GREMLIN Database
DUF3160 - Protein of unknown function (DUF3160)
PFAM: PF11369 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 630 (623)
Sequences: 1917 (1626)
Seq/√Len: 65.2
META: 0.895

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
344_R414_D5.2911.00
509_K520_E4.6741.00
432_I555_A4.5911.00
73_L177_Y4.0151.00
103_F202_I3.9591.00
133_E172_R3.7341.00
162_T612_E3.4721.00
425_A569_E3.3911.00
607_D613_E3.3851.00
131_L142_P3.2751.00
473_R497_E3.2671.00
165_E168_K3.1461.00
150_E155_Y3.1311.00
310_S428_R3.0991.00
137_G153_S3.0671.00
580_V588_L3.0301.00
517_T520_E3.0221.00
575_D626_R3.0111.00
306_F311_Y2.9941.00
128_E152_Y2.9391.00
69_L219_I2.8481.00
364_Q367_K2.7741.00
603_Q607_D2.7631.00
328_R335_D2.7411.00
456_G524_I2.7271.00
480_E490_K2.7091.00
337_M420_A2.6161.00
465_Y507_S2.6121.00
156_K613_E2.5761.00
110_L173_A2.5711.00
438_S558_H2.4971.00
62_E164_S2.4771.00
44_S527_F2.4761.00
337_M417_L2.4581.00
150_E179_R2.4331.00
50_H430_D2.4141.00
130_A134_A2.3961.00
31_N38_V2.3951.00
504_K508_E2.3691.00
502_F520_E2.3471.00
155_Y179_R2.3441.00
508_E512_A2.3401.00
39_F406_F2.3001.00
469_A501_E2.2971.00
332_R355_D2.2831.00
308_P372_F2.2451.00
15_V595_V2.2301.00
244_K266_E2.2221.00
68_D218_R2.2221.00
307_T435_A2.2031.00
424_W557_V2.1991.00
175_M304_Q2.1871.00
388_W423_S2.1791.00
7_L11_N2.1771.00
502_F523_F2.1371.00
505_E520_E2.1241.00
598_Y627_P2.1221.00
310_S438_S2.1161.00
266_E269_K2.1071.00
7_L10_K2.0921.00
466_A504_K2.0731.00
74_K107_L2.0581.00
122_K126_E2.0501.00
231_D436_K2.0441.00
422_A596_F2.0301.00
135_A156_K2.0261.00
360_N363_E2.0241.00
425_A553_L2.0201.00
54_D160_H2.0121.00
476_R497_E2.0101.00
58_R163_R2.0031.00
557_V569_E1.9811.00
232_D300_R1.9721.00
66_Y166_E1.9411.00
333_G598_Y1.9311.00
581_V591_A1.9281.00
311_Y371_E1.9221.00
168_K172_R1.9031.00
469_A504_K1.8941.00
476_R494_E1.8871.00
226_F384_L1.8841.00
154_Q439_Y1.8831.00
560_D563_T1.8571.00
509_K514_E1.8421.00
129_L133_E1.8141.00
6_A10_K1.8091.00
49_Y475_T1.7991.00
346_L369_R1.7961.00
179_R439_Y1.7861.00
79_A82_A1.7791.00
471_L475_T1.7701.00
28_Y44_S1.7631.00
462_P507_S1.7601.00
89_G93_K1.7601.00
234_T237_E1.7601.00
259_K262_A1.7561.00
106_A109_L1.7541.00
99_N198_Q1.7481.00
506_I523_F1.7431.00
157_P168_K1.7431.00
77_L107_L1.7331.00
154_Q175_M1.7170.99
390_Y467_R1.7050.99
506_I516_L1.7020.99
333_G424_W1.7010.99
129_L132_I1.6930.99
72_L301_F1.6740.99
220_Y223_T1.6500.99
571_V596_F1.6490.99
