	0.897	0.96
172_T	175_G	0.889	0.95
7_H	15_F	0.887	0.95
2_I	7_H	0.887	0.95
120_T	123_F	0.886	0.95
72_V	278_V	0.883	0.95
30_G	33_L	0.881	0.95
242_R	245_S	0.879	0.95
230_L	237_A	0.879	0.95
256_R	269_D	0.878	0.95
78_A	278_V	0.877	0.95
90_A	99_V	0.876	0.95
123_F	156_A	0.876	0.95
73_A	277_R	0.874	0.95
183_L	188_L	0.873	0.95
279_A	293_G	0.873	0.95
251_A	256_R	0.873	0.95
20_I	44_L	0.870	0.95
27_G	279_A	0.869	0.95
117_V	191_V	0.858	0.94
23_V	33_L	0.857	0.94
13_A	26_S	0.857	0.94
116_T	122_K	0.852	0.94
103_T	107_T	0.850	0.94
63_A	66_D	0.847	0.94
287_Q	290_G	0.846	0.94
13_A	27_G	0.842	0.94
37_L	41_V	0.842	0.94
236_G	239_V	0.838	0.94
19_A	23_V	0.836	0.94
86_V	106_L	0.834	0.94
271_V	280_L	0.830	0.93
293_G	296_G	0.827	0.93
73_A	278_V	0.825	0.93
38_E	42_D	0.817	0.93
26_S	272_D	0.814	0.93
18_L	21_G	0.810	0.93
187_G	191_V	0.807	0.92
34_V	40_Q	0.803	0.92
245_S	250_S	0.801	0.92
160_L	189_L	0.800	0.92
210_G	214_P	0.796	0.92
152_L	157_G	0.794	0.92
129_A	133_D	0.790	0.92
10_S	17_A	0.787	0.91
24_L	29_L	0.786	0.91
146_L	150_A	0.783	0.91
12_V	15_F	0.781	0.91
54_Q	58_L	0.779	0.91
13_A	17_A	0.779	0.91
167_G	171_V	0.778	0.91
105_A	108_D	0.775	0.91
8_V	12_V	0.773	0.91
281_V	285_A	0.772	0.91
155_R	159_L	0.772	0.91
107_T	113_V	0.771	0.91
55_N	59_Q	0.770	0.91
101_A	277_R	0.769	0.91
253_A	258_D	0.769	0.91
9_V	26_S	0.769	0.91
30_G	34_V	0.764	0.90
12_V	24_L	0.763	0.90
252_V	270_D	0.758	0.90
26_S	32_G	0.758	0.90
162_R	233_A	0.757	0.90
253_A	256_R	0.756	0.90
3_D	22_I	0.755	0.90
238_V	242_R	0.753	0.90
200_D	206_T	0.753	0.90
239_V	265_V	0.752	0.90
51_L	54_Q	0.750	0.89
20_I	24_L	0.747	0.89
115_G	195_P	0.745	0.89
241_G	245_S	0.743	0.89
131_A	188_L	0.740	0.89
270_D	276_G	0.740	0.89
29_L	37_L	0.738	0.89
19_A	41_V	0.737	0.89
130_D	134_A	0.737	0.89
32_G	38_E	0.732	0.88
20_I	33_L	0.730	0.88
33_L	38_E	0.728	0.88
12_V	26_S	0.727	0.88
132_L	188_L	0.725	0.88
200_D	203_V	0.723	0.88
15_F	37_L	0.718	0.87
27_G	37_L	0.718	0.87
166_T	173_D	0.716	0.87
302_D	305_L	0.715	0.87
7_H	17_A	0.715	0.87
156_A	159_L	0.714	0.87
36_G	39_D	0.713	0.87
139_L	182_A	0.712	0.87
54_Q	57_A	0.710	0.87
287_Q	291_G	0.707	0.86
153_G	163_A	0.703	0.86
99_V	205_V	0.699	0.86
241_G	252_V	0.699	0.86
202_V	236_G	0.697	0.86
