DUF3160 - PFAM28P - GREMLIN Contacts

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DUF3160 - Protein of unknown function (DUF3160)

PFAM:	PF11369	Sequences: NDEEKALLAKNGFVVVPRPYFDEFFDLYEDNRYKDLPVFVTTDSLLHAYHLSFDYLLRDLEEEYLYPDLKELLKAMLAASLAQYEALKGTELKEAARRNVAYFAVALKLLDPKPEPVPAEVKDLVEAELALIEAAEGFAPSPIFGYGRKEDYSQYKPRGHYTRSEELKRYFRAMMWYGRMTFRLALDSEEDARRQTRQALLIADALANDSEALELWDRIYEPTSFFVGESDDLTPYEYAELLDKVFGEDFDLLDLDEAKLDAFKAELAKLRPPQINGGTSVPIPPFTPEQDDEEPTKGFRFMGQRFTPDSYIFQQLVYPRVGTYTGPRMLPRGLDVMAALGSDRALEILDEELGDTEYPNYAEQLAKLREEFDALDEEDWTQNLYWSWLYALRPLLEPKGEGYPSFMQTEAWQDKELNTALASWAELRHDTILYAKQSYAEMGGGGPPPPEPPPRGYVEPNPEFYARLAALARMTREGLESRGLLDEEIKERLERLEELLEFLKEISEKELAGEPLTEEEYEFIRNFGGYLELILEGVDGWSDVSEADKKMALVADVHTDPNTGQVLEEGVGYPDLIYVVVPDPDGKLRLARGPVFSYYEFKQPMSDRLTDEEWREMLESGNAPPRPEWT	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	630 (623)
Sequences:	1917 (1626)
Seq/√Len:	65.2
META:	0.895

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
344_R	414_D	5.291	1.00
509_K	520_E	4.674	1.00
432_I	555_A	4.591	1.00
73_L	177_Y	4.015	1.00
103_F	202_I	3.959	1.00
133_E	172_R	3.734	1.00
162_T	612_E	3.472	1.00
425_A	569_E	3.391	1.00
607_D	613_E	3.385	1.00
131_L	142_P	3.275	1.00
473_R	497_E	3.267	1.00
165_E	168_K	3.146	1.00
150_E	155_Y	3.131	1.00
310_S	428_R	3.099	1.00
137_G	153_S	3.067	1.00
580_V	588_L	3.030	1.00
517_T	520_E	3.022	1.00
575_D	626_R	3.011	1.00
306_F	311_Y	2.994	1.00
128_E	152_Y	2.939	1.00
69_L	219_I	2.848	1.00
364_Q	367_K	2.774	1.00
603_Q	607_D	2.763	1.00
328_R	335_D	2.741	1.00
456_G	524_I	2.727	1.00
480_E	490_K	2.709	1.00
337_M	420_A	2.616	1.00
465_Y	507_S	2.612	1.00
156_K	613_E	2.576	1.00
110_L	173_A	2.571	1.00
438_S	558_H	2.497	1.00
62_E	164_S	2.477	1.00
44_S	527_F	2.476	1.00
337_M	417_L	2.458	1.00
150_E	179_R	2.433	1.00
50_H	430_D	2.414	1.00
130_A	134_A	2.396	1.00
31_N	38_V	2.395	1.00
504_K	508_E	2.369	1.00
502_F	520_E	2.347	1.00
155_Y	179_R	2.344	1.00
508_E	512_A	2.340	1.00
39_F	406_F	2.300	1.00
469_A	501_E	2.297	1.00
332_R	355_D	2.283	1.00
308_P	372_F	2.245	1.00
15_V	595_V	2.230	1.00
244_K	266_E	2.222	1.00
68_D	218_R	2.222	1.00
307_T	435_A	2.203	1.00
424_W	557_V	2.199	1.00
175_M	304_Q	2.187	1.00
388_W	423_S	2.179	1.00
7_L	11_N	2.177	1.00
502_F	523_F	2.137	1.00
505_E	520_E	2.124	1.00
598_Y	627_P	2.122	1.00
310_S	438_S	2.116	1.00
266_E	269_K	2.107	1.00
7_L	10_K	2.092	1.00
466_A	504_K	2.073	1.00
74_K	107_L	2.058	1.00
122_K	126_E	2.050	1.00
231_D	436_K	2.044	1.00
422_A	596_F	2.030	1.00
135_A	156_K	2.026	1.00
360_N	363_E	2.024	1.00
425_A	553_L	2.020	1.00
54_D	160_H	2.012	1.00
476_R	497_E	2.010	1.00
58_R	163_R	2.003	1.00
557_V	569_E	1.981	1.00
232_D	300_R	1.972	1.00
66_Y	166_E	1.941	1.00
333_G	598_Y	1.931	1.00
581_V	591_A	1.928	1.00
311_Y	371_E	1.922	1.00
168_K	172_R	1.903	1.00
469_A	504_K	1.894	1.00
476_R	494_E	1.887	1.00
226_F	384_L	1.884	1.00
154_Q	439_Y	1.883	1.00