333_G421_L1.6440.99
42_T461_N1.6140.99
339_A365_L1.6090.99
317_V438_S1.6080.99
73_L103_F1.5990.99
141_S152_Y1.5870.99
576_L592_R1.5840.99
376_D379_D1.5810.99
128_E141_S1.5680.99
338_A365_L1.5680.99
574_P594_P1.5620.99
529_G533_L1.5460.99
566_V605_M1.5430.99
76_M103_F1.5310.99
158_R556_D1.5290.99
126_E130_A1.5280.99
407_M510_E1.5250.99
106_A173_A1.5230.99
440_A558_H1.5170.99
557_V567_L1.5100.99
394_P467_R1.5050.99
154_Q179_R1.4990.99
97_R121_V1.4940.99
73_L106_A1.4930.99
603_Q609_L1.4800.98
196_T238_Y1.4800.98
183_R195_Q1.4770.98
68_D215_L1.4770.98
69_L110_L1.4680.98
583_D589_R1.4680.98
80_S103_F1.4580.98
333_G425_A1.4560.98
555_A568_E1.4550.98
163_R168_K1.4520.98
346_L365_L1.4510.98
407_M511_L1.4480.98
29_E33_Y1.4470.98
237_E271_R1.4440.98
551_M574_P1.4440.98
575_D597_S1.4380.98
49_Y471_L1.4350.98
330_L602_K1.4340.98
73_L107_L1.4280.98
315_Q364_Q1.4220.98
80_S99_N1.4210.98
200_L242_L1.4190.98
337_M396_L1.4160.98
79_A209_D1.4150.98
196_T199_A1.4150.98
75_A209_D1.4140.98
505_E508_E1.4100.98
425_A554_V1.4040.98
392_L423_S1.3990.98
225_F478_G1.3980.98
165_E169_R1.3940.98
390_Y393_R1.3890.98
310_S558_H1.3880.98
75_A212_A1.3870.98
101_A143_I1.3840.98
404_P407_M1.3810.98
313_F557_V1.3780.97
127_A131_L1.3710.97
468_L500_L1.3620.97
348_I414_D1.3580.97
131_L139_A1.3410.97
583_D587_K1.3400.97
441_E444_G1.3380.97
192_A196_T1.3380.97
569_E598_Y1.3360.97
227_V431_T1.3350.97
581_V589_R1.3330.97
553_L570_G1.3290.97
323_T327_P1.3290.97
383_N386_W1.3270.97
263_F267_L1.3220.97
442_M529_G1.3210.97
53_F431_T1.3170.97
53_F57_L1.3160.97
181_T298_G1.3080.97
317_V440_A1.3050.96
618_L623_A1.3040.96
154_Q437_Q1.3010.96
28_Y41_T1.2970.96
307_T310_S1.2960.96
81_L100_V1.2950.96
603_Q613_E1.2940.96
400_G403_Y1.2890.96
256_D259_K1.2890.96
499_L523_F1.2880.96
66_Y70_K1.2820.96
77_L100_V1.2760.96
39_F579_V1.2570.96
230_S234_T1.2550.96
223_T302_M1.2520.96
424_W428_R1.2450.95
315_Q320_R1.2450.95
505_E509_K1.2440.95
312_I339_A1.2410.95
100_V104_A1.2400.95
206_L235_P1.2360.95
4_E14_V1.2350.95
518_E522_E1.2350.95
424_W569_E1.2300.95
609_L617_M1.2290.95
521_Y524_I1.2280.95
98_R198_Q1.2260.95
50_H53_F1.2220.95
42_T464_F1.2140.95
38_V592_R1.2130.95
56_L226_F1.2130.95
83_Q205_A1.2100.95
199_A202_I1.2040.94
227_V383_N1.2000.94
321_V364_Q1.1980.94
72_L215_L1.1940.94
307_T428_R1.1860.94
39_F412_W1.1830.94
73_L173_A1.1830.94
77_L104_A1.1810.94
458_V503_L1.1800.94
395_L464_F1.1790.94
473_R501_E1.1780.94
