GREMLIN Database
DUF3185 - Protein of unknown function (DUF3185)
PFAM: PF11381 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 59 (58)
Sequences: 4292 (2826)
Seq/√Len: 371.1
META: 0.958

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
4_G58_L3.0381.00
25_F29_V2.5601.00
12_I16_I2.4731.00
8_L52_A2.2001.00
19_Y23_D2.0711.00
15_L52_A1.9611.00
7_L51_A1.9451.00
28_Q31_R1.8701.00
16_I20_N1.8311.00
43_W47_G1.6151.00
42_M46_I1.5011.00
21_A41_T1.4701.00
11_G48_G1.4581.00
22_S25_F1.3881.00
27_S37_P1.3741.00
37_P41_T1.3501.00
52_A56_L1.3491.00
13_V17_F1.3211.00
27_S38_T1.3051.00
40_K44_L1.2991.00
27_S41_T1.2901.00
15_L49_A1.2801.00
19_Y45_L1.2481.00
36_S40_K1.2021.00
49_A53_V1.1881.00
2_I6_A1.1591.00
15_L48_G1.1311.00
30_S38_T1.1271.00
41_T44_L1.0741.00
41_T45_L1.0421.00
51_A58_L1.0361.00
11_G52_A1.0151.00
29_V32_F1.0121.00
10_V50_V0.9651.00
16_I19_Y0.9271.00
28_Q32_F0.9071.00
5_I8_L0.8931.00
26_G29_V0.8611.00
20_N23_D0.8561.00
21_A40_K0.8171.00
23_D28_Q0.8101.00
24_S27_S0.7871.00
17_F42_M0.7601.00
10_V51_A0.7561.00
39_D42_M0.7551.00
47_G51_A0.7511.00
45_L49_A0.7491.00
9_V13_V0.7121.00
6_A10_V0.7110.99
27_S30_S0.7100.99
36_S41_T0.7090.99
15_L45_L0.7090.99
14_L47_G0.7060.99
31_R37_P0.7040.99
22_S45_L0.7000.99
18_G45_L0.6940.99
21_A44_L0.6930.99
22_S41_T0.6910.99
15_L19_Y0.6910.99
21_A27_S0.6830.99
7_L54_V0.6790.99
13_V49_A0.6790.99
4_G10_V0.6740.99
8_L56_L0.6710.99
23_D31_R0.6690.99
47_G54_V0.6680.99
30_S33_F0.6520.99
22_S28_Q0.6500.99
17_F44_L0.6390.99
5_I9_V0.6380.99
38_T41_T0.6250.99
14_L44_L0.6050.98
15_L43_W0.5970.98
3_I10_V0.5900.98
48_G55_G0.5860.98
50_V57_V0.5740.98
22_S42_M0.5720.98
18_G41_T0.5610.97
21_A36_S0.5590.97
46_I50_V0.5580.97
22_S37_P0.5460.97
53_V57_V0.5390.97
50_V54_V0.5380.97
23_D26_G0.5380.97
12_I35_G0.5030.95
17_F21_A0.5020.95
23_D36_S0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ayfA 2 0.9831 41.6 0.74 Contact Map
4o6yA 2 0.9661 24.2 0.77 Contact Map
3b5dA 2 0.322 11.8 0.8 Contact Map
4p79A 1 0.8644 11.1 0.803 Contact Map
3x29A 1 0.7627 10.4 0.806 Contact Map
2i68A 2 0.3051 8.8 0.812 Contact Map
3ux4A 3 0.8136 5.8 0.827 Contact Map
3c75L 1 0 5.2 0.831 Contact Map
4a2nB 1 0.9661 5.1 0.831 Contact Map
3j1zP 8 0.8305 4.9 0.832 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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