560_D	563_T	1.857	1.00
509_K	514_E	1.842	1.00
129_L	133_E	1.814	1.00
6_A	10_K	1.809	1.00
49_Y	475_T	1.799	1.00
346_L	369_R	1.796	1.00
179_R	439_Y	1.786	1.00
79_A	82_A	1.779	1.00
471_L	475_T	1.770	1.00
28_Y	44_S	1.763	1.00
462_P	507_S	1.760	1.00
89_G	93_K	1.760	1.00
234_T	237_E	1.760	1.00
259_K	262_A	1.756	1.00
106_A	109_L	1.754	1.00
99_N	198_Q	1.748	1.00
506_I	523_F	1.743	1.00
157_P	168_K	1.743	1.00
77_L	107_L	1.733	1.00
154_Q	175_M	1.717	0.99
390_Y	467_R	1.705	0.99
506_I	516_L	1.702	0.99
333_G	424_W	1.701	0.99
129_L	132_I	1.693	0.99
72_L	301_F	1.674	0.99
220_Y	223_T	1.650	0.99
571_V	596_F	1.649	0.99
333_G	421_L	1.644	0.99
42_T	461_N	1.614	0.99
339_A	365_L	1.609	0.99
317_V	438_S	1.608	0.99
73_L	103_F	1.599	0.99
141_S	152_Y	1.587	0.99
576_L	592_R	1.584	0.99
376_D	379_D	1.581	0.99
128_E	141_S	1.568	0.99
338_A	365_L	1.568	0.99
574_P	594_P	1.562	0.99
529_G	533_L	1.546	0.99
566_V	605_M	1.543	0.99
76_M	103_F	1.531	0.99
158_R	556_D	1.529	0.99
126_E	130_A	1.528	0.99
407_M	510_E	1.525	0.99
106_A	173_A	1.523	0.99
440_A	558_H	1.517	0.99
557_V	567_L	1.510	0.99
394_P	467_R	1.505	0.99
154_Q	179_R	1.499	0.99
97_R	121_V	1.494	0.99
73_L	106_A	1.493	0.99
603_Q	609_L	1.480	0.98
196_T	238_Y	1.480	0.98
183_R	195_Q	1.477	0.98
68_D	215_L	1.477	0.98
69_L	110_L	1.468	0.98
583_D	589_R	1.468	0.98
80_S	103_F	1.458	0.98
333_G	425_A	1.456	0.98
555_A	568_E	1.455	0.98
163_R	168_K	1.452	0.98
346_L	365_L	1.451	0.98
407_M	511_L	1.448	0.98
29_E	33_Y	1.447	0.98
237_E	271_R	1.444	0.98
551_M	574_P	1.444	0.98
575_D	597_S	1.438	0.98
49_Y	471_L	1.435	0.98
330_L	602_K	1.434	0.98
73_L	107_L	1.428	0.98
315_Q	364_Q	1.422	0.98
80_S	99_N	1.421	0.98
200_L	242_L	1.419	0.98
337_M	396_L	1.416	0.98
79_A	209_D	1.415	0.98
196_T	199_A	1.415	0.98
75_A	209_D	1.414	0.98
505_E	508_E	1.410	0.98
425_A	554_V	1.404	0.98
392_L	423_S	1.399	0.98
225_F	478_G	1.398	0.98
165_E	169_R	1.394	0.98
390_Y	393_R	1.389	0.98
310_S	558_H	1.388	0.98
75_A	212_A	1.387	0.98
101_A	143_I	1.384	0.98
404_P	407_M	1.381	0.98
313_F	557_V	1.378	0.97
127_A	131_L	1.371	0.97
468_L	500_L	1.362	0.97
348_I	414_D	1.358	0.97
131_L	139_A	1.341	0.97
583_D	587_K	1.340	0.97
441_E	444_G	1.338	0.97
192_A	196_T	1.338	0.97
569_E	598_Y	1.336	0.97
227_V	431_T	1.335	0.97
581_V	589_R	1.333	0.97
553_L	570_G	1.329	0.97
323_T	327_P	1.329	0.97
383_N	386_W	1.327	0.97
263_F	267_L	1.322	0.97
442_M	529_G	1.321	0.97
53_F	431_T	1.317	0.97
53_F	57_L	1.316	0.97
181_T	298_G	1.308	0.97
317_V	440_A	1.305	0.96
618_L	623_A	1.304	0.96
154_Q	437_Q	1.301	0.96
28_Y	41_T	1.297	0.96
307_T	310_S	1.296	0.96
81_L	100_V	1.295	0.96
603_Q	613_E	1.294	0.96
400_G	403_Y	1.289	0.96
256_D	259_K	1.289	0.96
499_L	523_F	1.288	0.96
66_Y	70_K	1.282	0.96
77_L	100_V	1.276	0.96
39_F	579_V	1.257	0.96
230_S	234_T	1.255	0.96
223_T	302_M	1.252	0.96
424_W	428_R	1.245	0.95
315_Q	320_R	1.245	0.95
505_E	509_K	1.244	0.95
312_I	339_A	1.241	0.95