360_N364_Q1.1740.94
200_L263_F1.1740.94
100_V120_E1.1730.94
71_E215_L1.1680.94
174_M302_M1.1670.94
318_Y321_V1.1560.93
347_E351_E1.1510.93
425_A598_Y1.1480.93
11_N411_A1.1460.93
344_R347_E1.1450.93
487_E490_K1.1420.93
217_D221_E1.1390.93
462_P465_Y1.1380.93
231_D303_G1.1310.92
554_V569_E1.1300.92
366_A369_R1.1290.92
123_D127_A1.1290.92
281_V285_P1.1250.92
102_Y301_F1.1170.92
582_P588_L1.1160.92
565_Q602_K1.1150.92
522_E525_R1.1140.92
111_D114_P1.1080.92
238_Y298_G1.1070.92
523_F530_Y1.1060.92
4_E16_V1.1030.91
330_L558_H1.1020.91
365_L369_R1.1010.91
232_D436_K1.0990.91
466_A508_E1.0950.91
220_Y302_M1.0920.91
199_A203_A1.0910.91
73_L80_S1.0890.91
317_V558_H1.0880.91
404_P511_L1.0870.91
272_P297_K1.0870.91
46_L464_F1.0860.91
350_D356_T1.0850.91
458_V528_G1.0820.91
469_A500_L1.0820.91
234_T299_F1.0800.91
192_A195_Q1.0800.91
283_I286_F1.0790.91
97_R124_L1.0780.90
227_V307_T1.0770.90
150_E180_M1.0690.90
443_G446_G1.0600.90
530_Y533_L1.0580.90
140_P149_K1.0490.89
184_L267_L1.0470.89
608_R611_D1.0440.89
104_A118_P1.0380.89
80_S100_V1.0370.89
379_D386_W1.0360.89
286_F289_E1.0310.88
330_L565_Q1.0300.88
31_N36_L1.0240.88
97_R120_E1.0220.88
74_K78_A1.0190.88
103_F177_Y1.0190.88
428_R558_H1.0190.88
251_D254_D1.0180.88
405_S408_Q1.0180.88
284_P287_T1.0150.88
314_Q320_R1.0130.88
185_A188_S1.0080.87
66_Y169_R1.0080.87
24_F574_P1.0020.87
271_R274_Q1.0010.87
568_E603_Q1.0010.87
30_D34_K1.0000.87
76_M301_F0.9990.87
98_R194_R0.9920.86
503_L528_G0.9880.86
46_L423_S0.9850.86
64_Y484_L0.9850.86
45_L500_L0.9840.86
213_L217_D0.9840.86
186_L190_E0.9840.86
8_L14_V0.9820.86
178_G303_G0.9790.86
280_S284_P0.9790.86
282_P285_P0.9780.86
24_F44_S0.9780.86
343_D369_R0.9770.86
304_Q434_Y0.9760.86
70_K111_D0.9740.85
337_M340_L0.9710.85
331_P558_H0.9690.85
154_Q559_T0.9690.85
578_Y590_L0.9680.85
494_E498_E0.9680.85
54_D555_A0.9670.85
241_L267_L0.9670.85
108_K111_D0.9640.85
401_E408_Q0.9640.85
573_Y618_L0.9630.85
342_S396_L0.9600.85
5_K9_A0.9580.84
8_L580_V0.9570.84
222_P484_L0.9560.84
178_G431_T0.9540.84
315_Q368_L0.9520.84
128_E131_L0.9520.84
285_P289_E0.9440.84
559_T608_R0.9430.83
560_D565_Q0.9410.83
428_R557_V0.9400.83
556_D559_T0.9390.83
437_Q556_D0.9370.83
40_V527_F0.9360.83
312_I336_V0.9360.83
325_T357_E0.9350.83
57_L160_H0.9340.83
31_N592_R0.9340.83
62_E163_R0.9330.83
237_E240_E0.9310.83
241_L263_F0.9300.83
399_K403_Y0.9280.83
95_A198_Q0.9270.82
103_F301_F0.9270.82
4_E19_P0.9250.82