237_A	241_G	0.695	0.86
226_L	230_L	0.694	0.85
77_V	110_G	0.694	0.85
102_V	205_V	0.694	0.85
84_R	201_L	0.691	0.85
131_A	134_A	0.689	0.85
72_V	281_V	0.687	0.85
279_A	306_P	0.680	0.84
19_A	26_S	0.679	0.84
229_G	233_A	0.676	0.84
31_G	34_V	0.674	0.84
19_A	22_I	0.670	0.83
156_A	162_R	0.667	0.83
73_A	108_D	0.665	0.83
201_L	206_T	0.664	0.83
287_Q	292_P	0.664	0.83
300_G	303_A	0.660	0.82
168_G	171_V	0.659	0.82
69_A	72_V	0.658	0.82
26_S	36_G	0.657	0.82
262_A	294_H	0.656	0.82
68_F	275_A	0.656	0.82
165_V	204_V	0.655	0.82
16_L	27_G	0.654	0.82
149_G	157_G	0.647	0.81
248_D	253_A	0.646	0.81
61_Q	66_D	0.646	0.81
217_G	225_G	0.645	0.81
177_T	181_A	0.645	0.81
26_S	270_D	0.642	0.81
269_D	306_P	0.640	0.81
101_A	105_A	0.640	0.81
53_A	56_D	0.639	0.80
123_F	222_F	0.637	0.80
69_A	274_P	0.637	0.80
158_A	229_G	0.635	0.80
4_F	10_S	0.635	0.80
109_A	113_V	0.634	0.80
291_G	299_P	0.633	0.80
72_V	78_A	0.633	0.80
227_A	265_V	0.632	0.80
6_Y	15_F	0.632	0.80
22_I	48_L	0.632	0.80
237_A	265_V	0.629	0.79
157_G	165_V	0.627	0.79
214_P	217_G	0.626	0.79
26_S	34_V	0.625	0.79
57_A	60_A	0.621	0.79
87_A	141_P	0.620	0.78
2_I	29_L	0.619	0.78
77_V	108_D	0.618	0.78
100_D	184_A	0.617	0.78
287_Q	295_Y	0.617	0.78
269_D	296_G	0.616	0.78
22_I	33_L	0.615	0.78
75_A	80_R	0.615	0.78
156_A	160_L	0.614	0.78
27_G	34_V	0.613	0.78
70_A	277_R	0.613	0.78
221_A	230_L	0.613	0.78
3_D	10_S	0.611	0.77
234_G	237_A	0.611	0.77
201_L	288_L	0.609	0.77
152_L	156_A	0.608	0.77
242_R	250_S	0.608	0.77
133_D	137_A	0.606	0.77
140_L	144_A	0.605	0.77
41_V	48_L	0.605	0.77
239_V	243_E	0.603	0.76
27_G	87_A	0.599	0.76
31_G	52_R	0.599	0.76
15_F	27_G	0.597	0.76
296_G	306_P	0.597	0.76
150_A	155_R	0.597	0.76
255_V	259_G	0.596	0.76
129_A	135_L	0.596	0.76
72_V	295_Y	0.593	0.75
23_V	28_L	0.593	0.75
245_S	252_V	0.590	0.75
276_G	281_V	0.589	0.75
132_L	153_G	0.588	0.75
42_D	46_A	0.588	0.75
50_A	56_D	0.586	0.74
203_V	206_T	0.586	0.74
22_I	28_L	0.585	0.74
3_D	28_L	0.585	0.74
87_A	117_V	0.583	0.74
157_G	161_A	0.583	0.74
287_Q	293_G	0.583	0.74
45_R	48_L	0.580	0.74
5_R	8_V	0.580	0.74
246_A	253_A	0.578	0.73
259_G	264_G	0.577	0.73
215_D	281_V	0.567	0.72
270_D	298_G	0.564	0.72
115_G	118_T	0.562	0.71
32_G	43_S	0.560	0.71
175_G	179_V	0.559	0.71