100_V	104_A	1.240	0.95
206_L	235_P	1.236	0.95
4_E	14_V	1.235	0.95
518_E	522_E	1.235	0.95
424_W	569_E	1.230	0.95
609_L	617_M	1.229	0.95
521_Y	524_I	1.228	0.95
98_R	198_Q	1.226	0.95
50_H	53_F	1.222	0.95
42_T	464_F	1.214	0.95
38_V	592_R	1.213	0.95
56_L	226_F	1.213	0.95
83_Q	205_A	1.210	0.95
199_A	202_I	1.204	0.94
227_V	383_N	1.200	0.94
321_V	364_Q	1.198	0.94
72_L	215_L	1.194	0.94
307_T	428_R	1.186	0.94
39_F	412_W	1.183	0.94
73_L	173_A	1.183	0.94
77_L	104_A	1.181	0.94
458_V	503_L	1.180	0.94
395_L	464_F	1.179	0.94
473_R	501_E	1.178	0.94
360_N	364_Q	1.174	0.94
200_L	263_F	1.174	0.94
100_V	120_E	1.173	0.94
71_E	215_L	1.168	0.94
174_M	302_M	1.167	0.94
318_Y	321_V	1.156	0.93
347_E	351_E	1.151	0.93
425_A	598_Y	1.148	0.93
11_N	411_A	1.146	0.93
344_R	347_E	1.145	0.93
487_E	490_K	1.142	0.93
217_D	221_E	1.139	0.93
462_P	465_Y	1.138	0.93
231_D	303_G	1.131	0.92
554_V	569_E	1.130	0.92
366_A	369_R	1.129	0.92
123_D	127_A	1.129	0.92
281_V	285_P	1.125	0.92
102_Y	301_F	1.117	0.92
582_P	588_L	1.116	0.92
565_Q	602_K	1.115	0.92
522_E	525_R	1.114	0.92
111_D	114_P	1.108	0.92
238_Y	298_G	1.107	0.92
523_F	530_Y	1.106	0.92
4_E	16_V	1.103	0.91
330_L	558_H	1.102	0.91
365_L	369_R	1.101	0.91
232_D	436_K	1.099	0.91
466_A	508_E	1.095	0.91
220_Y	302_M	1.092	0.91
199_A	203_A	1.091	0.91
73_L	80_S	1.089	0.91
317_V	558_H	1.088	0.91
404_P	511_L	1.087	0.91
272_P	297_K	1.087	0.91
46_L	464_F	1.086	0.91
350_D	356_T	1.085	0.91
458_V	528_G	1.082	0.91
469_A	500_L	1.082	0.91
234_T	299_F	1.080	0.91
192_A	195_Q	1.080	0.91
283_I	286_F	1.079	0.91
97_R	124_L	1.078	0.90
227_V	307_T	1.077	0.90
150_E	180_M	1.069	0.90
443_G	446_G	1.060	0.90
530_Y	533_L	1.058	0.90
140_P	149_K	1.049	0.89
184_L	267_L	1.047	0.89
608_R	611_D	1.044	0.89
104_A	118_P	1.038	0.89
80_S	100_V	1.037	0.89
379_D	386_W	1.036	0.89
286_F	289_E	1.031	0.88
330_L	565_Q	1.030	0.88
31_N	36_L	1.024	0.88
97_R	120_E	1.022	0.88
74_K	78_A	1.019	0.88
103_F	177_Y	1.019	0.88
428_R	558_H	1.019	0.88
251_D	254_D	1.018	0.88
405_S	408_Q	1.018	0.88
284_P	287_T	1.015	0.88
314_Q	320_R	1.013	0.88
185_A	188_S	1.008	0.87
66_Y	169_R	1.008	0.87
24_F	574_P	1.002	0.87
271_R	274_Q	1.001	0.87
568_E	603_Q	1.001	0.87
30_D	34_K	1.000	0.87
76_M	301_F	0.999	0.87
98_R	194_R	0.992	0.86
503_L	528_G	0.988	0.86
46_L	423_S	0.985	0.86
64_Y	484_L	0.985	0.86
45_L	500_L	0.984	0.86
213_L	217_D	0.984	0.86
186_L	190_E	0.984	0.86
8_L	14_V	0.982	0.86
178_G	303_G	0.979	0.86
280_S	284_P	0.979	0.86
282_P	285_P	0.978	0.86
24_F	44_S	0.978	0.86
343_D	369_R	0.977	0.86
304_Q	434_Y	0.976	0.86
70_K	111_D	0.974	0.85
337_M	340_L	0.971	0.85
331_P	558_H	0.969	0.85
154_Q	559_T	0.969	0.85
578_Y	590_L	0.968	0.85
494_E	498_E	0.968	0.85
54_D	555_A	0.967	0.85
241_L	267_L	0.967	0.85
108_K	111_D	0.964	0.85
401_E	408_Q	0.964	0.85
573_Y	618_L	0.963	0.85
342_S	396_L	0.960	0.85
5_K	9_A	0.958	0.84
8_L	580_V	0.957	0.84
222_P	484_L	0.956	0.84
178_G	431_T	0.954	0.84