158_R437_Q0.9190.82
564_G605_M0.9180.82
282_P286_F0.9180.82
354_G357_E0.9170.82
231_D310_S0.9150.82
156_K607_D0.9130.81
11_N14_V0.9120.81
616_E620_S0.9110.81
551_M571_V0.9100.81
101_A124_L0.9090.81
418_N626_R0.9080.81
100_V121_V0.9070.81
27_L594_P0.9060.81
339_A368_L0.9050.81
195_Q199_A0.9030.81
252_L255_L0.9020.81
335_D361_Y0.9020.81
519_E522_E0.9000.81
333_G557_V0.8990.80
407_M465_Y0.8980.80
416_E461_N0.8970.80
384_L475_T0.8970.80
428_R438_S0.8960.80
67_P166_E0.8950.80
541_W544_V0.8940.80
240_E244_K0.8920.80
469_A497_E0.8920.80
162_T168_K0.8880.80
350_D365_L0.8870.80
572_G599_Y0.8870.80
577_I595_V0.8860.79
548_D615_R0.8830.79
178_G304_Q0.8810.79
242_L263_F0.8800.79
324_Y327_P0.8800.79
509_K517_T0.8790.79
220_Y224_S0.8790.79
158_R433_L0.8780.79
96_A99_N0.8770.79
222_P227_V0.8770.79
193_R261_D0.8770.79
464_F468_L0.8770.79
461_N465_Y0.8770.79
420_A461_N0.8760.79
72_L219_I0.8740.79
217_D236_Y0.8730.78
437_Q559_T0.8710.78
387_S474_M0.8700.78
156_K172_R0.8690.78
426_E596_F0.8690.78
344_R413_Q0.8690.78
314_Q317_V0.8650.78
311_Y368_L0.8630.78
570_G573_Y0.8600.77
477_E481_S0.8590.77
229_E382_Q0.8580.77
70_K74_K0.8580.77
339_A372_F0.8560.77
332_R602_K0.8540.77
572_G597_S0.8520.77
322_G327_P0.8500.77
230_S303_G0.8500.77
45_L465_Y0.8500.77
429_H611_D0.8490.77
101_A121_V0.8480.76
151_D154_Q0.8460.76
323_T360_N0.8440.76
552_A573_Y0.8440.76
456_G521_Y0.8360.75
107_L112_P0.8310.75
394_P464_F0.8300.75
346_L356_T0.8300.75
578_Y592_R0.8300.75
53_F227_V0.8270.75
68_D71_E0.8260.75
105_V176_W0.8250.74
127_A130_A0.8250.74
483_G514_E0.8240.74
54_D430_D0.8240.74
79_A83_Q0.8240.74
568_E605_M0.8230.74
108_K114_P0.8230.74
316_L361_Y0.8210.74
437_Q608_R0.8210.74
490_K494_E0.8200.74
24_F551_M0.8190.74
625_P628_E0.8190.74
516_L521_Y0.8180.74
136_E139_A0.8180.74
406_F460_P0.8160.74
330_L560_D0.8150.74
84_Y97_R0.8130.73
578_Y594_P0.8120.73
69_L173_A0.8120.73
245_V266_E0.8120.73
66_Y110_L0.8110.73
329_M560_D0.8100.73
556_D608_R0.8090.73
333_G569_E0.8080.73
76_M202_I0.8080.73
194_R199_A0.8060.73
186_L189_E0.8060.73
352_E355_D0.8050.73
501_E504_K0.8040.73
70_K107_L0.8030.72
411_A414_D0.8010.72
196_T200_L0.8010.72
547_A615_R0.8000.72
287_T291_D0.7990.72
427_L430_D0.7980.72
122_K125_V0.7970.72
550_K573_Y0.7960.72
264_K267_L0.7950.72
366_A370_E0.7950.72
142_P152_Y0.7950.72
338_A361_Y0.7940.72
462_P466_A0.7920.71
118_P121_V0.7920.71
11_N15_V0.7910.71
457_Y510_E0.7900.71
171_F433_L0.7890.71
