GREMLIN Database
DUF3180 - Protein of unknown function (DUF3180)
PFAM: PF11377 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 136 (136)
Sequences: 2793 (1897)
Seq/√Len: 162.6
META: 0.702

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
112_G116_V2.9671.00
108_A112_G2.9271.00
119_L123_A2.8751.00
123_A127_W2.7841.00
109_V113_V2.6781.00
39_A124_A2.4881.00
46_A128_L2.4181.00
81_G122_V2.3071.00
50_R54_R2.2291.00
42_E125_A2.0471.00
36_L117_A2.0471.00
80_V84_V2.0261.00
65_L68_A2.0241.00
49_V62_L2.0171.00
65_L69_R1.8751.00
85_A115_A1.7971.00
46_A131_A1.7921.00
127_W131_A1.7811.00
77_S121_L1.7631.00
124_A128_L1.7631.00
49_V70_T1.7441.00
47_R51_R1.7131.00
128_L131_A1.6881.00
105_R109_V1.6871.00
16_V90_G1.6851.00
43_A47_R1.6331.00
74_A125_A1.6291.00
85_A119_L1.5791.00
99_L108_A1.5781.00
131_A134_V1.5211.00
8_A83_L1.5071.00
75_K79_L1.5031.00
42_E77_S1.4651.00
75_K129_E1.4481.00
4_A8_A1.4361.00
11_L15_L1.4291.00
55_G58_G1.4101.00
47_R131_A1.3551.00
1_L78_A1.3321.00
5_A85_A1.3071.00
77_S125_A1.3021.00
41_A45_L1.2921.00
12_G87_W1.2711.00
35_L118_A1.2671.00
53_I131_A1.2601.00
8_A12_G1.2601.00
40_V44_V1.2491.00
87_W91_V1.2321.00
42_E121_L1.2171.00
89_A115_A1.2161.00
92_L112_G1.1991.00
44_V47_R1.1581.00
55_G61_P1.1511.00
71_V79_L1.1371.00
14_L17_R1.1271.00
45_L70_T1.1251.00
78_A126_L1.1211.00
85_A118_A1.1191.00
109_V112_G1.1091.00
92_L111_A1.1041.00
12_G16_V1.0951.00
17_R20_A1.0851.00
97_G100_D1.0830.99
101_L104_A1.0750.99
32_P117_A1.0740.99
70_T74_A1.0690.99
62_L67_A1.0660.99
88_Y114_A1.0510.99
71_V78_A1.0430.99
28_P31_A1.0240.99
44_V48_P1.0140.99
99_L105_R1.0130.99
7_V11_L1.0050.99
104_A107_D1.0030.99
32_P113_V0.9920.99
28_P80_V0.9890.99
89_A92_L0.9850.99
120_A124_A0.9850.99
75_K78_A0.9820.99
68_A71_V0.9770.99
19_L23_S0.9610.99
48_P66_R0.9550.99
85_A122_V0.9460.99
92_L108_A0.9410.99
6_V9_A0.9370.99
63_D66_R0.9250.98
66_R70_T0.9240.98
67_A71_V0.9130.98
62_L70_T0.9060.98
30_T114_A0.8920.98
4_A79_L0.8910.98
126_L130_R0.8860.98
15_L18_L0.8700.98
122_V125_A0.8690.98
46_A49_V0.8680.98
71_V75_K0.8580.97
55_G60_R0.8550.97
53_I135_P0.8370.97
95_L107_D0.8350.97
43_A127_W0.8350.97
43_A124_A0.8330.97
100_D105_R0.8300.97
91_V111_A0.8190.97
81_G125_A0.8110.96
52_R128_L0.8030.96
31_A88_Y0.8010.96
21_Y107_D0.7990.96
131_A135_P0.7970.96
67_A70_T0.7960.96
85_A89_A0.7930.96
50_R131_A0.7900.96
78_A129_E0.7880.96
92_L115_A0.7770.95
84_V118_A0.7710.95
33_V37_L0.7610.95
4_A83_L0.7490.94
9_A12_G0.7470.94
9_A89_A0.7400.94
32_P114_A0.7390.94
4_A68_A0.7380.94
95_L103_A0.7280.94
59_R87_W0.7280.94
87_W90_G0.7280.94
9_A16_V0.7260.93
73_L78_A0.7080.93
116_V120_A0.7060.92
122_V126_L0.7020.92
7_V10_V0.7010.92
4_A90_G0.6990.92
79_L83_L0.6970.92
87_W129_E0.6830.91
51_R55_G0.6820.91
27_L110_A0.6820.91
82_A86_G0.6790.91
36_L40_V0.6790.91
36_L120_A0.6720.90
70_T132_C0.6700.90
98_R105_R0.6700.90
47_R50_R0.6680.90
32_P39_A0.6660.90
89_A93_L0.6620.90
74_A81_G0.6620.90
56_R59_R0.6570.89
41_A66_R0.6540.89
3_A7_V0.6470.89
96_L108_A0.6270.87
46_A127_W0.6250.87
39_A117_A0.6240.87
54_R131_A0.6240.87
21_Y25_P0.6240.87
16_V94_Y0.6230.87
68_A72_V0.6230.87
2_V5_A0.6220.87
113_V117_A0.6210.87
8_A16_V0.6200.87
9_A93_L0.6180.86
26_P106_E0.6160.86
95_L108_A0.6160.86
115_A118_A0.6160.86
32_P110_A0.6060.85
5_A9_A0.6000.85
14_L118_A0.5980.85
78_A87_W0.5950.84
76_A120_A0.5920.84
69_R73_L0.5910.84
22_G103_A0.5820.83
125_A136_P0.5800.83
13_W90_G0.5750.82
93_L112_G0.5720.82
27_L36_L0.5720.82
33_V36_L0.5690.82
15_L19_L0.5680.82
10_V14_L0.5670.81
56_R60_R0.5630.81
48_P101_L0.5630.81
32_P90_G0.5630.81
74_A77_S0.5600.81
52_R60_R0.5600.81
126_L129_E0.5580.80
16_V91_V0.5550.80
20_A24_L0.5510.80
32_P46_A0.5490.79
1_L5_A0.5480.79
45_L66_R0.5470.79
29_W33_V0.5450.79
48_P51_R0.5430.79
49_V67_A0.5420.78
131_A136_P0.5350.78
35_L84_V0.5340.77
118_A121_L0.5330.77
11_L14_L0.5330.77
104_A111_A0.5310.77
93_L113_V0.5300.77
98_R102_P0.5280.77
20_A23_S0.5250.76
2_V14_L0.5250.76
37_L40_V0.5250.76
29_W32_P0.5220.76
71_V135_P0.5180.75
49_V53_I0.5120.74
43_A131_A0.5120.74
74_A78_A0.5030.73
31_A69_R0.5010.73
94_Y97_G0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4mt1A 3 0.9118 13.7 0.916 Contact Map
4xnjA 1 0.9853 11.4 0.92 Contact Map
4k0jA 3 0.9118 8.4 0.924 Contact Map
2l2tA 2 0.3015 8 0.925 Contact Map
1pw4A 1 0.9338 7.6 0.926 Contact Map
2drnC 1 0.0882 7.1 0.927 Contact Map
3wdoA 1 0.9706 6.3 0.928 Contact Map
2gfpA 2 0.9706 6 0.929 Contact Map
2cfqA 1 0.9706 5.9 0.929 Contact Map
3ne5A 3 0.9044 5.6 0.93 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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