GREMLIN Database
DUF3176 - Protein of unknown function (DUF3176)
PFAM: PF11374 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 109 (108)
Sequences: 865 (758)
Seq/√Len: 72.9
META: 0.424

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
33_K102_D4.4391.00
2_A6_V4.0411.00
48_K66_D3.6641.00
13_P51_W3.0141.00
66_D70_R2.9321.00
13_P18_G2.6521.00
37_L95_T2.2631.00
7_Y21_L2.2491.00
19_I23_A2.1681.00
51_W65_F1.9651.00
29_S105_L1.8871.00
66_D69_S1.8731.00
19_I43_G1.7941.00
37_L98_A1.7381.00
45_S69_S1.7281.00
68_A74_G1.6811.00
71_G74_G1.6741.00
24_L28_L1.6641.00
104_F107_Q1.6300.99
20_T23_A1.5980.99
57_R61_D1.5690.99
23_A107_Q1.5300.99
52_F62_L1.4890.99
64_R81_R1.4630.99
32_A36_L1.3840.98
25_I105_L1.3830.98
29_S93_L1.3620.98
26_S103_P1.3610.98
101_F104_F1.3440.98
97_L104_F1.3000.97
7_Y13_P1.2910.97
29_S108_A1.2690.97
26_S30_T1.2560.97
8_D21_L1.2080.96
2_A5_A1.1810.96
21_L51_W1.1750.95
70_R74_G1.1720.95
67_E77_K1.1710.95
74_G79_L1.1690.95
83_R89_A1.1660.95
60_S64_R1.1600.95
27_I100_A1.1460.95
37_L40_V1.0970.93
65_F78_L1.0780.93
86_N91_G1.0730.93
102_D108_A1.0710.93
26_S34_A1.0500.92
13_P16_P1.0400.91
38_V64_R1.0350.91
21_L63_E1.0330.91
24_L54_R1.0310.91
10_K55_R1.0270.91
15_W24_L1.0220.91
17_L75_S0.9970.90
52_F63_E0.9950.90
35_A38_V0.9940.89
29_S101_F0.9920.89
37_L105_L0.9750.89
1_V6_V0.9730.88
43_G98_A0.9670.88
38_V42_E0.9600.88
39_P42_E0.9530.87
23_A80_W0.9500.87
85_R90_L0.9500.87
51_W85_R0.9470.87
1_V15_W0.9430.87
44_L95_T0.9150.85
34_A37_L0.8880.83
15_W26_S0.8780.83
26_S33_K0.8760.83
51_W61_D0.8710.82
51_W57_R0.8630.82
86_N89_A0.8500.81
39_P43_G0.8490.81
56_G93_L0.8460.80
73_W77_K0.8300.79
3_V60_S0.8270.79
45_S74_G0.8240.79
3_V24_L0.8230.78
67_E100_A0.8160.78
45_S48_K0.8120.78
10_K14_D0.7870.75
101_F107_Q0.7850.75
34_A69_S0.7740.74
34_A72_P0.7720.74
103_P106_Q0.7690.74
32_A101_F0.7660.73
46_Q70_R0.7600.73
5_A10_K0.7530.72
16_P21_L0.7470.71
1_V36_L0.7320.70
32_A94_I0.7200.69
44_L88_A0.7140.68
13_P25_I0.7100.68
45_S66_D0.7060.67
40_V75_S0.7050.67
28_L39_P0.7010.67
36_L39_P0.6990.66
41_A92_A0.6900.65
97_L108_A0.6890.65
42_E100_A0.6850.65
2_A10_K0.6820.64
77_K93_L0.6810.64
11_P14_D0.6740.64
4_L22_N0.6670.63
36_L94_I0.6630.62
59_L96_I0.6570.62
44_L66_D0.6560.61
6_V18_G0.6510.61
8_D59_L0.6450.60
1_V41_A0.6410.60
30_T33_K0.6390.59
32_A39_P0.6380.59
9_G35_A0.6360.59
35_A59_L0.6350.59
19_I76_L0.6310.58
3_V28_L0.6310.58
27_I63_E0.6270.58
4_L26_S0.6080.56
6_V10_K0.6070.56
26_S29_S0.6050.55
30_T40_V0.6030.55
11_P53_S0.6000.55
44_L50_L0.5920.54
8_D14_D0.5910.54
72_P99_L0.5910.54
71_G78_L0.5900.53
30_T62_L0.5900.53
21_L104_F0.5880.53
55_R76_L0.5850.53
25_I48_K0.5840.53
82_L93_L0.5790.52
89_A93_L0.5780.52
36_L102_D0.5760.52
13_P21_L0.5750.52
60_S95_T0.5590.50
14_D58_P0.5500.49
43_G46_Q0.5490.48
14_D83_R0.5460.48
51_W88_A0.5440.48
27_I36_L0.5380.47
62_L91_G0.5360.47
45_S100_A0.5310.46
27_I103_P0.5300.46
41_A105_L0.5290.46
10_K73_W0.5280.46
78_L83_R0.5270.46
5_A17_L0.5260.46
18_G76_L0.5230.45
68_A75_S0.5220.45
26_S59_L0.5190.45
55_R79_L0.5150.44
71_G85_R0.5090.43
79_L90_L0.5070.43
41_A69_S0.5060.43
8_D13_P0.5060.43
91_G94_I0.5050.43
25_I33_K0.5040.43
5_A8_D0.5030.43
38_V61_D0.5000.42
12_L17_L0.5000.42
18_G27_I0.5000.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4wutA 1 0.1743 3.2 0.93 Contact Map
4uqqA 3 0.4037 3 0.931 Contact Map
4v2xA 2 0.0092 2.8 0.933 Contact Map
3w3sA 2 0.3394 2 0.937 Contact Map
4p0tA 1 0.1651 1.8 0.939 Contact Map
4ldeA 1 0.4679 1.4 0.943 Contact Map
2lrgA 1 0.3394 1.3 0.943 Contact Map
3rqwA 4 0.3028 1.3 0.943 Contact Map
2dlgA 1 0.3119 1.2 0.945 Contact Map
1rh5C 1 0.2936 1.1 0.946 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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