315_Q	368_L	0.952	0.84
128_E	131_L	0.952	0.84
285_P	289_E	0.944	0.84
559_T	608_R	0.943	0.83
560_D	565_Q	0.941	0.83
428_R	557_V	0.940	0.83
556_D	559_T	0.939	0.83
437_Q	556_D	0.937	0.83
40_V	527_F	0.936	0.83
312_I	336_V	0.936	0.83
325_T	357_E	0.935	0.83
57_L	160_H	0.934	0.83
31_N	592_R	0.934	0.83
62_E	163_R	0.933	0.83
237_E	240_E	0.931	0.83
241_L	263_F	0.930	0.83
399_K	403_Y	0.928	0.83
95_A	198_Q	0.927	0.82
103_F	301_F	0.927	0.82
4_E	19_P	0.925	0.82
158_R	437_Q	0.919	0.82
564_G	605_M	0.918	0.82
282_P	286_F	0.918	0.82
354_G	357_E	0.917	0.82
231_D	310_S	0.915	0.82
156_K	607_D	0.913	0.81
11_N	14_V	0.912	0.81
616_E	620_S	0.911	0.81
551_M	571_V	0.910	0.81
101_A	124_L	0.909	0.81
418_N	626_R	0.908	0.81
100_V	121_V	0.907	0.81
27_L	594_P	0.906	0.81
339_A	368_L	0.905	0.81
195_Q	199_A	0.903	0.81
252_L	255_L	0.902	0.81
335_D	361_Y	0.902	0.81
519_E	522_E	0.900	0.81
333_G	557_V	0.899	0.80
407_M	465_Y	0.898	0.80
416_E	461_N	0.897	0.80
384_L	475_T	0.897	0.80
428_R	438_S	0.896	0.80
67_P	166_E	0.895	0.80
541_W	544_V	0.894	0.80
240_E	244_K	0.892	0.80
469_A	497_E	0.892	0.80
162_T	168_K	0.888	0.80
350_D	365_L	0.887	0.80
572_G	599_Y	0.887	0.80
577_I	595_V	0.886	0.79
548_D	615_R	0.883	0.79
178_G	304_Q	0.881	0.79
242_L	263_F	0.880	0.79
324_Y	327_P	0.880	0.79
509_K	517_T	0.879	0.79
220_Y	224_S	0.879	0.79
158_R	433_L	0.878	0.79
96_A	99_N	0.877	0.79
222_P	227_V	0.877	0.79
193_R	261_D	0.877	0.79
464_F	468_L	0.877	0.79
461_N	465_Y	0.877	0.79
420_A	461_N	0.876	0.79
72_L	219_I	0.874	0.79
217_D	236_Y	0.873	0.78
437_Q	559_T	0.871	0.78
387_S	474_M	0.870	0.78
156_K	172_R	0.869	0.78
426_E	596_F	0.869	0.78
344_R	413_Q	0.869	0.78
314_Q	317_V	0.865	0.78
311_Y	368_L	0.863	0.78
570_G	573_Y	0.860	0.77
477_E	481_S	0.859	0.77
229_E	382_Q	0.858	0.77
70_K	74_K	0.858	0.77
339_A	372_F	0.856	0.77
332_R	602_K	0.854	0.77
572_G	597_S	0.852	0.77
322_G	327_P	0.850	0.77
230_S	303_G	0.850	0.77
45_L	465_Y	0.850	0.77
429_H	611_D	0.849	0.77
101_A	121_V	0.848	0.76
151_D	154_Q	0.846	0.76
323_T	360_N	0.844	0.76
552_A	573_Y	0.844	0.76
456_G	521_Y	0.836	0.75
107_L	112_P	0.831	0.75
394_P	464_F	0.830	0.75
346_L	356_T	0.830	0.75
578_Y	592_R	0.830	0.75
53_F	227_V	0.827	0.75
68_D	71_E	0.826	0.75
105_V	176_W	0.825	0.74
127_A	130_A	0.825	0.74
483_G	514_E	0.824	0.74
54_D	430_D	0.824	0.74
79_A	83_Q	0.824	0.74
568_E	605_M	0.823	0.74
108_K	114_P	0.823	0.74
316_L	361_Y	0.821	0.74
437_Q	608_R	0.821	0.74
490_K	494_E	0.820	0.74
24_F	551_M	0.819	0.74
625_P	628_E	0.819	0.74
516_L	521_Y	0.818	0.74
136_E	139_A	0.818	0.74
406_F	460_P	0.816	0.74
330_L	560_D	0.815	0.74
84_Y	97_R	0.813	0.73
578_Y	594_P	0.812	0.73
69_L	173_A	0.812	0.73
245_V	266_E	0.812	0.73
66_Y	110_L	0.811	0.73
329_M	560_D	0.810	0.73
556_D	608_R	0.809	0.73
333_G	569_E	0.808	0.73
76_M	202_I	0.808	0.73
194_R	199_A	0.806	0.73
186_L	189_E	0.806	0.73
352_E	355_D	0.805	0.73
501_E	504_K	0.804	0.73