193_R264_K0.7880.71
24_F27_L0.7870.71
57_L434_Y0.7850.71
504_K507_S0.7840.71
280_S283_I0.7830.71
265_A268_A0.7830.71
415_K419_T0.7830.71
502_F505_E0.7820.70
184_L196_T0.7820.70
124_L143_I0.7810.70
603_Q617_M0.7800.70
117_V125_V0.7790.70
193_R257_E0.7790.70
502_F506_I0.7780.70
573_Y619_E0.7760.70
245_V259_K0.7760.70
403_Y407_M0.7750.70
566_V603_Q0.7710.69
15_V414_D0.7700.69
474_M478_G0.7700.69
469_A473_R0.7680.69
91_E197_R0.7670.69
134_A446_G0.7670.69
318_Y322_G0.7670.69
472_A497_E0.7660.69
65_L226_F0.7650.69
174_M305_R0.7610.68
191_D194_R0.7610.68
476_R490_K0.7610.68
433_L436_K0.7600.68
101_A125_V0.7590.68
59_D489_I0.7580.68
323_T359_P0.7570.68
421_L598_Y0.7500.67
430_D555_A0.7480.67
539_D543_D0.7480.67
107_L114_P0.7470.67
193_R197_R0.7460.67
53_F430_D0.7460.67
69_L174_M0.7440.67
328_R361_Y0.7420.66
129_L172_R0.7420.66
466_A474_M0.7400.66
342_S420_A0.7390.66
396_L420_A0.7350.66
95_A99_N0.7310.65
338_A346_L0.7300.65
400_G408_Q0.7270.65
429_H433_L0.7270.65
261_D264_K0.7260.65
503_L507_S0.7250.65
538_V541_W0.7240.64
506_I510_E0.7240.64
332_R352_E0.7230.64
179_R304_Q0.7230.64
55_Y59_D0.7230.64
308_P386_W0.7220.64
158_R171_F0.7210.64
601_F604_P0.7190.64
309_D385_Y0.7170.64
534_I537_G0.7170.64
94_E97_R0.7170.64
223_T227_V0.7170.64
174_M231_D0.7150.63
391_A394_P0.7150.63
461_N464_F0.7150.63
187_D191_D0.7130.63
131_L141_S0.7120.63
51_L55_Y0.7120.63
153_S559_T0.7120.63
203_A239_A0.7110.63
135_A386_W0.7100.63
194_R198_Q0.7090.63
197_R206_L0.7080.63
175_M179_R0.7070.63
331_P361_Y0.7030.62
537_G540_G0.7030.62
155_Y180_M0.7000.62
55_Y58_R0.6990.62
154_Q556_D0.6990.62
441_E445_G0.6980.62
25_F31_N0.6980.62
95_A197_R0.6980.62
4_E18_R0.6970.62
609_L613_E0.6950.61
85_E90_T0.6920.61
196_T264_K0.6920.61
211_E214_E0.6910.61
106_A177_Y0.6910.61
427_L431_T0.6910.61
121_V125_V0.6910.61
321_V360_N0.6900.61
410_E413_Q0.6890.61
210_S514_E0.6870.60
334_L380_W0.6860.60
348_I598_Y0.6860.60
62_E166_E0.6840.60
370_E374_A0.6830.60
162_T555_A0.6820.60
185_A190_E0.6790.60
342_S345_A0.6790.60
138_F561_P0.6770.59
213_L236_Y0.6760.59
455_R521_Y0.6750.59
210_S213_L0.6750.59
382_Q386_W0.6750.59
70_K169_R0.6740.59
82_A86_A0.6730.59
472_A500_L0.6720.59
214_E258_A0.6720.59
101_A141_S0.6710.59
22_D550_K0.6710.59
199_A238_Y0.6710.59
50_H54_D0.6690.58
80_S83_Q0.6680.58
119_A122_K0.6670.58
233_L237_E0.6650.58
175_M437_Q0.6650.58
287_T290_Q0.6640.58
458_V510_E0.6630.58
109_L172_R0.6620.58
