GREMLIN Database
DUF3181 - Protein of unknown function (DUF3181)
PFAM: PF11378 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 90 (90)
Sequences: 501 (271)
Seq/√Len: 28.6
META: 0.75

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_L36_C4.5011.00
9_G24_G3.4021.00
12_V86_I3.0981.00
16_I62_L2.8401.00
35_E57_A2.3980.99
62_L74_L2.1570.98
2_E6_A2.1460.98
48_E82_D2.0830.97
14_I74_L1.9520.96
10_E24_G1.8050.94
37_Y63_G1.8020.94
62_L67_R1.7620.93
52_R56_E1.7570.93
62_L69_L1.7280.92
20_H76_P1.7020.92
22_Y25_D1.6420.90
46_L84_E1.5720.88
46_L87_L1.5400.87
7_E11_N1.5390.87
81_V85_D1.5370.87
35_E43_G1.4830.85
31_V58_I1.4660.84
13_Y76_P1.4360.83
56_E72_A1.4130.82
67_R70_P1.3210.77
8_I18_K1.3150.77
2_E5_A1.3130.77
44_A50_A1.2830.75
61_K78_Q1.2670.74
85_D89_E1.2280.72
78_Q85_D1.2120.71
77_S85_D1.1970.70
32_L58_I1.1580.67
60_V74_L1.1450.67
49_D56_E1.1430.66
41_D50_A1.0860.62
83_L87_L1.0810.62
15_D20_H1.0750.62
32_L77_S1.0730.61
79_Q86_I1.0610.60
35_E47_S1.0560.60
3_D6_A1.0360.59
12_V51_V1.0190.57
75_I79_Q1.0150.57
59_P68_E0.9960.56
50_A84_E0.9910.55
60_V85_D0.9880.55
67_R73_D0.9650.53
37_Y76_P0.9570.53
13_Y58_I0.9510.52
66_K77_S0.9460.52
5_A63_G0.9380.51
61_K68_E0.9370.51
69_L90_Y0.9340.51
18_K37_Y0.9340.51
77_S81_V0.9270.50
5_A13_Y0.9170.49
55_L75_I0.9110.49
56_E73_D0.8790.47
26_A74_L0.8620.45
46_L51_V0.8600.45
42_Q63_G0.8550.45
32_L47_S0.8480.44
77_S80_Q0.8010.41
20_H39_L0.7960.40
63_G76_P0.7950.40
36_C58_I0.7810.39
45_S61_K0.7750.39
11_N24_G0.7740.39
2_E15_D0.7650.38
13_Y20_H0.7630.38
60_V73_D0.7600.38
36_C54_V0.7550.37
47_S50_A0.7550.37
11_N82_D0.7450.36
45_S90_Y0.7430.36
57_A66_K0.7400.36
2_E34_E0.7310.35
53_Q56_E0.7310.35
5_A42_Q0.7240.35
49_D72_A0.7090.34
39_L47_S0.7000.33
49_D52_R0.6990.33
16_I39_L0.6950.33
54_V87_L0.6910.33
50_A53_Q0.6900.33
35_E72_A0.6710.31
86_I90_Y0.6680.31
44_A52_R0.6610.31
61_K77_S0.6560.30
43_G47_S0.6560.30
66_K72_A0.6430.30
78_Q81_V0.6410.29
48_E88_E0.6400.29
36_C59_P0.6390.29
22_Y83_L0.6380.29
10_E29_H0.6370.29
17_A76_P0.6320.29
64_G74_L0.6320.29
24_G35_E0.6280.29
82_D86_I0.6240.28
86_I89_E0.6110.28
79_Q85_D0.6100.27
18_K55_L0.6070.27
12_V31_V0.5970.27
32_L43_G0.5970.27
35_E61_K0.5910.26
17_A40_L0.5850.26
55_L66_K0.5840.26
16_I67_R0.5770.25
56_E67_R0.5770.25
10_E45_S0.5740.25
70_P84_E0.5730.25
47_S75_I0.5680.25
52_R80_Q0.5670.25
48_E52_R0.5640.25
1_I89_E0.5590.24
57_A67_R0.5480.24
5_A15_D0.5460.24
22_Y69_L0.5450.24
14_I84_E0.5440.24
14_I26_A0.5370.23
40_L56_E0.5370.23
36_C57_A0.5350.23
2_E63_G0.5240.22
6_A9_G0.5220.22
37_Y40_L0.5220.22
5_A9_G0.5220.22
18_K61_K0.5180.22
13_Y61_K0.5150.22
72_A75_I0.5140.22
50_A62_L0.5050.21
2_E38_P0.5040.21
18_K26_A0.5030.21
7_E46_L0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4uelC 1 0.2222 33.7 0.91 Contact Map
3urgA 1 0.9778 27 0.915 Contact Map
1dw9A 6 0.8333 19.6 0.92 Contact Map
3kz5E 2 0.5111 15.7 0.924 Contact Map
1urjA 1 0.6556 12.6 0.927 Contact Map
2kqzA 1 0.5778 11.5 0.928 Contact Map
1k7hA 2 0.8556 8.5 0.932 Contact Map
4n4pA 3 0.9222 8 0.933 Contact Map
2qtlA 1 0.7556 7.9 0.933 Contact Map
2bkxA 1 0.6889 7.7 0.934 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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