GREMLIN Database
DUF3179 - Protein of unknown function (DUF3179)
PFAM: PF11376 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 292 (288)
Sequences: 6315 (5087)
Seq/√Len: 299.7
META: 0.931

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
202_Y215_D4.2041.00
32_E37_A3.9561.00
75_D125_E3.3741.00
137_W144_T3.3281.00
24_D135_G3.2301.00
73_V129_S3.0181.00
36_E145_L2.8441.00
29_I71_G2.8421.00
200_K215_D2.6871.00
188_E205_S2.6591.00
24_D138_K2.6281.00
79_D122_T2.5891.00
83_L102_Q2.5161.00
30_G137_W2.4931.00
58_V75_D2.4281.00
84_T102_Q2.3341.00
194_R199_A2.3271.00
81_R102_Q2.3191.00
8_D101_R2.2601.00
30_G144_T2.2461.00
84_T101_R2.2271.00
28_V39_A2.1901.00
13_V148_S2.1881.00
26_D43_R2.1371.00
61_A76_R2.1241.00
259_G262_V2.0951.00
113_E123_R2.0841.00
76_R82_V2.0511.00
39_A137_W1.9391.00
11_K150_D1.9191.00
54_T57_G1.9101.00
216_T221_P1.8841.00
36_E56_G1.8101.00
192_G284_W1.8041.00
50_I98_M1.7891.00
97_V115_I1.7731.00
70_T110_F1.7511.00
70_T279_A1.7131.00
36_E55_V1.6901.00
92_Y108_Q1.6631.00
32_E35_G1.6501.00
156_D159_R1.6461.00
40_Y53_D1.6331.00
260_E270_Q1.6001.00
108_Q111_T1.6001.00
78_V122_T1.5901.00
216_T219_G1.5901.00
103_T119_L1.5881.00
105_S114_A1.5781.00
47_W155_R1.5691.00
33_I58_V1.5601.00
195_V220_T1.5571.00
203_P206_E1.5541.00
284_W291_T1.5541.00
39_A144_T1.5361.00
95_N109_Q1.5181.00
13_V21_Y1.5141.00
75_D127_L1.5001.00
136_E227_D1.5001.00
42_L131_T1.4931.00
259_G264_G1.4901.00
88_S106_L1.4811.00
191_L276_A1.4791.00
86_G99_Y1.4731.00
214_N223_V1.4511.00
31_V55_V1.4471.00
13_V18_A1.4471.00
206_E210_E1.4471.00
255_S261_A1.4001.00
60_V127_L1.4001.00
6_A84_T1.3921.00
38_R53_D1.3851.00
19_D134_W1.3751.00
1_K6_A1.3731.00
201_A291_T1.3691.00
12_F38_R1.3651.00
77_R82_V1.3601.00
65_C68_C1.3421.00
185_P188_E1.3361.00
50_I63_T1.3281.00
136_E139_A1.3241.00
241_G244_L1.3191.00
256_T263_S1.3151.00
14_S17_E1.3061.00
236_Y239_V1.3031.00
148_S151_T1.3001.00
21_Y149_R1.2941.00
90_L106_L1.2911.00
264_G268_G1.2851.00
59_P77_R1.2801.00
261_A264_G1.2611.00
114_A119_L1.2511.00
133_T136_E1.2461.00
6_A99_Y1.2461.00
198_E218_G1.2441.00
31_V60_V1.2441.00
281_W285_A1.2381.00
259_G263_S1.2361.00
212_V223_V1.2331.00
15_A138_K1.2321.00
55_V60_V1.2271.00
78_V81_R1.2231.00
38_R145_L1.2161.00
188_E203_P1.2141.00
78_V83_L1.2091.00
173_L177_V1.2031.00
1_K104_E1.1851.00
33_I36_E1.1831.00
63_T109_Q1.1801.00
34_N56_G1.1741.00
43_R149_R1.1741.00
237_R243_T1.1681.00
132_T140_R1.1511.00
260_E263_S1.1501.00
285_A291_T1.1231.00
14_S145_L1.1131.00
60_V73_V1.1001.00
114_A122_T1.0981.00
240_D269_E1.0941.00
87_V96_L1.0841.00
232_S235_D1.0811.00
148_S152_G1.0751.00
217_V222_V1.0751.00
177_V180_P1.0701.00
135_G139_A1.0671.00
23_D26_D1.0661.00
51_V147_L1.0621.00
22_L26_D1.0591.00
134_W146_V1.0561.00
34_N58_V1.0561.00
83_L119_L1.0521.00
239_V269_E1.0521.00
81_R119_L1.0521.00
119_L122_T1.0461.00
173_L176_P1.0341.00
241_G246_F1.0301.00
169_A173_L1.0291.00
62_V73_V1.0261.00
160_N166_D1.0211.00
15_A144_T1.0201.00
184_L190_V1.0201.00
58_V77_R1.0071.00
54_T59_P1.0041.00
50_I61_A1.0001.00
194_R288_H1.0001.00
29_I129_S0.9991.00
