GREMLIN Database
MctB - Copper transport outer membrane protein, MctB
PFAM: PF11382 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 306 (303)
Sequences: 2801 (2186)
Seq/√Len: 125.6
META: 0.794

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
106_L111_A10.4931.00
55_N58_L6.0271.00
11_L14_V4.8481.00
68_F72_V4.7551.00
48_L51_L3.2661.00
51_L55_N3.1901.00
72_V76_L3.1191.00
87_A199_A3.0211.00
7_H10_S2.8441.00
54_Q59_Q2.8391.00
62_L65_A2.7171.00
279_A305_L2.5651.00
239_V255_V2.4881.00
87_A115_G2.3981.00
132_L136_A2.3221.00
77_V281_V2.2651.00
86_V201_L2.1881.00
250_S255_V2.1871.00
77_V105_A2.1721.00
204_V227_A2.0491.00
88_V103_T2.0471.00
94_A205_V1.9941.00
7_H14_V1.9301.00
231_A287_Q1.9101.00
40_Q45_R1.9061.00
79_G82_A1.8941.00
37_L40_Q1.8621.00
153_G157_G1.8551.00
24_L28_L1.8551.00
131_A135_L1.8311.00
90_A118_T1.8271.00
102_V203_V1.8271.00
203_V280_L1.8261.00
238_V241_G1.8221.00
255_V267_T1.8221.00
142_G145_L1.8201.00
73_A105_A1.8031.00
67_A71_A1.7761.00
286_G291_G1.7731.00
102_V271_V1.7151.00
4_F9_V1.6861.00
267_T294_H1.6831.00
188_L191_V1.6621.00
251_A255_V1.6571.00
266_S287_Q1.6231.00
236_G241_G1.6141.00
44_L48_L1.6021.00
26_S29_L1.5801.00
135_L138_Q1.5741.00
3_D6_Y1.5631.00
10_S14_V1.5291.00
84_R200_D1.5081.00
87_A202_V1.5061.00
255_V261_L1.5061.00
33_L36_G1.4991.00
4_F8_V1.4981.00
251_A254_A1.4961.00
26_S30_G1.4871.00
70_A274_P1.4791.00
161_A229_G1.4641.00
6_Y10_S1.4481.00
258_D261_L1.4471.00
49_D52_R1.4431.00
58_L62_L1.4401.00
95_D98_V1.4391.00
252_V256_R1.4241.00
252_V255_V1.4141.00
266_S283_A1.4111.00
99_V103_T1.4001.00
303_A306_P1.3991.00
135_L139_L1.3961.00
49_D53_A1.3951.00
4_F7_H1.3901.00
6_Y9_V1.3881.00
68_F278_V1.3751.00
15_F18_L1.3631.00
91_L223_L1.3511.00
114_T199_A1.3411.00
96_D100_D1.3361.00
161_A230_L1.3271.00
15_F20_I1.3211.00
22_I27_G1.3111.00
193_G196_A1.3041.00
274_P277_R1.2911.00
105_A281_V1.2911.00
270_D273_T1.2771.00
65_A69_A1.2661.00
142_G146_L1.2621.00
202_V230_L1.2521.00
7_H11_L1.2511.00
89_V202_V1.2501.00
131_A136_A1.2491.00
123_F132_L1.2481.00
80_R285_A1.2451.00
104_A108_D1.2391.00
181_A185_D1.2340.99
156_A183_L1.2280.99
103_T116_T1.2280.99
100_D104_A1.2240.99
298_G301_A1.2150.99
6_Y14_V1.2080.99
106_L203_V1.2020.99
302_D306_P1.1930.99
10_S13_A1.1870.99
165_V234_G1.1870.99
85_R112_T1.1870.99
43_S47_E1.1840.99
34_V38_E1.1760.99
73_A77_V1.1730.99
132_L135_L1.1670.99
225_G229_G1.1610.99