199_A206_L0.6610.57
250_F255_L0.6610.57
217_D495_R0.6600.57
441_E447_P0.6590.57
39_F47_H0.6590.57
81_L85_E0.6590.57
456_G527_F0.6590.57
257_E261_D0.6570.57
174_M303_G0.6570.57
387_S471_L0.6570.57
94_E194_R0.6550.57
197_R260_L0.6550.57
75_A215_L0.6550.57
462_P504_K0.6540.57
559_T566_V0.6540.57
153_S437_Q0.6530.57
507_S628_E0.6530.57
72_L212_A0.6530.57
90_T93_K0.6520.56
80_S96_A0.6520.56
163_R612_E0.6520.56
332_R569_E0.6520.56
170_Y434_Y0.6510.56
24_F47_H0.6510.56
311_Y315_Q0.6510.56
71_E130_A0.6500.56
38_V456_G0.6500.56
101_A128_E0.6500.56
64_Y68_D0.6500.56
14_V112_P0.6460.56
403_Y511_L0.6460.56
126_E483_G0.6450.56
344_R348_I0.6440.56
174_M178_G0.6430.55
552_A574_P0.6430.55
174_M304_Q0.6420.55
426_E431_T0.6420.55
321_V328_R0.6410.55
158_R432_I0.6410.55
102_Y106_A0.6410.55
42_T416_E0.6410.55
160_H430_D0.6400.55
340_L420_A0.6390.55
159_G432_I0.6390.55
136_E401_E0.6370.55
203_A206_L0.6370.55
106_A176_W0.6360.55
433_L556_D0.6350.54
607_D617_M0.6340.54
232_D275_I0.6340.54
617_M623_A0.6340.54
275_I436_K0.6320.54
232_D568_E0.6310.54
302_M305_R0.6300.54
307_T385_Y0.6280.54
29_E32_R0.6270.54
526_N530_Y0.6270.54
394_P463_E0.6260.53
62_E167_L0.6260.53
331_P440_A0.6250.53
307_T312_I0.6250.53
425_A555_A0.6240.53
431_T434_Y0.6240.53
72_L206_L0.6230.53
46_L388_W0.6220.53
216_W431_T0.6200.53
350_D362_A0.6190.53
528_G532_E0.6190.53
154_Q178_G0.6180.52
388_W392_L0.6180.52
234_T626_R0.6180.52
196_T233_L0.6180.52
428_R432_I0.6170.52
370_E373_D0.6160.52
163_R547_A0.6160.52
475_T493_L0.6160.52
49_Y468_L0.6150.52
258_A261_D0.6150.52
24_F596_F0.6130.52
221_E482_R0.6130.52
374_A498_E0.6120.52
178_G300_R0.6120.52
4_E7_L0.6100.52
399_K416_E0.6090.51
487_E621_G0.6080.51
313_F336_V0.6070.51
170_Y421_L0.6070.51
139_A149_K0.6070.51
191_D195_Q0.6070.51
233_L238_Y0.6060.51
305_R433_L0.6050.51
621_G624_P0.6040.51
27_L592_R0.6040.51
27_L31_N0.6030.51
280_S285_P0.6030.51
419_T517_T0.6030.51
574_P589_R0.6030.51
153_S554_V0.6020.51
77_L81_L0.6010.50
57_L227_V0.6010.50
511_L528_G0.6000.50
108_K129_L0.5990.50
480_E483_G0.5990.50
86_A258_A0.5980.50
142_P145_G0.5970.50
178_G436_K0.5970.50
60_L66_Y0.5960.50
540_G543_D0.5960.50
160_H434_Y0.5950.50
470_A474_M0.5950.50
23_E29_E0.5950.50
593_G600_E0.5940.50
171_F556_D0.5940.50
158_R305_R0.5940.50
442_M447_P0.5940.50
8_L29_E0.5940.50
386_W474_M0.5930.50
16_V19_P0.5930.50
158_R434_Y0.5920.49
209_D212_A0.5910.49
270_L275_I0.5910.49
432_I568_E0.5890.49
