GREMLIN Database
DUF3175 - Protein of unknown function (DUF3175)
PFAM: PF11373 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 86 (86)
Sequences: 5589 (2656)
Seq/√Len: 286.4
META: 0.964

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
5_R9_T4.2721.00
22_L27_K3.3001.00
4_A8_E3.0631.00
69_R72_V2.6001.00
26_K30_R2.5761.00
44_S48_R2.4021.00
11_D41_R2.3501.00
37_E84_F2.1551.00
26_K79_E2.1331.00
18_G21_T2.0021.00
11_D14_D1.9541.00
33_K37_E1.9021.00
30_R83_L1.8651.00
67_A71_R1.8141.00
45_T48_R1.7621.00
68_S72_V1.6251.00
79_E82_K1.5811.00
72_V75_R1.5791.00
66_P69_R1.5791.00
48_R55_T1.5751.00
34_R38_R1.5331.00
14_D41_R1.5321.00
42_R46_P1.4811.00
3_S56_F1.4791.00
33_K84_F1.4481.00
13_L32_L1.3961.00
67_A70_R1.3411.00
24_D27_K1.2601.00
19_V22_L1.2591.00
15_L19_V1.2511.00
23_K69_R1.2491.00
78_D82_K1.2191.00
16_E22_L1.2071.00
32_L54_L1.1761.00
4_A7_T1.1701.00
58_I73_L1.1601.00
4_A64_N1.0931.00
7_T57_Y1.0881.00
71_R75_R1.0651.00
31_S35_S1.0651.00
47_F81_R1.0461.00
48_R51_M1.0271.00
5_R8_E1.0211.00
75_R78_D0.9791.00
27_K30_R0.9701.00
28_I58_I0.9351.00
16_E31_S0.9221.00
26_K82_K0.9201.00
19_V31_S0.9151.00
48_R52_S0.9141.00
51_M54_L0.9101.00
13_L36_A0.8961.00
61_A65_L0.8931.00
44_S47_F0.8561.00
44_S51_M0.8561.00
51_M55_T0.8531.00
23_K68_S0.8261.00
57_Y61_A0.8100.99
79_E83_L0.7970.99
24_D28_I0.7950.99
70_R74_E0.7910.99
23_K27_K0.7860.99
28_I73_L0.7710.99
56_F61_A0.7660.99
16_E19_V0.7630.99
51_M81_R0.7500.99
12_A15_L0.7400.99
26_K83_L0.7370.99
25_P75_R0.7350.99
18_G22_L0.7180.99
58_I74_E0.7120.99
13_L42_R0.6900.98
68_S71_R0.6840.98
33_K83_L0.6770.98
34_R40_R0.6640.98
19_V35_S0.6620.98
8_E11_D0.6460.98
25_P72_V0.6420.97
7_T61_A0.6340.97
47_F55_T0.6290.97
68_S75_R0.6280.97
78_D81_R0.6190.97
47_F52_S0.6180.97
59_N62_G0.6130.97
22_L72_V0.6110.97
58_I65_L0.6080.96
17_P40_R0.6060.96
39_S42_R0.5980.96
66_P72_V0.5950.96
64_N72_V0.5930.96
33_K47_F0.5870.96
32_L51_M0.5870.96
74_E78_D0.5830.95
32_L73_L0.5710.95
63_K66_P0.5660.95
21_T64_N0.5660.95
3_S7_T0.5650.95
51_M80_L0.5640.95
31_S36_A0.5580.94
49_S53_M0.5570.94
46_P84_F0.5550.94
1_R4_A0.5540.94
61_A66_P0.5530.94
12_A39_S0.5520.94
37_E46_P0.5480.94
66_P82_K0.5470.94
74_E82_K0.5470.94
28_I74_E0.5430.93
38_R67_A0.5410.93
55_T74_E0.5360.93
56_F59_N0.5360.93
75_R79_E0.5340.93
14_D61_A0.5330.93
37_E85_G0.5320.93
83_L86_R0.5250.92
35_S39_S0.5240.92
4_A9_T0.5240.92
39_S49_S0.5200.92
57_Y64_N0.5160.92
49_S52_S0.5160.92
16_E38_R0.5150.92
50_A80_L0.5150.92
17_P21_T0.5130.91
25_P79_E0.5120.91
39_S43_K0.5100.91
10_S39_S0.5090.91
58_I61_A0.5020.91
47_F51_M0.5010.90
13_L56_F0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1mwwA 3 0.3721 21.1 0.91 Contact Map
2lt3A 1 0.6744 21.1 0.91 Contact Map
4kbmB 1 0.907 8.7 0.925 Contact Map
3uncA 2 0.3837 8 0.926 Contact Map
3gh1A 3 0.3953 7.7 0.926 Contact Map
3ku7A 2 0.1628 6.9 0.928 Contact Map
4r7pA 4 0.4767 6.7 0.928 Contact Map
3hrdD 1 0.407 6.7 0.928 Contact Map
1rm6C 1 0.4186 5.6 0.931 Contact Map
4ka7A 1 0.8721 5.5 0.931 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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