122_K128_S1.1520.99
12_V16_L1.1470.99
14_V17_A1.1440.99
36_G40_Q1.1400.99
134_A137_A1.1390.99
11_L15_F1.1390.99
130_D133_D1.1380.99
272_D276_G1.1360.99
204_V230_L1.1340.99
50_A54_Q1.1230.99
105_A278_V1.1220.99
53_A57_A1.1100.99
34_V37_L1.1010.99
163_A179_V1.0990.99
201_L284_L1.0920.99
69_A278_V1.0910.99
59_Q63_A1.0890.99
266_S292_P1.0840.99
249_G253_A1.0770.99
116_T120_T1.0740.99
285_A289_A1.0730.99
151_D154_E1.0630.98
68_F76_L1.0620.98
21_G25_G1.0600.98
10_S15_F1.0580.98
85_R114_T1.0460.98
269_D301_A1.0450.98
98_V271_V1.0440.98
58_L61_Q1.0370.98
163_A178_A1.0360.98
2_I9_V1.0350.98
241_G250_S1.0230.98
34_V41_V1.0230.98
41_V44_L1.0200.98
297_V304_L1.0190.98
250_S253_A1.0180.98
266_S293_G1.0130.98
7_H13_A1.0110.98
219_T223_L1.0090.98
247_A250_S1.0080.98
48_L55_N1.0060.98
125_D128_S0.9990.98
46_A50_A0.9940.98
292_P295_Y0.9930.98
91_L119_L0.9920.98
134_A138_Q0.9870.98
28_L31_G0.9760.97
117_V195_P0.9670.97
249_G255_V0.9660.97
44_L47_E0.9600.97
19_A27_G0.9590.97
212_A216_A0.9580.97
268_V279_A0.9580.97
98_V101_A0.9550.97
240_A271_V0.9510.97
131_A138_Q0.9510.97
2_I16_L0.9470.97
174_G177_T0.9440.97
117_V189_L0.9390.97
223_L227_A0.9370.97
224_A228_A0.9330.97
46_A49_D0.9210.96
270_D279_A0.9150.96
255_V258_D0.9140.96
89_V226_L0.9130.96
102_V280_L0.9120.96
85_R200_D0.9080.96
184_A191_V0.9080.96
78_A82_A0.9070.96
159_L179_V0.9070.96
119_L123_F0.9050.96
47_E50_A0.8990.96
92_P118_T0.8970.96
172_T175_G0.8890.95
7_H15_F0.8870.95
2_I7_H0.8870.95
120_T123_F0.8860.95
72_V278_V0.8830.95
30_G33_L0.8810.95
242_R245_S0.8790.95
230_L237_A0.8790.95
256_R269_D0.8780.95
78_A278_V0.8770.95
90_A99_V0.8760.95
123_F156_A0.8760.95
73_A277_R0.8740.95
183_L188_L0.8730.95
279_A293_G0.8730.95
251_A256_R0.8730.95
20_I44_L0.8700.95
27_G279_A0.8690.95
117_V191_V0.8580.94
23_V33_L0.8570.94
13_A26_S0.8570.94
116_T122_K0.8520.94
103_T107_T0.8500.94
63_A66_D0.8470.94
287_Q290_G0.8460.94
13_A27_G0.8420.94
37_L41_V0.8420.94
236_G239_V0.8380.94
19_A23_V0.8360.94
86_V106_L0.8340.94
271_V280_L0.8300.93
293_G296_G0.8270.93
73_A278_V0.8250.93
38_E42_D0.8170.93
26_S272_D0.8140.93
18_L21_G0.8100.93
187_G191_V0.8070.92
34_V40_Q0.8030.92
245_S250_S0.8010.92
160_L189_L0.8000.92
210_G214_P0.7960.92
152_L157_G0.7940.92
129_A133_D0.7900.92
10_S17_A0.7870.91
24_L29_L0.7860.91
146_L150_A0.7830.91
12_V15_F0.7810.91
54_Q58_L0.7790.91
13_A17_A0.7790.91
167_G171_V0.7780.91
105_A108_D0.7750.91