70_K	107_L	0.803	0.72
411_A	414_D	0.801	0.72
196_T	200_L	0.801	0.72
547_A	615_R	0.800	0.72
287_T	291_D	0.799	0.72
427_L	430_D	0.798	0.72
122_K	125_V	0.797	0.72
550_K	573_Y	0.796	0.72
264_K	267_L	0.795	0.72
366_A	370_E	0.795	0.72
142_P	152_Y	0.795	0.72
338_A	361_Y	0.794	0.72
462_P	466_A	0.792	0.71
118_P	121_V	0.792	0.71
11_N	15_V	0.791	0.71
457_Y	510_E	0.790	0.71
171_F	433_L	0.789	0.71
193_R	264_K	0.788	0.71
24_F	27_L	0.787	0.71
57_L	434_Y	0.785	0.71
504_K	507_S	0.784	0.71
280_S	283_I	0.783	0.71
265_A	268_A	0.783	0.71
415_K	419_T	0.783	0.71
502_F	505_E	0.782	0.70
184_L	196_T	0.782	0.70
124_L	143_I	0.781	0.70
603_Q	617_M	0.780	0.70
117_V	125_V	0.779	0.70
193_R	257_E	0.779	0.70
502_F	506_I	0.778	0.70
573_Y	619_E	0.776	0.70
245_V	259_K	0.776	0.70
403_Y	407_M	0.775	0.70
566_V	603_Q	0.771	0.69
15_V	414_D	0.770	0.69
474_M	478_G	0.770	0.69
469_A	473_R	0.768	0.69
91_E	197_R	0.767	0.69
134_A	446_G	0.767	0.69
318_Y	322_G	0.767	0.69
472_A	497_E	0.766	0.69
65_L	226_F	0.765	0.69
174_M	305_R	0.761	0.68
191_D	194_R	0.761	0.68
476_R	490_K	0.761	0.68
433_L	436_K	0.760	0.68
101_A	125_V	0.759	0.68
59_D	489_I	0.758	0.68
323_T	359_P	0.757	0.68
421_L	598_Y	0.750	0.67
430_D	555_A	0.748	0.67
539_D	543_D	0.748	0.67
107_L	114_P	0.747	0.67
193_R	197_R	0.746	0.67
53_F	430_D	0.746	0.67
69_L	174_M	0.744	0.67
328_R	361_Y	0.742	0.66
129_L	172_R	0.742	0.66
466_A	474_M	0.740	0.66
342_S	420_A	0.739	0.66
396_L	420_A	0.735	0.66
95_A	99_N	0.731	0.65
338_A	346_L	0.730	0.65
400_G	408_Q	0.727	0.65
429_H	433_L	0.727	0.65
261_D	264_K	0.726	0.65
503_L	507_S	0.725	0.65
538_V	541_W	0.724	0.64
506_I	510_E	0.724	0.64
332_R	352_E	0.723	0.64
179_R	304_Q	0.723	0.64
55_Y	59_D	0.723	0.64
308_P	386_W	0.722	0.64
158_R	171_F	0.721	0.64
601_F	604_P	0.719	0.64
309_D	385_Y	0.717	0.64
534_I	537_G	0.717	0.64
94_E	97_R	0.717	0.64
223_T	227_V	0.717	0.64
174_M	231_D	0.715	0.63
391_A	394_P	0.715	0.63
461_N	464_F	0.715	0.63
187_D	191_D	0.713	0.63
131_L	141_S	0.712	0.63
51_L	55_Y	0.712	0.63
153_S	559_T	0.712	0.63
203_A	239_A	0.711	0.63
135_A	386_W	0.710	0.63
194_R	198_Q	0.709	0.63
197_R	206_L	0.708	0.63
175_M	179_R	0.707	0.63
331_P	361_Y	0.703	0.62
537_G	540_G	0.703	0.62
155_Y	180_M	0.700	0.62
55_Y	58_R	0.699	0.62
154_Q	556_D	0.699	0.62
441_E	445_G	0.698	0.62
25_F	31_N	0.698	0.62
95_A	197_R	0.698	0.62
4_E	18_R	0.697	0.62
609_L	613_E	0.695	0.61
85_E	90_T	0.692	0.61
196_T	264_K	0.692	0.61
211_E	214_E	0.691	0.61
106_A	177_Y	0.691	0.61
427_L	431_T	0.691	0.61
121_V	125_V	0.691	0.61
321_V	360_N	0.690	0.61
410_E	413_Q	0.689	0.61
210_S	514_E	0.687	0.60
334_L	380_W	0.686	0.60
348_I	598_Y	0.686	0.60
62_E	166_E	0.684	0.60
370_E	374_A	0.683	0.60
162_T	555_A	0.682	0.60
185_A	190_E	0.679	0.60
342_S	345_A	0.679	0.60
138_F	561_P	0.677	0.59
213_L	236_Y	0.676	0.59
455_R	521_Y	0.675	0.59
210_S	213_L	0.675	0.59
382_Q	386_W	0.675	0.59
70_K	169_R	0.674	0.59
82_A	86_A	0.673	0.59