239_V243_T0.9961.00
160_N163_G0.9951.00
243_T246_F0.9941.00
207_L211_G0.9891.00
134_W138_K0.9881.00
37_A144_T0.9871.00
30_G39_A0.9871.00
238_R243_T0.9841.00
48_H157_Y0.9761.00
12_F145_L0.9701.00
168_S171_D0.9651.00
212_V225_V0.9651.00
59_P82_V0.9631.00
22_L134_W0.9621.00
110_F279_A0.9621.00
259_G266_L0.9581.00
105_S119_L0.9541.00
242_R245_T0.9521.00
200_K217_V0.9491.00
198_E217_V0.9431.00
227_D230_T0.9411.00
22_L43_R0.9381.00
250_A253_T0.9381.00
257_I261_A0.9371.00
175_F179_N0.9371.00
30_G37_A0.9361.00
13_V17_E0.9361.00
165_Y187_K0.9351.00
30_G132_T0.9351.00
258_D261_A0.9321.00
261_A268_G0.9301.00
191_L235_D0.9271.00
264_G267_K0.9271.00
266_L269_E0.9221.00
93_N178_P0.9171.00
6_A87_V0.9141.00
18_A21_Y0.9111.00
138_K144_T0.9041.00
207_L226_W0.9021.00
202_Y224_V0.8991.00
258_D263_S0.8971.00
214_N221_P0.8941.00
240_D243_T0.8911.00
77_R80_G0.8891.00
239_V242_R0.8861.00
257_I262_V0.8851.00
263_S267_K0.8851.00
168_S173_L0.8821.00
12_F53_D0.8811.00
258_D262_V0.8801.00
25_D231_A0.8731.00
12_F55_V0.8691.00
46_G160_N0.8681.00
244_L248_A0.8681.00
255_S266_L0.8671.00
279_A283_A0.8661.00
108_Q115_I0.8581.00
86_G101_R0.8571.00
246_F249_D0.8551.00
239_V246_F0.8541.00
12_F147_L0.8501.00
162_Y165_Y0.8501.00
97_V106_L0.8481.00
181_D285_A0.8471.00
72_I126_E0.8451.00
193_V217_V0.8441.00
257_I260_E0.8391.00
261_A266_L0.8381.00
43_R158_G0.8361.00
44_I147_L0.8301.00
100_D103_T0.8281.00
31_V127_L0.8281.00
54_T82_V0.8251.00
237_R241_G0.8251.00
94_S177_V0.8231.00
46_G66_P0.8221.00
8_D84_T0.8221.00
134_W144_T0.8221.00
243_T247_E0.8161.00
268_G271_L0.8141.00
199_A288_H0.8131.00
190_V201_A0.8031.00
250_A256_T0.8031.00
107_W114_A0.8021.00
37_A141_H0.8001.00
281_W291_T0.8001.00
238_R241_G0.7951.00
95_N283_A0.7941.00
7_I147_L0.7910.99
87_V99_Y0.7830.99
69_G189_R0.7830.99
2_D86_G0.7830.99
95_N287_F0.7820.99
73_V127_L0.7800.99
25_D135_G0.7740.99
189_R278_V0.7690.99
240_D246_F0.7680.99
7_I12_F0.7610.99
210_E213_I0.7600.99
141_H144_T0.7560.99
31_V129_S0.7550.99
76_R83_L0.7550.99
68_C95_N0.7550.99
242_R246_F0.7520.99
1_K90_L0.7520.99
239_V244_L0.7520.99
151_T155_R0.7470.99
258_D264_G0.7470.99
1_K99_Y0.7420.99
67_L91_L0.7400.99
22_L146_V0.7320.99
245_T249_D0.7250.99
61_A85_F0.7240.99
192_G199_A0.7230.99
261_A265_P0.7220.99
93_N286_A0.7210.99
18_A148_S0.7210.99
195_V198_E0.7200.99
84_T99_Y0.7180.99
173_L186_P0.7180.99
236_Y272_E0.7180.99
215_D222_V0.7140.99
260_E264_G0.7140.99
236_Y243_T0.7140.99
2_D99_Y0.7100.99
36_E60_V0.7080.99
85_F107_W0.7070.99
195_V218_G0.7060.99
36_E57_G0.7050.99
170_S187_K0.6960.99
237_R272_E0.6940.99
184_L206_E0.6930.99
222_V274_V0.6920.99
95_N110_F0.6900.99
42_L46_G0.6900.99
244_L249_D0.6900.99
194_R197_G0.6890.99
47_W156_D0.6880.99
137_W141_H0.6870.99
196_G220_T0.6840.99
226_W230_T0.6810.98
50_I96_L0.6800.98
49_E88_S0.6780.98
52_N61_A0.6760.98
105_S117_G0.6760.98
78_V119_L0.6750.98
223_V271_L0.6730.98
21_Y43_R0.6700.98
58_V76_R0.6690.98
170_S173_L0.6680.98
71_G131_T0.6640.98
245_T248_A0.6640.98
19_D138_K0.6630.98
236_Y246_F0.6630.98
202_Y213_I0.6630.98
151_T157_Y0.6610.98