8_V12_V0.7730.91
281_V285_A0.7720.91
155_R159_L0.7720.91
107_T113_V0.7710.91
55_N59_Q0.7700.91
101_A277_R0.7690.91
253_A258_D0.7690.91
9_V26_S0.7690.91
30_G34_V0.7640.90
12_V24_L0.7630.90
252_V270_D0.7580.90
26_S32_G0.7580.90
162_R233_A0.7570.90
253_A256_R0.7560.90
3_D22_I0.7550.90
238_V242_R0.7530.90
200_D206_T0.7530.90
239_V265_V0.7520.90
51_L54_Q0.7500.89
20_I24_L0.7470.89
115_G195_P0.7450.89
241_G245_S0.7430.89
131_A188_L0.7400.89
270_D276_G0.7400.89
29_L37_L0.7380.89
19_A41_V0.7370.89
130_D134_A0.7370.89
32_G38_E0.7320.88
20_I33_L0.7300.88
33_L38_E0.7280.88
12_V26_S0.7270.88
132_L188_L0.7250.88
200_D203_V0.7230.88
15_F37_L0.7180.87
27_G37_L0.7180.87
166_T173_D0.7160.87
302_D305_L0.7150.87
7_H17_A0.7150.87
156_A159_L0.7140.87
36_G39_D0.7130.87
139_L182_A0.7120.87
54_Q57_A0.7100.87
287_Q291_G0.7070.86
153_G163_A0.7030.86
99_V205_V0.6990.86
241_G252_V0.6990.86
202_V236_G0.6970.86
237_A241_G0.6950.86
226_L230_L0.6940.85
77_V110_G0.6940.85
102_V205_V0.6940.85
84_R201_L0.6910.85
131_A134_A0.6890.85
72_V281_V0.6870.85
279_A306_P0.6800.84
19_A26_S0.6790.84
229_G233_A0.6760.84
31_G34_V0.6740.84
19_A22_I0.6700.83
156_A162_R0.6670.83
73_A108_D0.6650.83
201_L206_T0.6640.83
287_Q292_P0.6640.83
300_G303_A0.6600.82
168_G171_V0.6590.82
69_A72_V0.6580.82
26_S36_G0.6570.82
262_A294_H0.6560.82
68_F275_A0.6560.82
165_V204_V0.6550.82
16_L27_G0.6540.82
149_G157_G0.6470.81
248_D253_A0.6460.81
61_Q66_D0.6460.81
217_G225_G0.6450.81
177_T181_A0.6450.81
26_S270_D0.6420.81
269_D306_P0.6400.81
101_A105_A0.6400.81
53_A56_D0.6390.80
123_F222_F0.6370.80
69_A274_P0.6370.80
158_A229_G0.6350.80
4_F10_S0.6350.80
109_A113_V0.6340.80
291_G299_P0.6330.80
72_V78_A0.6330.80
227_A265_V0.6320.80
6_Y15_F0.6320.80
22_I48_L0.6320.80
237_A265_V0.6290.79
157_G165_V0.6270.79
214_P217_G0.6260.79
26_S34_V0.6250.79
57_A60_A0.6210.79
87_A141_P0.6200.78
2_I29_L0.6190.78
77_V108_D0.6180.78
100_D184_A0.6170.78
287_Q295_Y0.6170.78
269_D296_G0.6160.78
22_I33_L0.6150.78
75_A80_R0.6150.78
156_A160_L0.6140.78
27_G34_V0.6130.78
70_A277_R0.6130.78
221_A230_L0.6130.78
3_D10_S0.6110.77
234_G237_A0.6110.77
201_L288_L0.6090.77
152_L156_A0.6080.77
242_R250_S0.6080.77
133_D137_A0.6060.77
140_L144_A0.6050.77
41_V48_L0.6050.77
239_V243_E0.6030.76
27_G87_A0.5990.76
31_G52_R0.5990.76
15_F27_G0.5970.76
296_G306_P0.5970.76
150_A155_R0.5970.76
255_V259_G0.5960.76
129_A135_L0.5960.76