472_A	500_L	0.672	0.59
214_E	258_A	0.672	0.59
101_A	141_S	0.671	0.59
22_D	550_K	0.671	0.59
199_A	238_Y	0.671	0.59
50_H	54_D	0.669	0.58
80_S	83_Q	0.668	0.58
119_A	122_K	0.667	0.58
233_L	237_E	0.665	0.58
175_M	437_Q	0.665	0.58
287_T	290_Q	0.664	0.58
458_V	510_E	0.663	0.58
109_L	172_R	0.662	0.58
199_A	206_L	0.661	0.57
250_F	255_L	0.661	0.57
217_D	495_R	0.660	0.57
441_E	447_P	0.659	0.57
39_F	47_H	0.659	0.57
81_L	85_E	0.659	0.57
456_G	527_F	0.659	0.57
257_E	261_D	0.657	0.57
174_M	303_G	0.657	0.57
387_S	471_L	0.657	0.57
94_E	194_R	0.655	0.57
197_R	260_L	0.655	0.57
75_A	215_L	0.655	0.57
462_P	504_K	0.654	0.57
559_T	566_V	0.654	0.57
153_S	437_Q	0.653	0.57
507_S	628_E	0.653	0.57
72_L	212_A	0.653	0.57
90_T	93_K	0.652	0.56
80_S	96_A	0.652	0.56
163_R	612_E	0.652	0.56
332_R	569_E	0.652	0.56
170_Y	434_Y	0.651	0.56
24_F	47_H	0.651	0.56
311_Y	315_Q	0.651	0.56
71_E	130_A	0.650	0.56
38_V	456_G	0.650	0.56
101_A	128_E	0.650	0.56
64_Y	68_D	0.650	0.56
14_V	112_P	0.646	0.56
403_Y	511_L	0.646	0.56
126_E	483_G	0.645	0.56
344_R	348_I	0.644	0.56
174_M	178_G	0.643	0.55
552_A	574_P	0.643	0.55
174_M	304_Q	0.642	0.55
426_E	431_T	0.642	0.55
321_V	328_R	0.641	0.55
158_R	432_I	0.641	0.55
102_Y	106_A	0.641	0.55
42_T	416_E	0.641	0.55
160_H	430_D	0.640	0.55
340_L	420_A	0.639	0.55
159_G	432_I	0.639	0.55
136_E	401_E	0.637	0.55
203_A	206_L	0.637	0.55
106_A	176_W	0.636	0.55
433_L	556_D	0.635	0.54
607_D	617_M	0.634	0.54
232_D	275_I	0.634	0.54
617_M	623_A	0.634	0.54
275_I	436_K	0.632	0.54
232_D	568_E	0.631	0.54
302_M	305_R	0.630	0.54
307_T	385_Y	0.628	0.54
29_E	32_R	0.627	0.54
526_N	530_Y	0.627	0.54
394_P	463_E	0.626	0.53
62_E	167_L	0.626	0.53
331_P	440_A	0.625	0.53
307_T	312_I	0.625	0.53
425_A	555_A	0.624	0.53
431_T	434_Y	0.624	0.53
72_L	206_L	0.623	0.53
46_L	388_W	0.622	0.53
216_W	431_T	0.620	0.53
350_D	362_A	0.619	0.53
528_G	532_E	0.619	0.53
154_Q	178_G	0.618	0.52
388_W	392_L	0.618	0.52
234_T	626_R	0.618	0.52
196_T	233_L	0.618	0.52
428_R	432_I	0.617	0.52
370_E	373_D	0.616	0.52
163_R	547_A	0.616	0.52
475_T	493_L	0.616	0.52
49_Y	468_L	0.615	0.52
258_A	261_D	0.615	0.52
24_F	596_F	0.613	0.52
221_E	482_R	0.613	0.52
374_A	498_E	0.612	0.52
178_G	300_R	0.612	0.52
4_E	7_L	0.610	0.52
399_K	416_E	0.609	0.51
487_E	621_G	0.608	0.51
313_F	336_V	0.607	0.51
170_Y	421_L	0.607	0.51
139_A	149_K	0.607	0.51
191_D	195_Q	0.607	0.51
233_L	238_Y	0.606	0.51
305_R	433_L	0.605	0.51
621_G	624_P	0.604	0.51
27_L	592_R	0.604	0.51
27_L	31_N	0.603	0.51
280_S	285_P	0.603	0.51
419_T	517_T	0.603	0.51
574_P	589_R	0.603	0.51
153_S	554_V	0.602	0.51
77_L	81_L	0.601	0.50
57_L	227_V	0.601	0.50
511_L	528_G	0.600	0.50
108_K	129_L	0.599	0.50
480_E	483_G	0.599	0.50
86_A	258_A	0.598	0.50
142_P	145_G	0.597	0.50
178_G	436_K	0.597	0.50
60_L	66_Y	0.596	0.50
540_G	543_D	0.596	0.50
160_H	434_Y	0.595	0.50
470_A	474_M	0.595	0.50
23_E	29_E	0.595	0.50
593_G	600_E	0.594	0.50
