GREMLIN Database
Stealth_CR2 - Stealth protein CR2, conserved region 2
PFAM: PF11380 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 107 (103)
Sequences: 5301 (3935)
Seq/√Len: 387.7
META: 0.841

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
24_K45_R4.7501.00
26_F45_R3.2341.00
84_F90_L2.9281.00
19_A90_L2.8871.00
53_F57_Y2.7891.00
18_F93_P2.1561.00
11_S15_I2.1051.00
68_E85_N2.0731.00
28_V52_I1.9391.00
31_G48_D1.9281.00
95_K98_D1.8971.00
31_G50_K1.7491.00
29_T48_D1.6561.00
12_L27_I1.5911.00
53_F66_A1.5851.00
33_V46_I1.5661.00
54_P70_N1.5291.00
12_L16_E1.4821.00
71_L83_Y1.4661.00
61_T66_A1.4501.00
15_I22_V1.4361.00
70_N73_R1.4311.00
53_F70_N1.4161.00
26_F78_S1.4071.00
101_T104_G1.4001.00
33_V39_T1.3681.00
28_V71_L1.3621.00
94_V98_D1.3461.00
9_R13_R1.3331.00
94_V99_F1.2951.00
68_E83_Y1.2941.00
30_D48_D1.2931.00
23_R78_S1.2871.00
14_S91_G1.2841.00
19_A94_V1.2421.00
22_V82_L1.2261.00
90_L94_V1.2261.00
74_I77_L1.1911.00
30_D46_I1.1771.00
16_E43_K1.1761.00
48_D51_D1.1741.00
63_N66_A1.1471.00
6_D9_R1.1251.00
8_L27_I1.1041.00
19_A82_L1.1031.00
45_R76_G1.0861.00
9_R36_W1.0701.00
15_I84_F1.0471.00
66_A70_N1.0361.00
32_Q48_D1.0341.00
7_E11_S1.0271.00
30_D50_K1.0051.00
45_R51_D0.9941.00
12_L25_I0.9901.00
11_S14_S0.9811.00
57_Y70_N0.9801.00
27_I44_I0.9771.00
98_D101_T0.9631.00
84_F88_M0.9631.00
54_P73_R0.9551.00
14_S18_F0.9451.00
54_P57_Y0.9321.00
56_E70_N0.9311.00
26_F47_V0.9201.00
11_S84_F0.9121.00
51_D75_P0.9051.00
38_N41_H0.8891.00
77_L81_F0.8861.00
26_F76_G0.8831.00
66_A69_S0.8761.00
49_H67_I0.8691.00
14_S90_L0.8511.00
29_T32_Q0.8431.00
97_E101_T0.8411.00
22_V84_F0.8241.00
18_F91_G0.8241.00
53_F61_T0.8161.00
15_I25_I0.8111.00
49_H62_F0.8091.00
82_L99_F0.8071.00
8_L11_S0.8051.00
15_I19_A0.8011.00
49_H85_N0.8011.00
53_F56_E0.7981.00
19_A22_V0.7971.00
15_I90_L0.7961.00
80_H100_F0.7931.00
24_K43_K0.7921.00
57_Y66_A0.7721.00
32_Q49_H0.7641.00
65_H88_M0.7621.00
85_N88_M0.7581.00
7_E89_F0.7521.00
21_W96_P0.7431.00
29_T46_I0.7411.00
32_Q46_I0.7401.00
39_T42_P0.7391.00
23_R26_F0.7381.00
8_L36_W0.7361.00
79_E100_F0.7161.00
65_H68_E0.7031.00
25_I41_H0.6950.99
36_W40_D0.6900.99
39_T46_I0.6820.99
10_Y13_R0.6770.99
97_E102_P0.6720.99
22_V25_I0.6660.99
64_S83_Y0.6660.99
28_V47_V0.6560.99
6_D35_D0.6560.99
10_Y14_S0.6500.99
65_H69_S0.6380.99
53_F59_L0.6350.99
8_L12_L0.6340.99
21_W94_V0.6320.99
31_G46_I0.6290.99
49_H59_L0.6140.99
64_S68_E0.5980.98
47_V74_I0.5960.98
32_Q62_F0.5960.98
30_D49_H0.5920.98
2_F49_H0.5900.98
26_F74_I0.5880.98
80_H104_G0.5870.98
49_H88_M0.5860.98
80_H96_P0.5840.98
26_F52_I0.5760.98
13_R36_W0.5730.98
98_D102_P0.5720.98
60_P63_N0.5700.98
37_L41_H0.5620.98
61_T65_H0.5560.98
49_H52_I0.5550.98
33_V48_D0.5550.98
13_R16_E0.5450.97
27_I46_I0.5450.97
28_V74_I0.5410.97
27_I37_L0.5410.97
4_D8_L0.5390.97
33_V38_N0.5370.97
65_H83_Y0.5350.97
7_E27_I0.5330.97
21_W99_F0.5310.97
61_T67_I0.5290.97
71_L81_F0.5290.97
10_Y36_W0.5290.97
8_L13_R0.5270.97
13_R41_H0.5210.96
9_R14_S0.5190.96
7_E12_L0.5170.96
21_W95_K0.5120.96
9_R35_D0.5090.96
52_I70_N0.5030.96
33_V36_W0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1hm9A 3 0.8972 34.8 0.897 Contact Map
2ggoA 3 0.8692 25.5 0.904 Contact Map
2qh5A 1 0.8879 19 0.909 Contact Map
4fixA 3 0.9252 16.2 0.912 Contact Map
4fceA 3 0.8318 15.5 0.913 Contact Map
4g3qA 3 0.9065 15 0.913 Contact Map
4mndA 2 0.8692 14.3 0.914 Contact Map
2e3dA 3 0.8879 13.8 0.915 Contact Map
2v0hA 3 0.8879 13.7 0.915 Contact Map
4aylA 1 0.9439 12.2 0.917 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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