330_L563_T0.5890.49
323_T326_G0.5880.49
178_G231_D0.5870.49
196_T203_A0.5860.49
576_L594_P0.5850.49
54_D58_R0.5850.49
307_T431_T0.5850.49
50_H436_K0.5850.49
309_D429_H0.5850.49
466_A507_S0.5850.49
120_E124_L0.5850.49
262_A266_E0.5840.49
53_F615_R0.5840.49
340_L389_L0.5840.49
447_P454_P0.5830.48
78_A82_A0.5810.48
419_T462_P0.5810.48
535_L540_G0.5810.48
560_D567_L0.5800.48
18_R576_L0.5790.48
343_D346_L0.5790.48
158_R608_R0.5790.48
285_P290_Q0.5780.48
281_V284_P0.5780.48
566_V606_S0.5770.48
79_A103_F0.5770.48
154_Q608_R0.5750.47
430_D434_Y0.5740.47
415_K456_G0.5730.47
108_K117_V0.5730.47
426_E510_E0.5720.47
391_A468_L0.5720.47
381_T474_M0.5710.47
176_W412_W0.5700.47
227_V435_A0.5700.47
83_Q204_D0.5700.47
583_D591_A0.5700.47
154_Q304_Q0.5700.47
303_G309_D0.5690.47
129_L135_A0.5680.47
444_G447_P0.5680.47
580_V590_L0.5680.47
244_K265_A0.5680.47
428_R435_A0.5670.47
200_L487_E0.5670.47
47_H426_E0.5670.47
610_T613_E0.5660.46
404_P528_G0.5650.46
33_Y443_G0.5650.46
312_I316_L0.5650.46
72_L479_L0.5640.46
436_K608_R0.5640.46
440_A562_N0.5640.46
428_R440_A0.5640.46
202_I205_A0.5630.46
87_L90_T0.5620.46
326_G357_E0.5620.46
388_W427_L0.5620.46
369_R373_D0.5610.46
418_N464_F0.5610.46
50_H160_H0.5610.46
387_S470_A0.5610.46
61_E161_Y0.5590.46
379_D382_Q0.5590.46
457_Y511_L0.5580.45
306_F434_Y0.5580.45
42_T415_K0.5580.45
84_Y100_V0.5580.45
285_P288_P0.5570.45
289_E292_D0.5570.45
210_S214_E0.5560.45
50_H429_H0.5540.45
214_E218_R0.5540.45
597_S626_R0.5540.45
90_T96_A0.5540.45
309_D437_Q0.5530.45
63_E486_D0.5530.45
158_R175_M0.5530.45
154_Q158_R0.5530.45
107_L111_D0.5520.45
212_A215_L0.5520.45
134_A169_R0.5520.45
220_Y230_S0.5520.45
29_E441_E0.5520.45
350_D357_E0.5510.45
385_Y427_L0.5510.45
122_K590_L0.5500.45
98_R102_Y0.5500.45
443_G447_P0.5500.45
424_W598_Y0.5480.44
313_F424_W0.5470.44
175_M439_Y0.5470.44
184_L238_Y0.5470.44
599_Y624_P0.5470.44
535_L538_V0.5460.44
561_P585_D0.5460.44
17_P575_D0.5460.44
375_L382_Q0.5460.44
146_Y195_Q0.5460.44
372_F574_P0.5460.44
158_R429_H0.5450.44
24_F33_Y0.5450.44
6_A9_A0.5440.44
603_Q606_S0.5440.44
54_D510_E0.5430.44
162_T432_I0.5430.44
48_A52_S0.5430.44
383_N431_T0.5400.43
363_E366_A0.5400.43
225_F474_M0.5400.43
313_F331_P0.5400.43
321_V358_Y0.5400.43
79_A168_K0.5390.43
204_D208_N0.5390.43
550_K619_E0.5390.43
268_A297_K0.5380.43
544_V547_A0.5380.43
223_T434_Y0.5380.43
485_L490_K0.5370.43
433_L608_R0.5370.43
402_G478_G0.5360.43
362_A366_A0.5360.43