171_F	556_D	0.594	0.50
158_R	305_R	0.594	0.50
442_M	447_P	0.594	0.50
8_L	29_E	0.594	0.50
386_W	474_M	0.593	0.50
16_V	19_P	0.593	0.50
158_R	434_Y	0.592	0.49
209_D	212_A	0.591	0.49
270_L	275_I	0.591	0.49
432_I	568_E	0.589	0.49
330_L	563_T	0.589	0.49
323_T	326_G	0.588	0.49
178_G	231_D	0.587	0.49
196_T	203_A	0.586	0.49
576_L	594_P	0.585	0.49
54_D	58_R	0.585	0.49
307_T	431_T	0.585	0.49
50_H	436_K	0.585	0.49
309_D	429_H	0.585	0.49
466_A	507_S	0.585	0.49
120_E	124_L	0.585	0.49
262_A	266_E	0.584	0.49
53_F	615_R	0.584	0.49
340_L	389_L	0.584	0.49
447_P	454_P	0.583	0.48
78_A	82_A	0.581	0.48
419_T	462_P	0.581	0.48
535_L	540_G	0.581	0.48
560_D	567_L	0.580	0.48
18_R	576_L	0.579	0.48
343_D	346_L	0.579	0.48
158_R	608_R	0.579	0.48
285_P	290_Q	0.578	0.48
281_V	284_P	0.578	0.48
566_V	606_S	0.577	0.48
79_A	103_F	0.577	0.48
154_Q	608_R	0.575	0.47
430_D	434_Y	0.574	0.47
415_K	456_G	0.573	0.47
108_K	117_V	0.573	0.47
426_E	510_E	0.572	0.47
391_A	468_L	0.572	0.47
381_T	474_M	0.571	0.47
176_W	412_W	0.570	0.47
227_V	435_A	0.570	0.47
83_Q	204_D	0.570	0.47
583_D	591_A	0.570	0.47
154_Q	304_Q	0.570	0.47
303_G	309_D	0.569	0.47
129_L	135_A	0.568	0.47
444_G	447_P	0.568	0.47
580_V	590_L	0.568	0.47
244_K	265_A	0.568	0.47
428_R	435_A	0.567	0.47
200_L	487_E	0.567	0.47
47_H	426_E	0.567	0.47
610_T	613_E	0.566	0.46
404_P	528_G	0.565	0.46
33_Y	443_G	0.565	0.46
312_I	316_L	0.565	0.46
72_L	479_L	0.564	0.46
436_K	608_R	0.564	0.46
440_A	562_N	0.564	0.46
428_R	440_A	0.564	0.46
202_I	205_A	0.563	0.46
87_L	90_T	0.562	0.46
326_G	357_E	0.562	0.46
388_W	427_L	0.562	0.46
369_R	373_D	0.561	0.46
418_N	464_F	0.561	0.46
50_H	160_H	0.561	0.46
387_S	470_A	0.561	0.46
61_E	161_Y	0.559	0.46
379_D	382_Q	0.559	0.46
457_Y	511_L	0.558	0.45
306_F	434_Y	0.558	0.45
42_T	415_K	0.558	0.45
84_Y	100_V	0.558	0.45
285_P	288_P	0.557	0.45
289_E	292_D	0.557	0.45
210_S	214_E	0.556	0.45
50_H	429_H	0.554	0.45
214_E	218_R	0.554	0.45
597_S	626_R	0.554	0.45
90_T	96_A	0.554	0.45
309_D	437_Q	0.553	0.45
63_E	486_D	0.553	0.45
158_R	175_M	0.553	0.45
154_Q	158_R	0.553	0.45
107_L	111_D	0.552	0.45
212_A	215_L	0.552	0.45
134_A	169_R	0.552	0.45
220_Y	230_S	0.552	0.45
29_E	441_E	0.552	0.45
350_D	357_E	0.551	0.45
385_Y	427_L	0.551	0.45
122_K	590_L	0.550	0.45
98_R	102_Y	0.550	0.45
443_G	447_P	0.550	0.45
424_W	598_Y	0.548	0.44
313_F	424_W	0.547	0.44
175_M	439_Y	0.547	0.44
184_L	238_Y	0.547	0.44
599_Y	624_P	0.547	0.44
535_L	538_V	0.546	0.44
561_P	585_D	0.546	0.44
17_P	575_D	0.546	0.44
375_L	382_Q	0.546	0.44
146_Y	195_Q	0.546	0.44
372_F	574_P	0.546	0.44
158_R	429_H	0.545	0.44
24_F	33_Y	0.545	0.44
6_A	9_A	0.544	0.44
603_Q	606_S	0.544	0.44
54_D	510_E	0.543	0.44
162_T	432_I	0.543	0.44
48_A	52_S	0.543	0.44
383_N	431_T	0.540	0.43
363_E	366_A	0.540	0.43
225_F	474_M	0.540	0.43
313_F	331_P	0.540	0.43
321_V	358_Y	0.540	0.43
79_A	168_K	0.539	0.43
204_D	208_N	0.539	0.43
550_K	619_E	0.539	0.43