74_F112_G0.6590.98
263_S266_L0.6570.98
192_G288_H0.6570.98
196_G219_G0.6550.98
220_T237_R0.6520.98
201_A281_W0.6510.98
255_S264_G0.6490.98
257_I264_G0.6490.98
92_Y106_L0.6470.98
239_V245_T0.6450.98
31_V73_V0.6450.98
184_L203_P0.6440.98
193_V222_V0.6410.98
267_K270_Q0.6390.98
220_T236_Y0.6380.98
230_T233_A0.6310.98
105_S116_V0.6300.97
55_V145_L0.6280.97
264_G271_L0.6250.97
108_Q287_F0.6240.97
231_A235_D0.6240.97
193_V202_Y0.6230.97
168_S172_P0.6190.97
33_I56_G0.6190.97
50_I66_P0.6180.97
5_P155_R0.6170.97
80_G83_L0.6170.97
92_Y95_N0.6170.97
255_S259_G0.6160.97
132_T136_E0.6150.97
92_Y97_V0.6150.97
97_V108_Q0.6130.97
175_F178_P0.6120.97
126_E275_P0.6120.97
226_W231_A0.6110.97
265_P268_G0.6100.97
32_E141_H0.6060.97
34_N57_G0.6040.97
262_V265_P0.6030.97
151_T154_S0.6010.97
126_E129_S0.5970.97
273_R276_A0.5970.97
184_L188_E0.5970.97
88_S91_L0.5970.97
14_S18_A0.5960.96
259_G267_K0.5940.96
7_I11_K0.5920.96
15_A134_W0.5910.96
116_V120_T0.5850.96
204_L278_V0.5830.96
262_V266_L0.5830.96
35_G56_G0.5820.96
211_G248_A0.5800.96
240_D244_L0.5780.96
174_L177_V0.5770.96
94_S282_F0.5750.96
29_I42_L0.5740.96
263_S268_G0.5730.96
265_P269_E0.5730.96
26_D134_W0.5720.96
204_L226_W0.5700.95
65_C96_L0.5700.95
277_H288_H0.5690.95
67_L94_S0.5690.95
260_E267_K0.5690.95
226_W233_A0.5680.95
95_N108_Q0.5680.95
53_D60_V0.5670.95
46_G163_G0.5650.95
103_T107_W0.5640.95
83_L122_T0.5630.95
206_E209_K0.5630.95
71_G129_S0.5630.95
12_F40_Y0.5620.95
110_F288_H0.5600.95
205_S208_R0.5600.95
195_V202_Y0.5570.95
202_Y222_V0.5560.95
183_R285_A0.5550.95
31_V38_R0.5550.95
66_P162_Y0.5540.95
245_T253_T0.5540.95
1_K8_D0.5530.95
46_G161_P0.5510.95
171_D187_K0.5510.95
193_V200_K0.5510.95
176_P179_N0.5450.94
196_G218_G0.5440.94
58_V127_L0.5440.94
98_M112_G0.5430.94
181_D184_L0.5400.94
33_I38_R0.5390.94
215_D224_V0.5390.94
179_N285_A0.5390.94
132_T144_T0.5380.94
221_P238_R0.5380.94
29_I73_V0.5370.94
114_A120_T0.5360.94
288_H291_T0.5350.94
272_E275_P0.5340.94
63_T96_L0.5330.94
37_A137_W0.5310.93
44_I151_T0.5300.93
106_L116_V0.5300.93
148_S153_F0.5280.93
236_Y244_L0.5280.93
224_V233_A0.5280.93
32_E36_E0.5250.93
172_P177_V0.5240.93
214_N237_R0.5220.93
279_A288_H0.5220.93
176_P180_P0.5210.93
52_N84_T0.5210.93
159_R163_G0.5190.93
91_L94_S0.5190.93
241_G245_T0.5170.93
30_G141_H0.5160.93
264_G270_Q0.5140.92
184_L285_A0.5140.92
110_F283_A0.5110.92
227_D234_L0.5080.92
239_V248_A0.5080.92
157_Y162_Y0.5070.92
238_R242_R0.5070.92
284_W288_H0.5060.92
110_F192_G0.5050.92
100_D107_W0.5050.92
255_S268_G0.5030.92
169_A177_V0.5010.91
174_L179_N0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zylA 3 0.3664 21.2 0.963 Contact Map
5amhA 1 0.3048 18 0.965 Contact Map
4qdcA 3 0.3836 16.2 0.965 Contact Map
3gkeA 3 0.3459 15.1 0.966 Contact Map
3c0dA 1 0.3185 14.9 0.966 Contact Map
4qdfB 3 0.3493 14.4 0.966 Contact Map
1o73A 1 0.4075 9.9 0.968 Contact Map
2jzaA 1 0.3288 9.3 0.969 Contact Map
3gcfA 5 0.3836 8.1 0.97 Contact Map
2bmoA 3 0.4418 6.7 0.971 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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