550_K615_R0.5350.43
496_L500_L0.5350.43
112_P169_R0.5340.43
607_D610_T0.5340.43
534_I538_V0.5340.43
332_R349_L0.5330.43
222_P482_R0.5330.43
68_D219_I0.5330.43
226_F386_W0.5320.42
286_F290_Q0.5310.42
79_A97_R0.5310.42
22_D26_D0.5310.42
76_M206_L0.5300.42
565_Q605_M0.5300.42
65_L466_A0.5300.42
314_Q318_Y0.5290.42
473_R477_E0.5290.42
406_F459_E0.5290.42
304_Q431_T0.5280.42
154_Q433_L0.5280.42
330_L567_L0.5270.42
12_G405_S0.5270.42
40_V463_E0.5260.42
23_E32_R0.5260.42
469_A472_A0.5250.42
50_H57_L0.5250.42
613_E616_E0.5240.42
157_P172_R0.5240.42
214_E343_D0.5240.42
31_N454_P0.5240.42
134_A139_A0.5230.41
568_E606_S0.5230.41
280_S286_F0.5230.41
375_L379_D0.5230.41
596_F601_F0.5220.41
203_A299_F0.5220.41
318_Y323_T0.5220.41
23_E551_M0.5210.41
319_P441_E0.5210.41
96_A100_V0.5210.41
154_Q436_K0.5210.41
304_Q436_K0.5200.41
412_W579_V0.5190.41
154_Q431_T0.5190.41
265_A269_K0.5190.41
25_F38_V0.5180.41
200_L204_D0.5180.41
48_A102_Y0.5180.41
582_P594_P0.5170.41
390_Y394_P0.5170.41
286_F293_E0.5160.41
154_Q171_F0.5160.41
158_R559_T0.5160.41
486_D489_I0.5160.41
59_D63_E0.5150.41
197_R200_L0.5150.41
283_I290_Q0.5140.40
38_V507_S0.5140.40
410_E414_D0.5140.40
193_R202_I0.5140.40
265_A370_E0.5140.40
385_Y431_T0.5140.40
249_D252_L0.5140.40
306_F436_K0.5130.40
402_G513_G0.5130.40
158_R427_L0.5130.40
193_R196_T0.5130.40
144_F195_Q0.5120.40
310_S436_K0.5110.40
538_V543_D0.5110.40
565_Q606_S0.5090.40
223_T330_L0.5080.40
432_I556_D0.5080.40
231_D306_F0.5070.40
555_A569_E0.5070.40
310_S317_V0.5060.40
429_H434_Y0.5060.40
381_T387_S0.5050.39
323_T329_M0.5050.39
92_L95_A0.5050.39
52_S493_L0.5040.39
455_R517_T0.5040.39
7_L411_A0.5040.39
68_D213_L0.5040.39
307_T438_S0.5030.39
322_G359_P0.5030.39
321_V329_M0.5030.39
50_H426_E0.5020.39
54_D162_T0.5020.39
456_G525_R0.5010.39
47_H306_F0.5010.39
403_Y457_Y0.5010.39
575_D594_P0.5010.39
6_A119_A0.5000.39
421_L464_F0.5000.39
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4mnuA 2 0.1381 15.4 0.984 Contact Map
2fbkA 2 0.1111 14.1 0.984 Contact Map
3cdhA 4 0.1143 13.1 0.984 Contact Map
3boqA 2 0.1095 12.8 0.984 Contact Map
3s2wA 3 0.1254 12.6 0.984 Contact Map
2fa5A 2 0.1143 12.4 0.984 Contact Map
4iejA 1 0.0317 12.3 0.984 Contact Map
3deuA 2 0.1111 11.9 0.984 Contact Map
3u2rA 4 0.1127 11.4 0.985 Contact Map
4aikA 2 0.1238 11.3 0.985 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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