268_A	297_K	0.538	0.43
544_V	547_A	0.538	0.43
223_T	434_Y	0.538	0.43
485_L	490_K	0.537	0.43
433_L	608_R	0.537	0.43
402_G	478_G	0.536	0.43
362_A	366_A	0.536	0.43
550_K	615_R	0.535	0.43
496_L	500_L	0.535	0.43
112_P	169_R	0.534	0.43
607_D	610_T	0.534	0.43
534_I	538_V	0.534	0.43
332_R	349_L	0.533	0.43
222_P	482_R	0.533	0.43
68_D	219_I	0.533	0.43
226_F	386_W	0.532	0.42
286_F	290_Q	0.531	0.42
79_A	97_R	0.531	0.42
22_D	26_D	0.531	0.42
76_M	206_L	0.530	0.42
565_Q	605_M	0.530	0.42
65_L	466_A	0.530	0.42
314_Q	318_Y	0.529	0.42
473_R	477_E	0.529	0.42
406_F	459_E	0.529	0.42
304_Q	431_T	0.528	0.42
154_Q	433_L	0.528	0.42
330_L	567_L	0.527	0.42
12_G	405_S	0.527	0.42
40_V	463_E	0.526	0.42
23_E	32_R	0.526	0.42
469_A	472_A	0.525	0.42
50_H	57_L	0.525	0.42
613_E	616_E	0.524	0.42
157_P	172_R	0.524	0.42
214_E	343_D	0.524	0.42
31_N	454_P	0.524	0.42
134_A	139_A	0.523	0.41
568_E	606_S	0.523	0.41
280_S	286_F	0.523	0.41
375_L	379_D	0.523	0.41
596_F	601_F	0.522	0.41
203_A	299_F	0.522	0.41
318_Y	323_T	0.522	0.41
23_E	551_M	0.521	0.41
319_P	441_E	0.521	0.41
96_A	100_V	0.521	0.41
154_Q	436_K	0.521	0.41
304_Q	436_K	0.520	0.41
412_W	579_V	0.519	0.41
154_Q	431_T	0.519	0.41
265_A	269_K	0.519	0.41
25_F	38_V	0.518	0.41
200_L	204_D	0.518	0.41
48_A	102_Y	0.518	0.41
582_P	594_P	0.517	0.41
390_Y	394_P	0.517	0.41
286_F	293_E	0.516	0.41
154_Q	171_F	0.516	0.41
158_R	559_T	0.516	0.41
486_D	489_I	0.516	0.41
59_D	63_E	0.515	0.41
197_R	200_L	0.515	0.41
283_I	290_Q	0.514	0.40
38_V	507_S	0.514	0.40
410_E	414_D	0.514	0.40
193_R	202_I	0.514	0.40
265_A	370_E	0.514	0.40
385_Y	431_T	0.514	0.40
249_D	252_L	0.514	0.40
306_F	436_K	0.513	0.40
402_G	513_G	0.513	0.40
158_R	427_L	0.513	0.40
193_R	196_T	0.513	0.40
144_F	195_Q	0.512	0.40
310_S	436_K	0.511	0.40
538_V	543_D	0.511	0.40
565_Q	606_S	0.509	0.40
223_T	330_L	0.508	0.40
432_I	556_D	0.508	0.40
231_D	306_F	0.507	0.40
555_A	569_E	0.507	0.40
310_S	317_V	0.506	0.40
429_H	434_Y	0.506	0.40
381_T	387_S	0.505	0.39
323_T	329_M	0.505	0.39
92_L	95_A	0.505	0.39
52_S	493_L	0.504	0.39
455_R	517_T	0.504	0.39
7_L	411_A	0.504	0.39
68_D	213_L	0.504	0.39
307_T	438_S	0.503	0.39
322_G	359_P	0.503	0.39
321_V	329_M	0.503	0.39
50_H	426_E	0.502	0.39
54_D	162_T	0.502	0.39
456_G	525_R	0.501	0.39
47_H	306_F	0.501	0.39
403_Y	457_Y	0.501	0.39
575_D	594_P	0.501	0.39
6_A	119_A	0.500	0.39
421_L	464_F	0.500	0.39

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4mnuA	2	0.1381	15.4	0.984	Contact Map
2fbkA	2	0.1111	14.1	0.984	Contact Map
3cdhA	4	0.1143	13.1	0.984	Contact Map
3boqA	2	0.1095	12.8	0.984	Contact Map
3s2wA	3	0.1254	12.6	0.984	Contact Map
2fa5A	2	0.1143	12.4	0.984	Contact Map
4iejA	1	0.0317	12.3	0.984	Contact Map
3deuA	2	0.1111	11.9	0.984	Contact Map
3u2rA	4	0.1127	11.4	0.985	Contact Map
4aikA	2	0.1238	11.3	0.985	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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