72_V295_Y0.5930.75
23_V28_L0.5930.75
245_S252_V0.5900.75
276_G281_V0.5890.75
132_L153_G0.5880.75
42_D46_A0.5880.75
50_A56_D0.5860.74
203_V206_T0.5860.74
22_I28_L0.5850.74
3_D28_L0.5850.74
87_A117_V0.5830.74
157_G161_A0.5830.74
287_Q293_G0.5830.74
45_R48_L0.5800.74
5_R8_V0.5800.74
246_A253_A0.5780.73
259_G264_G0.5770.73
215_D281_V0.5670.72
270_D298_G0.5640.72
115_G118_T0.5620.71
32_G43_S0.5600.71
175_G179_V0.5590.71
221_A232_A0.5590.71
30_G143_G0.5580.71
266_S290_G0.5570.71
90_A103_T0.5550.70
240_A280_L0.5550.70
222_F225_G0.5520.70
8_V32_G0.5520.70
241_G298_G0.5510.70
136_A183_L0.5500.70
249_G254_A0.5500.70
66_D74_P0.5500.70
31_G41_V0.5480.69
23_V26_S0.5480.69
239_V251_A0.5480.69
286_G295_Y0.5460.69
39_D43_S0.5440.69
301_A304_L0.5430.69
191_V194_G0.5430.69
116_T124_V0.5410.68
7_H26_S0.5400.68
40_Q48_L0.5390.68
14_V69_A0.5390.68
28_L45_R0.5380.68
249_G252_V0.5370.68
192_S205_V0.5350.68
160_L164_L0.5350.68
34_V55_N0.5340.68
53_A216_A0.5340.68
129_A137_A0.5310.67
213_P217_G0.5300.67
26_S37_L0.5300.67
239_V242_R0.5300.67
9_V48_L0.5300.67
149_G153_G0.5290.67
194_G274_P0.5290.67
231_A292_P0.5280.67
246_A302_D0.5260.66
43_S63_A0.5260.66
216_A224_A0.5260.66
157_G163_A0.5250.66
16_L29_L0.5240.66
20_I37_L0.5230.66
161_A233_A0.5220.66
147_P151_D0.5200.65
57_A214_P0.5180.65
228_A261_L0.5160.65
248_D252_V0.5160.65
290_G295_Y0.5160.65
99_V114_T0.5150.65
11_L261_L0.5150.65
192_S197_G0.5140.65
3_D77_V0.5130.64
50_A79_G0.5110.64
238_V280_L0.5110.64
129_A146_L0.5110.64
154_E158_A0.5100.64
122_K125_D0.5100.64
301_A305_L0.5090.64
133_D151_D0.5070.64
96_D118_T0.5070.64
265_V292_P0.5060.63
243_E246_A0.5060.63
263_A294_H0.5050.63
159_L165_V0.5050.63
238_V243_E0.5030.63
105_A280_L0.5030.63
129_A158_A0.5030.63
261_L264_G0.5020.63
56_D60_A0.5020.63
166_T172_T0.5020.63
119_L197_G0.5010.63
18_L25_G0.5010.63
91_L94_A0.5000.62
243_E247_A0.5000.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1kd8A 1 0.1144 46.6 0.947 Contact Map
2q9uA 3 0.3889 42.2 0.949 Contact Map
1e5dA 2 0.3791 40 0.949 Contact Map
4dikA 2 0.3529 39.7 0.949 Contact Map
1ycgA 5 0.366 39.6 0.95 Contact Map
4u5tA 2 0.1209 36.6 0.95 Contact Map
3zg1A 2 0.3595 33.7 0.951 Contact Map
2oqqA 3 0.1373 33.5 0.951 Contact Map
2ohhA 3 0.4412 33.2 0.951 Contact Map
3rvyA 3 0.0882 32.6 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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