221_A	232_A	0.559	0.71
30_G	143_G	0.558	0.71
266_S	290_G	0.557	0.71
90_A	103_T	0.555	0.70
240_A	280_L	0.555	0.70
222_F	225_G	0.552	0.70
8_V	32_G	0.552	0.70
241_G	298_G	0.551	0.70
136_A	183_L	0.550	0.70
249_G	254_A	0.550	0.70
66_D	74_P	0.550	0.70
31_G	41_V	0.548	0.69
23_V	26_S	0.548	0.69
239_V	251_A	0.548	0.69
286_G	295_Y	0.546	0.69
39_D	43_S	0.544	0.69
301_A	304_L	0.543	0.69
191_V	194_G	0.543	0.69
116_T	124_V	0.541	0.68
7_H	26_S	0.540	0.68
40_Q	48_L	0.539	0.68
14_V	69_A	0.539	0.68
28_L	45_R	0.538	0.68
249_G	252_V	0.537	0.68
192_S	205_V	0.535	0.68
160_L	164_L	0.535	0.68
34_V	55_N	0.534	0.68
53_A	216_A	0.534	0.68
129_A	137_A	0.531	0.67
213_P	217_G	0.530	0.67
26_S	37_L	0.530	0.67
239_V	242_R	0.530	0.67
9_V	48_L	0.530	0.67
149_G	153_G	0.529	0.67
194_G	274_P	0.529	0.67
231_A	292_P	0.528	0.67
246_A	302_D	0.526	0.66
43_S	63_A	0.526	0.66
216_A	224_A	0.526	0.66
157_G	163_A	0.525	0.66
16_L	29_L	0.524	0.66
20_I	37_L	0.523	0.66
161_A	233_A	0.522	0.66
147_P	151_D	0.520	0.65
57_A	214_P	0.518	0.65
228_A	261_L	0.516	0.65
248_D	252_V	0.516	0.65
290_G	295_Y	0.516	0.65
99_V	114_T	0.515	0.65
11_L	261_L	0.515	0.65
192_S	197_G	0.514	0.65
3_D	77_V	0.513	0.64
50_A	79_G	0.511	0.64
238_V	280_L	0.511	0.64
129_A	146_L	0.511	0.64
154_E	158_A	0.510	0.64
122_K	125_D	0.510	0.64
301_A	305_L	0.509	0.64
133_D	151_D	0.507	0.64
96_D	118_T	0.507	0.64
265_V	292_P	0.506	0.63
243_E	246_A	0.506	0.63
263_A	294_H	0.505	0.63
159_L	165_V	0.505	0.63
238_V	243_E	0.503	0.63
105_A	280_L	0.503	0.63
129_A	158_A	0.503	0.63
261_L	264_G	0.502	0.63
56_D	60_A	0.502	0.63
166_T	172_T	0.502	0.63
119_L	197_G	0.501	0.63
18_L	25_G	0.501	0.63
91_L	94_A	0.500	0.62
243_E	247_A	0.500	0.62

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1kd8A	1	0.1144	46.6	0.947	Contact Map
2q9uA	3	0.3889	42.2	0.949	Contact Map
1e5dA	2	0.3791	40	0.949	Contact Map
4dikA	2	0.3529	39.7	0.949	Contact Map
1ycgA	5	0.366	39.6	0.95	Contact Map
4u5tA	2	0.1209	36.6	0.95	Contact Map
3zg1A	2	0.3595	33.7	0.951	Contact Map
2oqqA	3	0.1373	33.5	0.951	Contact Map
2ohhA	3	0.4412	33.2	0.951	Contact Map
3rvyA	3	0.0882	32.6	0.952	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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